Article
Neurosciences
Mizuki Sugiyama, Ichiko Nishijima, Wataru Nakamura, Takahiro J. Nakamura
Summary: The suprachiasmatic nucleus (SCN) is important for regulating circadian rhythms, while the food-entrainable oscillator (FEO) also plays a role in circadian regulation. This study found that secretin receptor signaling is not essential for the timekeeping mechanism of FEO.
NEUROSCIENCE LETTERS
(2022)
Article
Nutrition & Dietetics
Theo Gabloffsky, Sadaf Gill, Anna Staffeld, Ralf Salomon, Nicole Power Guerra, Sarah Joost, Alexander Hawlitschka, Markus Kipp, Linda Frintrop
Summary: This study investigated the relevance of food restriction on anorexia nervosa (AN) symptoms and found that chronic starvation most closely mimics AN-related behavioral changes. Increased locomotor activity and decreased circadian-rhythm-related activity may underlie the pathophysiology of AN.
Article
Physiology
David E. Ehichioya, S. K. Tahajjul Taufique, Isabel Magana, Sofia Farah, Yuuki Obata, Shin Yamazaki
Summary: The gut microbiota plays a critical role in regulating circadian rhythms in mice, but depleting the gut microbiota with antibiotics does not significantly impact voluntary wheel running activity and food anticipatory activity.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Antonio Fernandez-Perez, Adrian Sanz-Magro, Rosario Moratalla, Mario Vallejo
Summary: This response addresses the concerns raised by Scarpa et al. (2022) regarding the previous research findings and provides further analysis and additional results to support the original conclusions.
Article
Neurosciences
Louise Thiry, Chloe Lemaire, Ali Rastqar, Maxime Lemieux, Jimmy Peng, Julien Ferent, Marie Roussel, Eric Beaumont, James P. Fawcett, Robert M. Brownstone, Frederic Charron, Frederic Bretzner
Summary: Studies have shown that heterozygous Dcc mutant mice exhibit subtle motor deficits in specific movements, but do not have obvious bilateral impairments like those in humans.
Article
Physiology
Caitlin M. Daimon, Shane T. Hentges
Summary: Inhibition of POMC neurons reduces the severity of activity-based anorexia (ABA) without affecting body weight or food intake. POMC neurons may contribute to excessive exercise habits in patients with AN, while metabolic control during ABA appears to occur through mechanisms independent of POMC neurons.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Behavioral Sciences
Travis Larson, Vaibhav Khandelwal, Matthew A. Weber, Mariah R. Leidinger, David K. Meyerholz, Nandakumar S. Narayanan, Qiang Zhang
Summary: Interval timing is a crucial executive process that is impaired in patients with Alzheimer's disease (AD). Studying interval timing tasks in animal models of AD can provide insights into the human disease. This study evaluated the interval timing performance of P301S transgenic mice, a model of tauopathy, and found that they consistently underestimated temporal intervals. This finding may have relevance to human tauopathies such as AD.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Environmental Sciences
I-Hao Chen, Dimitra G. Georgopoulou, Lars O. E. Ebbesson, Dimitris Voskakis, Pradeep Lal, Nikos Papandroulakis
Summary: This study measures the food anticipatory behavior of European seabass using passive acoustic telemetry, and suggests the use of multiple approaches for detection. The results show that position- and density-based methods provide expressions of anticipatory behavior that can be interchangeable with locomotor-driven food anticipatory activity. Therefore, a unified framework should be used to describe these behaviors, and accurate assessment of fish welfare in the aquaculture industry can be achieved through these approaches.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Bibi S. van Thiel, Janette van der Linden, Yanto Ridwan, Ingrid M. Garrelds, Marcel Vermeij, Marian C. Clahsen-van Groningen, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Anton J. M. Roks, A. H. Jan Danser, Jeroen Essers, Ingrid van der Pluijm
Summary: Changes in the renin-angiotensin system may contribute to aging and age-related diseases, while the use of a renin-activatable probe can help detect increased renin activity in progeroid mice, aiding in the study of kidney disease progression and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Min-Kyung Nam, Hyun-Ah Shin, HeeJae Yun, Seung-Ah Yoo, Hyangshuk Rhim
Summary: The inactivation of HtrA2 leads to changes in skin color and delayed hair growth cycle in mice, caused by the retardation of adipocyte growth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Environmental Sciences
Hanying Xu, Ce Shi, Yangfang Ye, Changkao Mu, Chunlin Wang
Summary: This study aimed to investigate the effects of photoperiod and feeding regime on the growth, feed utilization, and food anticipatory activity (FAA) of juvenile rainbow trout. The results showed that scheduled feeding groups had better growth and feed utilization compared to the random feeding group. There was no difference between the mid-dark stage feeding and mid-light stage feeding groups. Food can strongly synchronize the feeding rhythm of juvenile rainbow trout even without light zeitgeber.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Jason Wu, Paola Solanes, Carl Nist-Lund, Sofia Spataro, Olga Shubina-Oleinik, Irina Marcovich, Hannah Goldberg, Bernard L. Schneider, Jeffrey R. Holt
Summary: AAV9-PHP.B gene therapy shows promise in rescuing hearing loss in mouse models by efficiently transducing inner and outer hair cells. Targeted gene therapies using single or dual AAV9-PHP.B vectors offer effective approaches for treating dominant and recessive deafness.
