Article
Cell Biology
B. Walia, T. M. Li, G. Crosio, A. M. Montero, A. H. Huang
Summary: This research found that activation of Wnt signaling pathway leads to proliferation of tendon cells, and the microenvironment plays a crucial role in the response of tendon cells to Wnt signaling. In addition, Wnt signaling cells are recruited and participate in proliferation and regeneration during tendon regeneration.
CONNECTIVE TISSUE RESEARCH
(2022)
Article
Neurosciences
Deng Pan, Lauren Schellhardt, Jesus A. Acevedo-Cintron, Daniel Hunter, Alison K. Snyder-Warwick, Susan E. Mackinnon, Matthew D. Wood
Summary: IL-4 plays a crucial role in nerve regeneration, promoting axonal extension and recovery after injury. Loss of IL-4 affects macrophage accumulation and delays axon regeneration, leading to delayed functional recovery. Exogenous IL-4 administration enhances early axonal extension and macrophage accumulation, but does not impact functional recovery compared to untreated mice.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Wei Zeng, Yasuhiro Kamei, Shuji Shigenobu, Jin-Chuan Sheu, Huai-Jen Tsai
Summary: The newly discovered SCI stress-responsive regenerating cells (SrRCs) play a crucial role in neuronal regeneration after spinal cord injury, forming a bridge across the lesion and connecting with neighboring undamaged motor neurons. Among different subtypes of SrRCs, rostral-SrRCs exhibit higher neuronal differentiation capability and increased expression of caveolin 1 (cav1), which is responsible for axonal regrowth and overall regenerative capability in neuronal regeneration post-SCI.
Article
Cell Biology
Qian Lei, Fei Gao, Teng Liu, Wenxiang Ren, Li Chen, Yulin Cao, Wenlan Chen, Shaojun Guo, Qiong Zhang, Weiqun Chen, Hongxiang Wang, Zhichao Chen, Qiubai Li, Yu Hu, An-Yuan Guo
Summary: Research has shown that extracellular vesicles derived from neonatal umbilical cord mesenchymal stem cells have anti-aging effects on aging adult stem cells, enhancing their vitality and function. These UC-EVs promote self-renewal and delay senescence in stem cells by transferring specific signaling molecules. These findings demonstrate the significant potential of UC-EVs in anti-aging interventions.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yanjie Wang, Jianqiang Lu, Yujian Liu
Summary: This article discusses the mechanisms of skeletal muscle regeneration after cardiotoxin-induced injury. The regeneration process is similar in different mouse strains but is inhibited by aging, obesity, and diabetes. Exercise, microcurrent electrical neuromuscular stimulation, and mechanical loading can improve regeneration. The mechanisms of regeneration are complex and strain-dependent, involving clearance of necrotic fiber debris, conversion of M1 to M2 macrophages, activation of satellite cells, myoblast proliferation, differentiation and fusion, as well as fibrosis and calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Immunology
Ke-huan Xie, Xiao-heng Liu, Jian Jia, Xia Zhong, Rang-yue Han, Rui-zhi Tan, Li Wang
Summary: The study found that Hederagenin (HDG) significantly improved cisplatin-induced acute kidney injury (AKI) by regulating the LncRNA-A330074k22Rik/Axin2/13-catenin signaling axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Rui Ma, Xudong Xie, Chunmei Xu, Peilei Shi, Yafei Wu, Jun Wang
Summary: This study aimed to evaluate the effects of beta-catenin deletion in Axin2(+) cells on cementogenesis. The results showed that loss of beta-catenin in Axin2(+) cells led to a sharp reduction in cementum formation and inhibited the differentiation of Axin2(+) cells into cementoblasts positive for osteopontin.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Review
Cell Biology
Xingyu Wang, Lan Zhou
Summary: Skeletal muscle plays a crucial role in physical activity and energy metabolism. Satellite cells, residing in skeletal muscle, are essential for maintaining homeostasis and regeneration post-injury. Macrophages, a diverse group of immune cells, are key regulators in the interaction with myogenic cells for proper muscle regeneration under both normal and diseased conditions like muscular dystrophy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laszlo Szabo, Andrea Telek, Janos Fodor, Nora Dobrosi, Klaudia Docs, Zoltan Hegyi, Monika Gonczi, Laszlo Csernoch, Beatrix Dienes
Summary: Sept7 isoform plays a critical role in forming diffusion barriers and scaffolds in phospholipid bilayers. The study investigated its role in skeletal muscle regeneration using a knock-down mouse model. Partial knock-down of Sept7 hindered muscle regeneration kinetics and resulted in inflammatory cell infiltration and abnormal myofibers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
R. El-Habta, G. Andersson, P. J. Kingham, L. J. Backman
Summary: This study investigates the effects of stromal vascular fraction (SVF) on muscle cell apoptosis following denervation. Results show that SVF can significantly reduce apoptosis in denervated muscles, both in vitro and in vivo, thereby preserving muscle tissue and potentially providing therapeutic benefits for muscle nerve injuries.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Gastroenterology & Hepatology
Yusuke Kimura, Yukinori Koyama, Kojiro Taura, Aoi Kudoh, Kanae Echizen, Daichi Nakamura, Xuefeng Li, Nguyen Hai Nam, Yusuke Uemoto, Takahiro Nishio, Gen Yamamoto, Satoru Seo, Keiko Iwaisako, Akira Watanabe, Etsuro Hatano
Summary: This study aimed to investigate the role of collagen gene expressing hepatic cells in liver regeneration following partial hepatectomy (PH). The analysis of collagen gene expressing cells revealed the presence of distinct hepatic stellate cell clusters during liver regeneration, with these cells promoting the regeneration process.
