期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 5, 页码 1247-1250出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm801278g
关键词
-
资金
- NIH [1U54MK074411]
A three-dimensional pharmacophore model was generated utilizing a set of known inhibitors of c-Myc-Max heterodimer formation. The model successfully identified a set of structurally diverse compounds with potential inhibitory activity against c-Myc. Nine compounds were tested in vitro. and four displayed affinities in the micromolar range and growth inhibitory activity against c-Myc-overexpressing cells. These studies demonstrate the applicability of pharmacophore modeling to the identification of novel and potentially more puissant inhibitors of the c-Myc oncoprotein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据