Article
Biochemistry & Molecular Biology
Julia Penas-Martinez, Gines Luengo-Gil, Salvador Espin, Nataliya Bohdan, Carmen Ortega-Sabater, Maria Carmen Rodenas, David Zaragoza-Huesca, Maria Jose Lopez-Andreo, Carme Plasencia, Vicente Vicente, Alberto Carmona-Bayonas, Irene Martinez-Martinez
Summary: Our study reveals the versatile anti-tumor properties of prelatent antithrombin on U-87 MG glioblastoma multiforme cells, inhibiting migration and invasion while having a lesser effect on proliferation. Prelatent antithrombin down-regulated the expression of VEGFA, pSTAT3, and pERK1/2 in U-87 MG cells.
Article
Oncology
Chien-Rui Lai, Yu-Ling Tsai, Wen-Chiuan Tsai, Tzu-Min Chen, Hsin-Han Chang, Chih-Ying Changchien, Sheng-Tang Wu, Hisao-Hsien Wang, Ying Chen, Yu-Huei Lin
Summary: This study investigated the effects of Farnesoid X Receptor (FXR) on cholesterol biosynthesis in bladder cancers. Results showed that FXR overexpression reduced migration, adhesion, and angiogenesis of bladder cancer cells by decreasing cholesterol levels. Additionally, treatment with statins further enhanced the inhibitory effects of FXR on these properties, and clinical observations suggested improved survival rates for early-stage bladder cancer patients.
Article
Medicine, Research & Experimental
Jing Han, Yun Bai, Jia Wang, Xiao-li Xie, Ai-di Li, Qian Ding, Zi-jin Cui, Jie Yin, Xiao-yu Jiang, Hui-qing Jiang
Summary: The study revealed that REC8 promotes the migration, invasion, and angiogenesis of HCC cells through the PKA pathway. REC8 was found to be mainly located in the nucleus of HCC tissue cells and cell lines, with a correlation between high expression and positive alpha-fetoprotein levels. Additionally, REC8 was shown to accelerate metastasis in vitro, while metastasis was suppressed after REC8 silencing.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Ilona Gurgul, Ewelina Janczy-Cempa, Olga Mazuryk, Malgorzata Lekka, Michal Lomzik, Franck Suzenet, Philippe C. Gros, Malgorzata Brindell
Summary: The effect of polypyridyl Ru(II) complexes on cancer cell migration and invasion was evaluated in this study. Low sub-toxic doses of these complexes were found to greatly inhibit cell detachment, migration, invasion, transmigration, and re-adhesion, as well as increase cell elasticity. Molecular studies revealed that these complexes impact the activity of integrins and upregulate the expression of focal adhesion components, leading to an increased number of focal adhesion contacts.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Gabriela Aust, Leyu Zheng, Marianne Quaas
Summary: Tumorigenesis is a complex process involving mutations, angiogenesis, cell invasion, and metastasis. Adhesion G protein-coupled receptors (aGPCRs) play important roles in tumor cell biology. CD97, a receptor closely associated with tumorigenesis, has been extensively studied.
Review
Oncology
Roland E. Kaelin, Rainer Glass
Summary: The upregulation of Apelin and its receptor in glioblastoma plays a crucial role in tumor progression by promoting angiogenesis and tumor cell invasiveness. Targeting APLN/APLNR signaling shows promise for anti-angiogenic and anti-invasive therapy, potentially improving outcomes for patients with GBM.
Article
Cell Biology
Katharina Joechle, Huda Jumaa, Kerstin Thriene, Claus Hellerbrand, Birte Kulemann, Stefan Fichtner-Feigl, Sven A. Lang, Jessica Guenzle
Summary: The study showed that OSI-027, a dual kinase inhibitor targeting mTOR complexes, can significantly impact the migratory and metastatic capacity of cholangiocarcinoma cells by reducing cell mobility and migration, decreasing colony-forming ability, and downregulating MMP2 and MMP9 expression. Additionally, OSI-027 impaired survival and anti-apoptotic signaling as determined by AKT and MAPK blotting, suggesting that dual targeting of mTORC1/2 may be a viable option for anti-neoplastic therapy in CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jakub Rech, Daniel Sypniewski, Dorota Zelaszczyk, Natalia Szkaradek, Wojciech Rogoz, Anna Waszkielewicz, Henryk Marona, Ilona Bednarek
Summary: The study revealed that four novel xanthone derivatives have the potential to inhibit proliferation, motility, and induce apoptosis in colon cancer cells, with comparable activity to cisplatin and 5-fluorouracil. Further research and development of these compounds as novel drugs for colorectal cancer treatment is recommended.
