Article
Respiratory System
Sara De Matteis, Debbie Jarvis, Lucy Darnton, Dario Consonni, Hans Kromhout, Sally Hutchings, Steven S. Sadhra, David Fishwick, Roel Vermeulen, Lesley Rushton, Paul Cullinan
Summary: This large population-based study found an association between occupational exposure to pesticides and risk of COPD. The risk was particularly pronounced among non-smokers and individuals without asthma.
Article
Respiratory System
Hyun Woo Lee, Jung-Kyu Lee, Myung Goo Lee, Kyung-Cheol Shin, Seung Won Ra, Tae-Hyung Kim, Yong-Il Hwang, Ki-Suck Jung, Kwang Ha Yoo, Deog Kyeom Kim
Summary: This study aimed to determine the risk factors and clinical outcomes for rapid FEV1 decline in COPD patients. The results showed that male sex, current smoking, blood eosinophil count <150/mu L, and high forced vital capacity were independent risk factors for rapid FEV1 decline. Rapid decliners had a faster decline in lung function, particularly in current smokers and patients with severe dyspnea. Triple combination therapy was found to slow down the decline in lung function compared to monotherapy. Rapid decliners also had a higher risk of severe exacerbation.
Article
Respiratory System
Nathaniel M. Hawkins, Sandra Peterson, Allison M. Ezzat, Rohit Vijh, Sean A. Virani, Andrew Gibb, G. B. John Mancini, Sabrina T. Wong
Summary: Cardiovascular risk factors are common in COPD patients, but they are inadequately monitored, treated, and controlled.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Medicine, General & Internal
Bo-Guen Kim, Hyun Lee, Min Gu Kang, Jong Seung Kim, Ji-Yong Moon
Summary: This study used a longitudinal database to investigate the risk of ischemic heart disease (IHD) in patients with chronic obstructive pulmonary disease (COPD) and found that COPD patients had a higher risk of developing IHD, independent of demographic characteristics and health-related behaviors.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Nebal S. Abu Hussein, Stephanie Giezendanner, Pascal Urwyler, Pierre-Olivier Bridevaux, Prashant N. Chhajed, Thomas Geiser, Ladina Joos Zellweger, Malcolm Kohler, David Miedinger, Zahra Pasha, Robert Thurnheer, Christophe von Garnier, Joerg D. Leuppi
Summary: This study describes recurrent exacerbations in a GP-based Swiss COPD cohort and develops a statistical model for predicting exacerbation rates. A nomogram is created to assist clinicians in the decision-making process of COPD care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Rafiqul Islam, Md Tarek Hossain, Nantu Chakma, Afroza Khanom, Tapas Mazumder, Md Tauhidul Islam
Summary: The scoping review will map the evidence on COPD in South Asia through literature review, focusing on prevalence, risk factors, and interventions. This review will contribute to the advancement of research on COPD and will provide valuable information for policy-makers, public health specialists, and clinicians.
SYSTEMATIC REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Patricio Lopez-Jaramillo, Philip Joseph, Jose P. Lopez-Lopez, Fernando Lanas, Alvaro Avezum, Rafael Diaz, Paul A. Camacho, Pamela Seron, Gustavo Oliveira, Andres Orlandini, Sumathy Rangarajan, Shofiqul Islam, Salim Yusuf
Summary: In a multinational South American cohort, variations in CVD incidence and mortality rates were examined between sub-populations stratified by country, sex, and urban or rural location. The study found that men had higher rates of CVD and death compared to women, and death rates were higher in rural areas. Hypertension, obesity, diabetes, and tobacco use were identified as leading risk factors for both CVD and death.
EUROPEAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Sky Chew, Deb Colville, Anastasia Hutchinson, Piers Canty, Lauren Hodgson, Judy Savige
Summary: This study examined the presence of hypertensive microvascular disease in individuals with obstructive sleep apnoea (OSA) compared to those with chronic obstructive pulmonary disease (COPD) and hospital controls. The results showed that individuals with OSA had higher mean arterial pressure, more microvascular retinopathy, and narrower retinal arterioles compared to other patients. These findings suggest that OSA is associated with a higher risk of microvascular disease.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Mengyao Li, Yanan Wan, Zheng Zhu, Pengfei Luo, Hao Yu, Jian Su, Dong Hang, Yan Lu, Ran Tao, Ming Wu, Jinyi Zhou, Xikang Fan
Summary: This study investigated the association between glycated haemoglobin (HbA1c) levels and the incidence of chronic obstructive pulmonary disease (COPD) in the general population, as well as the association between HbA1c levels and mortality in patients with COPD. The results showed that both lower and higher HbA1c levels were associated with an increased risk of COPD and all-cause death in COPD patients.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Gaelle Dauriat, Martine Reynaud-Gaubert, Vincent Cottin, Bouchra Lamia, David Montani, Mathieu Canuet, Clement Boissin, Cecile Tromeur, Ari Chaouat, Bruno Degano, Emmanuel Bergot, Olivier Sanchez, Gregoire Prevot, Olivier Sitbon, Gabriel Thabut, Drifa Belhadi, Yolande Costa de Beauregard, Amina Bencherif, Marc Humbert, Gerald Simonneau, Cedric Laouenan, Herve Mal
Summary: This study describes the characteristics of severe PH-COPD patients, showing moderate airway obstruction but marked dyspnea, hypoxemia, low DLCO, and high mPAP. This phenotype is associated with a poor prognosis.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Computer Science, Interdisciplinary Applications
Xuchun Wang, Hao Ren, Jiahui Ren, Wenzhu Song, Yuchao Qiao, Zeping Ren, Ying Zhao, Liqin Linghu, Yu Cui, Zhiyang Zhao, Limin Chen, Lixia Qiu
Summary: This study constructed a risk prediction model for chronic obstructive pulmonary disease (COPD) using machine learning methods to improve its prediction efficiency. The results showed that frequent coughing before the age of 14 and 9 other variables were important parameters for COPD. In addition, by performing feature selection and balancing data processing, machine learning models could automatically identify patients at risk of COPD, providing a simple and scientific approach for early identification of COPD.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Cristino C. Oliveira, Raquel Annoni, Annemarie L. Lee, Jennifer McGinley, Louis B. Irving, Linda Denehy
Summary: This systematic review synthesized falls outcomes in COPD patients, finding a 30% prevalence of fallers and a 24% prevalence of frequent fallers. Risk factors for falls in stable COPD include age, female gender, falls history, number of medications, comorbidities, coronary heart disease, use of supplemental oxygen, impaired balance performance, and smoking history. Further research with prospective recording is needed in COPD.
RESPIRATORY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Setor K. Kunutsor, Sae Young Jae, Timo H. Makikallio, Jari A. Laukkanen
Summary: The study found that higher cardiorespiratory fitness (CRF) can moderately attenuate the increased risk of chronic obstructive pulmonary disease (COPD) due to smoking.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Review
Peripheral Vascular Disease
Nicolas Renna, Daniel Piskorz, Diego Stisman, Diego Martinez, Ludmila Lescano, Sergio Vissani, Walter Espeche, Diego Marquez, Roberto Parodi, Diego Naninni, Marcos Baroni, Daniel Llanos, Rocio Martinez, Jessica Barochinner, Gustavo Staffieri, Fernando Lanas, Monica Velasquez, Marcos Marin, Bryan Williams, Irene Ennis
Summary: This document provides a comprehensive review of the scientific evidence on the use of single pill combinations (SPCs) in the treatment of hypertension. It highlights the importance of using multiple drugs to achieve blood pressure goals and the inverse relationship between treatment adherence and the number of drugs taken. The document also discusses the effectiveness and adverse effects of SPCs, their use in special populations, and their impact on hypertensive-mediated organ damage.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Sylvia Haas, John A. Camm, Darius Harald, Jan Steffel, Saverio Virdone, Karen Pieper, Marianne Brodmann, Sebastian Schellong, Frank Misselwitz, Gloria Kayani, Ajay K. Kakkar
Summary: There are similarities and dissimilarities in AF management and clinical outcomes between DACH and ORW regions. The increased use of NOACs in DACH is associated with a mismatch in risk-adapted anticoagulation. Suboptimal control of INR is observed in both regions. DACH region has higher rates of cardiovascular death and lower rates of non-haemorrhagic stroke.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Clinical Neurology
Andrew Smyth, Martin O'Donnell, Sumathy Rangarajan, Graeme J. Hankey, Shahram Oveisgharan, Michelle Canavan, Clodagh McDermott, Denis Xavier, Hongye Zhang, Albertino Damasceno, Alvaro Avezum, Nana Pogosova, Aytekin Oguz, Danuta Ryglewicz, Helle Klingenberg Iversen, Fernando Lanas, Annika Rosengren, Salim Yusuf, Peter Langhorne
Summary: This study examined the association between alcohol consumption and stroke in a large international population. It found that high and moderate alcohol intake increased the odds of stroke, while low intake was not associated with stroke. However, there were regional variations in the relationship.
