Article
Oncology
Sara Lahoz, Ivan Archilla, Elena Asensio, Eva Hernandez-Illan, Queralt Ferrer, Sandra Lopez-Prades, Ferran Nadeu, Javier Del Rey, Rebeca Sanz-Pamplona, Juan Jose Lozano, Antoni Castells, Miriam Cuatrecasas, Jordi Camps
Summary: This study investigated the prognostic value of genomic intratumor heterogeneity and aneuploidy for disease recurrence in stage II colon cancer patients. The results showed that high copy-number alteration load was associated with an elevated risk of recurrence, and specific chromosome aberrations were also correlated with recurrence. The machine learning model performed well in predicting individual relapse risk.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Jinluan Lin, Xinwu Wang, Xinwen Wang, Shenglin Wang, Rongkai Shen, Yanbing Yang, Jianyong Xu, Jianhua Lin
Summary: Hypoxia can induce stem cell-like phenotypes in some osteosarcoma cells, with increased expression of CSC markers and enhanced sphere formation and xenograft tumor growth. Rapamycin, by suppressing HIF-1 alpha protein levels, inhibits the hypoxic response and reduces stem cell marker expression, leading to decreased sphere and xenograft tumor formation efficiency in osteosarcoma cells.
Article
Critical Care Medicine
Julie L. Proctor, Juliana Medina, Parisa Rangghran, Pratistha Tamrakar, Catriona Miller, Adam Puche, Wei Quan, Turhan Coksaygan, Cinthia B. Drachenberg, Robert E. Rosenthal, Deborah M. Stein, Rosemary Kozar, Feng Wu, Gary Fiskum
Summary: The study found that exposure of rats with traumatic brain injury and mild hemorrhagic shock to hypobaria or hyperoxia results in increased mortality and exacerbated multi-organ inflammation. Therefore, limiting excessive oxygen administration and reducing aircraft cabin pressures can decrease critical complications during and following aeromedical transport.
Article
Biochemistry & Molecular Biology
Changcheng Guo, Yin Sun, Wei Zhai, Xudong Yao, Dongkui Gong, Bosen You, Chi-Ping Huang, Junhua Zheng, Chawnshang Chang
Summary: This study found that hypoxia can increase the cancer stem cell phenotype of RCC by altering the AR/lncTCFL5-2/YBX1/SOX2 signaling axis, making RCC cells more resistant to targeted therapy with Sunitinib.
CELL AND BIOSCIENCE
(2022)
Article
Cell & Tissue Engineering
Marijn C. Peters, Renee G. C. Maas, Iris van Adrichem, Pieter A. M. Doevendans, Mark Mercola, Tomo Saric, Jan W. Buikema, Alain van Mil, Steven A. J. Chamuleau, Joost P. G. Sluijter, Anna P. Hnatiuk, Klaus Neef
Summary: Developing new cardioprotective approaches using in vivo models is challenging due to differences between humans and animals. However, the development of human-induced pluripotent stem cell-derived cardiomyocytes provides new opportunities for in vitro studies. Metabolic maturation enhances the susceptibility of these cells to hypoxia and allows for better modeling of ischemic heart disease.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Ying Zhao, Hui Huang, Chang-Hao Jia, Ke Fan, Tao Xie, Zeng-Yan Zhu, Mei-Lin Xie
Summary: This study investigated the radiosensitization effect of apigenin on glioma stem cells (GSCs) and its mechanisms. The results demonstrated that the combination of apigenin and radiation could synergistically increase the radiosensitivity of GSCs by reducing glycolysis.
Article
Biotechnology & Applied Microbiology
Shuang Song, Guanhua Zhang, Xutao Chen, Jian Zheng, Xiangdong Liu, Yiqing Wang, Zijun Chen, Yuxi Wang, Yingliang Song, Qin Zhou
Summary: This study demonstrates that overexpression of HIF-1a in adipose-derived stem cells (ADSCs) promotes their biological functions and enhances the angiogenic ability of human umbilical vein endothelial cells (HUVECs). Additionally, HIF-1a overexpression in ADSCs improves bone remodeling and osseointegration around titanium implants. It was also confirmed that HIF-1a promotes osteogenic differentiation and biological functions in ADSCs through the VEGF/AKT/mTOR pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenling Gao, Ronghan He, Jianhua Ren, Wenhui Zhang, Kun Wang, Lei Zhu, Tangzhao Liang
Summary: Mesenchymal stem cells (MSCs) have been reported to induce angiogenesis through the secretion of exosomes, especially under hypoxic conditions. Exosomes released by BMSCs cultured under hypoxia enhanced cell proliferation, migration, and angiogenesis of HUVECs. Exosomal HMGB1 promotes angiogenesis via the JNK/hypoxia-inducible factor-1 alpha signaling pathway and may have potential for developing novel treatment strategies for angiogenesis-related diseases.
Article
Genetics & Heredity
Kevin C. Johnson, Kevin J. Anderson, Elise T. Courtois, Floris P. Barthel, Frederick S. Varn, Diane Luo, Martine Seignon, Eunhee Yi, Hoon Kim, Marcos R. H. Estecio, Dacheng Zhao, Ming Tang, Nicholas E. Navin, Rahul Maurya, Chew Yee Ngan, Niels Verburg, Philip C. de Witt Hamer, Ketan Bulsara, Michael L. Samuels, Sunit Das, Paul Robson, Roel G. W. Verhaak
Summary: Single-cell DNA methylation and transcriptomic glioma analyses reveal the association between local DNA methylation disorder and cellular plasticity, with implications for disease progression and therapeutic response shaping. Glioma cells exhibit increased DNA methylation disorder under environmental stress, highlighting an epigenetically facilitated adaptive stress response process.