Article
Neurosciences
Natalia Smith-Cortinez, Ferry G. J. Hendriksen, Dyan Ramekers, Robert J. Stokroos, Huib Versnel, Louise V. Straatman
Summary: This study found that LGR5+ SCs persist in the adult mouse cochlea and can survive after severe hearing loss. This suggests the potential regenerative capacity of endogenous cochlear progenitor cells and provides potential target cells for future regenerative therapies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Developmental Biology
Corey G. K. Flynn, Paul R. Ginkel, Katharine A. Hubert, Qingyuan Guo, Steven M. Hrycaj, Aubrey E. McDermott, Angelo Madruga, Anna P. Miller, Deneen M. Wellik
Summary: Interstitial stromal cells are crucial for muscle development, regeneration, and repair. Hoxa11 and Hoxd11 are expressed in these cells and essential for embryonic patterning of muscles. Hoxa11eGFP expression continues in a subset of muscle interstitial cells through adult stages.
Review
Biochemistry & Molecular Biology
Yibin Jia, Guanyi Wang, Yuqing Ye, Enming Kang, Huijun Chen, Zishuo Guo, Xiaosheng He
Summary: TBI is a disease with high morbidity and disability worldwide, despite ongoing neural protection efforts. Due to patient heterogeneity, it is difficult to achieve satisfying results in clinic. Neuroinflammation appears since primary injury occurs, and recent studies suggest NSCs play a central role in neural regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
M. Arioka, I. M. Dawid, P. L. Cuevas, B. R. Coyac, B. Leahy, L. Wang, X. Yuan, Z. Li, X. Zhang, B. Liu, J. A. Helms
Summary: Research shows a correlation between the rate of socket healing and the number of Wnt-responsive osteoprogenitor cells and their progeny, with delivery of WNT3A to extraction sockets in osteoporotic animals accelerating socket repair. This study provides new insights into enhancing socket repair with WNT3A post tooth extraction to preserve alveolar ridge dimensions.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xu Cheng, Yixuan Huang, Yingmeng Liu, Jinfeng Dou, Ning Zhao, Jingtao Li, Bing Shi
Summary: Branchiomeric head muscle and somitic limb muscle present distinct regenerative characteristics, with the fibrosis mechanism in head muscle still elusive. FAPs play a persistent role in head muscle regeneration, possibly contributing to fibrosis due to their prolonged presence in the early regeneration stages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ye Tian, Steven J. Sadowsky, John B. Brunski, Xue Yuan, Jill A. Helms
Summary: This study aimed to compare the effects of masticatory loading on peri-implant and periodontal bone remodeling between implants and teeth. The results showed elevated strains and significant bone remodeling around implants. The accumulation of new bone helped reduce strains and stabilize the peri-implant bone.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chuxian Liu, Chunli Guo, Bing Shi, Qian Zheng, Jingtao Li
Summary: This study aimed to determine prognostic factors for postoperative velopharyngeal function in patients aged five and above who underwent primary cleft palate repair. The results showed that pharyngeal depth was the main factor associated with postoperative velopharyngeal function, with a pharyngeal depth greater than 16 mm significantly increasing the risk of velopharyngeal insufficiency. Pharyngeal depth may serve as a prognostic indicator for older patients undergoing cleft palate management, and pharyngoplasty may be considered when surgery is limited.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Wen-Jun Shen, Chris Still II, Lina Han, Pinglin Yang, Jia Chen, Michael Wosczyna, Benjamin Jean Rene Salmon, Kristy C. Perez, Jingtao Li, Pedro L. Cuevas, Bo Liu, Salman Azhar, Jill Helms, Lei S. Qi, Fredric B. Kraemer
