Article
Multidisciplinary Sciences
Jantima Upan, Napaporn Youngvises, Adisorn Tuantranont, Chanpen Karuwan, Philippe Banet, Pierre-Henri Aubert, Jaroon Jakmunee
Summary: A label-free electrochemical aptamer-based sensor was developed for AFP detection, utilizing a PtNPs/GO-COOH modified platform with an AFP aptamer as the recognition element. The sensor demonstrated good sensitivity, selectivity, and stability for sensitive detection of AFP in serum samples.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Jairo Pinto de Oliveira, Francisco Burgos-Florez, Isabella Sampaio, Pedro Villalba, Valtencir Zucolotto
Summary: In this study, a label-free impedimetric immunosensor was developed to detect OTA in coffee. The biosensor showed high selectivity and was not affected by matrix interference in coffee samples. It has the advantages of small sample volume, short analysis time, and potential miniaturization.
Article
Biophysics
Rocco Cancelliere, Alessio Di Tinno, Andrea Maria Di Lellis, Giorgio Contini, Laura Micheli, Emanuela Signori
Summary: This study presents two novel label-free voltammetric immunosensors for rapid and accurate detection of IL-6 in human serum. The immunosensors showed good analytical performances and outperformed a commercial ELISA kit in terms of sensitivity, reproducibility, and detection time. They were also successfully applied in blood samples, demonstrating good sensitivity and reproducibility.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemical Research Methods
Priscila D. Mendonca, Lorenna K. B. Santos, Marcos Foguel, Marco A. B. Rodrigues, Marli T. Cordeiro, Luis M. Goncalves, Ernesto T. A. Marques, Rosa F. Dutra
Summary: The incidence of dengue virus infection has grown dramatically worldwide, affecting 128 countries. The diagnosis is challenging due to similarities with other viruses such as Zika, and the underreporting of cases leads to potentially higher numbers of affected people. An immunosensor using carbon nanotube-ethylenediamine for NS1 detection shows promising results for diagnosis of dengue and Zika viruses.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Aiping Wang, Xiaojuan You, Hongliang Liu, Jingming Zhou, Yumei Chen, Chenyang Zhang, Kaikai Ma, Yankai Liu, Peiyang Ding, Yanhua Qi, Gaiping Zhang
Summary: An electrochemical immunosensor using Ag-GO nanocomposites and AuNPs was developed for the detection of tiamulin, showing enhanced conductivity and a low LOD in a wide linear range. This efficient and simple sensor demonstrated high accuracy in detecting tiamulin in real samples, suggesting its potential as a detection platform for veterinary antibiotics in animal derived foods.
Article
Biochemical Research Methods
Rosaceleste Zumpano, Manuela Manghisi, Francesca Polli, Cristine D'Agostino, Federica Ietto, Gabriele Favero, Franco Mazzei
Summary: This study developed a label-free electrochemical immunosensor for the quick, cheap, and straightforward determination of atrazine, achieving detection through a technological platform and specific treatment methods. Under optimal experimental conditions, the immunosensor exhibited good linearity range, limit of detection, reproducibility, and stability, making it suitable for successful application in the detection and monitoring of atrazine in real water samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Baha Ondes, Sinem Evli, Murat Uygun, Deniz Aktas Uygun
Summary: A new label-free electrochemical immunosensor modified with boron nitride nanosheets was developed for early detection of CA125 in this study. The immunosensor showed good detection properties and stability, successfully detecting CA125 in artificial serum samples. The prepared immunosensor has potential for point-of-care diagnosis in real cases.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Huan Zhao, Linlin Cao, Qing Liu, Feng Tang, Lei Chen, Shujun Wang, Yueyuan Li, Yang Li, Bo Li, Hui Liu
Summary: This study presents the synthesis of trimetallic nanoparticles with excellent catalytic performance and their combination with a unique hollow window structure material to construct a label-free electrochemical immunosensor with ultra-high sensitivity, providing an important reference for the sensitive detection of CTnI.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Wenjing Qian, Jingming Zhou, Yumei Chen, Hongliang Liu, Peiyang Ding, Yankai Liu, Chao Liang, Xifang Zhu, Ying Zhang, Enping Liu, Aiping Wang, Gaiping Zhang
