Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro

Abstract B15: Combination chemotherapy in melanoma using EZH2 inhibitor

(2015) Deepanwita Sengupta et al.   CANCER RESEARCH

EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors

(2015) Christine M. Fillmore et al.   NATURE

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

(2014) S. K. Knutson et al.   MOLECULAR CANCER THERAPEUTICS

EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression

(2014) Huihua Zhang et al.   Scientific Reports

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

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Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

The SWI/SNF tumor suppressor complex

(2013) Ping Lu et al.   Nucleus

Genome-wide recruitment to Polycomb-modified chromatin and activity regulation of the synovial sarcoma oncogene SYT-SSX2

(2012) Christina B Garcia et al.   BMC GENOMICS

Deconstruction of the SS18-SSX Fusion Oncoprotein Complex: Insights into Disease Etiology and Therapeutics

(2012) Le Su et al.   CANCER CELL

Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2)

(2012) Yi-Che Changchien et al.   Journal of Translational Medicine

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications

(2011) Roberta Ciarapica et al.   BMC Medicine

Keeping chromatin quiet

(2011) Jacqueline E. Mermoud et al.   CELL CYCLE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Loss of SMARCB1/INI1 expression in poorly differentiated chordomas

(2010) Bret C. Mobley et al.   ACTA NEUROPATHOLOGICA

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Synovial Sarcoma is a Stem Cell Malignancy

(2010) Norifumi Naka et al.   STEM CELLS

SMARCB1/INI1 Protein Expression in Round Cell Soft Tissue Sarcomas Associated With Chromosomal Translocations Involving EWS: A Special Reference to SMARCB1/INI1 Negative Variant Extraskeletal Myxoid Chondrosarcoma

(2009) Kenichi Kohashi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Genomic Analysis Using High-Density Single Nucleotide Polymorphism-Based Oligonucleotide Arrays and Multiplex Ligation-Dependent Probe Amplification Provides a Comprehensive Analysis of INI1/SMARCB1 in Malignant Rhabdoid Tumors

(2009) E. M. Jackson et al.   CLINICAL CANCER RESEARCH

Epigenetic Features of Human Mesenchymal Stem Cells Determine Their Permissiveness for Induction of Relevant Transcriptional Changes by SYT-SSX1

(2009) Luisa Cironi et al.   PLoS One

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

(2009) G. H. S. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Deacetylase Inhibitors Reverse SS18-SSX-Mediated Polycomb Silencing of the Tumor Suppressor Early Growth Response 1 in Synovial Sarcoma

(2008) J. M. Lubieniecka et al.   CANCER RESEARCH

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor

(2008) Kenichi Kohashi et al.   HUMAN PATHOLOGY

Diagnosis and management of synovial sarcoma

(2008) Fritz C. Eilber et al.   JOURNAL OF SURGICAL ONCOLOGY

Roles of the EZH2 histone methyltransferase in cancer epigenetics

(2008) Jeffrey A. Simon et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS