Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Nutrition & Dietetics
Ewelina A. Dziedzic, Jakub S. Gasior, Agnieszka Tuzimek, Marek Dabrowski, Waclaw Kochman
Summary: This study investigated the differences in monocyte-to-HDL ratio (MHR) and serum 25-hydroxyvitamin D (25(OH)D) concentration between male patients with different diagnoses of chronic coronary syndrome (CCS), and analyzed the correlation between 25(OH)D and MHR in this group. The results showed significant differences in 25(OH)D and MHR between acute coronary syndrome (ACS) patients and CCS patients, with the highest HDL and serum 25(OH)D concentrations observed in patients with CCS, and the highest value of MHR observed in patients with ST-elevation myocardial infarction (STEMI). There was also a significant correlation observed between 25(OH)D, HDL, and MHR.
Article
Radiology, Nuclear Medicine & Medical Imaging
Changjing Feng, Rui Chen, Siting Dong, Wei Deng, Shushen Lin, Xiaomei Zhu, Wangyan Liu, Yi Xu, Xiaohu Li, Yinsu Zhu
Summary: By analyzing clinical data and CCTA images of 400 patients, it was found that FAI and NCPB were independent risk factors for coronary plaque progression. Combining conventional parameters with radiomics features derived from CCTA can better predict plaque progression.
EUROPEAN RADIOLOGY
(2023)
Article
Nutrition & Dietetics
Zhenyu Zhong, Guannan Su, Liping Du, Qingyun Zhou, Fuzhen Li, Wei Chi, Shengyun Liu, Meifen Zhang, Xianbo Zuo, Peizeng Yang
Summary: This study using Mendelian randomization found that genetically increased serum 25-hydroxyvitamin D levels were associated with a higher risk of Behcet's disease, with data from Chinese and Turkish cohorts supporting this conclusion. The contribution to Behcet's disease risk may increase with higher levels of vitamin D.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Roger Bouillon, Jose Manuel Quesada Gomez
Summary: Vitamin D deficiency affects a significant portion of the world's population, with 7% having severe deficiency and one third having mild deficiency. This study compares the effectiveness of calcifediol or 25-hydroxyvitamin D (25OHD) versus vitamin D itself in preventing or treating deficiency. Calcifediol has higher absorption rates, is immediately accessible to the circulation, and is more potent than vitamin D, especially in cases of fat malabsorption or after bariatric surgery. It may be a preferred option for correcting deficiency in individuals with impaired liver 25-hydroxylase activity.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Review
Biochemistry & Molecular Biology
Alfonso Rodriguez-Gil, Estrella Carrillo-Cruz, Cristina Marrero-Cepeda, Guillermo Rodriguez, Jose A. Perez-Simon
Summary: Vitamin D plays a dual role in the immune system and tumor cells, potentially decreasing graft-versus-host disease and relapse rates.
Article
Endocrinology & Metabolism
Suyan Duan, Fang Lu, Buyun Wu, Chengning Zhang, Guangyan Nie, Lianqin Sun, Zhimin Huang, Honglei Guo, Bo Zhang, Changying Xing, Yanggang Yuan
Summary: This study found that decreased levels of 25-hydroxyvitamin D (25(OH)D) in patients with type 2 diabetes mellitus (T2DM) were associated with deteriorated renal function and increased risk of chronic kidney disease (CKD) progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fangjing Zhou, Ning Ma, Ruiting Su, Xiaoyu He, Xiaona Wang, Yang Zhou, Jing Shi
Summary: This study explored the relationship between serum 25 (OH)D and severe periodontitis using data from 2928 participants. The results revealed a nonlinear association between serum 25 (OH)D and severe periodontitis, with a negative correlation observed when serum 25 (OH)D levels were less than 102 nmol/L. Subgroup analysis showed significant changes in non-Hispanic white, alcohol consumption, diabetes, and health insurance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Liu Yang, Peng Peng Xu, U. Joseph Schoepf, Christian Tesche, Balakrishnan Pillai, Rock H. Savage, Chun Xiang Tang, Fan Zhou, Hao Dong Wei, Zhong Qiang Luo, Qing Gen Wang, Chang Sheng Zhou, Meng Jie Lu, Guang Ming Lu, Long Jiang Zhang
Summary: Fractional flow reserve and plaque progression assessed by serial coronary CT angiography predicted the risk of future major adverse cardiovascular events (MACE), demonstrating better accuracy compared to traditional assessment markers.
