Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications

(2015) Biswajit Das et al.   VIROLOGY

Lactic Acid, a Vaginal Microbiota Metabolite, Elicits an Anti-inflammatory Response from Vaginal and Cervical Epithelial Cells

(2014) Anna Hearps et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Vaginal Concentrations of Lactic Acid Potently Inactivate HIV-1 Compared to Short Chain Fatty Acids Present During Bacterial Vaginosis

(2014) Muriel Aldunate et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Bacterial Vaginosis and the Cervicovaginal Immune Response

(2014) Caroline Mitchell et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Structure of the Human VaginalStratum Corneumand its Role in Immune Defense

(2014) Deborah J. Anderson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Barrier to HIV Transmission Provided by Genital TractLactobacillusColonization

(2014) Paria Mirmonsef et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Rifaximin Modulates the Vaginal Microbiome and Metabolome in Women Affected by Bacterial Vaginosis

(2014) Luca Laghi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

(2014) Suleyman Yildirim et al.   ISME Journal

Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women

(2014) Hanneke Borgdorff et al.   ISME Journal

Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

(2014) H. Shime et al.   JOURNAL OF IMMUNOLOGY

Vaginal Microbiota and Sexually Transmitted Infections That May Influence Transmission of Cell-Associated HIV

(2014) R. A. Cone   JOURNAL OF INFECTIOUS DISEASES

Human α-amylase Present in Lower-Genital-Tract Mucosal Fluid Processes Glycogen to Support Vaginal Colonization by Lactobacillus

(2014) Gregory T. Spear et al.   JOURNAL OF INFECTIOUS DISEASES

Characteristics and Quantities of HIV Host Cells in Human Genital Tract Secretions

(2014) J. A. Politch et al.   JOURNAL OF INFECTIOUS DISEASES

Bacteria in the Vaginal Microbiome Alter the Innate Immune Response and Barrier Properties of the Human Vaginal Epithelia in a Species-Specific Manner

(2014) Sylvie Y. Doerflinger et al.   JOURNAL OF INFECTIOUS DISEASES

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Lactobacilli Inactivate Chlamydia trachomatis through Lactic Acid but Not H2O2

(2014) Zheng Gong et al.   PLoS One

Free Glycogen in Vaginal Fluids Is Associated with Lactobacillus Colonization and Low Vaginal pH

(2014) Paria Mirmonsef et al.   PLoS One

Microbial metabolites control gut inflammatory responses: Fig. 1.

(2014) Nicholas Arpaia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

(2014) Roberto Romero et al.   Microbiome

Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection

(2013) Josué Pérez-Santiago et al.   AIDS

The global epidemiology of bacterial vaginosis: a systematic review

(2013) Chris Kenyon et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Theaflavin-3,3′-Digallate and Lactic Acid Combinations Reduce Herpes Simplex Virus Infectivity

(2013) Charles E. Isaacs et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of probiotics for the treatment of bacterial vaginosis in adult women: a meta-analysis of randomized clinical trials

(2013) Haohai Huang et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Effects of tampons and menses on the composition and diversity of vaginal microbial communities over time

(2013) RJ Hickey et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Vaginal microbiome in women from Greenland assessed by microscopy and quantitative PCR

(2013) Raluca Datcu et al.   BMC INFECTIOUS DISEASES

Homeostatic properties of Lactobacillus jensenii engineered as a live vaginal anti-HIV microbicide

(2013) Hidemi S Yamamoto et al.   BMC MICROBIOLOGY

Interactions between Lactobacillus crispatus and Bacterial Vaginosis (BV)-Associated Bacterial Species in Initial Attachment and Biofilm Formation

(2013) António Machado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vaginal concentrations of lactic acid potently inactivate HIV

(2013) Muriel Aldunate et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Proteome profiles of vaginal fluids from women affected by bacterial vaginosis and healthy controls: outcomes of rifaximin treatment

(2013) F. Cruciani et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?

