Article
Medicine, Research & Experimental
Jason Sadek, Derek T. Hall, Bianca Colalillo, Amr Omer, Anne-Marie K. Tremblay, Virginie Sanguin-Gendreau, William Muller, Sergio Di Marco, Marco Emilio Bianchi, Imed-Eddine Gallouzi
Summary: The study reveals that iNOS induces muscle wasting in cachexia by disrupting mitochondrial function and energy production processes. Clinically tested iNOS inhibitor GW274150 shows protective effects against muscle wasting in septic and cancer cachexia models.
EMBO MOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Elysse A. Phillips, Nora Hendricks, Matthew Bucher, Alina Maloyan
Summary: The study investigates the association between maternal obesity, vitamin D deficiency, placental dysfunction, and fetal health. The findings suggest that vitamin D deficiency contributes to mitochondrial dysfunction and increased inflammation in the placentae of obese women. Vitamin D supplementation may be beneficial in improving placental dysfunction in obese women.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Catherine L. Ly, Jinyeon Shin, Noa Schwartz, Theresa T. Lu, Sagrario Ortega, Babak J. Mehrara
Summary: The study shows that intracellular modulation of the VEGF-C signaling pathway can induce the formation of functional lymphatic networks without off-target effects and inflammation.
Article
Chemistry, Medicinal
Pei Qian, Qian Wang, Fang-Zheng Wang, Hang-Bing Dai, Hong-Yu Wang, Qing Gao, Hong Zhou, Ye-Bo Zhou
Summary: This study aimed to investigate the protective role of adrenomedullin (ADM) in cardiac remodeling and function in obesity-related hypertension (OH) rats. The results showed that ADM improved systemic inflammation and oxidative stress in OH rats, and had inhibitory effects on cardiac inflammation and oxidative stress. ADM also improved cardiac remodeling and function in OH rats.
Article
Nutrition & Dietetics
Lili Chen, Kuanping Ye, Xiaocheng Feng, Lianxi Li, Qin Li, Ying Huang, Xuanchun Wang, Rumei Li, Cheng Hu, Zhen Yang, Bin Lu, Yehong Yang, Jie Wen, Zhaoyun Zhang, Min He, Qinghua Wang, Wenbai Zhou, Yintao Li, Naijia Liu, Jinya Huang, Qiwei Shen, Qiyuan Yao, Renming Hu
Summary: The TM4 protein is involved in metabolic inflammation, and the ubiquitin-proteasome inhibitor PS-341 can regulate its function and improve obesity and glucose intolerance. Polymorphisms of TM4 are associated with obesity in the Han Chinese population. PS-341 alleviates chronic low-grade inflammation and improves insulin sensitivity by inhibiting TM4 degradation.
NUTRITION & METABOLISM
(2021)
Article
Nutrition & Dietetics
Anja Saalbach, Anna-Theresa Seitz, Johannes Kohlmann, Lena Kalweit, Lisa Vogt, Lars Selig, Kathrin M. Engel, Jan C. Simon
Summary: Obesity and high abdominal fat mass increase the risk of developing psoriasis and worsen its severity. Weight loss has been shown to have a positive effect on psoriasis. The dysregulation of glucose and lipid metabolism, adipose tissue activation, and persistent low-grade inflammation may be the links between obesity and inflammatory diseases. In this study, a dietary intervention focusing on reducing saturated free fatty acids (SFAs) improved psoriatic disease activity independently of weight loss and inhibited the overall pro-inflammatory activation status in psoriasis patients.
Article
Pharmacology & Pharmacy
Wanqing Li, Hongxiang Zeng, Min Xu, Chenglong Huang, Linfen Tao, Jun Li, Ting Zhang, Hong Chen, Jing Xia, Chunli Li, Xi Li
Summary: Oleanolic acid improves insulin resistance and reduces adipose tissue inflammation in obese mice by modulating macrophage activation and mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Priscila G. G. Pereira, Luciana L. L. Alves, Bianca T. T. Ciambarella, Kissila Rabelo, Ana Lucia R. Nascimento, Alan Cesar N. Moraes, Andressa Bernardi, Fernanda V. V. Guimaraes, Gabriela M. M. Carvalho, Jemima F. R. da Silva, Jorge J. J. de Carvalho
Summary: In this study, treatment with capybara oil (CO) was found to improve lipid profile and reduce blood pressure levels in obese mice. It also showed positive effects on renal histopathology, reducing inflammation, oxidative stress, and fibrosis. However, improvement in renal function was not significant.
