Review
Microbiology
Bin Zhu, Zhi Tao, Laahirie Edupuganti, Myrna G. Serrano, Gregory A. Buck
Summary: The microbiome of the female reproductive tract has a unique biodiversity, with a homogeneous Lactobacillus-based microbiome associated with health and other taxa associated with dysbiosis and disease. Recent research efforts have focused on understanding how these microorganisms influence gynecologic and reproductive health.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2022)
Article
Emergency Medicine
Tamar R. Lubell, Jonathan M. Barasch, Benjamin King, Julie B. Ochs, Weijia Fan, Jimmy Duong, Manasi Chitre, Peter S. Dayan
Summary: The study found that uNGAL levels from bagged and catheterized samples cannot be used interchangeably, and the sampling technique for bagged samples affects uNGAL levels.
ACADEMIC EMERGENCY MEDICINE
(2022)
Review
Endocrinology & Metabolism
Claudia Blancafort, Joaquin Llacer
Summary: Modifications in vaginal and endometrial microbiome have been linked to poor pregnancy outcomes, making it a significant biomarker in reproductive medicine. Despite the widespread use of probiotics for vaginal dysbiosis and infertility, there is still no clear evidence to support their recommendation. This review aims to assess the effectiveness of probiotics in altering the genital tract microbiota in non-symptomatic women.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Health Care Sciences & Services
Anthony E. Rizzo, Jennifer C. Gordon, Alicia R. Berard, Adam D. Burgener, Stefanie Avril
Summary: Recent studies have shown the existence of a microbiome in the upper female reproductive tract, previously assumed to be sterile under non-pathologic conditions. While the vaginal microbiome and its impact on reproductive health have been extensively studied, research on the microbiome of the upper female reproductive tract in gynecologic cancers is limited.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Celia Fuentes-Chust, Claudio Parolo, Giulio Rosati, Lourdes Rivas, Karla Perez-Toralla, Stephanie Simon, Itziar de Lecuona, Christophe Junot, Jonel Trebicka, Arben Merkoci
Summary: This review article discusses the potential of nanomaterials and nanobiosensing technologies in developing diagnostic devices for the human microbiome, defines the current and future landscape of microbiome-based diagnostics, and addresses the principal ethical, legal, and societal issues related to microbiome research and innovation.
ADVANCED MATERIALS
(2021)
Review
Reproductive Biology
Anna Marie Hugon, Thaddeus G. Golos
Summary: The microbiome plays a significant role in human health and disease, affecting various aspects such as gastrointestinal health, metabolism, immunity, and neurology. While most research focuses on the gut microbiome, other communities like the vaginal or cervical microbiome also contribute to physiological balance. Understanding the microbial niches in the female reproductive tract, including their impact on reproductive success and adverse pregnancy outcomes, can improve reproductive health. Non-human primate (NHP) studies provide valuable insights into the reproductive microbiome and can potentially aid in diagnosing microbial dysfunctions associated with reproductive pathologies.
BIOLOGY OF REPRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
Anna Kawalec, Danuta Zwolinska
Summary: The urinary tract microbiome is crucial for maintaining health and preventing urinary tract infections. However, the characteristics and role of the urobiome in children, as well as strategies for treating pediatric patients with recurrent urinary tract infections, are still not completely understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Jakub Smolinski, Natalia Szeligowska, Paulina Cholewinska, Katarzyna Czyz, Marzena Janczak
Summary: The study found that the parity and age of the females may affect the gastrointestinal microbiome, but further studies are recommended.
Review
Medicine, General & Internal
Tomislav Mestrovic, Mario Matijasic, Mihaela Peric, Hana Cipcic Paljetak, Anja Baresic, Donatella Verbanac
Summary: The current research focuses on the relationship between gut microbiota and the development of bacteriuria and UTI, as well as the potential impact of vaginal dysbiosis and urinary microbiome perturbations on infections. Further research and exploration are needed to understand and potentially utilize these findings for the diagnosis and treatment of UTIs.
Article
Infectious Diseases
Richard A. Watson
Summary: The potential role of probiotics in preventing and treating recurrent urinary tract infections has been extensively studied. However, a successful strategy has been difficult to achieve. A new targeted approach, involving the instillation of specific lactobacilli directly into the bladder, shows promise but may require a long-term campaign for clinically proven success.
