Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

The Antiparasitic Clioquinol Induces Apoptosis in Leukemia and Myeloma Cells by Inhibiting Histone Deacetylase Activity

(2013) Biyin Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells

(2013) W-T Tai et al.   Cell Death & Disease

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blocking Autophagy Prevents Bortezomib-Induced NF-κB Activation by Reducing I-κBα Degradation in Lymphoma Cells

(2012) Li Jia et al.   PLoS One

Regulation of autophagy by lysosomal positioning

(2011) Viktor I. Korolchuk et al.   Autophagy

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline)

(2011) Hongchao Jiang et al.   CANCER LETTERS

Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation

(2011) Changyou Li et al.   CANCER LETTERS

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Targeting Autophagy Augments In Vitro and In Vivo Antimyeloma Activity of DNA-Damaging Chemotherapy

(2011) Y. Pan et al.   CLINICAL CANCER RESEARCH

Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore

(2011) Mi-Ha Park et al.   NEUROBIOLOGY OF DISEASE

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway

(2010) X. Mao et al.   BLOOD

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Lysosome Dysfunction Triggers Atg7-dependent Neural Apoptosis

(2010) Ken C. Walls et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of Autophagy and the Proteasome in Resolving Endoplasmic Reticulum Stress

(2010) X. Chen et al.   VETERINARY PATHOLOGY

Synthesis and pharmacological exploitation of clioquinol-derived copper-binding apoptosis inducers triggering reactive oxygen species generation and MAPK pathway activation

(2009) Hui-Ling Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bortezomib induces autophagic death in proliferating human endothelial cells

(2009) Daniela Belloni et al.   EXPERIMENTAL CELL RESEARCH

Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901

(2008) Chungen Xing et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma

(2008) X Mao et al.   LEUKEMIA