Review
Biochemistry & Molecular Biology
Irina P. Voronova
Summary: This review discusses the influence of serotonin receptors on body temperature regulation in warm-blooded animals, covering different receptor types and their activation effects on temperature.
Article
Chemistry, Multidisciplinary
Barbara A. Bricker, Chandrashekhar Voshavar, Edem K. Onyameh, Uma M. Gonela, Xinsong Lin, Tracy L. Swanson, Laura B. Kozell, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: In this study, we synthesized and separated the enantiomers of SYA0340, identified their absolute configurations, and evaluated their binding affinities and functional characteristics at the 5-HT1A and 5-HT7A receptors. The results showed that both enantiomers have similar agonist properties at the 5-HT1A receptor and antagonist properties at the 5-HT7A receptor, with SYA0340-P1 displaying higher potency as a 5-HT1A receptor antagonist. Therefore, SYA0340-P1 is considered the eutomer and these enantiomers may serve as new pharmacological probes for the 5-HT1A and 5-HT7A receptors.
Article
Biochemistry & Molecular Biology
Martyna Z. Wrobel, Andrzej Chodkowski, Maciej Dawidowski, Agata Siwek, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Grzegorz Satala, Andrzej J. Bojarski, Jadwiga Turlo
Summary: The synthesis and evaluation of new compounds targeting the serotonin 1A receptors and serotonin transporter in the treatment of central nervous system diseases, especially depression, were conducted. Compound 4f emerged as the most promising with good activity, stability, and potential as a therapeutic agent.
BIOORGANIC CHEMISTRY
(2023)
Article
Clinical Neurology
Darakhshan Jabeen Haleem
Summary: The global prevalence of depression is increasing, but the current treatment outcome is unsatisfactory. Stress-related epigenetic changes and the role of serotonin and 5-HT1A receptors in the pathogenesis and treatment of depression are important. Synthetic compounds targeting GC and 5-HT1A receptors may be better therapeutic agents for depression.
Article
Clinical Neurology
Gordana Nedic Erjavec, Lucija Tudor, Matea Nikolac Perkovic, Josip Podobnik, Katarina Dodig Curkovic, Mario Curkovic, Dubravka Svob Strac, Melita Cusek, Marco Bortolato, Nela Pivac
Summary: This study found an association between genetic polymorphisms of the 5-HT2A receptor and conduct disorder (CD). Certain genetic variations were strongly linked to irritability, physical aggression, and antisocial behavior. Additionally, CD subjects had significantly higher platelet 5-HT concentrations, which correlated with smoking status.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Developmental Biology
Carla Arganaraz, Tamara S. Adjimann, Paula P. Perissinotti, Mariano Soiza-Reilly
Summary: Serotonin neurons are involved in anxiety and depression. This study investigated the developmental trajectory of synaptic inputs to these neurons and found that cortical glutamate and subcortical GABA inputs undergo refinement during postnatal development, while subcortical glutamate inputs do not. This refinement process is accompanied by the presence of inhibitory mechanisms. These findings contribute to our understanding of neurodevelopmental vulnerability to psychiatric disorders.
Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Adrian Newman-Tancredi, Ronan Y. Depoortere, Mark S. Kleven, Marcin Kolaczkowski, Luc Zimmer
Summary: Biased agonism at G-protein-coupled receptors has gained increasing interest for the discovery of more effective and safer drugs. However, most studies are limited to in vitro tests, and few biased agonists have been tested in vivo. The study of biased agonism at 5-HT1A receptors has been limited by the availability of ligands with poor target selectivity or partial agonism. However, the development of new selective and efficacious agonists has advanced the study of biased agonism at this receptor and opened up new therapeutic opportunities.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Nina K. Popova, Anton S. Tsybko, Vladimir S. Naumenko
Summary: This article reviews the neurobiological links between aggression, depression, and suicidal behavior, focusing on the involvement of different types of 5-HT receptors. It provides evidence that specific 5-HT receptors are associated with depression-related and aggression-related behaviors, and highlights the potential of targeting these receptors for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
William H. Powell, Lucy E. Annett, Ronan Depoortere, Adrian Newman-Tancredi, Mahmoud M. Iravani
Summary: Anxiety is a common neuropsychiatric disorder with abnormalities in serotonergic function playing a role in its pathogenesis. NLX-112, a highly selective 5-HT1A receptor full agonist, has been shown to alleviate anxiety-like behaviors in mice, potentially possessing anxiolytic properties.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Neurosciences
Arianna Gentile Polese, Sunny Nigam, Laura M. Hurley
Summary: The study found that serotonin in the inferior colliculus may have differential effects on auditory processing of different BBVs, partly through inhibition of the 5-HT1A receptor.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Neurosciences
Marcus Saarinen, Ioannis Mantas, Ivana Flais, Richard Agren, Kristoffer Sahlholm, Mark J. Millan, Per Svenningsson
Summary: SEP-383856 (SEP-856) is a novel antipsychotic with a unique pattern of receptor interaction, showing agonist activity at TAAR1 and 5-HT1A receptors. Research indicates its potential advantages in treating schizophrenia and other psychotic disorders.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeong-Hee Kim, Hang-Keun Kim, Young-Don Son, Jong-Hoon Kim
Summary: This study explored the relationship between 5-HT2A receptor availability and aggression traits in healthy individuals, and found significant positive correlations between 5-HT2A receptor availability and overall aggression score as well as scores on different aggression subscales in multiple brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Hirohito Esaki, Yuki Sasaki, Naoya Nishitani, Hikari Kamada, Satoko Mukai, Yoshitaka Ohshima, Sao Nakada, Xiyan Ni, Satoshi Deyama, Katsuyuki Kaneda
Summary: This study examined whether the prosocial effects induced by MDMA are mediated by 5-HT neurotransmission in the medial prefrontal cortex (mPFC) and the basolateral nucleus of amygdala (BLA). The results showed that selective inhibition of 5-HT transporters before MDMA administration did not suppress the prosocial effects. However, the 5-HT1A receptor antagonist WAY100635 significantly suppressed the prosocial effects of MDMA. Furthermore, local administration of WAY100635 into the BLA, but not the mPFC, suppressed the MDMA-induced prosocial effects. These findings suggest that MDMA induces prosocial effects through the stimulation of 5-HT1A receptors in the BLA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Psychology, Multidisciplinary
Kajol V. Sontate, Mohammad Rahim Kamaluddin, Isa Naina Mohamed, Rashidi Mohamed Pakri Mohamed, Mohd. Farooq Shaikh, Haziq Kamal, Jaya Kumar