Article
Medicine, Research & Experimental
Li Wang, Zhendong Niu, Xia Wang, Zhixi Li, Yanyang Liu, Feng Luo, Xi Yan
Review
Dentistry, Oral Surgery & Medicine
Jiahe Wang, Xiaoyu Yang, Xiaolong Zou, Yunhan Zhang, Jiantao Wang, Yan Wang
JOURNAL OF PERIODONTAL RESEARCH
(2020)
Article
Oncology
Zhi-qin Lu, Jing Cai, Xia Wang, Jian-ping Wei, Zhi-min Zeng, Long Huang, An-wen Liu
Summary: The study revealed that osimertinib combined with bevacizumab is an effective treatment option for patients with LM from EGFRm NSCLC, showing good LM progression-free survival and objective response rate.
Article
Oncology
Xia Wang, Zhimin Zeng, Jing Cai, Peng Xu, Pingan Liang, Yuxi Luo, Anwen Liu
Summary: Real world data demonstrate that TKIs plus thoracic SBRT significantly prolong PFS with tolerable toxicity. The mutation ratio of T790M was increased in the TKIs +SBRT group compared to the TKIs only group. Further randomized studies are warranted.
Article
Biotechnology & Applied Microbiology
Zhiqin Lu, Xia Wang, Yuxi Luo, Jianping Wei, Zhimin Zeng, Qiang Xiong, Jing Cai, Anwen Liu
Summary: LM is a severe complication of LAC, and EGFR/ALK co-alterations are rare. Treatment with afatinib led to improved symptoms and reduced lesions in a patient with EGFR and EML4-ALK mutations.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Xia Wang, Jing Cai, Zhimin Zeng, Anwen Liu
Summary: The study found that osimertinib can significantly reduce the incidence of LM in patients with advanced NSCLC harboring common EGFR mutations. Therefore, osimertinib should be encouraged in clinical practice for specific patient populations.
Article
Medicine, General & Internal
Xia Wang, Jianping Wei, Zhimin Zeng, Jing Cai, Zhiqin Lu, Anwen Liu
Summary: Primary pleural angiosarcoma is a rare malignancy with poor prognosis, but anti-PD-1 therapy has shown efficacy as a viable treatment option for patients.
Article
Oncology
Xia Wang, Jiaqi Song, Jie Long, Zhimin Zeng, Anwen Liu
Summary: This study found that postoperative radiotherapy did not have a significant impact on cardiovascular-pulmonary disease mortality in patients with stage IIIA-N2 resected non-small cell lung cancer. Further research is needed to confirm these results, emphasizing the importance of long-term surveillance for NSCLC patients.
RADIATION ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xia Wang, Long Huang, Jing Cai, Anwen Liu
Summary: EGFR fusions are rare genomic events in NSCLC with no standard treatment options, but TKIs have shown promising results in patients with rare fusions like KIF5B-EGFR, leading to partial responses and extended PFS. Utilizing NGS for the identification of uncommon EGFR mutations in NSCLC patients is crucial for personalized treatment strategies.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Yan Wang, Jiatong Li, Haonan Zhang, Xin Zheng, Jiantao Wang, Xiaoyue Jia, Xian Peng, Qian Xie, Jing Zou, Liwei Zheng, Jiyao Li, Xuedong Zhou, Xin Xu
Summary: The study evaluated the therapeutic effect of probiotic Streptococcus salivarius K12 on radiation-induced oral mucositis (RIOM) mice and found that S. salivarius K12 could help treat oral mucositis and promote oral mucosal healing. RIOM mice exhibited dysbiosis in their oral microbiota, which could be restored by S. salivarius K12 treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xia Wang, Weiwei Peng, Zhimin Zeng, Jing Cai, Anwen Liu
Summary: This case report highlights a rare VOPP1-EGFR fusion gene in an NSCLC patient, which led to resistance to icotinib but a prolonged progression-free survival interval with osimertinib treatment. It suggests a potential additional resistance mechanism to EGFR tyrosine kinase inhibitors and supports the use of osimertinib for EGFR fusion-positive NSCLC patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Ling Ji, Siyuan Hao, Jiantao Wang, Jing Zou, Yan Wang
Summary: Radiotherapy and/or chemotherapy-induced oral mucositis (RIOM/CIOM) is a common complication in cancer patients. TLRs have a significant role in RIOM/CIOM and may serve as a novel mechanism for therapeutic interventions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Multidisciplinary Sciences
Jiantao Wang, Siyuan Hao, Junjie Gu, Sean G. Rudd, Yan Wang
Summary: This systematic review and meta-analysis found that high expression of Desmoglein 2 (DSG2) is associated with worse prognosis in patients with non-small cell lung cancer (NSCLC), suggesting that DSG2 expression could serve as a biomarker for prognosis in NSCLC.
Article
Biotechnology & Applied Microbiology
Chen Hong, Jianping Wei, Tao Zhou, Xia Wang, Jing Cai
Summary: This case report demonstrates that anlotinib may be an effective treatment option for NSCLC patients with an FGFR2-ERC1 fusion gene, as shown by a patient who had a prolonged progression-free survival interval after receiving anlotinib treatment.
ONCOTARGETS AND THERAPY
(2022)
Article
Surgery
Xia Wang, Xiaojuan Lu, Junxing Chen, Hanjie Yi, Qiongyu Lan
Summary: This study demonstrated that Surgery + PORT was associated with improved overall survival (OS) and cancer-specific survival (CSS) in patients with locally advanced cervical adenocarcinoma compared to primary radiotherapy (RT). Surgery + PORT may be a preferable therapeutic option for carefully selected patients with cervical AC.