Article
Obstetrics & Gynecology
Mengyao Zeng, Liu Yang, Yanyan Mao, Yang He, Min Li, Jun Liu, Qianxi Zhu, Liang Chen, Weijin Zhou
Summary: Preconception reproductive tract infections may be associated with adverse pregnancy outcomes, including spontaneous abortion, preterm birth, and macrosomia.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Immunology
Manoj Kumar, Marwa Saadaoui, Souhaila Al Khodor
Summary: Pregnancy brings about physiological and immunological adaptations that enable precise communication between the mother and fetus, promoting a healthy pregnancy. However, these adaptations may also make pregnant women more prone to infections and lead to various pregnancy complications. Certain microbial pathogens have evolved mechanisms to bypass the placental barrier and cause congenital diseases. Recent studies have shed light on the significant role of maternal microbiota in pregnancy outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Infectious Diseases
Farhan Cyprian, Muhammad Umar Sohail, Ibrahim Abdelhafez, Salma Salman, Zakria Attique, Layla Kamareddine, Maha Al-Asmakh
Summary: By the beginning of 2020, COVID-19 caused by SARS-CoV-2 had become a global pandemic, mainly spread through the respiratory system and associated with various chronic diseases. Recent studies suggest that the pulmonary and gut microbiomes may modulate the course of COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Veronika Guenther, Leila Allahqoli, Rafal Watrowski, Nicolai Maass, Johannes Ackermann, Soeren von Otte, Ibrahim Alkatout
Summary: The human microbiome, particularly the vaginal microbiome, has gained importance in reproductive medicine due to its potential influence on infertility and implantation failure. Non-Lactobacillus-dominated microbiomes have been associated with dysbiosis and may negatively impact reproductive outcomes. Screening the microbiome and administering antibiotic and/or probiotic treatment could improve pregnancy outcomes.
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Immunology
Janice Cho, Scott Cunningham, Meng Pu, Ryan J. Lennon, Jennifer Dens Higano, Patricio Jeraldo, Priya Sampathkumar, Samantha Shannon, Purna C. Kashyap, Robin Patel
Summary: Through WGS analysis of C. difficile isolates from CDI patients, it was found that 40% of community-acquired CDI patients may have transmission within the same zip code. WGS better differentiates between relapse and reinfection than definitions based on the timing of recurrence.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Scott Van Nguyen, Scott A. Cunningham, Patricio Jeraldo, Anthony Tran, Robin Patel
Summary: The taxonomic position of Yersinia kristensenii rochesterensis subspecies and Yersinia occitanica has been re-evaluated, confirming that they belong to the same genospecies. Y. kristensenii rochesterensis should be elevated to a new species status named Yersinia rochesterensis sp. nov. The taxonomy of Yersinia genus has recently expanded with the description of new species, including important human zoonotic pathogens.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Meng Pu, Janice M. Cho, Scott A. Cunningham, Gaurav K. Behera, Sarah Becker, Talal Amjad, Kerryl E. Greenwood-Quaintance, Helena Mendes-Soares, Yava Jones-Hall, Patricio R. Jeraldo, Jun Chen, Gary Dunny, Robin Patel, Purna C. Kashyap
Summary: The study identified a potential plasmid-mediated mechanism leading to decreased sensitivity of C difficile to vancomycin, which may contribute to treatment failure, and further experimental results supported this hypothesis.
Article
Microbiology
Nkechi Martina Odogwu, Jun Chen, Chinedum Amara Onebunne, Patricio Jeraldo, Lu Yang, Stephen Johnson, Funmilola A. Ayeni, Marina R. S. Walther-Antonio, Oladapo O. Olayemi, Nicholas Chia, Akinyinka O. Omigbodun
Summary: Preterm birth is a major cause of infant mortality in sub-Saharan Africa and globally, with Nigeria having the third highest rate of PTB worldwide. This study found that PTB vaginal samples were characterized by increased microbial richness, high diversity, and depletion of lactobacilli, with Atopobium vaginae-dominated vagitype being highly predictive of PTB. Understanding the vaginal microbiome composition and steroid hormone levels during pregnancy could help predict and reduce the incidence of preterm birth.
Letter
Gastroenterology & Hepatology
Ferga C. Gleeson, Patricio Jeraldo, Michael J. Levy, Stephen J. Murphy, Helena Mendes-Soares, Giannoula Karagouga, Alexa F. Mccune, Ana Garcia Garcia Deparedes, Benjamin R. Kipp, Stephanie D. Song, Sahil Khanna, Darrell S. Pardi, Nicholas Chia
Review
Endocrinology & Metabolism
Madeline E. Graham, William G. Herbert, Stephanie D. Song, Harshini N. Raman, Jade E. Zhu, Paulina E. Gonzalez, Marina R. S. Walther-Antonio, Marc J. Tetel
Summary: Women's health is influenced by the interactions of steroids with the gut and vaginal microbiomes at different life stages, with the microbiota playing a crucial role. Despite well-defined associations between host health and microbiome composition, the exact mechanistic role of the microbiome in women's health outcomes remains largely unknown.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Chemistry, Multidisciplinary
Yuguang Liu, Patricio Jeraldo, Helena Mendes-Soares, Thao Masters, Abigail E. Asangba, Heidi Nelson, Robin Patel, Nicholas Chia, Marina Walther-Antonio
Summary: A digital microfluidic device was developed for rapid whole genome amplification of low-abundance bacterial DNA, allowing for identification of target bacteria within 30 minutes. This new method can accurately detect microbes in samples depleted of human cells, providing a new possibility for clinical diagnosis and research.
