Article
Environmental Sciences
Eugene P. Sokolov, Linda Adzigbli, Stephanie Markert, Amanda Bundgaard, Angela Fago, Doerte Becher, Claudia Hirschfeld, Inna M. Sokolova
Summary: The study found that the mitochondria of mussels exhibit increased respiration flux, reduced oxidative stress, and mitochondrial damage under H/R stress through intrinsic mechanisms such as reversible protein phosphorylation, contributing to their hypoxia-tolerant mitochondrial phenotype.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Medicine, General & Internal
Teresa Cunha-Oliveira, Daniela Franco Silva, Luis Segura, Ines Baldeiras, Ricardo Marques, Tatiana Rosenstock, Paulo J. Oliveira, Filomena S. G. Silva
Summary: Distinct redox signatures were found in lymphoblasts from mutSOD1, undSOD1, and healthy controls, which can serve as therapeutic targets for ALS drug development. High heterogeneity in redox profiles between cohorts was observed, but clustering analysis successfully segregated healthy controls from ALS samples based on specific parameters. These findings provide valuable insights for understanding oxidative stress profiles in different forms of ALS and potential treatment strategies.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Nonhlakanipho F. Sangweni, Phiwayinkosi V. Dludla, Nireshni Chellan, Lawrence Mabasa, Jyoti R. Sharma, Rabia Johnson
Summary: The study found that DMSO concentrations lower than 0.5% can enhance respiratory control ratio and cellular viability in cardiomyoblasts, while exposure to 3.7% DMSO increases apoptosis in cardiomyoblasts due to mitochondrial dysfunction and oxidative stress. In cancer cells, DMSO at concentrations equal to or higher than 0.009 reduces maximal respiratory capacity and ATP-linked respiration, leading to increased ROS production and apoptosis. Surprisingly, 0.001% DMSO exposure resulted in increased proliferative activity in cancer cells. These findings suggest caution when using DMSO in cancer cells, while demonstrating no cytotoxic effects or therapeutic benefits at concentrations equal to or lower than 0.5% in cardiomyoblasts.
Article
Neurosciences
Teresa Cunha-Oliveira, Marcelo Carvalho, Vilma Sardao, Elisabete Ferreiro, Debora Mena, Francisco B. Pereira, Fernanda Borges, Paulo J. Oliveira, Filomena S. G. Silva
Summary: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with mitochondrial alterations in lymphoblasts that may have diagnostic and therapeutic implications.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elena Obrador, Rosario Salvador-Palmer, Rafael Lopez-Blanch, ALi Jihad-Jebbar, Soraya L. Valles, Jose M. Estrela
Summary: Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease characterized by motor neuron degeneration leading to muscle weakness and paralysis. Mitochondrial dysfunction plays a significant role in ALS pathophysiology, affecting disease progression. Research indicates that targeting mitochondrial biology may offer potential therapeutic approaches to slow down ALS progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Joao Paulo Cavalcanti-de-Albuquerque, Eduardo de-Souza-Ferreira, Denise Pires de Carvalho, Antonio Galina
Summary: The interaction between hexokinase (HK) and the GABA shunt plays a role in controlling mitochondrial metabolism in the cortex and hypothalamus. The GABA shunt stimulates mitochondrial oxygen consumption and H2O2 production in the hypothalamus, while increasing the coupling of HK to OXPHOS activity.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Arduino Aleksander Mangoni, Elisabetta Zinellu, Gianfranco Pintus, Ciriaco Carru, Alessandro Giuseppe Fois, Pietro Pirina, Angelo Zinellu
Summary: The study found that whole blood SOD concentrations were significantly lower in patients with obstructive sleep apnoea, while serum/plasma SOD concentrations did not show a significant difference. This suggests an impaired antioxidant defence in OSA patients.
Article
Biochemistry & Molecular Biology
Jonathan Hirschenson, Ryan J. Mailloux
Summary: The study demonstrates that glutathionylation can enhance ROS production by mitochondria, with different effects depending on the oxidizing sources and inhibitors used.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Slavica Borkovic-Mitic, Aleksandar Stojsavljevic, Ljiljana Vujotic, Sinisa Matic, Bojan Mitic, Dragan Manojlovic, Sladan Pavlovic
Summary: This study examined the impact of oxidative stress on patients with benign and malignant brain tumors, finding that tumor cells showed altered cell metabolism and an adaptive response to increased oxidative stress. The study identified significant differences in antioxidant system parameters and key trace elements between control, benign, and malignant brain tissues. Furthermore, principal component analysis effectively distinguished between benign and malignant tissue, with correlative relationships linked to selenium in benign tumors and copper in malignant tumors.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Mengli Zheng, Yating Liu, Guanfeng Zhang, Zhikang Yang, Weiwei Xu, Qinghua Chen
Summary: Superoxide dismutase (SOD) is an enzyme that can respond to cellular oxidative stress and has shown effectiveness in anti-tumor, anti-radiation, and anti-aging studies. This research summarizes the types, biological functions, and applications of SODs, and highlights the challenges of membrane permeability and enzyme persistence.
