Article
Neurosciences
Fabrics Bertile, Marine Plumel, Pauline Maes, Aurelie Hirschler, Etienne Challet
Summary: The study identified day-night variations in the cerebellar proteome of mice fed during daytime or nighttime, showing changes in proteins related to heat-shock proteins, enzymes, and neuronal activity in daytime food-restricted mice. Additionally, a significant feeding x time-of-day interaction was found for changes in the intensity of 20 spots.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Mizuki Sugiyama, Ichiko Nishijima, Wataru Nakamura, Takahiro J. Nakamura
Summary: The suprachiasmatic nucleus (SCN) is important for regulating circadian rhythms, while the food-entrainable oscillator (FEO) also plays a role in circadian regulation. This study found that secretin receptor signaling is not essential for the timekeeping mechanism of FEO.
NEUROSCIENCE LETTERS
(2022)
Article
Endocrinology & Metabolism
Haoran Xin, Rongfeng Huang, Meiyu Zhou, Jianghui Chen, Jianxin Zhang, Tingting Zhou, Shushen Ji, Xiao Liu, He Tian, Sin Man Lam, Xinyu Bao, Lihua Li, Shifei Tong, Fang Deng, Guanghou Shui, Zhihui Zhang, Catherine C. L. Wong, Min-Dian Li
Summary: Meal timing, specifically day/sleep time-restricted feeding, enhances running endurance and regulates muscle diurnal rhythms in mice. The circadian clock and a mitochondrial oxidative metabolism-centric network play key roles in mediating the effects of meal timing on physical endurance. Knockdown of the myocyte lipid droplet protein perilipin-5 in muscle tissues mimics the effects of day/sleep time-restricted feeding.
Article
Nutrition & Dietetics
Theo Gabloffsky, Sadaf Gill, Anna Staffeld, Ralf Salomon, Nicole Power Guerra, Sarah Joost, Alexander Hawlitschka, Markus Kipp, Linda Frintrop
Summary: This study investigated the relevance of food restriction on anorexia nervosa (AN) symptoms and found that chronic starvation most closely mimics AN-related behavioral changes. Increased locomotor activity and decreased circadian-rhythm-related activity may underlie the pathophysiology of AN.
Article
Physiology
Megan K. Rhoads, Joshua S. Speed, Kaehler J. Roth, Dingguo Zhang, Chunhua Jin, Karen L. Gamble, David M. Pollock
Summary: Night shift work increases the risk of cardiovascular disease associated with an irregular eating schedule. High-salt intake disrupts the diurnal rhythm of renal sodium excretion. Limiting food intake to the inactive period in addition to high-salt feeding impairs circadian mechanisms associated with renal sodium excretion.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Editorial Material
Cell Biology
Zhangyuan Yin, Daniel J. Klionsky
Summary: Macroautophagy/autophagy plays a crucial role in aging and age-related diseases. A recent study showed that a newly designed dietary regimen, called intermittent time-restricted feeding (iTRF), can extend the healthspan and lifespan of flies through the circadian rhythm-dependent activation of autophagy. Specifically, the induction of autophagy during the night is both necessary and sufficient for the health benefits of iTRF. This study suggests that novel interventions promoting night-specific autophagy could be used to promote healthy aging.
Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Article
Immunology
Krisztina Ella, Agnes R. Sudy, Zsofia Bur, Bence Koos, Armin S. Kisiczki, Attila Mocsai, Krisztina Kaldi
Summary: Time restricted eating can reduce the symptoms of autoinflammatory joint arthritis and modulate the rhythm and inflammatory potential of leukocytes, leading to a milder reactivity of the immune system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yao Guo, Qiang-Jun Wang, Ke-Hao Zhang, Chun-Yan Yao, Jie Huang, Qin Li, Zhong-Ying Liu, Yu Zhang, Chun-Hua Shan, Peng Liu, Mei-Zhi Wang, Lei An, Jian-Hui Tian, Zhong-Hong Wu
Summary: Night-restricted feeding (NRF) promotes growth and reduces fat content in rabbits models by improving circadian rhythm, enhancing metabolism, and preventing obesity. Research indicates that NRF can improve metabolic function by regulating protein synthesis and muscle formation.
Article
Multidisciplinary Sciences
Ashleigh G. Wilcox, R. Sonia Bains, Debbie Williams, Elizabeth Joynson, Lucie Vizor, Peter L. Oliver, Elizabeth S. Maywood, Michael H. Hastings, Gareth Banks, Patrick M. Nolan
Summary: The study describes a mouse mutant with the central pacemaker SCN genetically ablated, leading to arrhythmicity in circadian rhythms and metabolic parameters, although the mutants could still anticipate food availability. Despite disruptions to SCN cell identity and circuitry, the mutants' activity levels were altered and other zeitgebers could not restore rhythmicity.
Article
Endocrinology & Metabolism
Molly R. Gallop, Selene Y. Tobin, Amandine Chaix
Summary: The ability to store energy and maintain energy balance is crucial for mammalian survival. Time-restricted feeding (TRF), a dietary intervention that limits feeding to the active phase, has shown potential in preventing and treating obesity and metabolic dysfunction in rodents. However, the mechanisms behind the effects of TRF on energy balance and metabolic adaptation are still not fully understood.
Article
Biochemistry & Molecular Biology
Kazuo Nakazawa, Minako Matsuo, Naobumi Kimura, Rika Numano
Summary: All organisms have an internal clock called the circadian rhythm, which matches the Earth's rotation over a period of 24 hours. In this study, transgenic mice with the Per1::luc reporter gene were used to monitor the expression rhythms of the Per1 clock gene in different tissues in real time. The results showed that the peripheral clocks in the digestive system could be entrained by restricted feeding, while the central clock in the SCN remained unchanged.
