Review
Biochemistry & Molecular Biology
Supattra Chaithongyot, Phatcharida Jantaree, Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, with environmental factors and dysregulation of the transcription factor nuclear factor kappa B (NF-kappa B) playing crucial roles in its development. NF-kappa B actively participates in tumor microenvironment cell crosstalk, with diverse effects on tumor cell and immune cell populations.
Article
Plant Sciences
Han Zhu, Gaorui Wang, Yuyan Bai, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: Bear bile powder (BBP) has been used to treat neuroinflammation, and its mechanism of action may involve the TGR5/AKT/NF-κB signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiaohong Xu, Fang Cui, Xiaodong Li, Nan Wang, Yingrui Gao, Shiping Yin, Fangdi Hu
Summary: Dangshen, a medicinal and edible plant, has been found to have protective effects on gastric mucosa. It can improve chronic non-atrophic gastritis by enhancing antioxidant capacity, suppressing inflammatory responses, and reducing cell apoptosis. This study reveals the potential value of Dangshen in the treatment of gastric diseases.
Article
Pharmacology & Pharmacy
Jie Xu, Shixu Li, Xuefeng Yang, Haibo Wang, Lina Ma, Yuan Shen, Jie Yu
Summary: Studies have found a positive correlation between the intake of environmental endocrine disruptors and the occurrence of gastric diseases. This study investigated the effects of nonylphenol (NP) exposure on gastric inflammation and its mechanism related to the NF-kappa B/NLRP3 signaling pathway. The findings from in vivo and in vitro experiments revealed that NP exposure induced gastric inflammation and affected the expression of genes and proteins in the NF-kappa B/NLRP3 signaling pathway. These findings provide a new perspective on the mechanism of inflammatory response caused by exposure to environmental endocrine disruptors and suggest potential therapeutic strategies for treating inflammatory diseases through targeting the NF-kappa B/NLRP3 signaling pathway.
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Cell Biology
Jianping Hu, Chaokui Wang, Xinyue Huang, Shenglan Yi, Su Pan, Yiting Zhang, Gangxiang Yuan, Qingfeng Cao, Xingsheng Ye, Hong Li
Summary: The study demonstrates that gut microbiota-mediated secondary bile acids play a crucial role in maintaining innate immune responses and potentially have therapeutic implications in autoimmune uveitis. These bile acids attenuate severity of autoimmune uveitis by inhibiting pro-inflammatory cytokines and NF-kappa B activation. The TGR5 signaling pathway is also identified as a key player in inhibiting DC activation and NF-kappa B-related inflammation.
Article
Plant Sciences
Maryam Roozbehani, Mohammad Hossein Abdolmohammadi, Maryam Hamzeloo-Moghadam, Shiva Irani, Faranak Fallahian
Summary: Gaillardin exerts its anti-cancer properties in gastric cancer cells by inducing apoptosis through inhibition of NF-kappa B pathway and upregulation of ROS production. This study suggests Gaillardin could be a potential natural agent for future anticancer drug development.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jinglei Liu, Fangxu Zhang, Zheming Zhang, Chunning Zheng
Summary: This study found that Everolimus has a pharmacological role in protecting gastric epithelial cells from H.pylori-induced damage. It achieves this by reducing oxidative stress and inhibiting inflammatory response, as well as inhibiting the attachment of monocytes to epithelial cells.
Article
Gastroenterology & Hepatology
Julia Leonhardt, Raphael S. Haider, Christoph Sponholz, Silke Leonhardt, Julia Drube, Katrin Spengler, Diana Mihaylov, Sophie Neugebauer, Michael Kiehntopf, Nevin A. Lambert, Andreas Kortgen, Tony Bruns, Frank Tacke, Carsten Hoffmann, Michael Bauer, Regine Heller
Summary: The study found that serum bile acids in patients with liver failure can activate TGR5, leading to compromised monocyte function and reduced response to bacterial challenge, which is significantly associated with mortality.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Han Zhu, Yuyan Bai, Gaorui Wang, Yousong Su, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: The present study demonstrated that HDCA prevents LPS-induced microglial inflammation in vitro and in vivo via regulating the TGR5/AKT/NF-kappa B signaling pathway.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Plant Sciences
Hyeon Hwa Nam, Byung Kil Choo
Summary: The study demonstrated that Geranium koreanum has protective effects against HCl/EtOH-induced gastritis through anti-inflammatory response, reducing gastric mucosal damage and inflammation. This indicates the potential of using Geranium koreanum as a natural preventive medicine for treating gastritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Nutrition & Dietetics
Moon-Young Song, Da-Young Lee, Young-Min Han, Eun-Hee Kim
Summary: Research has shown that Korean propolis (KP) has anti-inflammatory effects on gastric mucosal injury caused by Helicobacter pylori infection. KP inhibits the growth of H. pylori and reduces the expression of virulence factors. It also decreases inflammation and pathological damage by suppressing the NF-kappa B signaling pathway. These findings suggest that KP could be a natural supplement for patients with gastric mucosal injury caused by H. pylori infection.