Article
Biochemistry & Molecular Biology
Jacopo Morroni, Leonardo Schirone, Valentina Valenti, Clemens Zwergel, Carles Sanchez Riera, Sergio Valente, Daniele Vecchio, Sonia Schiavon, Rino Ragno, Antonello Mai, Sebastiano Sciarretta, Biliana Lozanoska-Ochser, Marina Bouche
Summary: Chronic cardiac muscle inflammation and subsequent fibrotic tissue deposition are key features in Duchenne Muscular Dystrophy (DMD). Corticosteroids are currently the treatment of choice for delaying DMD progression, but there is a need for new anti-inflammatory therapies due to the adverse effects associated with long-term corticosteroid use. In this study, the inhibition of PKC theta was found to significantly reduce immune cell infiltration, necrosis, and fibrosis in the heart. Functional improvements were also observed in left ventricle fractional shortening. These findings suggest that PKC theta pharmacological inhibition could be an attractive therapeutic approach for treating dystrophic cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Lavinia Rech, Mahmoud Abdellatif, Verena Stangl, Nishani Mabotuwana, Sean Hardy, Peter P. Rainer, Maria Poettler
Summary: This study investigated the protective effects of pharmacologic STING inhibition after myocardial infarction. The results showed that pharmacologic STING inhibition can reduce infarct expansion and scarring, improve left ventricular systolic function, and attenuate myocardial hypertrophy. This suggests that selective small-molecule STING inhibition has the potential to improve wound healing responses and pathological remodeling after myocardial infarction.
Article
Immunology
Jae-Sung Kim, Hyo Keun Kim, Joongho Lee, Sein Jang, Euni Cho, Seok-Jun Mun, Seokhyun Yoon, Chul-Su Yang
Summary: This study found that CD82 suppresses the activation of the NLRP3 inflammasome, but CD82 deficiency reduces the severity of colitis in mice. CD82 interacts with NLRP3 and BRCC3, leading to increased degradation of NLRP3 by blocking BRCC3-dependent K63-specific deubiquitination. Previous research has shown that B. vulgatus in the colon microbiota regulates CD82 expression and promotes NLRP3 inflammasome activation. Therefore, B. vulgatus may be a potential therapeutic candidate for colitis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Paolo Carai, Laura Florit Gonzalez, Stijn Van Bruggen, Valerie Spalart, Daria De Giorgio, Nadeche Geuens, Kimberly Martinod, Elizabeth Anne Vincent Jones, Stephane Heymans
Summary: The study investigates the contribution of neutrophils to the progression of viral myocarditis (VM) and found that inhibiting neutrophils and neutrophil extracellular traps (NETs) in the acute phase of VM can reduce cardiac inflammation and improve the pathological phenotype.
CARDIOVASCULAR RESEARCH
(2022)
Article
Medicine, Research & Experimental
Moritz J. Strowitzki, Gwendolyn Kimmer, Julian Wehrmann, Alina S. Ritter, Praveen Radhakrishnan, Vanessa M. Opitz, Christopher Tuffs, Marvin Biller, Julia Kugler, Ulrich Keppler, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt, Alfonso Blanco, Cormac T. Taylor, Martin Schneider
Summary: The study found that pharmacologic PHI improves healing of colonic anastomoses in ischemic or septic conditions by Phd2(+/-)-mediated M2 polarization of macrophages, creating a favorable microenvironment for anastomotic healing.
Article
Microbiology
Isabel Huber-Ruano, Enrique Calvo, Jordi Mayneris-Perxachs, M-Mar Rodriguez-Pena, Victoria Ceperuelo-Mallafre, Lidia Cedo, Catalina Nunez-Roa, Joan Miro-Blanch, Maria Arnoriaga-Rodriguez, Aurelie Balvay, Claire Maudet, Pablo Garcia-Roves, Oscar Yanes, Sylvie Rabot, Ghjuvan Micaelu Grimaud, Annachiara De Prisco, Angela Amoruso, Jose Manuel Fernandez-Real, Joan Vendrell, Sonia Fernandez-Veledo
Summary: The study reveals that gut microbiota is a significant source of elevated succinate in obese individuals. Therapeutic treatments with selected bacteria can reduce circulating succinate levels in obese mice, and Odoribacter laneus shows promise as a probiotic to deplete succinate and improve glucose tolerance.
Article
Nutrition & Dietetics
Chwan-Li Shen, Sivapriya Ramamoorthy, Gurvinder Kaur, Jannette M. Dufour, Rui Wang, Huanbiao Mo, Bruce A. Watkins
Summary: This study investigated the effects of dietary tocotrienols (TT) on obese mice and found that TT supplementation could reduce inflammation and oxidative stress levels, increase levels of key metabolites, and help to reduce obesity-related complications.