Article
Biology
Alessia Ricci, Amelia Cataldi, Simone Carradori, Susi Zara
Summary: Breast cancer is a commonly diagnosed cancer in women. Newly synthesized thiadiazole-based Eg5 inhibitors 2 and 41 have been found to negatively modulate proliferation, invasiveness, and migration of cancer cells, as well as affect angiogenesis and extracellular matrix remodeling, showing potential as a new drug strategy to control breast cancer.
Article
Cell Biology
Feng-Cheng Pai, Hsiang-Wei Huang, Yu-Ling Tsai, Wen-Chiuan Tsai, Yu-Chen Cheng, Hsin-Han Chang, Ying Chen
Summary: The study demonstrated the impact of FABP6 on invasion, angiogenesis, and progression of malignant glioma. Knockdown of FABP6 inhibited migration, invasion, and tube formation capabilities of glioma cells, suggesting FABP6 as a potential therapeutic target for gliomas when combined with TMZ.
Article
Oncology
Ping Chen, Tao Wang, Qi Chen
Summary: A new mechanism of Ginkgo biloba leaf extract (GGLE) in inhibiting melanoma cell invasion and angiogenesis was discovered. GGLE inhibited total RNase activities in melanoma cells and suppressed angiogenin synthesis and secretion, resulting in inhibition of tumor cell invasion and tumor-induced angiogenesis.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Multidisciplinary Sciences
Niroz Abu-Saleh, Chiung-Chi Kuo, Wei Jiang, Ronald Levy, Shoshana Levy
Summary: Metastases are decreased in CD81KO mice. Moreover, a specific anti-CD81 antibody, 5A6, can inhibit metastasis in vivo and invasion and migration in vitro. Removing cholesterol or the intracellular domains of CD81 doesn't affect 5A6's inhibitory effect. The uniqueness of 5A6 is attributed to its recognition of a specific epitope on CD81's large extracellular loop. Finally, several CD81 membrane-associated partners, such as integrins and transferrin receptors, may contribute to the antimetastatic attributes of 5A6.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Developmental Biology
Yan Yu, Qiaohua Peng, Peng Zhao, Lingfang Wang, Yang Weng, Xiaojing Chen, Xingxia Li, Suwen Feng, Xinyu Wang, Weiguo Lu, Xing Xie, Xiaodong Cheng
Summary: MIIP plays a role in inhibiting cellular motility in choriocarcinoma, acting as a tumor suppressor gene. The downregulation of MIIP promotes cell migration and invasion, while the upregulation of MIIP slows down cell migration and invasion. MIIP expression is negatively correlated with histone deacetylase (HDAC6) expression and positively correlated with acetylated alpha-tubulin expression.
Article
Biochemical Research Methods
Berke Bilgenur Sener, Deniz Yigit, Abdullah Tahir Bayrac, Ceren Bayrac
Summary: The study generated DNA aptamers against ICAM-1 using cell-SELEX and protein SELEX methods, which can specifically detect ICAM-1 expressing tumor cells and inhibit migration and invasion by blocking ICAM-1 related interactions.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yuxue Xu, Feixue Ni, Daxi Sun, Yue Peng, Yaxuan Zhao, Xiaojun Wu, Shasha Li, Xiangyu Qi, Xinkang He, Min Li, Yizi Zhou, Chao Zhang, Miao Yan, Cuifang Yao, Shuaishuai Zhu, Yang Yang, Baijiao An, Chunhua Yang, Guilong Zhang, Wenguo Jiang, Jia Mi, Xinju Chen, Pengfei Wei, Geng Tian, Yin Zhang
Summary: This study reveals a novel role of glucagon in anti-cancer therapy by inhibiting angiogenesis and vascular mimicry, which enhances chemotherapy efficacy.
Article
Multidisciplinary Sciences
Javier Cuenca-Guardiola, Belen de la Morena-Barrio, Juan L. Garcia, Alba Sanchis-Juan, Javier Corral, Jesualdo T. Fernandez-Breis
Summary: Whole-genome sequencing using nanopore technologies can detect large structural variants with high accuracy. However, existing software for nanopore sequencing data analysis still has limitations in reporting complete and accurate variant sets, hindering molecular diagnosis and genotyping.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Surgery
Clara Gene Skrabec, Anna Vidal Carne, Manel Cremades Perez, Javier Corral, Andrea Fernandez Pujol, Marta Cuadrado, Jose Troya, Joan-Francesc Julian Ibanez, David Pares
Summary: The aim of this study was to review and assess the quality of scientific articles on early and late anastomotic leak (AL) after colorectal surgery and their risk factors. A systematic search was conducted using the MEDLINE database via PubMed, Cochrane, and Embase. The selected articles were reviewed and assessed for methodological quality using a validated methodology quality score (MINCIR score). The review was registered in the PROSPERO registry. Nine articles were finally reviewed, indicating the differentiation between early and late anastomotic leak based on technical factors and impaired healing.
Article
Biochemistry & Molecular Biology
Rosa Cifuentes, Jose Padilla, Maria Eugenia de la Morena-Barrio, Belen de la Morena-Barrio, Carlos Bravo-Perez, Pedro Garrido-Rodriguez, Maria Llamas, Antonia Minano, Vicente Vicente, Maria Luisa Lozano, Javier Corral
Summary: Multiplex ligation-dependent probe amplification (MLPA) is effective in identifying genetic structural variants in SERPINC1 in 5% of antithrombin deficiency (ATD) cases. However, MLPA has limitations in detecting intronic structural variants, and can produce imprecise and false-positive results for genetic defects affecting MLPA probes. Validation of MLPA results is encouraged based on our study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Information Systems
Daniel Deniz, Gabriel Jimenez-Perera, Ricardo Nolasco, Javier Corral, Francisco Barranco
Summary: The pace of population ageing is increasing and becoming a significant challenge. The introduction of Cyber-Physical Systems (CPS) has facilitated the development of e-Health solutions for alleviating the associated burden. This study presents a CPS-based solution, a Deep Multimodal Habit Tracking system, to monitor and improve the autonomy and healthy lifestyles of individuals living alone at home. The system combines video and heart rate cues for accurate indoor action identification, with local processing ensuring data privacy and reducing bandwidth usage. The solution achieves high accuracy and additional heart rate information improves performance, especially in detecting critical actions like falls. The optimized model is embedded in a Nvidia Jetson Nano device, providing real-time performance with low power consumption. Additionally, a dataset specifically for indoor action recognition using synchronized video and heart rate pulses has been collected.
JOURNAL OF SIGNAL PROCESSING SYSTEMS FOR SIGNAL IMAGE AND VIDEO TECHNOLOGY
(2023)
Article
Hematology
Joanna Natorska, Javier Corral, Maria Eugenia de la Morena-Barrio, Carlos Bravo-Perez, Zsuzsa Bagoly, Zsuzsanna Bereczky, Jacek Trelinski, Michal Witkowski, Adrianna Klajmon, Anetta Undas, Michal Zabczyk
Summary: This study found that antithrombin deficiency increases the risk of thrombosis. It was discovered that antithrombin deficiency is associated with changes in fibrin clot permeability and lysis time.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Esmeralda Garcia-Torralba, Miguel Perez Ramos, Alejandra Ivars Rubio, Esther Navarro-Manzano, Noel Blaya Boluda, Pilar de la Morena Barrio, Elisa Garcia-Garre, Francisco Martinez Diaz, Asuncion Chaves-Benito, Elena Garcia-Martinez, Francisco Ayala de la Pena
Summary: This study aimed to investigate the predictive and prognostic value of stromal lymphocytic infiltration (sTIL) in early luminal breast cancer (BC). The results showed that sTIL can predict pathologic complete response after neoadjuvant chemotherapy and has an independent prognostic impact on the relapse-free interval. The prognostic impact of sTIL is mainly observed in luminal B BC.
Article
Oncology
Esmeralda Garcia-Torralba, Esther Navarro Manzano, Gines Luengo-Gil, Pilar De la Morena Barrio, Asuncion Chaves Benito, Miguel Perez-Ramos, Beatriz Alvarez-Abril, Alejandra Ivars Rubio, Elisa Garcia-Garre, Francisco Ayala de la Pena, Elena Garcia-Martinez
Summary: This study aimed to analyze the predictive capacity of several markers associated with immune response and cell proliferation combined with clinical parameters in breast cancer patients treated with neoadjuvant chemotherapy. The results showed that neutrophil-to-lymphocyte ratio (NLR), tumor-infiltrating lymphocytes (TILs), AURKA, and MYBL2 have prognostic value for overall survival. These biomarkers may provide valuable information for the management of early breast cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Carmen Rodenas, Julia Penas-Martinez, Irene Pardo-Sanchez, David Zaragoza-Huesca, Carmen Ortega-Sabater, Jorge Pena-Garcia, Salvador Espin, Guillermo Ricote, Sofia Montenegro, Francisco Ayala-De La Pena, Gines Luengo-Gil, Andres Nieto, Francisco Garcia-Molina, Vicente Vicente, Francesco Bernardi, Maria Luisa Lozano, Victoriano Mulero, Horacio Perez-Sanchez, Alberto Carmona-Bayonas, Irene Martinez-Martinez
Summary: This study aims to explore the molecular role of hepsin in colorectal cancer. The results showed higher plasma hepsin levels in metastatic patients, especially those with thrombosis. Hepsin overexpression increased colorectal cancer cell invasion, Erk1/2 and STAT3 phosphorylation, and thrombin generation in plasma. In addition, venetoclax was identified as a potent hepsin inhibitor that reduced the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Ascension M. de los Reyes-Garcia, Laura Zapata-Martinez, Sonia Aguila, Maria L. Lozano, Constantino Martinez, Rocio Gonzalez-Conejero
Summary: Atrial fibrillation is a complex disease and microRNAs play a crucial role in the development of major adverse cardiovascular events (MACE) in these patients. MicroRNAs have been investigated as potential biomarkers for various diseases, including cardiovascular diseases. Some studies have associated certain microRNAs in plasma with the occurrence of MACE in atrial fibrillation. However, the lack of standardization in the purification and detection of microRNAs has produced contradictory results. Additionally, microRNAs have a functional impact on MACE in atrial fibrillation through the dysregulation of immunothrombosis, suggesting their potential use as therapy against thromboinflammatory processes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Hematology
Belen de la Morena-Barrio, Angeles Palomo, Jose Padilla, Laura Martin-Fernandez, Juan Jose Rojo-Carrillo, Rosa Cifuentes, Carlos Bravo-Perez, Pedro Garrido-Rodriguez, Antonia Minand, Ana Maria Rubio, Javier Pagan, Maria Llamas, Vicente Vicente, Francisco Vidal, Maria Luisa Lozano, Javier Corral, Maria Eugenia de la Morena-Barrio
Summary: This study identified three structural variants affecting the F11 gene, which may have significant implications for the molecular pathology of congenital FXI deficiency.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Francisco Ayala de la Pena, Silvia Antolin Novoa, Joaquin Gavila Gregori, Lucia Gonzalez Cortijo, Fernando Henao Carrasco, Maria Teresa Martinez Martinez, Cristina Morales Estevez, Agostina Stradella, Maria Jesus Vidal Losada, Eva Ciruelos
Summary: Breast cancer is the main cause of cancer in women in Spain, with a rapidly increasing annual incidence. Despite the potential impact of the COVID-19 pandemic on screening programs (not yet quantified), almost 90% of breast cancer cases are detected early and can be potentially cured. New diagnostic tools have improved the balance between toxicity and clinical benefit in locoregional and systemic therapies, and new therapeutic strategies such as immunotherapy, targeted drugs, and antibody-drug conjugates have improved outcomes in certain patient subgroups.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jose Rayas, Mariam Hassan, Rivers A. Hock, Bryan Nguyen, Swathi Prakash, Adrian Rojas Murguia, Ilma Vahora, Javier Corral, Osvaldo Padilla, Fatma Dihowm
Summary: Paroxysmal nocturnal hemoglobinuria (PNH) is a acquired X-linked, clonal hematopoietic stem cell disease with vague symptomatology, which poses difficulties in diagnosis, especially when coexisting with other hematologic disorders. The authors encourage screening for PNH clones in patients initially diagnosed with aplastic anemia (AA), treating underlying hematologic disease to prevent clonal expansion, and further research on the effectiveness of eculizumab in an unusual classical PNH secondary to AA with hypercellular bone marrow.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Mariam Hassan, Swathi Prakash, Jose Rayas, Jared J. Bies, Sukhila Reddy, Sahithi Nadella, Sara Alhariri, Yousf Radwan, Nawar Hakim, Javier Corral
Summary: In this report, the authors present an unusual case of a 75-year-old female with a history of COVID-19 infection who developed transient ischemic attack, thrombocytopenia, and amegakaryocytopenia.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Oncology
Ruth Vera, Oscar Juan-Vidal, Maria Jose Safont-Aguilera, Francisco Ayala de la Pena, Aranzazu Gonzalez del Alba
Summary: Precision medicine in oncology aims to provide personalized treatment based on individual features, but disparities in cancer care based on sex exist. Genetic and environmental factors contribute to these differences, highlighting the importance of increasing awareness among healthcare professionals.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)