标题
Binding kinetics of cariprazine and aripiprazole at the dopamine D3 receptor
作者
关键词
-
出版物
Scientific Reports
Volume 8, Issue 1, Pages -
出版商
Springer Nature America, Inc
发表日期
2018-08-15
DOI
10.1038/s41598-018-30794-y
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Drug target residence time: a misleading concept
- (2018) Rutger H.A. Folmer DRUG DISCOVERY TODAY
- The preclinical discovery and development of cariprazine for the treatment of schizophrenia
- (2018) Anna Wesołowska et al. Expert Opinion on Drug Discovery
- BiKi Life Sciences: A New Suite for Molecular Dynamics and Related Methods in Drug Discovery
- (2018) Sergio Decherchi et al. Journal of Chemical Information and Modeling
- Fast Dynamic Docking Guided by Adaptive Electrostatic Bias: The MD-Binding Approach
- (2018) Andrea Spitaleri et al. Journal of Chemical Theory and Computation
- Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
- (2018) Sheng Wang et al. NATURE
- Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism
- (2017) Alessandro Bonifazi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial
- (2017) György Németh et al. LANCET
- Trends in GPCR drug discovery: new agents, targets and indications
- (2017) Alexander S. Hauser et al. NATURE REVIEWS DRUG DISCOVERY
- Binding Kinetics and Pathways of Ligands to GPCRs
- (2017) Andrea Strasser et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Synthesis, Molecular Properties Estimations, and Dual Dopamine D2 and D3 Receptor Activities of Benzothiazole-Based Ligands
- (2017) Moritz Schübler et al. Frontiers in Chemistry
- The dopamine D3 receptor, a quarter century later
- (2016) Pierre Sokoloff et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Ligand Binding Pathways of Clozapine and Haloperidol in the Dopamine D2 and D3 Receptors
- (2016) Trayder Thomas et al. Journal of Chemical Information and Modeling
- The role of kinetic context in apparent biased agonism at GPCRs
- (2016) Carmen Klein Herenbrink et al. Nature Communications
- Rotigotine is a potent agonist at dopamine D1receptors as well as at dopamine D2and D3receptors
- (2015) Martyn Wood et al. BRITISH JOURNAL OF PHARMACOLOGY
- ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
- (2015) James A. Maier et al. Journal of Chemical Theory and Computation
- Kinetics of protein-ligand unbinding via smoothed potential molecular dynamics simulations
- (2015) Luca Mollica et al. Scientific Reports
- A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands
- (2014) David C Swinney et al. BRITISH JOURNAL OF PHARMACOLOGY
- The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue
- (2014) Ralf Brisch et al. Frontiers in Psychiatry
- GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
- (2013) Sander Pronk et al. BIOINFORMATICS
- A general and Robust Ray-Casting-Based Algorithm for Triangulating Surfaces at the Nanoscale
- (2013) Sergio Decherchi et al. PLoS One
- Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors
- (2012) Éva Ágai-Csongor et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism
- (2012) Georges Vauquelin et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Bridging the gap: bitopic ligands of G-protein-coupled receptors
- (2012) J. Robert Lane et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Slow dissociation of partial agonists from the D2 receptor is linked to reduced prolactin release
- (2011) Lucia Carboni et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Discovery of -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy
- (2011) J. A. Allen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
- (2010) E. Y. T. Chien et al. SCIENCE
- Antagonism of dopamine D2 receptor/ -arrestin 2 interaction is a common property of clinically effective antipsychotics
- (2008) B. Masri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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