EUROPEAN RADIOLOGY
(2021)
Article
Veterinary Sciences
Jared A. Jaffey, Michael R. Lappin, Randy Ringold, Rachael Kreisler, Nancy Bradley-Siemens, Jennifer Hawley, Andrew Sun, Cody Blakeman, Nancy Mayer
Summary: The study revealed that shelter dogs with CIRDC symptoms had lower 25(OH)D concentrations compared to healthy shelter dogs, and dogs testing positive for canine herpesvirus (CHV)-1 DNA also showed significantly lower 25(OH)D levels.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Pawel Zebryk, Jan Krzysztof Nowak, Tomasz Piorunek, Tatiana Mularek-Kubzdela, Mariusz Puszczewicz
Summary: This study evaluated the associations between vitamin D levels and clinical and laboratory features of systemic sclerosis (SSc). The study found that vitamin D deficiency was associated with arterial hypertension, proteinuria, lung involvement, and increased CRP in SSc patients.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Jie Gao, Arve Ulvik, Adrian McCann, Per Magne Ueland, Klaus Meyer
Summary: The study investigated the stability of inflammatory and renal function markers in blood samples, finding high stability and reproducibility of CRP and SAA proteoforms under different conditions, while minor changes were identified in S100A8/9 and CnC. These findings contribute to the selection of appropriate biomarkers in future biobank studies.
Article
Gastroenterology & Hepatology
Martin Kummen, Louise B. Thingholm, Malte C. Ruhlemann, Kristian Holm, Simen H. Hansen, Lucas Moitinho-Silva, Timur Liwinski, Roman Zenouzi, Christopher Storm-Larsen, Oyvind Midttun, Adrian McCann, Per M. Ueland, Marte L. Hoivik, Mette Vesterhus, Marius Troseid, Matthias Laudes, Wolfgang Lieb, Tom H. Karlsen, Corinna Bang, Christoph Schramm, Andre Franke, Johannes R. Hov
Summary: The study found significant functional differences in the gut microbiome of PSC patients, including microbial metabolism of essential nutrients. Changes in related circulating metabolites associated with disease course suggest that microbial functions may be relevant for the disease process in PSC.
Article
Nutrition & Dietetics
Ingrid Kvestad, Adrian McCann, Ram K. Chandyo, Lasse M. Giil, Merina Shrestha, Manjeswori Ulak, Mari Hysing, Per M. Ueland, Tor A. Strand
Summary: This study examined the relationship between one-carbon metabolism in Nepalese mother-infant pairs and child cognition. The findings suggest that elevated plasma cystathionine during infancy reflects impaired one-carbon metabolism and low vitamin B-12 status, which is associated with poorer cognitive function in 5-year-old children.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Janna L. Koole, Martijn J. L. Bours, Anne J. M. R. Geijsen, Biljana Gigic, Arve Ulvik, Dieuwertje E. Kok, Stefanie Brezina, Jennifer Ose, Andreas Baierl, Jurgen Bohm, Hermann Brenner, Stephanie O. Breukink, Jenny Chang-Claude, Franzel J. B. van Duijnhoven, Peter van Duijvendijk, Tanja Gumpenberger, Nina Habermann, Henk K. van Halteren, Michael Hoffmeister, Andreana N. Holowatyj, Maryska L. G. Janssen-Heijnen, Eric T. P. Keulen, Rama Kiblawi, Flip M. Kruyt, Christopher Li, Tengda Lin, Oivind Midttun, Anita R. Peoples, Eline H. van Roekel, Martin A. Schneider, Petra Schrotz-King, Alexis B. Ulrich, Kathy Vickers, Evertine Wesselink, Johannes H. W. de Wilt, Andrea Gsur, Per M. Ueland, Cornelia M. Ulrich, Ellen Kampman, Matty P. Weijenberg
Summary: The study found that higher levels of vitamin B6 in the body were associated with better quality of life, but there was limited evidence of an association between changes in B-vitamin concentrations in the blood and quality of life. Participants who stopped using B-vitamin supplements reported higher levels of fatigue.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ronald G. Munger, Rajarajeswari Kuppuswamy, Jyotsna Murthy, Kalpana Balakrishnan, Gurusamy Thangavel, Sankar Sambandam, Anura V. Kurpad, Anne M. Molloy, Per M. Ueland, Peter A. Mossey
