Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease

Inhibition of the Fe(III)-Catalyzed Dopamine Oxidation by ATP and Its Relevance to Oxidative Stress in Parkinson’s Disease

(2013) Dianlu Jiang et al.   ACS Chemical Neuroscience

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutation in theSYNJ1Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism

(2013) Marialuisa Quadri et al.   HUMAN MUTATION

The Sac1 Domain ofSYNJ1Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures

(2013) Catharine E. Krebs et al.   HUMAN MUTATION

PTL-1 regulates neuronal integrity and lifespan in C. elegans

(2013) Y. L. Chew et al.   JOURNAL OF CELL SCIENCE

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism

(2013) Raja Settivari et al.   NEUROTOXICOLOGY

Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective

(2013) Daniele Cartelli et al.   Scientific Reports

Metallochaperones Regulate Intracellular Copper Levels

(2013) W. Lee Pang et al.   PLoS Computational Biology

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

α-Synuclein knockout mice have cognitive impairments

(2012) V.S. Kokhan et al.   BEHAVIOURAL BRAIN RESEARCH

Dopamine D2 Receptor Antagonism Suppresses Tau Aggregation and Neurotoxicity

(2012) Allyson V. McCormick et al.   BIOLOGICAL PSYCHIATRY

Unincorporated iron pool is linked to oxidative stress and iron levels in Caenorhabditis elegans

(2012) Natalie A. Rangel et al.   BIOMETALS

Iron toxicity in neurodegeneration

(2012) Marco T. Núñez et al.   BIOMETALS

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration

(2012) Natalia VanDuyn et al.   JOURNAL OF NEUROCHEMISTRY

Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans

(2012) Sara Valentini et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

(2012) Gawain McColl et al.   Molecular Neurodegeneration

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability

(2012) Çiğdem Köroğlu et al.   PARKINSONISM & RELATED DISORDERS

A Deleterious Mutation in DNAJC6 Encoding the Neuronal-Specific Clathrin-Uncoating Co-Chaperone Auxilin, Is Associated with Juvenile Parkinsonism

(2012) Simon Edvardson et al.   PLoS One

Ceruloplasmin and iron in Alzheimer’s disease and Parkinson’s disease: a synopsis of recent studies

(2012) Jon Snaedal et al.   Neuropsychiatric Disease and Treatment

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

(2011) Marie-Christine Chartier-Harlin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis

(2011) Hélène Catoire et al.   ANNALS OF NEUROLOGY

Neurodegeneration Across Stages of Cognitive Decline in Parkinson Disease

(2011) Daniel Weintraub   ARCHIVES OF NEUROLOGY

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions

(2011) Linnea R. Freeman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The redox stress hypothesis of aging

(2011) Rajindar S. Sohal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms

(2011) Daniel F. Tardiff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport

(2011) Nicholas M. Kanaan et al.   NEUROBIOLOGY OF AGING

Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa

(2011) Yoland Smith et al.   NEUROPSYCHOPHARMACOLOGY

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

SKN-1/Nrf2 Inhibits Dopamine Neuron Degeneration in a Caenorhabditis elegans Model of Methylmercury Toxicity

(2010) Natalia VanDuyn et al.   TOXICOLOGICAL SCIENCES

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

(2009) L. J. Su et al.   Disease Models & Mechanisms

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Non-synonymous GIGYF2 variants in Parkinson’s disease from two Asian populations

(2009) Eng-King Tan et al.   HUMAN GENETICS

The Divalent Metal Transporter Homologues SMF-1/2 Mediate Dopamine Neuron Sensitivity in Caenorhabditis elegans Models of Manganism and Parkinson Disease

(2009) Raja Settivari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Caenorhabditis elegans Aβ1–42Model of Alzheimer Disease Predominantly Expresses Aβ3–42

(2009) Gawain McColl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditits elegansLRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth

(2009) Julia Sämann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron elevations in the aging Parkinsonian brain: a consequence of impaired iron homeostasis?

(2009) Donna W. Lee et al.   JOURNAL OF NEUROCHEMISTRY

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

(2009) S. Saha et al.   JOURNAL OF NEUROSCIENCE

Metalloproteins and metal sensing

(2009) Kevin J. Waldron et al.   NATURE

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease

(2009) Qingmin Ruan et al.   NEUROBIOLOGY OF DISEASE

Dopamine neuron degeneration induced by MPP+ is independent of CED-4 pathway in Caenorhabditis elegans

(2008) Pu Pu et al.   CELL RESEARCH

The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans

(2008) Patricia Gordon et al.   DEVELOPMENT GENES AND EVOLUTION

Lack of replication of association between GIGYF2 variants and Parkinson disease

(2008) J. Bras et al.   HUMAN MOLECULAR GENETICS

Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls

(2008) J. Simon-Sanchez et al.   HUMAN MOLECULAR GENETICS

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

(2008) Tomoki Kuwahara et al.   HUMAN MOLECULAR GENETICS

Metal ions in biological catalysis: from enzyme databases to general principles

(2008) Claudia Andreini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years

(2008) Mariese A. Hely et al.   MOVEMENT DISORDERS

Dementia and survival in Parkinson disease: A 12-year population study

(2008) T. C. Buter et al.   NEUROLOGY

Phosphorylation of tau and α-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer’s disease, and in Parkinson’s disease and related α-synucleinopathies

(2008) G. Muntané et al.   NEUROSCIENCE

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Tau-Induced Traffic Jams Reflect Organelles Accumulation at Points of Microtubule Polar Mismatching

(2008) Or A. Shemesh et al.   TRAFFIC

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics

A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

(2007) Roland Brandt et al.   NEUROBIOLOGY OF AGING