Article
Medicine, Research & Experimental
Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R. Bonser, Kyung Duk Koh, Olivier Le Tonqueze, Samaneh Bolourchi, Rodriel A. Bautista, Lorna Zlock, Theodore L. Roth, Alexander Marson, Nirav R. Bhakta, K. Mark Ansel, Walter E. Finkbeiner, David J. Erle, Prescott G. Woodruff
Summary: The study identifies miR-141 as a key regulator of pathological airway mucus production induced by IL-13, with disruption leading to decreased goblet cell frequency and reduced mucus secretion. This miRNA may offer a novel therapeutic target for airway diseases.
Article
Biochemistry & Molecular Biology
Lei Tian, Shancheng Guo, Zhiye Zhao, Yuxu Chen, Chunmei Wang, Qingzhang Li, Ye Li
Summary: The study reveals that miR-30a-3p plays a crucial role in regulating autophagy in the mammary glands of mice during lactation and involution. It negatively regulates autophagy by targeting Atg12 gene in mammary epithelial cells. Further experiments confirmed that overexpression of miR-30a-3p inhibits autophagy and alters mammary structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rongzhi Li, Tomomi Sano, Akiko Mizokami, Takao Fukuda, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Terukazu Sanui, Yusuke Nakatsu, Yusuke Sotomaru, Tomoichiro Asano, Takashi Kanematsu, Fusanori Nishimura
Summary: A well-tuned inflammatory response is crucial, and dysregulation of nuclear factor-kappa B (NF-kappa B) is associated with immune-related diseases. This study identified miR-582-5p as a miRNA that modulates NF-kappa B signaling during inflammation. It was found that miR-582-5p targets S-phase kinase-associated protein 1 (SKP1) and attenuates the NF-kappa B pathway, leading to reduced production of pro-inflammatory cytokines. This suggests that exogenous miR-582-5p could be a potential therapeutic strategy for inflammatory and immune diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Qi Xu, Demin Cheng, Guanru Li, Yi Liu, Ping Li, Wenqing Sun, Dongyu Ma, Chunhui Ni
Summary: Glycolysis is associated with pulmonary fibrosis, and the circHIPK3/miR-30a-3p/FOXK2 regulatory pathway plays a crucial role in promoting fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
R. K. Subbarao Malireddi, Ratnakar R. Bynigeri, Balabhaskararao Kancharana, Bhesh Raj Sharma, Amanda R. Burton, Stephane Pelletier, Thirumala-Devi Kanneganti
Summary: This study generated a new line of IL-1 alpha KO mice using CRISPR-Cas9 technology. Compared to the previous model, this new model showed normal induction and activation of IL-1 beta in macrophages and normal response to multiple innate immune triggers. Furthermore, it was found that IL-1 alpha played a critical role in the expression of the neutrophil chemoattractant KC/CXCL1 independent of IL-1 beta.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Heng Jiang, Xu Zhang, Xin Li, Xiaocen Wang, Nan Zhang, Pengtao Gong, Xichen Zhang, Yanhui Yu, Jianhua Li
Summary: This study found that Cryptosporidium parvum could manipulate autophagy through regulating host cellular miR-26a and miR-30a expression, facilitating parasite survival and proliferation.
PARASITES & VECTORS
(2022)
Article
Fisheries
Huiqin Niu, Yinghu Hao, Yifan Pang, Yubang Shen, Jiale Li, Xiaoyan Xu
Summary: Long non-coding RNAs (lncRNAs) have received significant attention as they impact gene expression following pathogen infections. Recent research has discovered that lncRNAs play a crucial role in fish immune responses to pathogen infections. Specifically, our study found that lncRNA-adm2 influences the antibacterial immune response in grass carp by interacting with cid-miR-n3 and targeting the 3' UTR of adm2. This research expands our understanding of the function of lncRNAs in fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Guolei Cao, Peiwen Fan, Ronghui Ma, Qinghe Wang, Lili He, Haiwen Niu, Qin Luo
Summary: This study investigated the role of microRNA-210 (miR-210) in lung adenocarcinoma (LUAD). The expression levels of miR-210 and its target genes were analyzed in LUAD tissues and normal tissues. It was found that miR-210 inhibited the expression of HIF-1a and VEGF, leading to decreased apoptosis and worse patient survival. These findings suggest that miR-210 could be a potential therapeutic target for LUAD treatment.