Article
Nutrition & Dietetics
Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Viswanathan Mohan, Sumathi Swaminathan, Alvaro Avezum, Scott A. Lear, Annika Rosengren, Paul Poirier, Fernando Lanas, Patricio Lopez-Jaramillo, Biju Soman, Chuangshi Wang, Andres Orlandini, Noushin Mohammadifard, Khalid F. AlHabib, Jephat Chifamba, Afzal Hussein Yusufali, Romaina Iqbal, Rasha Khatib, Karen Yeates, Thandi Puoane, Yuksel Altuntas, Homer Uy Co, Sidong Li, Weida Liu, Katarzyna Zatonska, Rita Yusuf, Noorhassim Ismail, Victoria Miller, Salim Yusuf
Summary: This study found that higher intake of ultra-processed foods (UPFs) is associated with increased risk of mortality and cardiovascular disease (CVD) in a diverse multinational cohort. The results showed that a diet high in UPFs is related to higher risk of total mortality, cardiovascular mortality, and non-cardiovascular mortality, but not major CVD events.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Cardiac & Cardiovascular Systems
Ruvistay Gutierrez-Arias, Jorge Hinojosa-Riadi, Adrian Sandoval-Canio, Hannelore Santana-Garrido, Nicolas Valdovinos-Guerrero, Pamela Seron
Summary: The effectiveness of respiratory muscle training in adult patients with pulmonary hypertension (PH) is uncertain. It is unclear whether respiratory muscle training can improve functional exercise capacity and reduce dyspnea sensation, and whether it has an impact on quality of life. Further well-designed randomized controlled trials are needed to determine the real effect of this intervention.
HEART LUNG AND CIRCULATION
(2023)
Article
Environmental Sciences
Ying Wang, MyLinh Duong, Michael Brauer, Sumathy Rangarajan, Antonio Dans, Fernando Lanas, Patricio Lopez-Jaramillo, Thandi Puoane, Karen Yeates, Jephat Chifamba, Rita Yusuf, Zhiguang Liu, Yang Li, Lap Ah Tse, Deepa Mohan, Rajeev Gupta, Sanjeev Nair, P. V. M. Lakshmi, Romaina Iqbal, Taniya Anto, Salim Yusuf, Perry Hystad
Summary: This study examines the association between household air pollution (HAP) from solid fuel cooking and respiratory health. It finds that using solid fuels is associated with lower lung function and an increased risk of respiratory diseases and mortality. However, switching from solid fuels to clean fuels can improve lung function and decrease the risk of respiratory events.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Review
Public, Environmental & Occupational Health
Edgar D. Hernandez, Elisa A. Cobo, Lawrence P. Cahalin, Pamela Seron
Summary: This study aimed to determine the effectiveness of structural-level environmental interventions on changes in physical activity (PA) levels in populations. A literature search was conducted to include natural experiments with structural modifications, and the results showed that such interventions can improve PA levels, with the greatest effect observed in parks and active transportation.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Ruvistay Gutierrez-Arias, Dawid Pieper, Carole Lunny, Rodrigo Torres-Castro, Raul Aguilera-Eguia, Pamela Seron
Summary: The purpose of this study is to describe the strategies used by authors of overviews focusing on exercise-related interventions to manage the overlap of primary studies. A comprehensive search strategy will be developed, and the information from the included overviews will be extracted. The findings of this study will be presented at scientific conferences and published in peer-reviewed scientific journals related to rehabilitation or research methods.