Summary: Long-term alcohol consumption can lead to morphological changes in the brain, increasing the risk of individuals committing violent crimes, especially under the influence of alcohol. Individuals prone to aggressive behaviors are more likely to impulsively commit violent crimes under the influence of alcohol.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Doretta Caramaschi, Gemma C. Sharp, Ellen A. Nohr, Katie Berryman, Sarah J. Lewis, George Davey Smith, Caroline L. Relton
HUMAN MOLECULAR GENETICS
(2017)
Article
Multidisciplinary Sciences
Nadine Provencal, Matthew J. Suderman, Doretta Caramaschi, Dongsha Wang, Michael Hallett, Frank Vitaro, Richard E. Tremblay, Moshe Szyf
Article
Psychiatry
Doretta Caramaschi, Amy E. Taylor, Rebecca C. Richmond, Karoline Alexandra Havdahl, Jean Golding, Caroline L. Relton, Marcus R. Munafo, George Davey Smith, Dheeraj Rai
TRANSLATIONAL PSYCHIATRY
(2018)
Review
Genetics & Heredity
Esther Walton, Caroline L. Relton, Doretta Caramaschi
Article
Nutrition & Dietetics
Veronika V. Odintsova, Fiona A. Hagenbeek, Matthew Suderman, Doretta Caramaschi, Catharina E. M. van Beijsterveldt, Noah A. Kallsen, Erik A. Ehli, Gareth E. Davies, Gennady T. Sukhikh, Vassilios Fanos, Caroline Belton, Meike Bartels, Dorret Boomsma, Jenny van Dongen
Article
Oncology
Doretta Caramaschi, Charlie Hatcher, Rosa H. Mulder, Janine F. Felix, Charlotte A. M. Cecil, Caroline L. Relton, Esther Walton
CLINICAL EPIGENETICS
(2020)
Article
Anthropology
Sinead English, India Wright, Verity Ashburn, Gemma Ford, Doretta Caramaschi
ANNALS OF HUMAN BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Justiina Ronkainen, Anni Heiskala, Florianne O. L. Vehmeijer, Estelle Lowry, Doretta Caramaschi, Guadalupe Estrada Gutierrez, Jonathan A. Heiss, Nadine Hummel, Elina Keikkala, Tuomas Kvist, Allison Kupsco, Phillip E. Melton, Giancarlo Pesce, Munawar H. Soomro, Marta Vives-Usano, Nour Baiz, Elisabeth Binder, Darina Czamara, Monica Guxens, Sanna Mustaniemi, Stephanie J. London, Sebastian Rauschert, Marja Vaarasmaki, Martine Vrijheid, Anette-G. Ziegler, Isabella Annesi-Maesano, Mariona Bustamante, Rae-Chi Huang, Sandra Hummel, Allan C. Just, Eero Kajantie, Jari Lahti, Deborah Lawlor, Katri Raikkonen, Marjo-Riitta Jarvelin, Janine F. Felix, Sylvain Sebert
Summary: This study did not find evidence for an association between maternal hemoglobin levels during pregnancy and offspring DNA methylation. However, it does not rule out the possibility that such associations could be seen in studies with more extreme maternal hemoglobin levels. Most participants had maternal hemoglobin levels within the normal range, while adverse perinatal outcomes typically arise in extreme cases.
Article
Biochemistry & Molecular Biology
Sara Sammallahti, Andrea P. Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder, Kelly J. Brunst, Silvia Alemany, Nancy S. McBride, Paul Yousefi, Jonathan A. Heiss, Nia McRae, Christian M. Page, Jianping Jin, Giancarlo Pesce, Doretta Caramaschi, Sheryl L. Rifas-Shiman, Nastassja Koen, Charleen D. Adams, Maria C. Magnus, Nour Baiz, Andrew Ratanatharathorn, Darina Czamara, Siri E. Haberg, Elena Colicino, Andrea A. Baccarelli, Andres Cardenas, Dawn L. DeMeo, Deborah A. Lawlor, Caroline L. Relton, Janine F. Felix, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, Eero Kajantie, Katri Raikkonen, Jordi Sunyer, Gemma C. Sharp, Lotte C. Houtepen, Ellen A. Nohr, Thorkild I. A. Sorensen, Martha M. Tellez-Rojo, Robert O. Wright, Isabella Annesi-Maesano, John Wright, Marie-France Hivert, Rosalind J. Wright, Heather J. Zar, Dan J. Stein, Stephanie J. London, Charlotte A. M. Cecil, Henning Tiemeier, Jari Lahti
Summary: This study did not find consistent evidence of robust associations between maternal anxiety during pregnancy and genome-wide DNAm in umbilical cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the foetal epigenome.