(2013) Stephen Yiu Chuen Choi et al.   JOURNAL OF PATHOLOGY

Defining the Interaction of HIV-1 with the Mucosal Barriers of the Female Reproductive Tract

(2013) A. M. Carias et al.   JOURNAL OF VIROLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease

(2013) Carl J. Yeoman et al.   PLoS One

Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota

(2013) Deirdre E. O’Hanlon et al.   PLoS One

Association Between Trichomonas vaginalis and Vaginal Bacterial Community Composition Among Reproductive-Age Women

(2013) Rebecca M. Brotman et al.   SEXUALLY TRANSMITTED DISEASES

Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis

(2013) Jacques Ravel et al.   Microbiome

Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis

(2013) Jean M Macklaim et al.   Microbiome

Interaction Between Lactobacilli, Bacterial Vaginosis-Associated Bacteria, and HIV Type 1 RNA and DNA Genital Shedding in U.S. and Kenyan Women

(2012) Caroline Mitchell et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Efficacy of Rifaximin Vaginal Tablets in Treatment of Bacterial Vaginosis: a Molecular Characterization of the Vaginal Microbiota

(2012) Federica Cruciani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quantification of bacterial species of the vaginal microbiome in different groups of women, using nucleic acid amplification tests

(2012) Vicky Jespers et al.   BMC MICROBIOLOGY

Reactivation of latent HIV-1 by a wide variety of butyric acid-producing bacteria

(2012) Kenichi Imai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of Bacterial Vaginosis and Trichomonas in HIV Transmission Across The Female Genital Tract

(2012) Paria Mirmonsef et al.   CURRENT HIV RESEARCH

A multicenter, double-blind, randomized, placebo-controlled study of rifaximin for the treatment of bacterial vaginosis

(2012) Gilbert G.G. Donders et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Altered Vaginal Microbiota Are Associated With Perinatal Mother-to-Child Transmission of HIV in African Women From Burkina Faso

(2012) Daniel N. Frank et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Comparative study of the protective capacity againstSalmonellainfection between probiotic and nonprobiotic lactobacilli

(2012) N.A. Castillo et al.   JOURNAL OF APPLIED MICROBIOLOGY

Extravaginal Reservoirs of Vaginal Bacteria as Risk Factors for Incident Bacterial Vaginosis

(2012) Jeanne M. Marrazzo et al.   JOURNAL OF INFECTIOUS DISEASES

Human cervicovaginal mucus contains an activity that hinders HIV-1 movement

(2012) S A Shukair et al.   Mucosal Immunology

Commensal Bacteria Modulate Innate Immune Responses of Vaginal Epithelial Cell Multilayer Cultures

(2012) William A. Rose et al.   PLoS One

Bacterial Communities in Women with Bacterial Vaginosis: High Resolution Phylogenetic Analyses Reveal Relationships of Microbiota to Clinical Criteria

(2012) Sujatha Srinivasan et al.   PLoS One

Comparison of Storage Conditions for Human Vaginal Microbiome Studies

(2012) Guoyun Bai et al.   PLoS One

The Cervical Microbiome over 7 Years and a Comparison of Methodologies for Its Characterization

(2012) Benjamin C. Smith et al.   PLoS One

Longitudinal qPCR Study of the Dynamics of L. crispatus, L. iners, A. vaginae, (Sialidase Positive) G. vaginalis, and P. bivia in the Vagina

(2012) Guido Lopes dos Santos Santiago et al.   PLoS One

Searching for Lower Female Genital Tract Soluble and Cellular Biomarkers: Defining Levels and Predictors in a Cohort of Healthy Caucasian Women

(2012) Jordan K. Kyongo et al.   PLoS One

Identification and Characterization of Bacterial Vaginosis-Associated Pathogens Using a Comprehensive Cervical-Vaginal Epithelial Coculture Assay

(2012) Colleen R. Eade et al.   PLoS One

Temporal Dynamics of the Human Vaginal Microbiota

(2012) P. Gajer et al.   Science Translational Medicine

Bacterial Vaginosis Associated with Increased Risk of Female-to-Male HIV-1 Transmission: A Prospective Cohort Analysis among African Couples

(2012) Craig R. Cohen et al.   PLOS MEDICINE

A Comparison of Lower Genital Tract Glycogen and Lactic Acid Levels in Women and Macaques: Implications for HIV and SIV Susceptibility

(2011) Paria Mirmonsef et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Intravaginal microbial flora by the 16S rRNA gene sequencing

(2011) Kazuaki Yoshimura et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

HIV-1 Infection in the Female Reproductive Tract: Role of Interactions between HIV-1 and Genital Epithelial Cells

(2011) Charu Kaushic   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Short-Chain Fatty Acids Induce Pro-Inflammatory Cytokine Production Alone and in Combination with Toll-Like Receptor Ligands

