Protein Carbonylation, Mitochondrial Dysfunction, and Insulin Resistance

What causes the insulin resistance underlying obesity?

(2013) Olga T. Hardy et al.   Current Opinion in Endocrinology Diabetes and Obesity

Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle

(2012) Michael J. Boden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Systems biology of antioxidants

(2012) Ramaroson Andriantsitohaina et al.   CLINICAL SCIENCE

Protein Oxidative Modification in the Aging Organism and the Role of the Ubiquitin Proteasomal System

(2012) Marc Kastle et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice

(2012) S. Paglialunga et al.   DIABETOLOGIA

The Lipid Peroxidation By-Product 4-Hydroxy-2-Nonenal (4-HNE) Induces Insulin Resistance in Skeletal Muscle through Both Carbonyl and Oxidative Stress

(2012) Nicolas J. Pillon et al.   ENDOCRINOLOGY

Protein Carbonylation and Adipocyte Mitochondrial Function

(2012) Jessica M. Curtis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal Muscle Lipid Peroxidation and Insulin Resistance in Humans

(2012) Katherine H. Ingram et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Overfeeding Reduces Insulin Sensitivity and Increases Oxidative Stress, without Altering Markers of Mitochondrial Content and Function in Humans

(2012) Dorit Samocha-Bonet et al.   PLoS One

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Protein carbonylation and metabolic control systems

(2012) Jessica M. Curtis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Peroxiredoxin 3 Is a Key Molecule Regulating Adipocyte Oxidative Stress, Mitochondrial Biogenesis, and Adipokine Expression

(2011) Joo Young Huh et al.   ANTIOXIDANTS & REDOX SIGNALING

Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells

(2011) C. T. Shearn et al.   BIOCHEMISTRY

Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models?

(2011) JennaLynn Styskal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quantitative Proteomic Profiling of Muscle Type-Dependent and Age-Dependent Protein Carbonylation in Rat Skeletal Muscle Mitochondria

(2011) J. Feng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

(2011) C. T. Shearn et al.   MOLECULAR PHARMACOLOGY

Increased Adipose Protein Carbonylation in Human Obesity

(2011) Brigitte I. Frohnert et al.   Obesity

The Drosophila carbonyl reductase sniffer is an efficient 4-oxonon-2-enal (4ONE) reductase

(2010) Hans-Jörg Martin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction

(2010) J. M. Curtis et al.   DIABETES

Trans-4-oxo-2-nonenal potently alters mitochondrial function

(2010) Matthew J. Picklo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lifelong Physical Activity Modulation of the Skeletal Muscle Mitochondrial Proteome in Mice

(2010) Renato M. P. Alves et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal

(2010) Kristina Hellberg et al.   PROTEIN SCIENCE

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK

(2009) Troy L. Merry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Redox Balance and Carbonylated Proteins in Limb and Heart Muscles of Cachectic Rats

(2009) Judith Marin-Corral et al.   ANTIOXIDANTS & REDOX SIGNALING

Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments

(2009) Markus Griesser et al.   JOURNAL OF LIPID RESEARCH

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of xanthine oxidase inhibition on oxidative stress and swimming performance in rats

(2008) Aristidis S. Veskoukis et al.   Applied Physiology Nutrition and Metabolism

RLIP76: A novel glutathione-conjugate and multi-drug transporter

(2008) Sharad S. Singhal et al.   BIOCHEMICAL PHARMACOLOGY

The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences

(2008) S. de Ferranti et al.   CLINICAL CHEMISTRY

FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes

(2008) D. Demozay et al.   DIABETES

Introduction to Oxidative Stress and Mitochondrial Dysfunction

(2008) Lester Mandelker   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Alterations inin vitrofunction and protein oxidation of rat sarcoplasmic reticulum Ca2+-ATPase during recovery from high-intensity exercise

(2007) Satoshi Matsunaga et al.   EXPERIMENTAL PHYSIOLOGY

Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling

(2007) Li Li Ji   FREE RADICAL BIOLOGY AND MEDICINE