Article
Chemistry, Analytical
Jittima Choosang, Suntisak Khumngern, Natha Nontipichet, Panote Thavarungkul, Proespichaya Kanatharana, Apon Numnuam
Summary: An electrochemical immunosensor was developed using a 3D porous chitosan cryogel incorporated with poly(3,4ethylenedioxythiophene), Prussian blue, and gold nanoparticles modified screen-printed carbon electrode. The immunosensor exhibited high sensitivity, a linear range from 1.0 x 10-4 to 1.0 x 103 pg mL-1, and a detection limit of 5.05 x 10-5 pg mL-1. It also demonstrated excellent reproducibility, reusability, stability, and selectivity. Furthermore, the immunosensor successfully quantified CEA in real samples with good agreement with the immunoturbidimetry technique.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Mahdi Habibi, Seyed Ali Mirhosseini, Sharareh Sajjadi, Amir Homayoun Keihan
Summary: A novel electrochemical label-free immunosensor was proposed for sensitive detection of heat-labile enterotoxin from Escherichia coli. The modified electrode was characterized by various techniques, and the analytical performance was evaluated under optimal conditions. The immunosensor exhibited good selectivity, long-term stability, and reproducibility.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Lin Huang, Shanjie Zha, Hongwei Yu, Yawen He, Yue Li, Yafang Shen, Yaping Peng, Guangxu Liu, Yingchun Fu
Summary: A label-free electrochemical magnetic biosensor was developed using a chemical and electrochemical conversion method. The method utilized the chemical and electrochemical properties of magnetic beads to generate electrochemically active Prussian blue for signal generation. The incorporation of chemical and electrochemical conversion improved the electroactivity of Prussian blue and an electrochemical refreshment method further enhanced the detection efficiency.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Supatinee Kongkaew, Suparat Cotchim, Proespichaya Kanatharana, Panote Thavarungkul, Warakorn Limbut
Summary: A compact and low-cost multi-electrode array (MEA) with four working electrodes, shared reference and auxiliary electrodes was developed. Prussian blue nanocubes (PBNCs) were electrodeposited on the MEA and used as a platform for a label-free immunosensor. The immunosensor successfully detected four breast cancer tumor markers with acceptable recoveries and demonstrated potential for point-of-care testing.
Article
Chemistry, Analytical
Jittima Choosang, Suntisak Khumngern, Panote Thavarungkul, Proespichaya Kanatharana, Apon Numnuam
Summary: A highly sensitive and selective label-free electrochemical immunosensor for measuring prostate-specific antigen (PSA) was successfully developed. The sensor utilized a CS-GR-IL-Fc composite deposited onto an SPCE, with added gold nanoparticles, resulting in enhanced detection of PSA with high accuracy and reliability.
Article
Food Science & Technology
Kaiwen Feng, Ting Li, Cuizhu Ye, Xiaoyu Gao, Tan Yang, Xuehua Liang, Xianglin Yue, Shuangyan Ding, Qiuling Dong, Mingqi Yang, Chunhong Xiong, Ganhui Huang, Jinsheng Zhang
Summary: The novel electrochemical immunosensor based on CoFe-MOFs-graphene nanocomposite offers an effective detection method for Salmonella in milk, with a wide linear range and low detection limit. The sensor demonstrates good stability, selectivity, and reproducibility.
Article
Chemistry, Analytical
Dan Liu, Aiping Wang, Jingming Zhou, Xuannian Wang, Hongliang Liu, Peiyang Ding, Ying Zhang, Xifang Zhu, Yiting Zhou, Gaiping Zhang
Summary: A label-free electrochemical immunosensor was developed for the detection of OLA in feedstuffs using graphene oxide nanocomposites decorated by silver nanoparticles. The sensor showed good stability and sensitivity, with a linear correlation between signal intensity and OLA concentration. The sensor has potential applications for detecting other additives in feedstuffs.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Jugal Suthar, Beatriz Prieto-Simon, Gareth R. Williams, Stefan Guldin
Summary: Extracellular vesicles, particularly exosomes, play a crucial role in intercellular communication and disease propagation. A novel biosensing platform, electrochemical quartz crystal microbalance with dissipation monitoring (EQCM-D), is demonstrated for dual-mode and label-free detection of plasma exosomes. By combining QCM-D with in situ electrochemical impedance spectroscopy measurement, relationships between mass, viscoelasticity, and impedance properties of each functional layer and analyte are revealed. This platform offers improved sensing specificity and lower limit of detection, making it an important technique for exosome analysis.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Thiago S. Martins, Jose L. Bott-Neto, Sergio A. S. Machado, Osvaldo N. Oliveira
Summary: This article introduces a flexible and fully printed immunosensor with optimized molecular structures and working conditions, which achieves high sensitivity for metabolite detection. The sensor is stable, reproducible, and unresponsive to interference from other molecules. It can also be used as a wearable sensor with mechanical flexibility and customization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Thiago S. Martins, Jose L. Bott-Neto, Sergio A. S. Machado, Osvaldo N. Oliveira Jr
Summary: In this study, flexible and fully printed immunosensor chips with tree-like gold dendrites were successfully fabricated using electrodeposition. The optimized molecular architectures of the immunosensors exhibited high sensitivity and stability, enabling accurate detection of metabolites in human samples.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Karutha Pandian Divya, Venkataraman Dharuman
Summary: A novel and rapid electrochemical immunosensing platform was developed for directly sensing antibody interactions with a virulence factor, utilizing various techniques to study molecular interactions and sensor performance.