Article
Medicine, General & Internal
Dan Shi, Gaofeng Fang, Qianyao Chen, Jianling Li, Xiongzhong Ruan, Xuemei Lian
Summary: Six-hour TRF inhibits lung cancer progression and reshapes circadian metabolism, which is partially mediated by the rhythmic downregulation of the TIM and the subsequent upregulation of autophagy.
Article
Physiology
David E. Ehichioya, S. K. Tahajjul Taufique, Isabel Magana, Sofia Farah, Yuuki Obata, Shin Yamazaki
Summary: The gut microbiota plays a critical role in regulating circadian rhythms in mice, but depleting the gut microbiota with antibiotics does not significantly impact voluntary wheel running activity and food anticipatory activity.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tianfei Hou, Wen Su, Marilyn J. Duncan, Vsevolozhskaya A. Olga, Zhenheng Guo, Ming C. Gong
Summary: The study reveals that restricting the timing of food intake can prevent nondipping blood pressure in diabetic mice and effectively restore disrupted blood pressure circadian rhythm.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Correction
Neurosciences
Julie S. Pendergast, Kevin D. Niswender, Shin Yamazaki
EUROPEAN JOURNAL OF NEUROSCIENCE
(2015)
Article
Behavioral Sciences
Danilo E. F. L. Flores, Crystal N. Bettilyon, Lori Jia, Shin Yamazaki
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Seung-Hee Yoo, Shihoko Kojima, Kazuhiro Shimomura, Nobuya Koike, Ethan D. Buhr, Tadashi Furukawa, Caroline H. Ko, Gabrielle Gloston, Christopher Ayoub, Kazunari Nohara, Bryan A. Reyes, Yoshiki Tsuchiya, Ook-Joon Yoo, Kazuhiro Yagita, Choogon Lee, Zheng Chen, Shin Yamazaki, Carla B. Green, Joseph S. Takahashi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Danilo E. F. L. Flores, Crystal N. Bettilyon, Shin Yamazaki
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Julie S. Pendergast, Robert H. Wendroth, Rio C. Stenner, Charles D. Keil, Shin Yamazaki
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
Oluwabukola Omotola, Sandra Legan, Emily Slade, Ayooluwatomiwa Adekunle, Julie S. Pendergast
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)
Article
Physiology
Tiffany N. Buckley, Oluwabukola Omotola, Luke A. Archer, Cameron R. Rostron, Ellora P. Kamineni, Josie D. Llanora, Jeffrey M. Chalfant, Feitong Lei, Emily Slade, Julie S. Pendergast
Summary: The study suggests that under high-fat diet conditions, obesity-prone mice are more likely to gain weight and adiposity compared to obesity-resistant mice, with a significant reduction in the daily rhythm of eating behavior observed in the former.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Biology
Megan Morris, Shin Yamazaki, Aneta Stefanovska
Summary: Circadian rhythms are internal processes in living organisms that repeat approximately every 24 hours and are synchronized to the light-dark cycle. This study investigated the rhythmic components and phase coupling in mice with a disabled circadian clock. The findings provide insights into the functional significance of different oscillators and their coupling. Understanding circadian rhythms is crucial for studying diseases and mood disorders.
JOURNAL OF BIOLOGICAL RHYTHMS
(2022)
Article
Biology
Michael D. Schwartz, Trinitat Cambras, Antoni Diez-Noguera, Ana Campuzano, Gisele A. Oda, Shin Yamazaki, Horacio O. de la Iglesia
Summary: Rats housed in a 22-hour light-dark cycle exhibit two distinct circadian locomotor activity bouts, which are associated with clock gene oscillations in different regions of the brain. Upon release into free-running conditions, these activity rhythms quickly resynchronize and have a longer period than rats housed in a typical 24-hour cycle. Both in vivo and ex vivo experiments support the presence of a dual oscillator system.
JOURNAL OF BIOLOGICAL RHYTHMS
(2022)
Article
Multidisciplinary Sciences
Shuzhang Yang, Shin Yamazaki, Kimberly H. Cox, Yi-Lin Huang, Evan W. Miller, Joseph S. Takahashi
Summary: This study reports the discovery of temperature-sensitive ultradian rhythms in mammalian fibroblasts, which are independent of the cell cycle and circadian clock. These ultradian rhythms are synchronized through cellular coupling and metabolic feedback mechanisms, and play a role in balancing energy demands in cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Takahiro J. Nakamura, Nana N. Takasu, Sayuri Sakazume, Yu Matsumoto, Natsuko Kawano, Julie S. Pendergast, Shin Yamazaki, Wataru Nakamura
Summary: Many female mammals have reproductive hormones that regulate ovulation and sexual behaviors, while circadian rhythms of locomotor activity also fluctuate across the estrous cycle in rodents. Disrupted circadian rhythms can lead to compromised estrous cycles and fewer pregnancies. Extending day length by only 2 hours per day can restore regular estrous cycles in mice with disabled molecular circadian clocks, and induce consistent 4-day cycles in wild-type mice. These findings suggest that extending daytime light exposure could enhance reproductive success.
Article
Medicine, Research & Experimental
J. Matthew Thomas, Philip A. Kern, Heather M. Bush, Kristen J. McQuerry, W. Scott Black, Jody L. Clasey, Julie S. Pendergast
Review
Biology
Alexandra J. Brown, Julie S. Pendergast, Shin Yamazaki
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2019)