期刊
ADVANCED MATERIALS
卷 33, 期 18, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202006104
关键词
biomarkers; biosensors; microbiome; nanomaterials; precision medicine
类别
资金
- European Union [825694, 795635]
- Marie Sklodowska-Curie Actions Individual Fellowship
- Marie Curie Actions (MSCA) [795635] Funding Source: Marie Curie Actions (MSCA)
This review article discusses the potential of nanomaterials and nanobiosensing technologies in developing diagnostic devices for the human microbiome, defines the current and future landscape of microbiome-based diagnostics, and addresses the principal ethical, legal, and societal issues related to microbiome research and innovation.
Monitoring of the human microbiome is an emerging area of diagnostics for personalized medicine. Here, the potential of different nanomaterials and nanobiosensing technologies is reviewed for the development of novel diagnostic devices for the detection and measurement of microbiome-related biomarkers. Moreover, the current and future landscape of microbiome-based diagnostics is defined by exploring the advantages and disadvantages of current nanotechnology-based approaches, especially in the context of developing point-of-care (PoC) devices that would meet the international guidelines known as REASSURED (Real-time connectivity; Ease of specimen collection; Affordability; Sensitivity; Specificity; User-friendliness; Rapid & robust operation; Equipment-free; and Deliverability). Finally, the strategies of the latest international scientific consortia working in this field are analyzed, the current microbiome diagnostics market are reported and the principal ethical, legal, and societal issues related to microbiome R&D and innovation are discussed.
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