Summary: In a case-control study conducted in Tamil Nadu state, India, it was found that low maternal vitamin B-12 status may be associated with an increased risk of isolated cleft lip, while folate levels did not show consistent association. Further studies are needed to determine the causal relationship between maternal vitamin B-12 or folate levels and cleft lip with or without cleft palate.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2021)
Article
Nutrition & Dietetics
Joanna L. Clasen, Alicia K. Heath, Heleen Van Puyvelde, Inge Huybrechts, Jin Young Park, Pietro Ferrari, Mattias Johansson, Ghislaine Scelo, Arve Ulvik, Oivind Midttun, Per Magne Ueland, Christina C. Dahm, Jytte Halkjaer, Anja Olsen, Theron Johnson, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Francesco Segrado, Maria Santucci de Magistris, Carlotta Sacerdote, Marga C. Ocke, Leila Lujan-Barroso, Ana Ching-Lopez, Jose Maria Huerta, Eva Ardanaz, Pilar Amiano, Ulrika Ericson, Jonas Manjer, Bjorn Gylling, Ingegerd Johansson, Julie Schmidt, Elisabete Weiderpass, Elio Riboli, Amanda J. Cross, David C. Muller
Summary: This study found that vitamin B6 intake was most strongly associated with PLP concentration, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr. PAr was most sensitive to age, while HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Beate S. Solvik, Jannike Oyen, Ingrid Kvestad, Maria W. Markhus, Per M. Ueland, Adrian McCann, Tor A. Strand
Summary: An intervention of fatty fish intake in preschool children resulted in significant effects on biomarkers such as n-3 PUFAs, UIC, hair mercury, and plasma 1-MH. No or limited effects were observed on biomarkers related to micronutrient status, inflammation, or essential amino acid, choline oxidation, and tryptophan pathways.
JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
Yiyang Yue, Jordan H. Creed, David J. Cote, Meir J. Stampfer, Molin Wang, Oivind Midttun, Adrian McCann, Per Magne Ueland, Jeremy Furtado, Kathleen M. Egan, Stephanie A. Smith-Warner
Summary: This study found no association between plasma concentrations of 25(OH)D and retinol with glioma risk in three cohorts. However, further investigation is needed on the potential association between alpha- and gamma-tocopherol and glioma risk.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Arve Ulvik, Adrian McCann, Oivind Midttun, Klaus Meyer, Keith M. Godfrey, Per M. Ueland
Summary: In mass spectrometry analysis, using stable isotope-labeled internal standards is a preferred method for reliable quantification, but dedicated internal standards for each metabolite may not always be feasible due to cost or availability constraints. Analysis of biomarkers with matching internal standards showed lower variability across platforms compared to non-matching pairs, with differences increasing with retention time disparities. Structural similarity between analytes and internal standards may affect the precision of non-matching pairs.
ANALYTICAL CHEMISTRY
(2021)
Article
Clinical Neurology
Katinka Nordheim Alme, Torunn Askim, Jorg Assmus, Tom Eirik Mollnes, Mala Naik, Halvor Naess, Ingvild Saltvedt, Per-Magne Ueland, Arve Ulvik, Anne-Brita Knapskog
Summary: This study found that sedentary time was significantly associated with various inflammation biomarkers, with the PAr index and KA showing independent associations with sedentary behaviour. The inflammatory biomarker PAr index may play a crucial role in future research, while the discovery of KA opens up new pathways for understanding the hazards of sedentary behaviour.
