Article
Biochemistry & Molecular Biology
Oscar J. Cordero, Carlos Rafael-Vidal, Ruben Varela-Calvino, Cristina Calvino-Sampedro, Beatriz Malvar-Fernandez, Samuel Garcia, Juan E. Vinuela, Jose M. Pego-Reigosa
Summary: Immune system CD4 T-cells with high cell-surface CD26 expression demonstrate anti-tumoral properties, especially when engineered with a chimeric antigen receptor. Different T helper cell subsets show variations in CD26 expression levels, which could impact research on CAR-T cells. The relationship between glycoprotein sCD26 and its enzymatic activity, as well as its correlation with specific T cell subsets, still requires further understanding.
Article
Immunology
Fatma Oner, Carla Alvarez, Wael Yaghmoor, Danielle Stephens, Hatice Hasturk, Erhan Firatli, Alpdogan Kantarci
Summary: RvE1 targets T(h)17 activation and DC function to achieve inflammatory resolution and acquired immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jian Yang, Ya-rong Lin, Bo -jun Xiong, Ze-hong Chen, Yu-fei Luo, Ying Xu, Yan-ping Su, Hui-hui Huang, Chang-xi Yu
Summary: Koumine, an alkaloid, has therapeutic effects against rheumatoid arthritis (RA) and may restore the homeostasis of Th subsets and cytokines by inhibiting T cell activation, subsequently regulating the polarization of Th subsets and the downstream imbalance of pro/anti-inflammatory cytokines in RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Miranda L. Curtiss, Alexander F. Rosenberg, Christopher D. Scharer, Betty Mousseau, Natalia A. Ballesteros Benavides, John E. Bradley, Beatriz Leon, Chad Steele, Troy D. Randall, Frances E. Lund
Summary: CHI3L1 is found to play a significant role in allergic diseases based on data from patient cohorts and mouse models. In this study, Chi3l1 was shown to modulate T(H)2 and IL-4-producing T-FH cells, which are crucial for IgE responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Bin Dou, Fuzhe Ma, Zhenyu Jiang, Ling Zhao
Summary: This study found a correlation between histone deacetylase 4 (HDAC4) and Th cells, inflammation, disease activity, and treatment response in patients with ankylosing spondylitis (AS).
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Shate Xiang, Jingjing Zhang, Mengge Zhang, Suhai Qian, Rongyun Wang, Yao Wang, Yingshi Xiang, Xinghong Ding
Summary: This meta-analysis found that SLE patients had lower percentage of Th1 cells and higher percentage of Th2 cells, with treatments normalizing some indicators. Gender and age affected the levels of Th1 and Th2 cells in SLE patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Enrique Huanosta-Murillo, Marcela Alcantara-Hernandez, Brenda Hernandez-Rico, Georgina Victoria-Acosta, Patricia Miranda-Cruz, Maria Antonieta Dominguez-Gomez, Fermin Jurado-Santacruz, Genaro Patino-Lopez, Vadim Perez-Koldenkova, Alam Palma-Guzman, Paula Licona-Limon, Ezequiel M. Fuentes-Panana, Alicia Lemini-Lopez, Laura C. Bonifaz
Summary: In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed, with TOX+ CD4(+) T cells producing IL-4(+) in early-stage skin lesions. The NLRP3 receptor plays a role in promoting a Th2 response by controlling IL-4 production, which may have significant implications in disease progression. This mechanism of IL-4 regulation mediated by NLRP3 is amplified in late-stage CTCL, indicating its importance in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ryan Zander, Moujtaba Y. Kasmani, Yao Chen, Paytsar Topchyan, Jian Shen, Shikan Zheng, Robert Burns, Jennifer Ingram, Can Cui, Nikhil Joshi, Joseph Craft, Allan Zajac, Weiguo Cui
Summary: This study found that CD4(+) T cells consist of three distinct subsets during chronic viral infection, and IL-21 derived from Tfh cells is critical for sustaining CD8(+) T cell responses and viral control.
Article
Oncology
Yi-Ling Chen, AKaychia T. Lowery, Samuel Lin, Ameae M. Walker, Kuan-Hui E. Chen
Summary: This study found that elevated levels of ADMA impair the proliferation and phagocytosis of macrophages, and can even lead to their death. ADMA also affects the phenotype of macrophages. However, the effects of ADMA on normal epithelial cells and breast cancer cells are relatively minor. Co-culturing tumor cells with primed splenocytes results in increased secretion of ADMA by tumor cells and alterations in arginine metabolism-related gene expression. These findings suggest that tumor cells manipulate macrophage polarization through ADMA secretion to promote tumor tolerance.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Article
Biochemistry & Molecular Biology
Xiguang Ye, Qilin Lu, Aofei Yang, Jun Rao, Wei Xie, Chengjian He, Weijun Wang, Hao Li, Zhiwen Zhang
Summary: The study found that high expression of miR-206 in patients with OA was positively correlated with peripheral Th17/Treg imbalance. MiR-206 disrupted the Th17/Treg balance by targeting SOCS3 and Foxp3. In vivo experiments showed that antagomiR against miR-206 restored the Th17/Treg balance during the development of OA.
