Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood–brain barrier integrity
出版年份 2022 全文链接
标题
Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood–brain barrier integrity
作者
关键词
-
出版物
Journal of Neuroinflammation
Volume 19, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-06-28
DOI
10.1186/s12974-022-02533-8
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities
- (2022) Eduardo Candelario-Jalil et al. STROKE
- Pericytes regulate vascular immune homeostasis in the CNS
- (2021) Orsolya Török et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel BRD4 inhibitor suppresses osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL-mediated MAPK and NF-κB pathways
- (2021) Ying Liu et al. Cell Death & Disease
- Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism
- (2021) Changjun Yang et al. Redox Biology
- Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke
- (2020) Changjun Yang et al. Frontiers in Neurology
- Blood-Brain Barrier Damage in Ischemic Stroke and Its Regulation by Endothelial Mechanotransduction
- (2020) Keqing Nian et al. Frontiers in Physiology
- Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke
- (2019) Kelly M. DeMars et al. NEUROCHEMISTRY INTERNATIONAL
- Bromodomains: a new target class for drug development
- (2019) Andrea G. Cochran et al. NATURE REVIEWS DRUG DISCOVERY
- Reactive Gliosis Contributes to Nrf2-Dependent Neuroprotection by Pretreatment with Dimethyl Fumarate or Korean Red Ginseng Against Hypoxic-Ischemia: Focus on Hippocampal Injury
- (2019) Lei Liu et al. MOLECULAR NEUROBIOLOGY
- BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis
- (2019) Yi Zhou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Validity and Reliability of Neurological Scores in Mice Exposed to Middle Cerebral Artery Occlusion
- (2019) Michael Bieber et al. STROKE
- Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia
- (2018) Kelly M. DeMars et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of bromodomain-containing protein 4 ameliorates oxidative stress-mediated apoptosis and cartilage matrix degeneration through activation of NF-E2-related factor 2-heme oxygenase-1 signaling in rat chondrocytes
- (2018) Qin-de An et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Blood-Brain Barrier: From Physiology to Disease and Back
- (2018) Melanie D. Sweeney et al. PHYSIOLOGICAL REVIEWS
- Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism
- (2018) Lei Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
- (2018) Changjun Yang et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Preconditioning in neuroprotection: From hypoxia to ischemia
- (2017) Sijie Li et al. PROGRESS IN NEUROBIOLOGY
- Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog
- (2017) Changjun Yang et al. STROKE
- Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers
- (2016) Ralf G Rempe et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice
- (2016) S. Wattananit et al. JOURNAL OF NEUROSCIENCE
- Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
- (2016) Ángel Chamorro et al. LANCET NEUROLOGY
- The role of microglia and macrophages in glioma maintenance and progression
- (2016) Dolores Hambardzumyan et al. NATURE NEUROSCIENCE
- Microglia and Monocyte-Derived Macrophages in Stroke
- (2016) Eunhee Kim et al. Neurotherapeutics
- PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
- (2016) Kanak Raina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interleukin-1 in Stroke
- (2016) Oluwaseun A. Sobowale et al. STROKE
- BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice
- (2015) Erica Korb et al. NATURE NEUROSCIENCE
- Astrocyte barriers to neurotoxic inflammation
- (2015) Michael V. Sofroniew NATURE REVIEWS NEUROSCIENCE
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones
- (2014) Tomohiko Kanno et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
- (2014) Joshua E. Burda et al. NEURON
- The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response
- (2014) M Hussong et al. Cell Death & Disease
- SOD2 in mitochondrial dysfunction and neurodegeneration
- (2013) James M. Flynn et al. FREE RADICAL BIOLOGY AND MEDICINE
- Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury
- (2013) Alexander V Glushakov et al. Journal of Neuroinflammation
- Reciprocal Modulation Between Microglia and Astrocyte in Reactive Gliosis Following the CNS Injury
- (2013) Zhongwen Gao et al. MOLECULAR NEUROBIOLOGY
- Capture, crawl, cross: the T cell code to breach the blood–brain barriers
- (2012) Britta Engelhardt et al. TRENDS IN IMMUNOLOGY
- Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice
- (2011) Yi Yang et al. Journal of Neuroinflammation
- Stroke research at a crossroad: asking the brain for directions
- (2011) Costantino Iadecola et al. NATURE NEUROSCIENCE
- Inflammatory mechanisms in ischemic stroke: role of inflammatory cells
- (2010) Rong Jin et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Vertical grid test and modified horizontal grid test are sensitive methods for evaluating motor dysfunctions in the MPTP mouse model of Parkinson's disease
- (2009) Sung Tae Kim et al. BRAIN RESEARCH
- Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation
- (2009) Diana C. Hargreaves et al. CELL
- Inflammatory mechanisms in ischemic stroke: therapeutic approaches
- (2009) Shaheen E Lakhan et al. Journal of Translational Medicine
- Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA
- (2008) B. Huang et al. MOLECULAR AND CELLULAR BIOLOGY
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