Article
Biochemistry & Molecular Biology
Yi-Ge Feng, Xiao-Yu Wang, Zhi-Wu Wang, Ai-Jun Wang, Li-Ping Mei, Xiliang Luo, Jiu-Ju Feng
Summary: Using porous nanomaterials as nanocarriers for immobilization and signal amplification of the probes, a label-free electrochemical immunosensor was efficiently designed for ultrasensitive detection of PCT. The immunosensor exhibited a good linear relationship and an ultra-low limit of detection.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Jairo Pinto de Oliveira, Francisco Burgos-Florez, Isabella Sampaio, Pedro Villalba, Valtencir Zucolotto
Summary: In this study, a label-free impedimetric immunosensor was developed to detect OTA in coffee. The biosensor showed high selectivity and was not affected by matrix interference in coffee samples. It has the advantages of small sample volume, short analysis time, and potential miniaturization.
Article
Chemistry, Analytical
Viviana Vasquez, Jahir Orozco
Summary: Cases of SARS-CoV-2 are still widespread due to the emergence of new variants worldwide. The severity and infectiousness of the virus are still not fully understood. Therefore, there is an urgent need for improved viral detection and diagnosis tools.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Sai Gourang Patnaik, David Pech
Summary: This work presents a low-temperature deposition process of a porous Prussian blue-based cathode on Si wafers, utilizing a pulsed deposition protocol under aqueous conditions. The high-voltage cathodes exhibit a large areal capacity and excellent cycle stability, making them promising for integrated energy storage components in self-powered microsystems.
Article
Chemistry, Applied
Andrea Macchia, Irene Angela Colasanti, Laura Rivaroli, Gabriele Favero, Tilde de Caro, Leonardo Pantoja Munoz, Luigi Campanella, Mauro Francesco La Russa
Summary: Copper alloys objects can deteriorate through irreversible corrosion, making it important to find suitable cleaning and conservation processes that prevent further degradation without altering their appearance. This study explored the use of ecologically friendly chelating agents as alternatives to traditional cleaning procedures for copper artifacts. The effectiveness of six natural-based chelators was tested on both corrosion compounds and corroded copper sheets. Among the amino acids tested, alanine showed the most effective cleaning results, preserving the noble patina and recovering copper effectively.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Analytical
Francesca Polli, Cristine D'Agostino, Rosaceleste Zumpano, Viviana De Martino, Gabriele Favero, Luciano Colangelo, Salvatore Minisola, Franco Mazzei
Summary: We report a new sensitive label-free electrochemical immunosensor that can accurately detect Vitamin D-3 in untreated serum samples. The immunosensor showed high sensitivity and a wide linear range, and showed good agreement with the reference method, suggesting its potential use for rapid monitoring of low Vitamin D levels.
Article
Biochemical Research Methods
Andrea Calcaterra, Francesca Polli, Lara Lamelza, Cristina Del Plato, Silvia Cammarone, Francesca Ghirga, Bruno Botta, Franco Mazzei, Deborah Quaglio
Summary: Recent efforts have focused on the development of selective, sensitive, fast response, and miniaturized immunosensors for analyte monitoring. However, the complexity of immobilizing antibodies to the sensor surface remains a challenge. Supramolecular chemistry has emerged as a suitable tool to preorganize artificial receptors and improve the properties of self-assembled monolayers, enabling the development of sensitive label-free electrochemical immunosensors.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Francesca Polli, Gabriele Cianfoni, Rem Elnahas, Laura Mangiardi, Francesca A. Scaramuzzo, Silvia Cammarone, Deborah Quaglio, Andrea Calcaterra, Marco Pierini, Franco Mazzei, Robertino Zanoni, Bruno Botta, Francesca Ghirga
Summary: A practical supramolecular Ab conjugation strategy based on resorc[4]arene modifiers was developed to immobilize antibodies onto the surface of carbon nanotubes (CNTs) for selective binding to target antigens (Ags). The study utilized host-guest approach and synthesized resorc[4]arene linkers R1 and R2 to improve the orientation of antibodies on CNTs and optimize the Ab/Ag interaction, showing potential applicability in label-free immunosensor development.