Article
Immunology
Carlo Brogna, Barbara Brogna, Domenico Rocco Bisaccia, Francesco Lauritano, Giuliano Marino, Luigi Montano, Simone Cristoni, Marina Prisco, Marina Piscopo
Summary: Recent studies show that microorganisms in the human gastrointestinal tract affect the severity of COVID-19 and indicate that the virus may replicate in gut bacteria. Observations of bacterial cultures from the human microbiome and SARS-CoV-2 suggest that the virus could infect bacteria in the gut microbiota and function as a bacteriophage. These findings are valuable for the vaccination campaign and provide insights into the interactions between SARS-CoV-2 and non-mammalian cells.
Article
Physiology
Yujiro Maeoka, Ryan J. Cornelius, Mohammed Zubaerul Ferdaus, Avika Sharma, Luan T. Nguyen, James A. McCormick
Summary: Mutations in CUL3 cause familial hyperkalemic hypertension by reducing the abundance of KLHL3 and impairing the degradation of WNK4. Our study shows that CUL3-Delta 9 cannot degrade other CUL3 targets and cannot rescue kidney injury or polyuria. These findings provide new insights into the function of CUL3-Delta 9 in the kidney.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Physiology
Caitlin M. Daimon, Shane T. Hentges
Summary: Anorexia nervosa has a high mortality rate, but the etiology is not well understood. Using a rodent model, researchers found that the Pomc gene may lead to increased beta-endorphin levels, activating the mu opioid receptor to promote the development of activity-based anorexia.
PHYSIOLOGICAL REPORTS
(2021)
Correction
Neurosciences
Julie S. Pendergast, Kevin D. Niswender, Shin Yamazaki
EUROPEAN JOURNAL OF NEUROSCIENCE
(2015)
Article
Behavioral Sciences
Danilo E. F. L. Flores, Crystal N. Bettilyon, Lori Jia, Shin Yamazaki
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Seung-Hee Yoo, Shihoko Kojima, Kazuhiro Shimomura, Nobuya Koike, Ethan D. Buhr, Tadashi Furukawa, Caroline H. Ko, Gabrielle Gloston, Christopher Ayoub, Kazunari Nohara, Bryan A. Reyes, Yoshiki Tsuchiya, Ook-Joon Yoo, Kazuhiro Yagita, Choogon Lee, Zheng Chen, Shin Yamazaki, Carla B. Green, Joseph S. Takahashi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Neurosciences
Julie S. Pendergast, Kevin D. Niswender, Shin Yamazaki
EUROPEAN JOURNAL OF NEUROSCIENCE
(2013)
Review
Biology
Julie S. Pendergast, Shin Yamazaki
JOURNAL OF BIOLOGICAL RHYTHMS
(2018)
Article
Psychology, Biological
Julie S. Pendergast, Shin Yamazaki
PHYSIOLOGY & BEHAVIOR
(2014)
Article
Multidisciplinary Sciences
Nana N. Takasu, Julie S. Pendergast, Cathya S. Olivas, Shin Yamazaki, Wataru Nakamura
Article
Multidisciplinary Sciences
Danilo E. F. L. Flores, Crystal N. Bettilyon, Shin Yamazaki
SCIENTIFIC REPORTS
(2016)
Article
Biology
Megan Morris, Shin Yamazaki, Aneta Stefanovska
Summary: Circadian rhythms are internal processes in living organisms that repeat approximately every 24 hours and are synchronized to the light-dark cycle. This study investigated the rhythmic components and phase coupling in mice with a disabled circadian clock. The findings provide insights into the functional significance of different oscillators and their coupling. Understanding circadian rhythms is crucial for studying diseases and mood disorders.
JOURNAL OF BIOLOGICAL RHYTHMS
(2022)
Article
Biology
Michael D. Schwartz, Trinitat Cambras, Antoni Diez-Noguera, Ana Campuzano, Gisele A. Oda, Shin Yamazaki, Horacio O. de la Iglesia
Summary: Rats housed in a 22-hour light-dark cycle exhibit two distinct circadian locomotor activity bouts, which are associated with clock gene oscillations in different regions of the brain. Upon release into free-running conditions, these activity rhythms quickly resynchronize and have a longer period than rats housed in a typical 24-hour cycle. Both in vivo and ex vivo experiments support the presence of a dual oscillator system.
JOURNAL OF BIOLOGICAL RHYTHMS
(2022)
Article
Multidisciplinary Sciences
Shuzhang Yang, Shin Yamazaki, Kimberly H. Cox, Yi-Lin Huang, Evan W. Miller, Joseph S. Takahashi
Summary: This study reports the discovery of temperature-sensitive ultradian rhythms in mammalian fibroblasts, which are independent of the cell cycle and circadian clock. These ultradian rhythms are synchronized through cellular coupling and metabolic feedback mechanisms, and play a role in balancing energy demands in cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Takahiro J. Nakamura, Nana N. Takasu, Sayuri Sakazume, Yu Matsumoto, Natsuko Kawano, Julie S. Pendergast, Shin Yamazaki, Wataru Nakamura
Summary: Many female mammals have reproductive hormones that regulate ovulation and sexual behaviors, while circadian rhythms of locomotor activity also fluctuate across the estrous cycle in rodents. Disrupted circadian rhythms can lead to compromised estrous cycles and fewer pregnancies. Extending day length by only 2 hours per day can restore regular estrous cycles in mice with disabled molecular circadian clocks, and induce consistent 4-day cycles in wild-type mice. These findings suggest that extending daytime light exposure could enhance reproductive success.
Review
Biology
Alexandra J. Brown, Julie S. Pendergast, Shin Yamazaki
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2019)
Article
Psychology, Multidisciplinary
Julie S. Pendergast, Katrina L. Branecky, Roya Huang, Kevin D. Niswender, Shin Yamazaki
FRONTIERS IN PSYCHOLOGY
(2014)