MOLECULAR PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Doretta Caramaschi, James Jungius, Christian M. Page, Boris Novakovic, Richard Saffery, Jane Halliday, Sharon Lewis, Maria C. Magnus, Stephanie J. London, Siri E. Haberg, Caroline L. Relton, Deborah A. Lawlor, Hannah R. Elliott
Summary: This study did not find strong evidence linking medically assisted reproduction with variation in infant blood cell DNA methylation. While some associations were detected in two study cohorts, they were not replicated in another cohort, suggesting the need for further research to identify replicable variation in DNA methylation due to medically assisted reproduction.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Doretta Caramaschi, Alexander Neumann, Andres Cardenas, Gwen Tindula, Silvia Alemany, Lea Zillich, Giancarlo Pesce, Jari M. T. Lahti, Alexandra Havdahl, Rosa Mulder, Janine F. Felix, Henning Tiemeier, Lea Sirignano, Josef Frank, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Karen Huen, Brenda Eskenazi, Tabea Sarah Send, Muriel Ferrer, Maria Gilles, Maria de Agostini, Nour Baiz, Sheryl L. Rifas-Shiman, Tuomas Kvist, Darina Czamara, Samuli T. Tuominen, Caroline L. Relton, Dheeraj Rai, Stephanie J. London, Katri Raikkonen, Nina Holland, Isabella Annesi-Maesano, Fabian Streit, Marie-France Hivert, Emily Oken, Jordi Sunyer, Charlotte A. M. Cecil, Gemma Sharp
Summary: The study found that there is little evidence to support the association between cord blood DNA methylation at single CpG sites and cognitive skills in children, except for a weak association in a region near DUSP22 on chromosome 6 with non-verbal cognition. Further studies are needed to confirm this association.
MOLECULAR PSYCHIATRY
(2022)
Article
Genetics & Heredity
Xueyi Shen, Doretta Caramaschi, Mark J. Adams, Rosie M. Walker, Josine L. Min, Alex Kwong, Gibran Hemani, Miruna C. Barbu, Heather C. Whalley, Sarah E. Harris, Ian J. Deary, Stewart W. Morris, Simon R. Cox, Caroline L. Relton, Riccardo E. Marioni, Kathryn L. Evans, Andrew M. McIntosh
Summary: This study found associations between polygenic risk scores for depression and DNA methylation, particularly in genes related to immune responses and neural development. Results from Mendelian randomization analysis suggested a causal effect of DNA methylation on depression.
Article
Biochemistry & Molecular Biology
Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortes Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Haberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Huls, Nastassja Koen, Stephanie J. London, Maria C. Magnus, Giulia Mancano, Rosa H. Mulder, Christian M. Page, Katri Raikkonen, Stefan Roeder, Rebecca J. Schmidt, Tabea S. Send, Gemma Sharp, Dan J. Stein, Fabian Streit, Johanna Tuhkanen, Stephanie H. Witt, Heather J. Zar, Ana C. Zenclussen, Yining Zhang, Lea Zillich, Rosalind Wright, Jari Lahti, Kelly J. Brunst
Summary: Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. This meta-analysis examined the association between maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of specific genes implicated in neurodevelopment, neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. These findings provide novel insights into potential mechanisms of neurodevelopment in offspring.
MOLECULAR PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Fernando Pires Hartwig, George Davey Smith, Andrew J. Simpkin, Cesar Gomes Victora, Caroline L. Relton, Doretta Caramaschi
Article
Psychiatry
Alexander Neumann, Esther Walton, Silvia Alemany, Charlotte Cecil, Juan Ramon Gonzalez, Dereje D. Jima, Jari Lahti, Samuli T. Tuominen, Edward D. Barker, Elisabeth Binder, Doretta Caramaschi, Angel Carracedo, Darina Czamara, Jorunn Evandt, Janine F. Felix, Bernard F. Fuemmeler, Kristine B. Gutzkow, Cathrine Hoyo, Jordi Julvez, Eero Kajantie, Hannele Laivuori, Rachel Maguire, Lea Maitre, Susan K. Murphy, Mario Murcia, Pia M. Villa, Gemma Sharp, Jordi Sunyer, Katri Raikkonen, Marian Bakermans-Kranenburg, Marinus van Ijzendoorn, Monica Guxens, Caroline L. Relton, Henning Tiemeier
TRANSLATIONAL PSYCHIATRY
(2020)