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Biochemistry & Molecular Biology
Carmen Ciavarella, Ilenia Motta, Francesco Vasuri, Silvia Fittipaldi, Sabrina Valente, Daniela Pollutri, Francesca Ricci, Mauro Gargiulo, Gianandrea Pasquinelli
Summary: The study reveals that End-MT serves as a crucial link between inflammation and vascular calcification. Moreover, miR-30a-5p and miR-30d can regulate both the End-MT and osteogenic processes, with an impact on key genes like SLUG, VIMENTIN, and RUNX-2.
Article
Oncology
Shuibo Gao, Haixia Gao, Liping Dai, Yongjun Han, Zhen Lei, Xinzhou Wang, Hongbo Chang, Shanshan Liu, Zhentao Wang, Haibin Tong, Hong Wu
Summary: miR-126 regulates angiogenesis during MI through HIF-1α and may serve as a potential therapeutic target.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jose L. Sanchez-Gloria, Roxana Carbo, Mabel Buelna-Chontal, Horacio Osorio-Alonso, Adrian Henandez-Diazcouder, Rosa Luz de la Fuente-leon, Julio Sandoval, Fausto Sanchez, I. Rubio-Gayosso, Fausto Sanchez-Munoz
Summary: Chronic cold exposure exacerbates MCT-induced pulmonary arterial hypertension in rats, resulting in increased levels of inflammatory markers and miRNAs in plasma EVs and lungs.
Article
Cell Biology
Yuxi Jia, Xiangru Chen, Jing Sun
Summary: The research found that Apremilast can protect epidermal stem cells from IL-1α-induced damage by inhibiting the activation of the Myd88/TRAF6/NF-kappa B signaling pathway, reducing oxidative stress and inflammation.
Article
Medicine, Research & Experimental
Fei Song, Jing-Zhou Li, Yao Wu, Wei-Yin Wu, Yan Wang, Gang Li
Summary: MiR-30a-5p plays a significant role in reducing atherosclerotic lesions, levels of lipoproteins and pro-inflammatory cytokines, and increasing anti-inflammatory cytokines in Apo E-/- mice. It also regulates the M1/M2 macrophage ratio through Smad-1/2 phosphorylation and reduces lipid uptake in macrophages by modulating the expression of certain proteins. Ubiquitinated ligase NEDD4L is identified as a target of miR-30a-5p, which further influences the M1/M2 ratio and lipid uptake in macrophages.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Sara R. Oliveira, Pedro A. Dionisio, Maria M. Gaspar, Leonor Correia Guedes, Miguel Coelho, Mario M. Rosa, Joaquim J. Ferreira, Joana D. Amaral, Cecilia M. P. Rodrigues
Summary: The study reveals a protective role of miR-335 in experimental models of Parkinson's disease, showing its ability to combat inflammation and neurodegenerative events.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Xiaoxi Ouyang, Xin Jiang, Dayong Gu, Yaou Zhang, S. K. Kong, Chaoxin Jiang, Weidong Xie
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2016)
Article
Oncology
Kai Cui, Shaobo Zhang, Xin Jiang, Weidong Xie
MOLECULAR MEDICINE REPORTS
(2016)
Article
Multidisciplinary Sciences
Xin Jiang, Irina Smirnova, Vladimir Kasho, Jianping Wu, Kunio Hirata, Meng Ke, Els Pardon, Jan Steyaert, Nieng Yan, H. Ronald Kaback
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemical Research Methods
Meng Ke, Yafei Yuan, Xin Jiang, Nieng Yan, Haipeng Gong
PLOS COMPUTATIONAL BIOLOGY
(2017)
Letter
Cell Biology
Xin Jiang, Jianping Wu, Meng Ke, Shuo Zhang, Yafei Yuan, Jason Ye Lin, Nieng Yan
Letter
Cell Biology
Meng Gao, Jian Huang, Xin Jiang, Yafei Yuan, Huanhuan Pang, Shuchen Luo, Nan Wang, Chengbo Yao, Zuwan Lin, Debing Pu, Shuo Zhang, Pengcheng Sun, Zhuoyi Liu, Yu Xiao, Qian Wang, Zeping Hu, Hang Yin
Article
Biochemistry & Molecular Biology
Xin Jiang, Yafei Yuan, Jian Huang, Shuo Zhang, Shuchen Luo, Nan Wang, Debing Pu, Na Zhao, Qingxuan Tang, Kunio Hirata, Xikang Yang, Yaqing Jiao, Tomoyo Sakata-Kato, Jia-Wei Wu, Chuangye Yan, Nobutaka Kato, Hang Yin, Nieng Yan
Article
Biochemistry & Molecular Biology
Nan Wang, Xin Jiang, Shuo Zhang, Angqi Zhu, Yafei Yuan, Hanwen Xu, Jianlin Lei, Chuangye Yan
Summary: The study presents cryo-EM structures of human MCT1 bound to lactate or inhibitors, shedding light on its substrate binding and transport mechanism, as well as providing a framework for structure-guided drug discovery targeting MCTs.