Summary: This study presents a label-free electrochemical immunosensor based on silver nanoparticles-reduced graphene oxide (AgNPs-rGO) nanocomposites and staphylococcal protein A (SPA) for the direct detection of Virginiamycin (VIR) M1. The immunosensor exhibits good catalytic currents and a wide linear range, providing high accuracy in detecting VIR M1.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Analytical
Noel Manring, Muzammil M. N. Ahmed, Nicholas Tenho, Jessica L. Smeltz, Pavithra Pathirathna
Summary: This article highlights the most promising studies reported over the past decade on the detection of a broad spectrum of viruses using voltammetry, amperometry, and electrochemical impedance spectroscopy, which provide rapid, cheap, fast, sensitive, and selective diagnosis for point-of-care facilities.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Xue Zhang, Xiaoning Liao, Yongfa Wu, Wanming Xiong, Juan Du, Zhui Tu, Wuying Yang, Dan Wang
Summary: A label-free electrochemical immunosensor for small molecular AFB(1) detection was constructed using functionalized black phosphorene and anti-AFB(1) nanobody, showing a linear range from 1.0 pM to 5.0 nM and an ultralow detection limit of 0.27 pM under optimized conditions. The fabricated immunosensor exhibited satisfactory stability, specificity, and reproducibility, providing a reliable reference for label-free sensing of small molecules in food samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Han Yan, Baoshan He, Wenjie Ren, Zhiguang Suo, Yiwei Xu, Lingling Xie, Liping Li, Jinping Yang, Renli Liu
Summary: In this study, an immunosensor for zearalenone (ZEN) detection was designed using PEI-rGO/Pt@Au NRs nanocomposite as the modification material. The immunosensor showed good stability, conductivity, and a large specific surface area, leading to improved detection performance for ZEN. The electrochemical response of the immunosensor exhibited a linear relation to a wide concentration range with a low detection limit, indicating its potential for trace detection of ZEN in real samples.
BIOELECTROCHEMISTRY
(2022)
Article
Chemistry, Analytical
Ching-Chou Wu, Yu-Huan Chiang, Hsin-Yu Chiang
Summary: This study developed an EIS-based immunosensor for the detection of SARS-CoV-2 nucleocapsid protein in saliva. The immunosensor showed high sensitivity, low limit of detection, and good reproducibility. It also exhibited minimal cross-reactivity with other viral antigens.
Article
Chemistry, Analytical
Shu Tian, Xiaoya Wang, Chenchen Wang, Liqun Li, Wei Wei
Summary: In this study, a simple and label-free method using differential pulse voltammetry (DPV) was proposed for the sensitive detection of menthol. Silica microspheres (SiO2) were introduced for better modification and enrichment of ferrocene (Fc) on the electrode surface to improve detection sensitivity. The electrochemical signal of Fc was inhibited due to the inclusion action of Fc and ss-cyclodextrins (ss-CD), but showed remarkable recovery in the presence of menthol. The recovered electrochemical signal increased linearly with the concentration of menthol, providing a high sensitivity for quantitative detection.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jing Ma, Dai Li, Bolu Sun, Xiaohui Hou, Xinru Zhang-Peng, Wen Li, Yan Zhang, Fangdi Hu, Xiaofeng Shi
Summary: In this study, a label-free electrochemical immunosensor for anti-CCP antibodies was developed using N-G and AuNPs, demonstrating high specificity, selectivity, and stability in the linear range of 0.125 to 2000 pg mL-1. This sensor was successfully applied for the detection of anti-CCP antibodies in human serum, providing a new approach for early diagnosis of RA.
Article
Biophysics
Vishal Chaudhary, Virat Khanna, Hafiz Taimoor Ahmed Awan, Kamaljit Singh, Mohammad Khalid, Yogendra Kumar Mishra, Shekhar Bhansali, Chen-Zhong Li, Ajeet Kaushik
Summary: This article introduces the fifth-generation portable intelligent and multifunctional biosensors embedded on a single chip, which are used for current public health emergencies. The article discusses in detail the advancements in MXene fabrication, physicochemical properties, and the application prospects of MXene-based biosensors in the medical field, as well as the sustainability and challenges associated with these technologies.
BIOSENSORS & BIOELECTRONICS
(2023)
Editorial Material
Cell Biology
Malgorzata Kujawska, Ajeet Kaushik
NEURAL REGENERATION RESEARCH
(2023)
Article
Materials Science, Biomaterials
Dhiraj Kumar, Mahdieh Moghiseh, Kenny Chitcholtan, Isha Mutreja, Chiara Lowe, Ajeet Kaushik, Anthony Butler, Peter Sykes, Nigel Anderson, Aamir Raja
Summary: Emerging multifunctional nanoparticulate formulations, with nano-meter scale size and surface chemistry, can act as therapeutic delivery agents and diagnostic tools for non-invasive real-time monitoring using imaging technologies. This study evaluated the selective uptake of 18 nm and 80 nm sized gold nanoparticles (AuNPs) by ovarian cancer (OC) cells in vitro, and found that the 18 nm AuNPs were taken up 4 times more by SKOV3 cells compared to OVCAR5 cells. Luteinizing hormone-releasing hormone (LHRH) was conjugated to the surface of the AuNPs, making them potential contrast agents for novel spectral photon-counting CT imaging technology and a promising approach for targeted therapy of ovarian cancer.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Multidisciplinary
Mehar Singh, Abhinav Kapur, Urmila Chakraborty, Moondeep Chauhan, Gurpreet Kaur, Ajeet Kaushik, Ebrahim Mostafavi, Ganga Ram Chaudhary
Summary: This research reports the fabrication of dodecylamine-capped hafnium oxide nanomaterial for highly selective and sensitive detection of sulfide electrochemically. The fabricated sensor exhibits remarkable electrocatalytic oxidation of sulfide with fast electron transfer and nanomolar limit of detection. The method provides a green and economic approach for sulfide detection with high stability and charge density.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Virology
Evelyn J. Franco, George L. Drusano, Kaley C. Hanrahan, Kelly L. Warfield, Ashley N. Brown
Summary: This study evaluated the effectiveness of the combination therapy of UV-4B and EIDD-1931 against SARS-CoV-2 beta, delta, and omicron BA.2 variants. The results demonstrated that the combination therapy significantly enhanced the antiviral activity against these three variants compared to monotherapy. The analysis using the Greco model also identified the interaction between UV-4B and EIDD-1931 as additive against the beta and omicron variants and synergistic against the delta variant.
Review
Immunology
Vivek P. Chavda, Rajashri Bezbaruah, Disha Valu, Bindra Patel, Anup Kumar, Sanjay Prasad, Bibhuti Bhusan Kakoti, Ajeet Kaushik, Mariya Jesawadawala
Summary: The COVID-19 breakout had a devastating impact globally, resulting in millions of deaths and significant economic burdens. However, the determination of the SARS-CoV-2 genetic sequence and global efforts to develop potential vaccines have provided a glimmer of hope. Adenoviral vector-based vaccines have shown promise due to their higher immune response, better manufacturing processes, safety, efficacy, and manageable storage procedures. As of April 2022, the WHO has approved three adenoviral vector-based vaccines, among a total of 10 vaccines approved worldwide for COVID-19.
Article
Microbiology
Evelyn J. J. Franco, Eleonora Cella, Xun Tao, Kaley C. C. Hanrahan, Taj Azarian, Ashley N. N. Brown
Summary: In a previous study, it was shown that the nucleoside analogue favipiravir (FAV) can inhibit Zika virus (ZIKV) replication in human-derived cell lines. This study aimed to explain the variation in FAV activity and investigate its mechanism of action and the host cell factors that contribute to tissue-specific differences in drug effect. The results revealed that FAV therapy caused an increase in mutations and the production of defective viral particles in all cell lines, with a higher proportion of defective particles released from HeLa cells. Overall, these companion papers highlight the lethal mutagenesis effect of FAV against ZIKV and demonstrate the influence of host cell factors on the activation and antiviral activity of nucleoside analogues.
