Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1

miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity

(2015) Naoto Fujiwara et al.   CANCER RESEARCH

Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes

(2015) Liang Cheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes

(2015) Fotini Kostopoulou et al.   ARTHRITIS RESEARCH & THERAPY

Identification and characterization of ANO9 in stage II and III colorectal carcinoma

(2015) Chunxiang Li et al.   Oncotarget

MiR-210 inhibits NF-κB signaling pathway by targeting DR6 in osteoarthritis

(2015) Dawei Zhang et al.   Scientific Reports

Associations of PI3KR1 and mTOR Polymorphisms with Esophageal Squamous Cell Carcinoma Risk and Gene-Environment Interactions in Eastern Chinese Populations

(2015) Jinhong Zhu et al.   Scientific Reports

Peroxisomal dysfunction is associated with up-regulation of apoptotic cell death via miR-223 induction in knee osteoarthritis patients with type 2 diabetes mellitus

(2014) Dongkyun Kim et al.   BONE

Effect of microRNA-145 on IL-1β-induced cartilage degradation in human chondrocytes

(2014) Bo Yang et al.   FEBS LETTERS

Protection of ginsenoside Rg1 on chondrocyte from IL-1β-induced mitochondria-activated apoptosis through PI3K/Akt signaling

(2014) Yumin Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis

(2014) Carolyn M Dancevic et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNA-127-5p Regulates Matrix Metalloproteinase 13 Expression and Interleukin-1β-Induced Catabolic Effects in Human Chondrocytes

(2013) Su Jin Park et al.   ARTHRITIS AND RHEUMATISM

Human Apurinic/Apyrimidinic Endonuclease siRNA Inhibits the Angiogenesis Induced by X-Ray Irradiation in Lung Cancer Cells

(2013) Xianqing Gu et al.   International Journal of Medical Sciences

Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritisviaAkt signalling

(2013) Honghai Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth

(2013) Suvi-Katri Leivonen et al.   Molecular Oncology

Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes

(2013) L.A. Vonk et al.   OSTEOARTHRITIS AND CARTILAGE

The inflammatory circuitry of miR-149 as a pathological mechanism in osteoarthritis

(2013) Paolo Santini et al.   RHEUMATOLOGY INTERNATIONAL

MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes

(2013) Tetsuya Matsukawa et al.   ARTHRITIS RESEARCH & THERAPY

Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis

(2012) Xinpeng Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes

(2012) Silvia Díaz-Prado et al.   BMC MUSCULOSKELETAL DISORDERS

Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes

(2012) Qingzhi Chen et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

(2012) Jing Li et al.   ARTHRITIS RESEARCH & THERAPY

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)

(2011) Malik M. Keshwani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetics and epigenetics of osteoarthritis

(2011) Louise N. Reynard et al.   MATURITAS

Chondrocyte death by apoptosis is associated with the initiation and severity of articular cartilage degradation

(2010) Carla M. THOMAS et al.   International Journal of Rheumatic Diseases

Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes

(2010) Frank Beier et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis

(2009) John D. Cravero et al.   ARTHRITIS AND RHEUMATISM

Mechanism of PDK1-catalyzed Thr-229 Phosphorylation of the S6K1 Protein Kinase

(2009) Malik M. Keshwani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13

(2008) S.W. Jones et al.   OSTEOARTHRITIS AND CARTILAGE

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation

(2008) T. Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA