The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture

(2010) Hafiz Mohmmad Abdul et al.   AGING CELL

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

A calcineurin/AKAP complex is required for NMDA receptor–dependent long-term depression

(2010) Sandra Jurado et al.   NATURE NEUROSCIENCE

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

(2010) Tara L. Spires-Jones et al.   NEUROSCIENCE LETTERS

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

(2010) Abhisek Mukherjee et al.   PLoS Pathogens

Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition

(2009) Giulio Taglialatela et al.   BEHAVIOURAL BRAIN RESEARCH

Involvement of Akt in neurite outgrowth

(2009) Danielle E. Read et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation

(2009) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cells

(2009) Yeni Kim et al.   JOURNAL OF NEUROCHEMISTRY

A Role for Synaptic Zinc in Activity-Dependent A  Oligomer Formation and Accumulation at Excitatory Synapses

(2009) A. Deshpande et al.   JOURNAL OF NEUROSCIENCE

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor-dependent signaling pathways that underlie amyloid β-protein disruption of LTP in the hippocampus

(2009) Ghiam Yamin   JOURNAL OF NEUROSCIENCE RESEARCH

MAP'ing CNS Development and Cognition: An ERKsome Process

(2009) Ivy S. Samuels et al.   NEURON

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER stress is involved in Aβ‐induced GSK‐3β activation and tau phosphorylation

(2008) Rosa Resende et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Overactivation of calcineurin induced by amyloid-beta and prion proteins

(2008) Paula Agostinho et al.   NEUROCHEMISTRY INTERNATIONAL

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease

(2007) Peter J. Crouch et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY