Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation

Desmosine, a biomarker for COPD: old and in the way

(2012) M. Luisetti et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease

(2012) Jeffrey T-J Huang et al.   THORAX

Protein fingerprints — Relying on and understanding the information of serological protein measurements

(2011) M.A. Karsdal et al.   CLINICAL BIOCHEMISTRY

Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM—Increased serum CIIM in subjects with severe radiographic osteoarthritis

(2011) Anne-Christine Bay-Jensen et al.   CLINICAL BIOCHEMISTRY

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis

(2011) Bela Desai et al.   EXPERIMENTAL LUNG RESEARCH

The Role of Matrix Metalloproteinase-9 in Cigarette Smoke–induced Emphysema

(2010) Jeffrey J. Atkinson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophage-Mediated Proteolytic Remodeling of the Extracellular Matrix in Atherosclerosis Results in Neoepitopes: A Potential New Class of Biochemical Markers

(2010) Helene Skjøt-Arkil et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A family with a new elastin gene mutation: broad clinical spectrum, including sudden cardiac death

(2010) André Jakob et al.   CARDIOLOGY IN THE YOUNG

A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen

(2010) N. Barascuk et al.   CLINICAL BIOCHEMISTRY

Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers—are they the cause or the consequence of the disease?

(2010) Morten Asser Karsdal et al.   CLINICAL BIOCHEMISTRY

Characterization of peptide fragments from lung elastin degradation in chronic obstructive pulmonary disease

(2010) Jiangtao He et al.   EXPERIMENTAL LUNG RESEARCH

Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines

(2010) Andrea Heinz et al.   FEBS Journal

Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

(2010) Sanne S. Veidal et al.   LIVER INTERNATIONAL

Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

(2009) M.A. Karsdal et al.   BIOMARKERS

Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in timeex vivo

(2009) Suzi Hoegh Madsen et al.   BIOMARKERS

What can naturally occurring mutations tell us about the pathogenesis of COPD?

(2009) S J Marciniak et al.   THORAX

Characterization of metalloprotease cleavage products of human articular cartilage

(2008) Eugene Y. Zhen et al.   ARTHRITIS AND RHEUMATISM

Desmosine as a biomarker of elastin degradation in COPD: current status and future directions

(2008) M. Luisetti et al.   EUROPEAN RESPIRATORY JOURNAL

Mapping of macrophage elastase cleavage sites in insoluble human skin elastin

(2008) Samuel Taddese et al.   MATRIX BIOLOGY

In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24

(2008) Samuel Taddese et al.   MATRIX BIOLOGY

Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort

(2008) D A Lomas et al.   THORAX