(2011) Paria Mirmonsef et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Bacterial Vaginosis, Gonorrhea, and Chlamydial Infection Among Women Attending a Sexually Transmitted Disease Clinic: A Longitudinal Analysis of Possible Causal Links

(2011) Maria F. Gallo et al.   ANNALS OF EPIDEMIOLOGY

Structure and Function of Intercellular Junctions in Human Cervical and Vaginal Mucosal Epithelia1

(2011) Caitlin D. Blaskewicz et al.   BIOLOGY OF REPRODUCTION

Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis

(2011) Evy Gillet et al.   BMC INFECTIOUS DISEASES

In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide

(2011) Deirdre E O'Hanlon et al.   BMC INFECTIOUS DISEASES

Characterisation of the oral, vaginal and rectal Lactobacillus flora in healthy pregnant and postmenopausal women

(2011) Ljubomir Petricevic et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

(2011) Laurence Macia et al.   IMMUNOLOGICAL REVIEWS

Anti-inflammatory properties of dairy lactobacilli

(2011) Clarissa Santos Rocha et al.   INFLAMMATORY BOWEL DISEASES

Lactobacillus johnsonii HY7042 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-κB activation

(2011) Hyun-Min Joo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

(2011) Kristina Goetze   INTERNATIONAL JOURNAL OF ONCOLOGY

Influence of Lactic Acid on Endogenous and Viral RNA-Induced Immune Mediator Production by Vaginal Epithelial Cells

(2011) Hannah Mossop et al.   OBSTETRICS AND GYNECOLOGY

Performance of Swabs, Lavage, and Diluents to Quantify Biomarkers of Female Genital Tract Soluble Mucosal Mediators

(2011) Charlene S. Dezzutti et al.   PLoS One

Longitudinal Study of the Dynamics of Vaginal Microflora during Two Consecutive Menstrual Cycles

(2011) Guido Lopes dos Santos Santiago et al.   PLoS One

The Natural History of Bacterial Vaginosis Diagnosed by Gram Stain Among Women in Rakai, Uganda

(2011) Marie E. Thoma et al.   SEXUALLY TRANSMITTED DISEASES

Novel Vaginal Microflora Colonization Model Providing New Insight into Microbicide Mechanism of Action

(2011) R. N. Fichorova et al.   mBio

Diagnosis of bacterial vaginosis in cases of abnormal vaginal discharge: comparison of clinical and microbiological criteria

(2011) Nilay Kanti Das et al.   Journal of Infection in Developing Countries

The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal lactobacilli during anaerobic growth

(2011) Michelle A Graver et al.   Annals of Clinical Microbiology and Antimicrobials

The Effects of Commensal Bacteria on Innate Immune Responses in the Female Genital Tract

(2010) Paria Mirmonsef et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Innate Immunity and Inflammatory Response to Trichomonas vaginalis and Bacterial Vaginosis: Relationship to HIV Acquisition

(2010) Andrea R. Thurman et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis

(2010) Xin Z Ling et al.   BMC GENOMICS

Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies

(2010) Michael D Harwich et al.   BMC GENOMICS

Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli

(2010) Deirdre E O'Hanlon et al.   BMC INFECTIOUS DISEASES

Lactic acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide

(2010) Steven S. Witkin et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Gardnerella Biofilm Involves Females and Males and Is Transmitted Sexually

(2010) Alexander Swidsinski et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Butyrate in vitro immune-modulatory effects might be mediated through a proliferation-related induction of apoptosis

(2010) Elvira Bailón et al.   IMMUNOBIOLOGY

Quantitative PCR Assessments of Bacterial Species in Women with and without Bacterial Vaginosis

(2010) M. Zozaya-Hinchliffe et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Comparison of Self-Collected and Physician-Collected Vaginal Swabs for Microbiome Analysis

(2010) L. J. Forney et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Bacterial Vaginosis Assessed by Gram Stain and Diminished Colonization Resistance to Incident Gonococcal, Chlamydial, and Trichomonal Genital Infection

(2010) Rebecca M. Brotman et al.   JOURNAL OF INFECTIOUS DISEASES

Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract

(2010) Kaei Nasu et al.   MEDIATORS OF INFLAMMATION

Lactobacillus rhamnosus GG attenuates interferon-  and tumour necrosis factor- -induced barrier dysfunction and pro-inflammatory signalling