Article
Microbiology
Emma Whittle, Jennifer A. Yonkus, Patricio Jeraldo, Roberto Alva-Ruiz, Heidi Nelson, Michael L. Kendrick, Thomas E. Grys, Robin Patel, Mark J. Truty, Nicholas Chia
Summary: This study evaluated the use of Nanopore sequencing in rapidly detecting microbial species and antimicrobial resistance genes in intraoperative bile aspirates. The results showed that Nanopore sequencing can achieve rapid identification of microbial species and antimicrobial resistance genes, which may be useful in guiding early antimicrobial therapy postsurgery.
Article
Microbiology
Adam L. Edwinson, Lu Yang, Stephanie Peters, Nikita Hanning, Patricio Jeraldo, Pratik Jagtap, Joshua B. Simpson, Tzu-Yi Yang, Praveen Kumar, Subina Mehta, Asha Nair, Margaret Breen-Lyles, Lakshmikanth Chikkamenahalli, Rondell P. Graham, Benedicte De Winter, Robin Patel, Surendra Dasari, Purna Kashyap, Timothy Griffin, Jun Chen, Gianrico Farrugia, Matthew R. Redinbo, Madhusudan Grover
Summary: Intestinal protease activity is suppressed by gut microbiota through the production of unconjugated bilirubin. In irritable bowel syndrome patients, an altered gut microbiota composition results in increased protease activity.
NATURE MICROBIOLOGY
(2022)
Article
Microbiology
Madiha Fida, Scott A. Cunningham, Stephan Beisken, Andreas E. Posch, Nicholas Chia, Patricio R. Jeraldo, Matthew P. Murphy, Nicole M. Zinsmaster, Robin Patel
Summary: Whole-genome sequencing is replacing traditional typing methods for investigating infectious disease outbreaks and predicting antimicrobial susceptibility. In this study, cgMLST was used to analyze a well-characterized collection of A. baumannii, showing concordance with previous PCR/ESI-MS results. There was a high level of agreement between genotypic and phenotypic antimicrobial susceptibility.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Prakhar Vijayvargiya, Adeline Feri, Mathilde Mairey, Cecile Rouillon, Patricio R. Jeraldo, Zerelda Esquer Garrigos, Matthew J. Thoendel, Kerryl E. Greenwood-Quaintance, M. Rizwan Sohail, Priya Sampathkumar, Megan T. Spychalla, A. K. Stewart, Mrinal M. Patnaik, Aaron J. Tande, Stephane Cruveiller, Irene Hannet, Pascale Beurdeley, Robin Patel
Summary: This study evaluated the utility of a metagenomic shotgun sequencing based assay for detection of bacteria and viruses in blood samples of patients with febrile neutropenia. The results showed that this method can detect clinically relevant viruses or bacteria, but further optimization is needed.
Article
Multidisciplinary Sciences
Yuguang Liu, Patricio Jeraldo, William Herbert, Samantha McDonough, Bruce Eckloff, Jean-Pierre De Vera, Charles Cockell, Thomas Leya, Mickael Baque, Jin Jen, Dirk Schulze-Makuch, Marina Walther-Antonio
Summary: The study investigated the impact of long-term exposure to space on single-cell genomic changes of a cyanobacterium, revealing significant alterations in biofilm and photosystem related loci. Further research is needed to understand the non-random alterations and their implications for the evolutionary potential of single bacterial cells under cosmic exposure.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Nancy Scott, Emma Whittle, Patricio Jeraldo, Nicholas Chia
Summary: Studies have shown that there is a potential association or causal role between ETBF and CRC, but the high heterogeneity in study design and reporting makes it difficult to draw a definitive conclusion. More comprehensive studies are needed to confirm the direct involvement of ETBF in the etiology of CRC.
Article
Obstetrics & Gynecology
Douglas Allan Leach, Jun Chen, Lu Yang, Heidi K. Chua, Marina R. S. Walther-Antonio, John A. Occhino
Summary: The rectal and vaginal microbiome in patients undergoing successful fistula repair showed higher species diversity compared to those with recurrence. Microbiome characteristics associated with fistula recurrence have been identified, suggesting potential targets for therapeutic intervention. Further expansion of the study is needed to confirm these findings.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)