标题
Smoothing a rugged protein folding landscape by sequence-based redesign
作者
关键词
-
出版物
Scientific Reports
Volume 6, Issue 1, Pages -
出版商
Springer Nature
发表日期
2016-09-26
DOI
10.1038/srep33958
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular Mechanism of Z α1-Antitrypsin Deficiency
- (2016) Xin Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein Frustratometer 2: a tool to localize energetic frustration in protein molecules, now with electrostatics
- (2016) R. Gonzalo Parra et al. NUCLEIC ACIDS RESEARCH
- Consensus protein design
- (2016) Benjamin T. Porebski et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain
- (2015) Benjamin T. Porebski et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Electrostatics, structure prediction, and the energy landscapes for protein folding and binding
- (2015) Min-Yeh Tsai et al. PROTEIN SCIENCE
- MX1: a bending-magnet crystallography beamline serving both chemical and macromolecular crystallography communities at the Australian Synchrotron
- (2015) Nathan Philip Cowieson et al. JOURNAL OF SYNCHROTRON RADIATION
- Energy landscapes of functional proteins are inherently risky
- (2014) Anne Gershenson et al. Nature Chemical Biology
- The Z Mutation Alters the Global Structural Dynamics of α1-Antitrypsin
- (2014) Victoria A. Hughes et al. PLoS One
- Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein
- (2014) Stefano Gianni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frustration in biomolecules
- (2014) Diego U. Ferreiro et al. QUARTERLY REVIEWS OF BIOPHYSICS
- Design of Protein Catalysts
- (2013) Donald Hilvert Annual Review of Biochemistry
- The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α1-Antitrypsin
- (2013) Anja S. Knaupp et al. PLoS One
- Native contacts determine protein folding mechanisms in atomistic simulations
- (2013) R. B. Best et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conformational Properties of the Disease-Causing Z Variant of α1-Antitrypsin Revealed by Theory and Experiment
- (2012) Itamar Kass et al. BIOPHYSICAL JOURNAL
- Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies
- (2012) Aleksandr E. Miklos et al. CHEMISTRY & BIOLOGY
- Principles for designing ideal protein structures
- (2012) Nobuyasu Koga et al. NATURE
- Folding mechanism of the metastable serpin 1-antitrypsin
- (2012) Y. Tsutsui et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Design of novel FN3 domains with high stability by a consensus sequence approach
- (2012) S. A. Jacobs et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease
- (2012) Mun Peak Nyon et al. STRUCTURE
- Therapeutic target-site variability in α1-antitrypsin characterized at high resolution
- (2011) Anathe O. M. Patschull et al. Acta Crystallographica Section F-Structural Biology and Crystallization Communications
- Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer
- (2011) Masayuki Yamasaki et al. EMBO REPORTS
- Structural Change in β-Sheet A of Z α1-Antitrypsin Is Responsible for Accelerated Polymerization and Disease
- (2011) Anja S. Knaupp et al. JOURNAL OF MOLECULAR BIOLOGY
- Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization
- (2011) Beena Krishnan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Refolding and Polymerization Pathways of Neuroserpin
- (2010) Sayaka Takehara et al. JOURNAL OF MOLECULAR BIOLOGY
- Defining the mechanism of polymerization in the serpinopathies
- (2010) U. I. Ekeowa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cleaved antitrypsin polymers at atomic resolution
- (2010) Michelle A. Dunstone et al. PROTEIN SCIENCE
- Human Neuroserpin: Structure and Time-Dependent Inhibition
- (2009) Stefano Ricagno et al. JOURNAL OF MOLECULAR BIOLOGY
- The 2.1-Å Crystal Structure of Native Neuroserpin Reveals Unique Structural Elements That Contribute to Conformational Instability
- (2009) Sayaka Takehara et al. JOURNAL OF MOLECULAR BIOLOGY
- Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design
- (2009) Bibek Gooptu et al. JOURNAL OF MOLECULAR BIOLOGY
- Kinetic Instability of the Serpin Z α1-Antitrypsin Promotes Aggregation
- (2009) Anja S. Knaupp et al. JOURNAL OF MOLECULAR BIOLOGY
- Folding landscapes of ankyrin repeat proteins: experiments meet theory
- (2008) Doug Barrick et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization
- (2008) Masayuki Yamasaki et al. NATURE
- Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding
- (2008) Mary C. Pearce et al. PROTEIN SCIENCE
- How Protein Stability and New Functions Trade Off
- (2008) Nobuhiko Tokuriki et al. PLoS Computational Biology
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