(2010) K. A. Donato et al.   MICROBIOLOGY-SGM

Temporal Variability of Human Vaginal Bacteria and Relationship with Bacterial Vaginosis

(2010) Sujatha Srinivasan et al.   PLoS One

Comparative Genomics of Gardnerella vaginalis Strains Reveals Substantial Differences in Metabolic and Virulence Potential

(2010) Carl J. Yeoman et al.   PLoS One

Vaginal microbiome of reproductive-age women

(2010) J. Ravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novos conhecimentos sobre a flora bacteriana vaginal

(2010) Iara Moreno Linhares et al.   Revista da Associacao Medica Brasileira

Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis

(2010) R. M. Brotman et al.   SEXUALLY TRANSMITTED INFECTIONS

Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

(2010) Aisha Nazli et al.   PLoS Pathogens

Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies

(2009) Julius Atashili et al.   AIDS

Pyrosequencing of the Chaperonin-60 Universal Target as a Tool for Determining Microbial Community Composition

(2009) J. Schellenberg et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification and genotyping of bacteria from paired vaginal and rectal samples from pregnant women indicates similarity between vaginal and rectal microflora

(2009) Nabil Abdullah El Aila et al.   BMC INFECTIOUS DISEASES

Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora

(2009) Hans Verstraelen et al.   BMC MICROBIOLOGY

The vaginal bacterial communities of Japanese women resemble those of women in other racial groups

(2009) Xia Zhou et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Vaginal Microbiota of Women with Frequent Vulvovaginal Candidiasis

(2009) X. Zhou et al.   INFECTION AND IMMUNITY

Heterogeneity of Vaginal Microbial Communities within Individuals

(2009) T. K. Kim et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection

(2009) Jesus F. Salazar-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bacterial Populations in the Vaginas of Healthy Adolescent Women

(2009) Ted Yamamoto et al.   Journal of Pediatric and Adolescent Gynecology

Identification and Quantification of Preterm Birth Biomarkers in Human Cervicovaginal Fluid by Liquid Chromatography/Tandem Mass Spectrometry

(2009) Sumit J. Shah et al.   JOURNAL OF PROTEOME RESEARCH

Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus

(2009) S. K. Lai et al.   JOURNAL OF VIROLOGY

Changes in the Vaginal Microenvironment with Metronidazole Treatment for Bacterial Vaginosis in Early Pregnancy

(2009) Caroline Mitchell et al.   JOURNAL OF WOMENS HEALTH

Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis-associated anaerobes

(2009) J. L. Patterson et al.   MICROBIOLOGY-SGM

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Glycerol monolaurate prevents mucosal SIV transmission

(2009) Qingsheng Li et al.   NATURE

Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection

(2009) B. Kantor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ORIGINAL ARTICLE: Quantification and Comparison of Toll-Like Receptor Expression and Responsiveness in Primary and Immortalized Human Female Lower Genital Tract Epithelia

(2008) Melissa M. Herbst-Kralovetz et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The lower genital tract microbiota in relation to cytokine-, SLPI- and endotoxin levels: application of checkerboard DNA-DNA hybridization (CDH)

(2008) NATALIA NIKOLAITCHOUK et al.   APMIS

Prevalence and Abundance of Uncultivated Megasphaera-Like Bacteria in the Human Vaginal Environment

(2008) M. Zozaya-Hinchliffe et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Diversity of Human Vaginal Bacterial Communities and Associations with Clinically Defined Bacterial Vaginosis

(2008) B. B. Oakley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Prevalence of Candida albicans and bacterial vaginosis in asymptomatic pregnant women in South Yorkshire, United Kingdom

(2008) A. A. Akinbiyi et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Quantitative variations in the vaginal bacterial population associated with asymptomatic infections: a real-time polymerase chain reaction study

(2008) E. Biagi et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Mass spectrometry-based proteomics in reproductive medicine

(2008) Aggeliki Kolialexi et al.   MASS SPECTROMETRY REVIEWS

Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis

(2008) Erika K. Libby et al.   MICROBES AND INFECTION

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

(2008) B. F. Keele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole

(2007) Alexander Swidsinski et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Hormonal contraceptive use modulates the local inflammatory response to bacterial vaginosis

(2007) T L Cherpes et al.   SEXUALLY TRANSMITTED INFECTIONS