Article
Chemistry, Physical
Seyedeh Nooshin Banitaba, Dariush Semnani, Elahe Heydari-Soureshjani, Waqas Ul Arifeen, Tae Jo Ko, Behzad Rezaei, Ali A. Ensafi, Masoud Latifi, Ebrahim Mostafavi, Ajeet Kumar Kaushik
Summary: This study investigated the use of NiNP@RF@Fe3O4 structures as a filler in a polymer electrolyte for solid-state lithium-ion batteries. The introduction of these particles improved the conductivity, resulting in a rougher surface, increased ion pair dissociation, fewer crystalline domains, and better thermal stability.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Vishal Chaudhary, Sarvesh Rustagi, Ajeet Kaushik
Summary: The current public health emergencies have increased the demand for efficient biosensors for rapid diagnosis, disease monitoring, and prevention of associated diseases and deaths. The widespread use of biosensors raises the urgent need for biosensor-associated waste management. However, little attention is being paid to addressing this serious issue. This article highlights the state-of-the-art green biosensors based on bioderived nanostructures used to construct their sensing layer, electrodes, circuitry, and substrates. The utilization of bioderived-NS, bio waste, and green solvents supports sustainable, circular, and green economy without harming planetary health.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2023)
Review
Materials Science, Biomaterials
Vivek Kamat, Preyojon Dey, Dhananjay Bodas, Ajeet Kaushik, Alicia Boymelgreen, Shekhar Bhansali
Summary: Fabricating high-performance nanoparticles with unique properties requires maintaining identical characteristics throughout the processing and application process system. Microfluidic technology provides a unique approach to synthesize nanoparticles with size control, making it suitable for potential biomedical applications. This review discusses various strategies for synthesizing nanoparticles using active microfluidic reactors and explores the challenges and prospects in this field.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Sarah Asgari, Bahareh Farasati Far, Gholamreza Charmi, Parisa Haji Maghsoudi, Shadi Keihankhadiv, Mohammad Seyedhamzeh, Ajeet Kumar Kaushik
Summary: This study demonstrates the development of a controlled-release drug delivery system for hydrocortisone using chitosan-grafted poly(N-vinylcaprolactam)-coated core-shell Fe3O4@SiO2 nanoformulations. The results show that the nanoparticles exhibit a higher release rate at lower pH values and temperature-responsive drug release. The nanoparticles effectively enhance the solubility, loading capacity, and targeted delivery of the drug, improving its therapeutic efficacy and bioavailability.
ACS APPLIED BIO MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Tuba Oz, Ajeet Kumar Kaushik, Malgorzata Kujawska
Summary: This review discusses the potential of tailored graphene-based nanomaterials (GBNs) for the treatment of Parkinson's disease (PD). GBNs show promise in targeting mechanisms contributing to PD neurodegeneration, such as alpha-synuclein aggregation, autophagy, inflammation, and oxidative stress. Furthermore, GBNs can be applied in nanomedicine, regenerative medicine, and biosensors, but so far, their use is limited to computational and early-stage experimental studies, and their biocompatibility and safety need further evaluation.
MATERIALS ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Kamil Reza Khondakar, M. S. Anwar, Hirak Mazumdar, Ajeet Kaushik
Summary: The number of cancer cases is increasing globally, without difference between rich and undeveloped countries. Many nations still face serious obstacles in cancer screening and treatment. Therefore, there is an urgent requirement for quick screening tools and better cancer management to reduce the mortality rate.
MATERIALS ADVANCES
(2023)
Review
Chemistry, Inorganic & Nuclear
Nahid Tyagi, Gaurav Sharma, Deepak Kumar, Pashupati Pratap Neelratan, Deepanshu Sharma, M. Khanuja, Manoj K. Singh, Vishal Singh, Ajeet Kaushik, Sanjeev K. Sharma
Summary: Due to their controlled and manipulative properties, 2D MXenes-based sensors are highly efficient in detecting various types of organic or pharmaceutical contaminants. MXene's photocatalytic and adsorption capabilities make it a promising material for wastewater treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Mehar Singh, Moondeep Chauhan, Yogendra K. Mishra, Scott L. Wallen, Gurpreet Kaur, Ajeet Kaushik, Ganga Ram Chaudhary
Summary: In this study, a novel nanomaterial based on CP-capped HfO2 was developed for efficient electrochemical sensing of the noxious pollutant 2-NPT. The CP@HfO2 nanomaterials showed electron-rich and surface-active sites, which improved the stability of the nanomaterials and enabled selective detection of 2-NPT. The CP@HfO2-NMs/Au sensor exhibited high sensitivity, low detection limit, and wide linear dynamic range, making it an effective analytical tool for selective 2-NPT detection in environmental water samples.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