Article
Multidisciplinary Sciences
Jian Huang, Yafei Yuan, Na Zhao, Debing Pu, Qingxuan Tang, Shuo Zhang, Shuchen Luo, Xikang Yang, Nan Wang, Yu Xiao, Tuan Zhang, Zhuoyi Liu, Tomoyo Sakata-Kato, Xin Jiang, Nobutaka Kato, Nieng Yan, Hang Yin
Summary: Artemisinin-resistant malaria parasites have become a significant public health challenge, necessitating the development of antimalarial drugs with novel mechanisms of action. By utilizing a selective starvation strategy and designing specific inhibitors, it is possible to effectively combat multidrug-resistant malaria parasites.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Xi Peng, Nan Wang, Angqi Zhu, Hanwen Xu, Jialu Li, Yanxia Zhou, Chen Wang, Qingjie Xiao, Li Guo, Fei Liu, Zhi-jun Jia, Huaichuan Duan, Jianping Hu, Weidan Yuan, Jia Geng, Chuangye Yan, Xin Jiang, Dong Deng
Summary: The high-resolution structures provide the molecular basis for further antimalarial drug design, revealing the inhibitory effect of MMV007839 on PfFNT.
Review
Biochemistry & Molecular Biology
Xin Jiang
Summary: Despite efforts to eliminate it, human malaria caused by Plasmodium infection remains the deadliest parasitic disease. With drug-resistant Plasmodium parasites becoming more prevalent, there is an urgent need for new plasmodial drug targets. This review focuses on the identification and characterization of the Plasmodium falciparum hexose transporter (PfHT1) and the development of selective inhibitors.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, Nis Halland, Kaihui Hu He, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang, Nieng Yan
Summary: Human glucose transporters (GLUTs), specifically GLUT1 and GLUT3, are potential targets for anticancer therapy. In this study, an engineered GLUT3 variant was used to identify and understand the inhibitory mechanism of an exofacial GLUT3 inhibitor, SA47. This research provides a foundation for the discovery of exofacial inhibitors of GLUTs for therapeutic development.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xin Jiang, Nieng Yan, Dong Deng, Chuangye Yan
Summary: The Warburg effect refers to the phenomenon in which cancer cells shift their glucose metabolism from aerobic respiration to lactic fermentation even in the presence of oxygen. Elevated expression levels of human glucose transporters (GLUTs) and human monocarboxylate transporters (MCTs) are observed to maintain metabolic homeostasis and prevent lactate accumulation. Inhibition of GLUTs and/or MCTs shows potential as therapeutic strategies for cancer treatment. Recent advances in the structural characterization of GLUTs and MCTs provide a comprehensive understanding of their transport and inhibition mechanisms, contributing to the development of anticancer therapies.
Article
Integrative & Complementary Medicine
Tian Cai-Ming, Jiang Xin, Ouyang Xiao-Xi, Zhang Ya-Ou, Xie Wei-Dong
CHINESE JOURNAL OF NATURAL MEDICINES
(2016)