Article
Multidisciplinary Sciences
Anita Alexa, Peter Sok, Fridolin Gross, Krisztian Albert, Evan Kobori, Adam L. Poti, Gergo Gogl, Isabel Bento, Ersheng Kuang, Susan S. Taylor, Fanxiu Zhu, Andrea Ciliberto, Attila Remenyi
Summary: The herpesvirus protein ORF45 can bind to host kinases ERK and RSK, affecting cell signaling by interfering with the host kinases' docking systems. It uses optimized linear binding motifs to hijack the ERK-RSK complex and manipulate ERK-RSK signaling, resulting in enhanced kinase protection and selective up-regulation of RSK substrate phosphorylation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yuhan Yan, Chao Chen, Zhiguo Li, Jing Zhang, Narin Park, Cheng-Kui Qu
Summary: A continuous supply of exogenous arginine is crucial for the maintenance and function of normal hematopoietic stem cells (HSCs), but the L-arginine transporter CAT3 is dispensable for normal hematopoiesis and leukemogenesis.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Zhenshan Liu, Chengrong Liu, Xin Wang, Wenwei Li, Jingfan Zhou, Peixian Dong, Maggie Z. X. Xiao, Chunxia Wang, Yucai Zhang, Joyce Fu, Fanxiu Zhu, Qiming Liang
Summary: RSK1 is SUMOylated at lysine residues K110, K335, and K421 during KSHV lytic replication, which is essential for efficient viral replication. The SUMOylation of RSK1 regulates the phosphorylation of downstream substrates, such as eIF4B, and is crucial for KSHV lytic replication.
Article
Biochemistry & Molecular Biology
Sheikh Tahir Majeed, Rabiya Majeed, Aijaz A. Malik, Khurshid Iqbal Andrabi
Summary: S6K1 is regulated by mTORC1 and is involved in cell growth and proliferation. We have identified eIF4E as an intermediate in transmitting signals from mTORC1 to S6K1 and found that mTORC1 induces eIF4E phosphorylation and interaction with S6K1. We further discovered that mTORC2 acts as a physiological kinase for S6K1's hydrophobic motif phosphorylation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hui Ma, Jiayan Cui, Zehui Liu, Wenqing Fang, Sisi Lu, Shuying Cao, Yuanyuan Zhang, Ji-An Chen, Lixue Lu, Qiong Xie, Yonghui Wang, Ying Huang, Kongfei Li, Hongyan Tong, Jin Huang, Weiqiang Lu
Summary: This study demonstrates that induction of degradation of FLT3-ITD protein by DHODH blockade may offer a promising therapeutic strategy for AML patients harboring FLT3-ITD mutation.
Article
Virology
Maxim Cherneha, Johannes Korth, Meike Kaulfuss, Mirko Trilling, Marek Widera, Hana Rohn, Sebastian Dolff, Nina Babel, Andre Hoerning, Andreas Kribben, Oliver Witzke
Summary: Reactivations of BK polyoma virus and human cytomegalovirus can cause complications in renal transplant recipients. The phosphorylation of P70S6k in peripheral lymphocytes is associated with BKPyV reactivations and, to a lesser extent, with HCMV infections in these recipients, independent of immunosuppressive drug levels.
Article
Entomology
Heng Jiang, Nan Zhang, Huichen Ge, Jiaping Wei, Xin Xu, Xiangkun Meng, Kun Qian, Yang Zheng, Jianjun Wang
Summary: In this study, the researchers identified a gene called TcS6K1, which plays a crucial role in the reproduction of red flour beetles. They found that TcS6K1 regulates the production of eggs by affecting the FOXO/JH signaling pathway.
JOURNAL OF INSECT PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyue Ji, Junhong Chen, Chaoying You, Jing Sun, Xiulong Xu
Summary: Leflunomide controls obesity in part by activating AMPK and inducing lipophagy.
Review
Biochemistry & Molecular Biology
Stefania Battaglioni, Don Benjamin, Matthias Waelchli, Timm Maier, Michael N. Hall
Summary: The target of rapamycin (TOR), a highly conserved serine/threonine protein kinase, plays a central role in regulating cell growth and metabolism by responding to nutrients, growth factors, and cellular energy. Forming two distinct complexes, TORC1 and TORC2, TOR signaling activates cell growth by stimulating anabolic metabolism and inhibiting catabolic processes. This comprehensive review focuses on mammalian TOR (mTOR) and discusses the phosphorylation of different substrates by mTORC1 and mTORC2, despite sharing a common catalytic subunit. The conclusion is that these two complexes recruit different substrates to phosphorylate a common, minimal motif.
Article
Microbiology
Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang
Summary: This study reveals the crucial role of the mTORC1 signaling pathway in the replication of white spot syndrome virus (WSSV) in Marsupenaeus japonicus. WSSV activates calmodulin, leading to the activation of mTORC1 and its downstream effector S6Ks for viral protein translation. This finding suggests that mTORC1 may serve as a potential therapeutic target for controlling WSSV in shrimp aquaculture.
Article
Biochemistry & Molecular Biology
Ewan M. Smith, Nour El Houda Benbahouche, Katherine Morris, Ania Wilczynska, Sarah Gillen, Tobias Schmidt, Hedda A. Meijer, Rebekah Jukes-Jones, Kelvin Cain, Carolyn Jones, Mark Stoneley, Joseph A. Waldron, Cameron Bell, Bruno D. Fonseca, Sarah Blagden, Anne E. Willis, Martin Bushell
Summary: mTOR regulates cell growth by controlling the binding of specific mRNAs to the protein synthesis machinery, with the binding of LARP1 and PABPC1 playing key roles in translation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Microbiology
Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang
Summary: Previous studies have shown that the mTORC1 signaling pathway plays a role in antiviral functions or benefits viral replication, but the detailed mechanisms by which mTORC1 enhances viral infection are unclear. Our study reveals that WSSV utilizes the mTORC1 pathway for replication in shrimp, suggesting a potential clinical target for controlling WSSV in shrimp aquaculture.
Article
Oncology
Zhi-Feng Guo, Fan-Long Kong
Summary: This study investigated the relationship between Akt and H2A.X in human breast cancer cells. It found that Akt negatively regulated the phosphorylation of H2A.X, promoting cellular survival and migration. The findings shed light on the pathogenesis and treatment mechanisms of breast cancer.
Article
Biochemistry & Molecular Biology
Eric B. Wright, Shinji Fukuda, Mingzong Li, Yu Li, George A. O'Doherty, Deborah A. Lannigan
Summary: The study identified a natural product, SL0101, that binds specifically to RSK1/2 by inducing conformational rearrangement, but not to RSK3/4 due to a single amino acid difference. Kinetic analysis revealed that regions outside of the N-terminal kinase domain also contribute to stable inhibitor binding towards RSK2. Additionally, a modification on SL0101 was discovered to form a highly stable inhibitor complex with RSK2, suggesting potential for identifying RSK2-specific inhibitors.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Pathology
Junpeng Xu, Qingge Jia, Yan Zhang, Yuan Yuan, Tianqi Xu, Kangjie Yu, Jia Chai, Kaijing Wang, Ligang Chen, Tian Xiao, Mingyang Li
Summary: RSK4 is a Ser/Thr protein kinase that regulates cell survival and proliferation in various types of cancer. Its role as a tumor suppressor gene or an oncogene is controversial, and specific inhibitors for RSK4 have not been found.
PATHOLOGY RESEARCH AND PRACTICE
(2021)