Article
Chemistry, Multidisciplinary
Gwang-Bum Im, Young Geon Kim, Tae Yong Yoo, Yeong Hwan Kim, Kang Kim, Jiyu Hyun, Min Soh, Taeghwan Hyeon, Suk Ho Bhang
Summary: Copper-deposited ceria nanoparticles (CuCe NPs) exhibit enhanced antioxidant effects and therapeutic performance through the upregulation of specific biological factors, scavenging reactive oxygen species, and promoting anti-inflammation and M2 polarization of macrophages. In ischemic vascular diseases, CuCe NPs afford increased perfusion and alleviate tissue damage.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Pengfei Zhai, Yinyan Ma, Huan Xu, Ling Lu
Summary: This study demonstrates that MtmA is involved in responding to oxidative stress by activating mitochondrial SodB activity in A. fumigatus. MtmA, especially for the first Mito-carr domain, is essential for colony growth by regulating cellular Zn2+ equilibrium and responses to oxidative stress. This study reveals the vital and unique role of the MtmA protein in pathogenic fungi, suggesting its potential as a target for antifungal drugs.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Neurosciences
Katarin Gorski, Christopher B. B. Jackson, Tuula A. A. Nyman, Veronika Rezov, Brendan J. J. Battersby, Anna-Elina Lehesjoki
Summary: Mitochondrial dysfunction is associated with cystatin B deficiency and contributes to the onset and progression of neurodegeneration and myoclonus in a mouse model. The deficiency of cystatin B leads to differential expression of mitochondrial and synaptic proteins and impairs mitochondrial function in synaptic mitochondria, without affecting mitochondrial DNA copy number or membrane ultrastructure.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Namrata Singh, Somanathapura K. NaveenKumar, Motika Geethika, Govindasamy Mugesh
Summary: The study demonstrates that CeVO4 nanozyme can substitute the function of SOD1 and SOD2 in neuronal cells even when the natural enzymes are down-regulated. The nanozyme prevents mitochondrial damage by regulating superoxide levels and restores physiological levels of anti-apoptotic proteins. Additionally, it effectively prevents mitochondrial depolarization and improves cellular ATP levels under oxidative stress.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medicine, Research & Experimental
Ken-Ichiro Tanaka, Mikako Shimoda, Maho Kubota, Ayaka Takafuji, Masahiro Kawahara, Tohru Mizushima
Summary: Lecithinized superoxide dismutase (PCSOD) effectively ameliorates renal ischemia/reperfusion (I/R) injury by inhibiting ROS production, reducing markers of renal damage and fibrosis, and preventing the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). This suggests that PCSOD could be a promising therapeutic agent for I/R-induced renal injury.
Article
Oncology
Marco Demaria, Monique N. O'Leary, Jianhui Chang, Lijian Shao, Su Liu, Fatouma Alimirah, Kristin Koenig, Catherine Le, Natalia Mitin, Allison M. Deal, Shani Alston, Emmeline C. Academia, Sumner Kilmarx, Alexis Valdovinos, Boshi Wang, Alain de Bruin, Brian K. Kennedy, Simon Melov, Daohong Zhou, Norman E. Sharpless, Hyman Muss, Judith Campisi
Review
Multidisciplinary Sciences
Judith Campisi, Pankaj Kapahi, Gordon J. Lithgow, Simon Melov, John C. Newman, Eric Verdin
Article
Biochemistry & Molecular Biology
Hoi-Shan Wong, Martin D. Brand, Vojtech Mezera, Pratiksha Dighe, Simon Melov, Akos A. Gerencser, Ramzi F. Sweis, Marina Pliushchev, Zhi Wang, Tim Esbenshade, Bryan McKibben, Stephan Riedmaier, Martin D. Brand
Summary: The study demonstrated the effectiveness of novel variants of S1QELs in vivo, showing that mitochondrial site I-Q plays a significant role in driving pathology in Sod2(-/-) mice, while site IIIQo does not significantly contribute to mitochondrial superoxide production in these mice. Treatment with S1QEL352 and S1QEL712 improved cardiac and hepatic pathologies in Sod2(-/-) mice, confirming the importance of superoxide production from mitochondrial site I-Q in hepatic steatosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Peripheral Vascular Disease
Zachary S. Clayton, Vienna E. Brunt, David A. Hutton, Abigail G. Casso, Brian P. Ziemba, Simon Melov, Judith Campisi, Douglas R. Seals
Summary: Research suggests that doxorubicin can induce aortic stiffening by increasing intrinsic mechanical wall stiffness and causing collagen deposition, elastin degradation, and AGEs formation, ultimately increasing the risk of cardiovascular diseases.
Article
Cardiac & Cardiovascular Systems
Zachary S. Clayton, David A. Hutton, Vienna E. Brunt, Nicholas S. VanDongen, Brian P. Ziemba, Abigail G. Casso, Nathan T. Greenberg, Amanda N. Mercer, Matthew J. Rossman, Judith Campisi, Simon Melov, Douglas R. Seals
Summary: The study shows that oral supplementation with apigenin can improve arterial endothelial dysfunction and arterial stiffening related to aging, prevent foam cell formation, and provide insights into the biological mechanisms of action of apigenin. These findings suggest that apigenin may have therapeutic potential for treating arterial dysfunction and reducing cardiovascular disease risk associated with aging.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Geriatrics & Gerontology
Alyssa N. Cavalier, Zachary S. Clayton, David A. Hutton, Devin Wahl, Daniel S. Lark, Julie A. Reisz, Simon Melov, Judith Campisi, Douglas R. Seals, Thomas J. LaRocca
Summary: The study reveals that chemotherapeutic agents like doxorubicin may induce brain neuronal/gene expression and behavioral changes similar to those observed during brain aging. While the mitochondrial therapeutic MitoQ partially prevents doxorubicin-induced transcriptome changes in the brain, it has no effect on behavior or cognitive function.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Chandani Limbad, Ryosuk Doi, Julia McGirr, Serban Ciotlos, Kevin Perez, Zachary S. Clayton, Radha Daya, Douglas R. Seals, Judith Campisi, Simon Melov
Summary: Cellular senescence is a leading cause of age-related pathologies, and researchers have identified the gene CRYAB as a key regulator of senescence. Through single-cell RNA sequencing, they discovered that 25-hydroxycholesterol (25HC), a metabolite of cholesterol biosynthesis, has potential as a senolytic drug. They confirmed the senolytic effect of 25HC through inhibitor screening and in vivo experiments.
Article
Multidisciplinary Sciences
Brian A. Hodge, Geoffrey T. Meyerhof, Subhash D. Katewa, Ting Lian, Charles Lau, Sudipta Bar, Nicole Y. Leung, Menglin Li, David Li-Kroeger, Simon Melov, Birgit Schilling, Craig Montell, Pankaj Kapahi
Summary: The research shows that dietary restriction extends the lifespan of fruit flies by promoting rhythmic homeostatic mechanisms in the visual system. Altering the core molecular clock transcription factor CLOCK or its output genes accelerates visual aging and shortens lifespan. Photoreceptor activation shortens lifespan, while inactivation extends it.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Samantha Haller, Subir Kapuria, Rebeccah R. Riley, Monique N. O'Leary, Katherine H. Schreiber, Julie K. Andersen, Simon Melov, Jianwen Que, Thomas A. Rando, Jason Rock, Brian K. Kennedy, Joseph T. Rodgers, Heinrich Jasper
Article
Cell Biology
Christopher D. Wiley, James M. Flynn, Christapher Morrissey, Ronald Lebofsky, Joe Shuga, Xiao Dong, Marc A. Unger, Jan Vijg, Simon Melov, Judith Campisi
Article
Biochemistry & Molecular Biology
Alejandra Hernandez-Segura, Tristan V. de Jong, Simon Melov, Victor Guryev, Judith Campisi, Marco Demaria
Letter
Cardiac & Cardiovascular Systems
Paul C. Simpson, Bat-Erdene Myagmar, Philip M. Swigart, Simon Melov, Anthony J. Baker
CIRCULATION RESEARCH
(2017)
Article
Cardiac & Cardiovascular Systems
Bat-Erdene Myagmar, James M. Flynn, Patrick M. Cowley, Philip M. Swigart, Megan D. Montgomery, Kevin Thai, Divya Nair, Rumita Gupta, David X. Deng, Chihiro Hosoda, Simon Melov, Anthony J. Baker, Paul C. Simpson
CIRCULATION RESEARCH
(2017)
Article
Endocrinology & Metabolism
Daniel S. Evans, Monique N. O'Leary, Ryan Murphy, Minna Schmidt, Kristin Koenig, Michael Presley, Brittany Garrett, Ha-Neui Kim, Li Han, Emmeline C. Academia, Matt J. Laye, Daniel Edgar, Christopher A. Zambataro, Tracey Barhydt, Colleen M. Dewey, Jarrott Mayfield, Joy Wilson, Silvestre Alavez, Mark Lucanic, Brian K. Kennedy, Maria Almeida, Julie K. Andersen, Pankaj Kapahi, Gordon J. Lithgow, Simon Melov
Summary: The study found that benzoxazole tested in mouse models can slow down skeletal aging. The research brings new insights for the study of preclinical physiological aging and therapies targeting aging. Additionally, an online application was created to calculate rate of change and enable power and variance to be calculated for clinically important metrics of aging with a focus on bone.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)