Article
Humanities, Multidisciplinary
Andrea Macchia, Camilla Zaratti, Chiara Biribicchi, Irene Angela Colasanti, Francesca Irene Barbaccia, Gabriele Favero
Summary: Organic solvents are commonly used in restoration treatments, but they are toxic and have harmful effects on the environment and restorers. This study aims to find a new green solvent for chromatic reintegration that maintains desired properties. Six solutions based on acetals and ethanol were proposed and tested, and they were found to be suitable alternatives for diluting Gamblin Conservation Color and Maimeri Restoration Colors.
Article
Marine & Freshwater Biology
Michelle Gelippi, Monica Francesca Blasi, Marco Friedrich Walter Gauger, Gabriele Favero, Daniela Mattei, Sandra Hochscheid, Andrea Camedda, Giuseppe Andrea de Lucia, Davide Cicala
Summary: Marine turtles, specifically Mediterranean loggerhead turtles, are important indicator species for ecosystem function and environmental health. This study examines the feeding habits of these turtles through analysis of carbon and nitrogen isotope ratios in their blood and epidermis. The results suggest variability in feeding habitats and preferences for lower trophic level prey. The study highlights the importance of sampling live and wild animals to investigate different ecological features of sea turtles.
ESTUARINE COASTAL AND SHELF SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Adele Bosi, Greta Peruzzi, Alessandro Ciccola, Ilaria Serafini, Flaminia Vincenti, Camilla Montesano, Paolo Postorino, Manuel Sergi, Gabriele Favero, Roberta Curini
Summary: This study presents a minimally invasive approach for dye identification, allowing for research on cultural heritage without compromising its integrity. Liquid extraction of madder, turmeric, and indigo dyes directly from paint layers and textiles is performed, supported by hydrogels. Various techniques, such as SERS and HPLC-MS/MS, are applied for dye identification. Color change perceptivity measurements confirm the gentleness of the procedure, protecting the cultural heritage.
Article
Biochemistry & Molecular Biology
Cristine D'Agostino, Claudia Chillocci, Francesca Polli, Luca Surace, Federica Simonetti, Marco Agostini, Sergio Brutti, Franco Mazzei, Gabriele Favero, Rosaceleste Zumpano
Summary: This study aimed to develop a user-friendly smartphone-based electrochemical biosensor for the rapid assessment of total polyphenols content in coffee blends. The biosensor, based on modified carbon-based screen-printed electrode, demonstrated high sensitivity and a wide linear range, and was validated for quantifying polyphenols in coffee blends.
Article
Electrochemistry
Juan Pinuela-Noval, Daniel Fernandez-Gonzalez, Sergio Brutti, Marta Suarez, Franco Mazzei, Maria Assunta Navarra, Luis Felipe Verdeja, Adolfo Fernandez, Marco Agostini
Summary: This study proposes for the first time the use of molybdenum and chromium carbides as additives to stabilize graphite/silicon composites. Spark plasma sintering technology is utilized to sinter the electrode powders. It is demonstrated that the presence of molybdenum or chromium carbides enhances the performance of C/Si electrodes, improving the cycling stability in lithium cells.
Review
Engineering, Mechanical
Alessandro Vigano, Claudia Celletti, Giada Giuliani, Tommaso B. Jannini, Francesco Marenco, Ilaria Maestrini, Rosaceleste Zumpano, Edoardo Vicenzini, Marta Altieri, Filippo Camerota, Vittorio Di Piero, Massimiliano Toscano
Summary: Despite the availability of new therapies for acute stroke and innovative prevention strategies, stroke continues to be a leading cause of disability-adjusted life-years (DALYs) lost worldwide. Focal muscle vibration (fMV) is gaining interest as a safe and non-invasive brain stimulation technique to promote motor recovery after stroke, showing long-lasting and clinically relevant improvement in various parameters.
Article
Green & Sustainable Science & Technology
Chiara Biribicchi, Laura Giuliani, Andrea Macchia, Gabriele Favero
Summary: This paper explores the application of Low-Molecular-Weight Gelators (LMWGs) in the field of cultural heritage conservation, focusing on their potential to gel low-polar organic solvents. LMWGs offer biodegradable and biocompatible options by forming supramolecular gels that immobilize solvents and reduce their release into the environment. The study highlights the need to transition to greener and more sustainable cleaning systems by emphasizing LMWGs' biodegradability, biocompatibility, and sustainability.
Article
Humanities, Multidisciplinary
Claudia Moricca, Valeria Stagno, Nagmeldeen Morshed Hamza, Gabriele Favero, Laura Sadori, Silvia Capuani
Summary: This study explores the potential of micro-magnetic resonance imaging (mu-MRI) for identifying archaeological reeds. The results show that mu-MRI can yield clear images and maintain the integrity of the sample, making it a valuable tool for analyzing archaeological remains in the field of cultural heritage.
