The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
出版年份 2017 全文链接
标题
The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
作者
关键词
-
出版物
Scientific Reports
Volume 7, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-04-25
DOI
10.1038/s41598-017-01510-z
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
- (2015) Yongsheng Shi et al. GENES & DEVELOPMENT
- Making (anti-) sense out of huntingtin levels in Huntington disease
- (2015) Melvin M Evers et al. Molecular Neurodegeneration
- Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice
- (2015) Eloise Larson et al. NEUROBIOLOGY OF DISEASE
- Discovery of Novel Isoforms of Huntingtin Reveals a New Hominid-Specific Exon
- (2015) Albert Ruzo et al. PLoS One
- Huntington disease
- (2015) Gillian P. Bates et al. Nature Reviews Disease Primers
- Evidence of Extensive Alternative Splicing in Post Mortem Human Brain HTT Transcription by mRNA Sequencing
- (2015) Adam T. Labadorf et al. PLoS One
- RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression
- (2015) Adam Labadorf et al. PLoS One
- A common gene expression signature in Huntington’s disease patient brain regions
- (2014) Andreas Neueder et al. BMC Medical Genomics
- HTT-lowering reverses Huntington’s disease immune dysfunction caused by NFκB pathway dysregulation
- (2014) Ulrike Träger et al. BRAIN
- Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures
- (2014) Philipp Trepte et al. Essays in Biochemistry
- Silencing Mutant Huntingtin by Adeno-Associated Virus-Mediated RNA Interference Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington's Disease
- (2014) Lisa M. Stanek et al. HUMAN GENE THERAPY
- Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease
- (2014) Brett A. Barbaro et al. HUMAN MOLECULAR GENETICS
- Identification of Novel Alternative Splicing Events in the Huntingtin Gene and Assessment of the Functional Consequences Using Structural Protein Homology Modelling
- (2014) Alis C. Hughes et al. JOURNAL OF MOLECULAR BIOLOGY
- Targets for future clinical trials in Huntington's disease: What's in the pipeline?
- (2014) Edward J. Wild et al. MOVEMENT DISORDERS
- Huntingtin-lowering strategies in Huntington's disease: Antisense oligonucleotides, small RNAs, and gene editing
- (2014) Neil Aronin et al. MOVEMENT DISORDERS
- Huntington's disease is a four-repeat tauopathy with tau nuclear rods
- (2014) Marta Fernández-Nogales et al. NATURE MEDICINE
- Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease
- (2014) Michal Mielcarek et al. PLoS Genetics
- Choosing an animal model for the study of Huntington's disease
- (2013) Mahmoud A. Pouladi et al. NATURE REVIEWS NEUROSCIENCE
- Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
- (2013) K. Sathasivam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aberrantly splicedHTT,a new player in Huntington’s disease pathogenesis
- (2013) Theresa A Gipson et al. RNA Biology
- Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression
- (2012) Andreas Weiss et al. JOURNAL OF CLINICAL INVESTIGATION
- Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis
- (2012) Holly B. Kordasiewicz et al. NEURON
- Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin
- (2011) Jeffrey B Carroll et al. MOLECULAR THERAPY
- Quantification of Age-Dependent Somatic CAG Repeat Instability in Hdh CAG Knock-In Mice Reveals Different Expansion Dynamics in Striatum and Liver
- (2011) Jong-Min Lee et al. PLoS One
- Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease
- (2010) Christian Landles et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset
- (2009) Meera Swami et al. HUMAN MOLECULAR GENETICS
- Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease
- (2009) Kirupa Sathasivam et al. HUMAN MOLECULAR GENETICS
- DNA instability in postmitotic neurons
- (2008) R. Gonitel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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