Summary: There is an inverse relationship between the differentiation of MSCs along adipocyte or osteoblast lineages mediated by PPAR gamma and Runx2. HSL knockout in mice improved fracture repair and enhanced MSC differentiation and recruitment, while inhibiting HSL. This study highlights the potential role of HSL in bone injury repair and the importance of pre-osteoclasts and osteoclasts.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Anette Wu, Radhika Patel, Cecilia Brassett, Sean McWatt, Mandeep G. Sagoo, Richard Wingate, Chung-Liang Chien, Hannes Traxler, Jens Waschke, Franziska Vielmuth, Anna Sigmund
Meeting Abstract
Biochemistry & Molecular Biology
Joseph Vigoda, Adedeji Adeniyi, Lisl Tudor, Cecilia Brassett, Sean McWatt, Mandeep G. Sagoo, Richard Wingate, Chung-Liang Chien, Hannes Traxler, Jens Waschke, Franziska Vielmuth, Anna Sigmund, Takeshi Sakurai, Yukari Yamada, Mina Zeroual, Jorgen Olsen, Salma El-Batti, Suvi Viranta-Kovanen, Kevin Keay, Shuji Kitahara, Neus Martinez-Abadias, Maria E. Esteban-Torne, Jill Helms, Chiarella Sforza, Nicoletta Gagliano, Madeleine Norris, Derek Harmon, Masato Yasui, Midori Ichiko, Sammi Lee, Shaina Reid, Ariella Lang, Carol Kunzel, Michael Joseph, Leo Buehler, Mark Hardy, Snehal Patel, Paulette Bernd, Heike Kielstein, William Stewart, Anne Kellett, Anette Wu, Geoffroy Noel
Article
Dentistry, Oral Surgery & Medicine
Pavla Ticha, Igor Pilawski, Jill A. Helms
Summary: This study compares the rate of reparative osteogenesis in different types of implant sites using a mini pig model. The findings suggest that the mechanisms and rates of bone regeneration are equivalent between fresh extraction sockets and osteotomies, but the volume of new bone required for socket filling is significantly greater than that for osteotomy filling.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Pediatrics
Chao Yang, Jiang Li, Huo Li, Nan Chen, Xing Yin, Bing Shi, Jingtao Li, Hanyao Huang
Summary: This study used computational fluid dynamics to examine the airflow dynamics of the upper airway after posterior pharyngeal flap palatoplasty (PPF). The results showed that the inspiration process of the upper airway was dependent on the velopharyngeal structure, with different velocities between one-port and two-port structures. Based on the CFD analyses, it was suggested that the one-port structure might be a better choice for secondary velopharyngeal insufficiency reconstruction.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Oded Bahat, Xing Yin, Stefan Holst, Ion Zabalegui, Eva Berroeta, Javier Perez, Peter Woehrle, Norbert Soergel, John Brunski, Jill A. Helms
Summary: The study aims to assess the efficiency, ease-of-use, and general performance of a novel osseoshaping tool based on first-user clinical experiences. The results show that the tool is easy to handle and meets the surgical requirements, improving the ability to preserve important structures and simplifying the surgical procedure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Benjamin R. Coyac, Benjamin J. Wolf, Daniel J. Bahat, Masaki Arioka, John B. Brunski, Jill A. Helms
Summary: This study found that compared to autografts, bone graft substitutes (BGSs) are bioinert and lack osteoprogenitor cells, resulting in slower consolidation. However, the researchers discovered that treating BGSs with a pro-osteogenic protein called liposomal WNT3A (L-WNT3A) can accelerate the consolidation process, leading to faster new bone formation comparable to autografts. The use of WNT-treated BGSs may be superior to autografts for sinus augmentation due to their resistance to resorption.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Wen-Jun Shen, Chris Still, Lina Han, Pinglin Yang, Jia Chen, Michael Wosczyna, Thomas A. Rando, Benjamin Jean Rene Salmon, Kristy C. Perez, Jingtao Li, Pedro L. Cuevase, Bo Liu, Salman Azhar, Jill Helms, Lei S. Qi, Fredric B. Kraemer
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Balazs Feher, Carina Kampleitner, Patrick Heimel, Stefan Tangl, Jill A. Helms, Ulrike Kuchler, Reinhard Gruber
Summary: This study assessed the function of osteocyte-derived RANKL in bone graft remodeling. The results suggest that RANKL plays an important role in stimulating bone resorption activity.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)