Article
Cardiac & Cardiovascular Systems
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Martin O'Donnell, Weihong Hu, Gilles Dagenais, Andreas Wielgosz, Scott A. Lear, Li Wei, Rafael Diaz, Alvaro Avezum, Patricio Lopez-Jaramillo, Fernando Lanas, Sumathi Swaminathan, Manmeet Kaur, K. Vijayakumar, Viswanathan Mohan, Rajeev Gupta, Andrzej Szuba, Romaina Iqbal, Rita Yusuf, Noushin Mohammadifard, Rasha Khatib, Nafiza Mat Nasir, Kubilay Karsidag, Annika Rosengren, Afzalhussein Yusufali, Edelweiss Wentzel-Viljoen, Jephat Chifamba, Antonio Dans, Khalid F. Alhabib, Karen Yeates, Koon Teo, Hertzel C. Gerstein, Salim Yusuf
Summary: A healthy diet score based on fruits, vegetables, nuts, legumes, fish, and whole-fat dairy is associated with lower risk of all-cause mortality, cardiovascular disease, myocardial infarction, and stroke in a global population. This score exhibits stronger associations with death or CVD compared to other common diet scores.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Darryl P. Leong, Philip Joseph, John J. Mcmurray, Jean Rouleau, Aldo P. Maggioni, Fernando Lanas, Sanjib K. Sharma, Julio Nunez, Bishav Mohan, Ahmet Celik, Jabir Abdullakutty, Okechukwu S. Ogah, Lisa M. Mielniczuk, Kumar Balasubramanian, Tara Mccready, Alex Grinvalds, Salim Yusuf, G CHF Investigators
Summary: Frailty has incremental prognostic importance in predicting death and HF hospitalization in HF populations, beyond conventional prognostic variables. This relationship is consistent across countries at all income levels.
EUROPEAN HEART JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Daniela Gomez-Perez, Pamela Seron, Maria Jose Oliveros, Gladys Morales Illanes, Maria Jose Arancibia, Sherry L. Grace
Summary: This study evaluated the usefulness of a booklet as support material for counseling in a hybrid CR program developed for low-resource settings. The results showed that the booklet was easy to understand, contained practical suggestions, and was useful for future questions. Both patients and delivering professionals found the booklet to be helpful in counseling. This resource can be disseminated for use by other Spanish CR programs.
PATIENT EDUCATION AND COUNSELING
(2023)
Review
Medicine, General & Internal
Raul Alberto Aguilera-Eguia, Ruvistay Gutierrez-Arias, Carlos Zaror, Pamela Seron
Summary: This study aims to evaluate the effectiveness of different physical exercise programmes in reducing the volume of lymphoedema, pain intensity, and improving quality of life in breast cancer-related lymphoedema patients. The researchers will collect data by searching databases and assess the overall quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation System. The results will be published in peer-reviewed journals and disseminated in scientific conferences.
Article
Medicine, General & Internal
Ruvistay Gutierrez-Arias, Dawid Pieper, Peter Nydahl, Felipe Gonzalez-Seguel, Yorschua Jalil, Maria-Jose Oliveros, Rodrigo Torres-Castro, Pamela Seron
Summary: This study aims to evaluate the redundancy, methodological and reporting quality, and potential reasons for discordance in systematic reviews (SRs) conducted to determine the effectiveness of early mobilisation in critically ill adult patients. Through searching multiple databases, reviewing literature and assessing the quality of studies, the effectiveness of this intervention will be explored. Findings of this study will be disseminated at conferences and published in a peer-reviewed journal.
Article
Biochemistry & Molecular Biology
Cristian Morales, Raul Arias-Carrasco, Vinicius Maracaja-Coutinho, Pamela Seron, Fernando Lanas, Luis A. Salazar, Nicolas Saavedra
Summary: This study aimed to identify differences in bacterial small RNAs between hypercholesterolemic and normocholesterolemic individuals at the gut level. Most of the small RNAs were of bacterial origin and had a higher number of readings in normocholesterolemic participants. Small RNA ID 2909606 associated with Coprococcus eutactus and small RNA ID 2149569 from the species Blautia wexlerae were upregulated in hypercholesterolemic subjects, and other bacterial and archaeal small RNAs interacting with the LDL receptor were identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Patricio Lopez-Jaramillo, Diego Gomez-Arbelaez, Daniel Martinez-Bello, Marc Evans M. Abat, Khalid F. Alhabib, Alvaro Avezum, Olga Barbarash, Jephat Chifamba, Maria L. Diaz, Sadi Gulec, Noorhassim Ismail, Romaina Iqbal, Roya Kelishadi, Rasha Khatib, Fernando Lanas, Naomi S. Levitt, Yang Li, Viswanathan Mohan, Prem K. Mony, Paul Poirier, Annika Rosengren, Biju Soman, Chuangshi Wang, Yang Wang, Karen Yeates, Rita Yusuf, Afzalhussein Yusufali, Katarzyna Zatonska, Sumathy Rangarajan, Salim Yusuf
Summary: The TyG index is associated with cardiovascular diseases and mortality, especially in Asia. It is significantly related to the risk of cardiovascular diseases, myocardial infarction, stroke, and type 2 diabetes, indicating that insulin resistance plays a promoting role in the development of these diseases.
LANCET HEALTHY LONGEVITY
(2023)