Review
Medicine, Research & Experimental
Joseph H. Dayan, Catherine L. Ly, Raghu P. Kataru, Babak J. Mehrara
ANNUAL REVIEW OF MEDICINE, VOL 69
(2018)
Article
Surgery
Geoffrey E. Hespe, Catherine L. Ly, Raghu P. Kataru, Babak J. Mehrara
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Surgery
Catherine L. Ly, Daniel A. Cuzzone, Raghu P. Kataru, Babak J. Mehrara
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Medical Laboratory Technology
Catherine L. Ly, Gabriela D. Garcia Nores, Raghu P. Kataru, Babak J. Mehrara
TRANSLATIONAL RESEARCH
(2019)
Review
Medical Laboratory Technology
Raghu P. Kataru, Itay Wiser, Jung Eun Baik, Hyeung Ju Park, Sonia Renal, Jin Peon Shin, Babak J. Mehrara
TRANSLATIONAL RESEARCH
(2019)
Article
Oncology
Raghu P. Kataru, Catherine L. Ly, Jinyeon Shin, Hyeung Ju Park, Jung Eun Baik, Sonia Rehal, Sagrario Ortega, David Lyden, Babak J. Mehrara
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Multidisciplinary Sciences
Shiri Gur-Cohen, Hanseul Yang, Sanjeethan C. Baksh, Yuxuan Miao, John Levorse, Raghu P. Kataru, Xiaolei Liu, June de la Cruz-Racelis, Babak J. Mehrara, Elaine Fuchs
Article
Cell Biology
Elizabeth J. Haining, Kate L. Lowe, Surasak Wichaiyo, Raghu P. Kataru, Zoltan Nagy, Dean Pj Kavanagh, Sian Lax, Ying Di, Bernhard Nieswandt, Benoit Ho-Tin-Noe, Babak J. Mehrara, Yotis A. Senis, Julie Rayes, Steve P. Watson
Summary: The study found that CLEC-2 expression on platelets is not necessary to maintain a barrier between the blood and lymphatic systems in unchallenged mice, but deficiency in CLEC-2 can lead to lymphatic vessel blood filling under conditions of chronic vascular remodeling. CLEC-2-driven platelet activation plays an essential role in vascular developmental programs.
Review
Biochemistry & Molecular Biology
Claire Y. Li, Raghu P. Kataru, Babak J. Mehrara
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Physiology
Raghu P. Kataru, Hyeong Ju Park, Jung Eun Baik, Claire Li, Jinyeon Shin, Babak J. Mehrara
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Endocrinology & Metabolism
Sonia Rehal, Raghu P. Kataru, Geoffrey E. Hespe, Jung Eun Baik, Hyeung Ju Park, Catherine Ly, JinYeon Shin, Babak J. Mehrara
MOLECULAR METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Catherine L. Ly, Jinyeon Shin, Noa Schwartz, Theresa T. Lu, Sagrario Ortega, Babak J. Mehrara
Summary: The study shows that intracellular modulation of the VEGF-C signaling pathway can induce the formation of functional lymphatic networks without off-target effects and inflammation.
Article
Multidisciplinary Sciences
Daniel Szoke, Gabor Kovacs, Eva Kemecsei, Laszlo Balint, Kitti Szotak-Ajtay, Petra Aradi, Andrea Styevkone Dinnyes, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Katalin Kariko, Raghu P. Kataru, Michael J. Hope, Drew Weissman, Babak J. Mehrara, Norbert Pardi, Zoltan Jakus
Summary: Dysfunction of the lymphatic system leads to secondary lymphedema and decreases quality of life. Researchers demonstrate that delivery of nucleoside-modified Vascular Endothelial Growth Factor C (VEGFC) mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Babak J. Mehrara, Hyeung Ju Park, Raghu P. Kataru, Jacqueline Bromberg, Michelle Coriddi, Jung Eun Baik, Jinyeon Shin, Claire Li, Michele R. Cavalli, Elizabeth M. Encarnacion, Meghan Lee, Kimberly J. Van Zee, Elyn Riedel, Joseph H. Dayan
Summary: The study aimed to examine the effect of inhibiting Th2 inflammation in lymphedema by using QBX258, a combination of IL4/13 neutralizing antibodies, and found that it improved quality of life and reduced pathological skin changes in women with breast cancer-related lymphedema. Treatment with QBX258 showed improvements in skin stiffness and quality of life measurements, particularly in physical and social aspects, with histological evidence of decreased epidermal changes and cytokine expression in lymphedematous skin.
Review
Immunology
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Itay Wiser, Sonia Rehal, Jin Yeon Shin, Babak J. Mehrara
FRONTIERS IN IMMUNOLOGY
(2019)