Article
Endocrinology & Metabolism
Yan-Dong Wang, Wei-Dong Chen, Cunbao Li, Cong Guo, Yanyan Li, Hui Qi, Hailing Shen, Jing Kong, Xuecheng Long, Frank Yuan, Xichun Wang, Wendong Huang
MOLECULAR ENDOCRINOLOGY
(2015)
Article
Oncology
Cong Guo, Jia Su, Zhijun Li, Rui Xiao, Jianxun Wen, Yanyan Li, Meng Zhang, Xueting Zhang, Donna Yu, Wendong Huang, Wei-Dong Chen, Yan-Dong Wang
Review
Physiology
Cong Guo, Wei-Dong Chen, Yan-Dong Wang
FRONTIERS IN PHYSIOLOGY
(2016)
Article
Oncology
Jia Su, Qiqi Zhang, Hui Qi, Linlin Wu, Yuanqiang Li, Donna Yu, Wendong Huang, Wei-Dong Chen, Yan-Dong Wang
Review
Microbiology
Qingqing Feng, Wei-Dong Chen, Yan-Dong Wang
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Shizhen Zhao, Xinping Li, Le Wang, Wenjing Peng, Wenling Ye, Weiguo Li, Yan-Dong Wang, Wei-Dong Chen
Summary: The novel 1-benzyl-1H-imidazole-5-carboxamide derivatives 19d and 19e exhibited potent agonistic activities against hTGR5 and significant glucose-lowering effects in vivo, suggesting them as promising candidates for the treatment of diabetes and obesity.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Qingqing Feng, Hongli Zhang, Denglin Yao, Xiantong Zhang, Wei-Dong Chen, Yan-Dong Wang
Summary: Activation of FXR inhibits proliferation and migration of esophageal squamous cell carcinoma, induces apoptosis and cell cycle arrest, and suppresses inflammatory genes while promoting pro-apoptotic genes. Activation of FXR also decreases phosphorylation levels of ERK1/2 induced by TNF-alpha, leading to suppression of ESCC tumorigenesis both in vitro and in vivo. These findings suggest that targeting FXR may be a promising therapeutic approach for ESCC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Pathology
Xiaobo Nie, Haisheng Wang, Xiaoyun Wei, Lanqing Li, Ting Xue, Lili Fan, Han Ma, Yubing Xia, Yan-Dong Wang, Wei-Dong Chen
Summary: LRP5 is overexpressed in gastric cancer tissues and its expression is positively associated with advanced clinical stages and poor prognosis. Overexpression of LRP5 enhances proliferation, invasiveness, and drug resistance of gastric cancer cells through activating the canonical Wnt/β-catenin pathway and upregulating glycolysis. LRP5 and glycolysis-related genes also show a positive correlation in gastric cancer tissues.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Xiaobo Nie, Huiyang Liu, Wenling Ye, Xiaoyun Wei, Lili Fan, Han Ma, Lanqing Li, Wanting Xue, Wenting Qi, Yan-Dong Wang, Wei-Dong Chen
Summary: The activation of low-density lipoprotein receptor-related protein 5 (LRP5) promotes cancer stem cell-like phenotypes in colorectal cancer (CRC) cells through activating the canonical Wnt/beta-catenin and IL-6/STAT3 signaling pathways. The upregulation of LRP5 expression is closely associated with clinical stages of CRC patients. Silencing LRP5 gene can suppress the cancer stem cell-like phenotypes of CRC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zixuan Wang, Wei-Dong Chen, Yan-Dong Wang
Summary: Nuclear receptors play crucial roles in the crosstalk between the gut microbiome and the host, regulating metabolic processes, immune activity, and impacting various physiological and pathological conditions. These nuclear receptors may serve as effective targets for treating different diseases.
MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Shizhen Zhao, Le Wang, Jie Wang, Chenwei Wang, Shaowei Zheng, Yajie Fu, Yunfu Li, Wei-Dong Chen, Ruifang Hou, Dongbin Yang, Yan-Dong Wang
Summary: TGR5 is an important target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus, and obesity. Novel compounds have been discovered with excellent agonist activity.
Review
Pharmacology & Pharmacy
Yang Zhao, Wenling Ye, Yan-Dong Wang, Wei-Dong Chen
Summary: Hepatocyte growth factor (HGF) is a multifunctional cytokine that regulates cell growth, proliferation, and survival by activating the c-Met signaling pathway, and it plays a crucial role in liver regeneration.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Abbas Yadegar, Ali Nabavi-Rad, Javier Ochoa-Reparaz, Toshifumi Ohkusa, Yan-Dong Wang
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Xiao-Bo Nie, Bao-Sheng Shi, Lin Zhang, Wei-Li Niu, Ting Xue, Lan-Qing Li, Xiao-Yun Wei, Yan-Dong Wang, Wei-Dong Chen, Rui-Fang Hou
Summary: This study characterizes the epidemiological features and dynamic changes in blood biochemical indices for SARS-CoV-2-infected patients in Hebi, a representative city in North China. The study identifies potential diagnostic markers and dynamic biochemical indices that can aid in the prevention, diagnosis, and treatment of COVID-19 infection.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Cell Biology
Chao Zhang, Zixuan Wang, Qingqing Feng, Wei-Dong Chen, Yan-Dong Wang
HISTOLOGY AND HISTOPATHOLOGY
(2020)