Article
Cell Biology
DongWei Liu, FengXun Liu, ZhengYong Li, ShaoKang Pan, JunWei Xie, ZiHao Zhao, ZhenJie Liu, JiaHui Zhang, ZhangSuo Liu
Summary: This study found that miR-483-5p is decreased in kidney tissues of diabetic mice and in tubular epithelial cells stimulated with high glucose, but increased in exosomes derived from diabetic mouse kidney tissues. miR-483-5p inhibits fibrosis-related gene expressions by binding to TIMP2 and MAPK1, thus alleviating the progression of DN-induced renal interstitial fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Songda Chen, Huijie Wu, Lingyu Zhu, Mengjie Jiang, Shuli Wei, Jinhua Luo, Aiqun Liu
Summary: The study identified miR-199b-5p as significantly upregulated in gastric cancer tissue and associated with poor prognosis. MiR-199b-5p promotes gastric cancer cell proliferation, migration, and the EMT process, indicating its oncogenic role in gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chong Yin, Ye Tian, Yang Yu, Dijie Li, Zhiping Miao, Peihong Su, Yipu Zhao, Xue Wang, Jiawei Pei, Kewen Zhang, Airong Qian
Summary: Osteoporosis, a threat to human health caused by aging and menopause, is associated with reduced osteoblast differentiation. Long non-coding RNAs (LncRNAs) may serve as potential therapeutic targets for osteoporosis. In this study, two LncRNAs (AK039312 and AK079370) were identified to inhibit osteoblast differentiation and bone formation by suppressing osteogenic transcription factors, providing new insights for osteoporosis therapy.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Urology & Nephrology
Taoxia Wang, Shubei Cui, Xiaoli Liu, Li Han, Xiaoting Duan, Shuning Feng, Sen Zhang, Guiying Li
Summary: This study explores the role of long noncoding RNA taurine-up-regulated gene 1 (TUG1) in tubular fibrosis caused by high glucose and its target genes. Results show that downregulation of TUG1 contributes to renal injury and fibrosis, while overexpression of TUG1 alleviates these effects through the miR-145-5p/DUSP6 axis. These findings provide insights into the mechanism of diabetic nephropathy and potential therapeutic targets.
Article
Immunology
Rong Fang, Xiangchang Cao, Yaping Zhu, Qiming Chen
Summary: This study found that hsa_circ_0037128 promotes high glucose-induced podocyte injury by regulating the miR-31-5p/KLF9 axis, suggesting that hsa_circ_0037128 may be a target for DN treatment.
Article
Physiology
Wenmin Dong, Huiqian Zhang, Cheng Zhao, Yun Luo, Ying Chen
Summary: The study revealed that silencing miR-150-5p played a protective role in the kidneys of DN mice by targeting SIRT1, leading to activation of AMPK-dependent autophagy.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Physiology
B. M. Williams, C. L. Cliff, K. Lee, P. E. Squires, C. E. Hills
Summary: The NLRP3 inflammasome plays a role in chronic inflammation in diabetic nephropathy, particularly in the glomerulus and proximal tubule. Targeting the NLRP3 inflammasome or its downstream components may offer potential therapeutic strategies for diabetic nephropathy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zheli Niu, Guangwei Ren, Lijing Huang, Liqin Mu
Summary: A study found that circ_0008529 plays a key role in the progression of diabetic nephropathy (DN), regulating DN development through the miR-185-5p/SMAD2 signaling pathway. Additionally, the expression of circ_0008529 was upregulated in urinary exosomes of DN patients and showed diagnostic value.
BIOCHEMICAL GENETICS
(2023)
Article
Cell Biology
Shiqi Jin, Yu Song, Li Zhou, Wei Jiang, Liping Qin, Yufeng Wang, Ruiqi Yu, Yuting Liu, Yujie Diao, Fan Zhang, Kaixuan Liu, Peishan Li, Huili Hu, Baichun Jiang, Wei Tang, Fan Yi, Yaoqin Gong, Guangyi Liu, Gongping Sun
Summary: Diabetic kidney disease (DKD) is the most prevalent chronic kidney disease, and macrophage infiltration plays a critical role in its progression. This study reveals that myeloid deficiency of CUL4B alleviates diabetes-induced renal injury and fibrosis. The mechanism involves the CUL4B/miR-194-5p/ITGA9 axis, where CUL4B promotes migration and adhesion of macrophages by repressing miR-194-5p expression and increasing ITGA9 levels.
Article
Pharmacology & Pharmacy
Li Zang, Fang Gao, Aijing Huang, Yalan Zhang, Yangyan Luo, Lijia Chen, Nan Mao
Summary: This study revealed that Icariin (ICA) attenuated epithelial mesenchymal transition (EMT) and renal injury in diabetic nephropathy (DN) rats by inhibiting miR-122-5p and promoting FOXP2 transcription.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Ying Hu, Xiaofeng Wang, Chong Li, Liang Jiao, Yi Du
Summary: Growing studies have shown that LINC01783 is up-regulated in TSCC and promotes TSCC cell growth, cycle, and EMT progression by sponging miR-199b-5p, suggesting it may serve as a treatment target for TSCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Rong Zheng, Weijie Zhang, Jufang Song, Yifei Zhong, Rong Zhu
Summary: The study found that cordycepin produced by Cordyceps militaris can alleviate oxidative stress and inflammation in diabetic nephropathy by regulating the expression of the miR-193b-5p/MCL-1 axis.
Article
Oncology
Zhigang Zhao, Shankun Zhao, Lianmin Luo, Qian Xiang, Zhiguo Zhu, Jiamin Wang, Yangzhou Liu, Jintai Luo
Summary: The study demonstrates a tumor-suppressive role of miR-199b-5p in invasion and metastasis of PCa by inhibiting DDR1 expression and EMT, leading to poor prognosis in patients. Additionally, the miR-199b-5p-DDR1-ERK signaling axis represents a novel mechanism for regulating EMT in PCa metastases.
BRITISH JOURNAL OF CANCER
(2021)
Article
Endocrinology & Metabolism
Li Zhao, Huaqian Chen, Lin Wu, Zhengdong Li, Ren Zhang, Yan Zeng, Tao Yang, Hualing Ruan
Summary: This study revealed that upregulated KCNQ1OT1 in DN patients and cell models inhibited cell proliferation and fibrosis while inducing apoptosis. It was found that miR-93-5p is a direct target of KCNQ1OT1, and targeting ROCK2, miR-93-5p overexpression can suppress cell proliferation and fibrosis. KCNQ1OT1 regulates ROCK2 expression by binding to miR-93-5p, providing potential value for DN treatment.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Jie Yun, Jinyu Ren, Yufei Liu, Lijuan Dai, Liqun Song, Xiaopeng Ma, Shan Luo, Yexu Song
Summary: The study revealed that circ-ACTR2 is upregulated in both DN samples and HG-treated HRMCs. Silencing circ-ACTR2 expression partially attenuated the effects of HG-induced cell proliferation, inflammation, extracellular matrix accumulation, and oxidative stress in HRMCs. Circ-ACTR2 acts as a sponge for miR-205-5p and regulates HG effects through miR-205-5p targeting HMGA2. The circ-ACTR2/miR-205-5p/HMGA2 axis contributes to HG-induced DN progression in HRMCs.
DIABETOLOGY & METABOLIC SYNDROME
(2021)