Review
Oncology
Karine Jacquet, Olivier Binda
Summary: The INhibitor of Growth (ING) family of proteins was originally identified in 1996 with ING1 as a tumor suppressor. However, subsequent research has shown that most ING family members play a key role in cellular proliferation and may not all function as tumor suppressors. Some ING family members have been found to correlate with poor prognosis in certain cancers.
Review
Cell Biology
Anna Melekhova, Aria Baniahmad
Summary: ING proteins have been identified as potential drug targets in prostate cancer research, playing a role in inhibiting cell growth and tumor development. Their splice variants offer a novel direction for investigating the biology of ING factors in various malignancies.
Article
Biochemistry & Molecular Biology
Donghui Zhang, Yanmei Zhu, Yanmin Ju, Hongyong Zhang, Xiaopeng Zou, Shangrong She, Danping Zhu, Yiting Guan
Summary: Dramatic changes in chromatin structure occur during cellular senescence, affecting genome accessibility and transcription. This study investigates the redistribution of accessible chromatin regions during senescence and identifies the transcription factor TEAD4 as a key regulator of chromatin state and SASP gene transcription.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Oncology
Mohammad Taheri, Bashdar Mahmud Hussen, Sajad Najafi, Atefe Abak, Soudeh Ghafouri-Fard, Majid Samsami, Aria Baniahmad
Summary: ING genes are members of the tumor suppressor gene family and play important roles in regulating cell proliferation, apoptosis, and cellular senescence. They interact with chromatin structures and other proteins involved in biological processes such as cell cycle regulation, exerting their regulatory effects through epigenetic mechanisms. INGs have a role in restricting the proliferative and invasive potentials of normal cells and are particularly involved in cancer development and progression. However, further research and experimental confirmation are needed to validate these models.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Fabrizio Marcucci, Cristiano Rumio
Summary: Reprogramming of energy production from mitochondrial respiration to glycolysis is a characteristic of cancer. Glycolysis can be upregulated in the early stages of tumorigenesis, as many oncoproteins involved in tumor initiation and progression promote glycolysis. In addition, recent evidence suggests that upregulated glycolysis itself may contribute to tumorigenesis through various mechanisms. This article provides a summary of the role of upregulated glycolysis in tumor initiation and proposes a mechanistic model to explain its involvement.
Review
Biochemistry & Molecular Biology
Michela Cortesi, Michele Zanoni, Francesca Pirini, Maria Maddalena Tumedei, Sara Ravaioli, Ilario Giovanni Rapposelli, Giovanni Luca Frassineti, Sara Bravaccini
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to immune suppression and the tumor microenvironment. This review explores the interplay between senescent and non-senescent cell types and their impact on PDAC progression. The non-tumoral cells in the tumor microenvironment influence key aspects of tumor growth, metabolism, cell death, and treatment resistance. Understanding these interactions is crucial for PDAC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Azucena Rocha, Audrey Dalgarno, Nicola Neretti
Summary: The article provides an overview of the nuclear changes that occur in different forms of senescence, including changes in chromatin state and composition, three-dimensional organization of the genome, nuclear envelope, and accessibility of repetitive genomic regions. These changes are shared across all forms of senescence, indicating that nuclear organization plays a fundamental role in the senescent state and interaction of senescent cells with the surrounding tissue.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2022)
Article
Immunology
Jiaxiong Tan, Chaoyu Wang, Yan Jin, Yuren Xia, Baocheng Gong, Qiang Zhao
Summary: The study found that a signature constructed with six genes can better predict the prognosis of neuroblastoma and evaluate the immunosuppressed and aging tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yan Mao, Jinwen Xu, Xuejiao Xu, Jiayun Qiu, Zhengyun Hu, Feng Jiang, Guoping Zhou
Summary: Cellular senescence plays a critical role in carcinogenesis, development, and immunological regulation. This study identified a cellular senescence-related gene signature that can serve as a reliable predictor for clinical outcome and immunotherapeutic response in patients with acute myeloid leukemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Weihao Lin, Xin Wang, Zhen Wang, Fei Shao, Yannan Yang, Zheng Cao, Xiaoli Feng, Yibo Gao, Jie He
Summary: Cellular senescence plays a crucial role in tumorigenesis, development, and immune modulation in lung adenocarcinoma (LUAD). A cellular senescence-related signature (SRS) was identified as an independent prognostic predictor for LUAD patients, showing potential value in predicting clinical outcomes and immunotherapy response. High SRS scores correlated with senescence-associated secretory phenotype (SASP) and an immunosuppressive phenotype, highlighting SRS as a robust biomarker for immunotherapeutic response and prognosis in LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Respiratory System
Olivier Burgy, Arnaud A. Mailleux
Summary: Integrated multi-omic single cell analyses in IPF lungs identify TWIST1 as a crucial transcriptional regulator for myofibroblasts.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Laureline Roger, Fanny Tomas, Veronique Gire
Summary: Cellular senescence is an essentially irreversible proliferative arrest state where cells release pro-inflammatory and proteolytic factors. Different types of senescent cells accumulate in various tissues and organs with unique functions. Understanding how cells undergo extensive changes to induce a common cellular state is crucial for cancer prevention and improving health during aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Ewa Sikora, Anna Bielak-Zmijewska, Grazyna Mosieniak
Summary: Cellular senescence is a significant biological phenomenon that mainly participates in aging and aging-related diseases through secretion activity and cell cycle arrest. In this process, DNA damage, nuclear changes, and chromatin rearrangement play important roles.
AGEING RESEARCH REVIEWS
(2021)
Review
Oncology
Andreas Domen, Christophe Deben, Jasper Verswyvel, Tal Flieswasser, Hans Prenen, Marc Peeters, Filip Lardon, An Wouters
Summary: Cellular senescence is a mechanism in which cells enter a state of stable cell-cycle arrest with secretory features in response to cellular stress. It has been historically seen as a protective mechanism against cancer by eliminating damaged cells. However, the accumulation of senescent cells can have long-term detrimental effects and contribute to age-related diseases, including cancer. The role of cellular senescence in cancer is ambiguous and controversial, and its detection and study in cancer patients present challenges. This review highlights the methods and challenges of detecting cellular senescence in cancer patients, and discusses its prognostic implications.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Cell Biology
Jing Yang, Mengmeng Liu, Dongchun Hong, Musheng Zeng, Xing Zhang
Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)