Article
Neurosciences
Adrian McCann, Dag Aarsland, Per Magne Ueland, Stein-Erik H. Solvang, Jan Erik Nordrehaug, Lasse M. Giil
Summary: The study found that higher serum tyrosine concentrations were positively associated with better cognitive performance in patients with Lewy body dementia over the 5-year follow-up period, but not in patients with Alzheimer's disease.
Article
Endocrinology & Metabolism
Lieke Bakker, Inez H. G. B. Ramakers, Martin P. J. van Boxtel, Miranda T. Schram, Coen D. A. Stehouwer, Carla J. H. van der Kallen, Pieter C. Dagnelie, Marleen M. J. van Greevenbroek, Anke Wesselius, Oivind Midttun, Per M. Ueland, Frans R. J. Verhey, Simone J. P. M. Eussen, Sebastian Kohler
Summary: This study investigated the cross-sectional associations between plasma kynurenines and cognitive function in a cohort of middle-aged participants with different glucose metabolism status. The results showed that several kynurenines were associated with lower odds of cognitive impairment and better cognitive functioning in individuals with type 2 diabetes, while less widespread associations were seen in prediabetes. Further studies are needed to explore the potential involvement of kynurenines in the pathway of type 2 diabetes and cognitive decline.
Article
Oncology
Nikos Papadimitriou, Marc J. Gunter, Neil Murphy, Audrey Gicquiau, David Achaintre, Stefanie Brezina, Tanja Gumpenberger, Andreas Baierl, Jennifer Ose, Anne J. M. R. Geijsen, Eline H. van Roekel, Andrea Gsur, Biljana Gigic, Nina Habermann, Cornelia M. Ulrich, Ellen Kampman, Matty P. Weijenberg, Per Magne Ueland, Rudolf Kaaks, Verena Katzke, Vittorio Krogh, Bas Bueno-de-Mesquita, Eva Ardanaz, Ruth C. Travis, Matthias B. Schulze, Maria-Jose Sanchez, Sandra M. Colorado-Yohar, Elisabete Weiderpass, Augustin Scalbert, Pekka Keski-Rahkonen
Summary: The study found that higher plasma tryptophan levels may be associated with a lower risk of colon cancer, while increased serotonin levels may be linked to a higher risk of colon cancer. Additionally, the kynurenine-to-tryptophan ratio may reflect altered tryptophan metabolism during colon cancer development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Hana Zahed, Mattias Johansson, Per M. Ueland, Oivind Midttun, Roger L. Milne, Graham G. Giles, Jonas Manjer, Malte Sandsveden, Arnulf Langhammer, Elin Pettersen Sorgjerd, Kjell Grankvist, Mikael Johansson, Neal D. Freedman, Wen-Yi Huang, Chu Chen, Ross Prentice, Victoria L. Stevens, Ying Wang, Loic Le Marchand, Lynne R. Wilkens, Stephanie J. Weinstein, Demetrius Albanes, Qiuyin Cai, William J. Blot, Alan A. Arslan, Anne Zeleniuch-Jacquotte, Xiao-Ou Shu, Wei Zheng, Jian-Min Yuan, Woon-Puay Koh, Kala Visvanathan, Howard D. Sesso, Xuehong Zhang, J. Michael Gaziano, Anouar Fanidi, David Muller, Paul Brennan, Florence Guida, Hilary A. Robbins
Summary: Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. Variations in blood biomarkers across demographic characteristics are generally small, with smoking cessation leading to normalization of multiple physiological processes.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Ninna Drivsholm, Andreas D. Knudsen, Maria Faurholt-Jepsen, Oivind Midttun, Marius Troseid, Ditte M. Kirkegaard-Klitbo, Per M. Ueland, Susanne D. Nielsen, Marco Gelpi
Summary: The study found that HIV-infected individuals have an increased risk of depression compared to uninfected controls, with alterations in kynurenine metabolism potentially playing a role in the development of depression in this population. Factors such as being unmarried and higher levels of quinolinic acid were associated with depression among HIV patients. Adjusted odds ratios showed that abnormalities in the kynurenine pathway of tryptophan metabolism were linked to the presence of depression in the context of HIV infection.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