MOLECULAR MEDICINE
(2021)
Review
Immunology
Lars Hellman, Srinivas Akula, Zhirong Fu, Sara Wernersson
Summary: Proteases stored in mast cells have multiple functions, including maintaining connective tissue homeostasis, regulating blood pressure, and exhibiting anticoagulant activity. They can also modulate immune responses and provide protection against ectoparasites.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Amania A. Sheikh, Joanna R. Groom
Summary: During viral infection, CD4(+) T cells differentiate into Th1 cells for inflammation and pathogen clearance, or Tfh cells for enhancing germinal center reactions. The lineage-defining transcription factors T-bet and Bcl6 play key roles in determining the fate of CD4(+) T cells toward Th1 or Tfh. Transcriptional networks guided by cytokine cues dynamically shape the fate and function of these cells during infection.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Summary: Regulatory T cells play a crucial role in controlling autoimmunity and inflammation. Inhibiting the Itk signaling pathway can increase the frequency of noncanonical Tregs and reduce the incidence of acute graft-versus-host disease without affecting graft-versus-leukemia effects. Targeting Itk signaling could be a potential therapeutic strategy for autoimmune disorders.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Julia Ritzau-Jost, Andreas Hutloff
Summary: This review discusses the optimization of Tfh cell generation and their interaction with B cells for therapeutic purposes. It also summarizes different T cell subsets, including Tph cells, and highlights the importance of T cell/B cell interaction in non-lymphoid tissues for the generation of protective antibodies.
Article
Gastroenterology & Hepatology
Tianyong Hu, Wenhui Hu, Li Ma, Xianhai Zeng, Jiangqi Liu, Baohui Cheng, Pingchang Yang, Shuqi Qiu, Gui Yang, Donghui Chen, Zhiqiang Liu
DIGESTIVE AND LIVER DISEASE
(2019)
Article
Otorhinolaryngology
Jin-Mei Xue, Mei-Zhen Zhao, Fei Ma, Shan-Shan Li, Li-Hua Mo, Xian-Hai Zeng, Yong-Jin Wu, Jiang-Qi Liu, Tian-Yong Hu, Rui-Di Xie, Zhi-Gang Liu, Chang-Qing Zhao, Ping-Chang Yang
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2019)
Article
Gastroenterology & Hepatology
Donghui Chen, Li Ma, Tianyong Hu, Jiangqi Liu, Baohui Chen, Pingchang Yang, Zhiqiang Liu
DIGESTIVE DISEASES AND SCIENCES
(2020)
Article
Biotechnology & Applied Microbiology
Hanrong Cheng, Benqing Wu, Lingwei Wang, Tianyong Hu, Zhuhui Deng, Dongcai Li
JOURNAL OF GENE MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Jiang-Qi Liu, Tian-Yong Hu, Kai-Yuan Diao, Dian Yu, Yan-Nan Song, Li-Hua Mo, Gui Yang, Zhi-Qiang Liu, Zhi-Gang Liu, Ping-Chang Yang
Article
Biophysics
Hanrong Cheng, Li Chen, Yongli Wei, Tianyong Hu, Dongcai Li, Benqing Wu
Summary: The study demonstrates that knockdown of miR-203a-3p alleviates hyperoxia-induced lung tissue damage in the BPD rat model, potentially linked to the up-regulation of VEGF.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Article
Immunology
Tian-Yong Hu, Hua Zhang, Yan-Yan Chen, Wei-Hua Jiao, Jun-Ting Fan, Zhi-Qiang Liu, Hou-Wen Lin, Bao-Hui Cheng
Summary: Our study demonstrated that dysiarenone possesses anti-inflammatory and anti-oxidative activities by inhibiting the 5-LOX/NF-κB/MAPK and Nrf2/HO-1 signaling pathways. Dysiarenone shows potential as a promising lead compound for inflammatory diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Analytical
Feipeng Duan, Yisheng Li, Meizhen Zhao, Tianyong Hu, Xinquan Pan, Yue Feng, Fang Ma, Shuqi Qiu, Yiqing Zheng
Summary: This study screened the active anti-inflammatory components of Qing Jin Hua Tan Tang (QJHTT) using multivariate statistical analysis and identified meranzin, baicalin, baicalein, chrysin-7-O-beta-D-glucuronide, and wogonoside as the potential anti-inflammatory active ingredients. These bioactive components were verified to significantly inhibit the secretion of inflammatory factors in macrophage cell lines, suggesting their potential as effective anti-inflammatory agents in COPD treatment.
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2021)
Article
Immunology
Jiang-Qi Liu, Xiao-Rui Geng, Tian-Yong Hu, Li-Hua Mo, Xiang-Qian Luo, Shu-Yao Qiu, Da-Bo Liu, Zhi-Gang Liu, Jian-Bo Shao, Zhi-Qiang Liu, Ping-Chang Yang
Summary: This study reveals that glutaminolysis plays a critical role in maintaining the immune regulatory capacity of IL-10-expressing B cells (B10 cells) in patients with allergic rhinitis. Glutamine metabolism is necessary for IL-10 expression in B cells and the generation of B10 cells. The activation of mTOR mediates the induction of glutaminolysis-associated B10 cells and suppresses the activation of B cell glycogen synthase kinase-3 (GSK3). GSK3 activation inhibits IL-10 expression in B cells.
MUCOSAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hanrong Cheng, Shoumei Jin, Simin Huang, Tianyong Hu, Miao Zhao, Dongcai Li, Benqing Wu
Summary: In this study, differentially expressed proteins in the serum of pediatric obstructive sleep apnea (OSA) patients were identified using tandem mass tag (TMT)-based proteomic analysis. The results suggested that several signaling pathways may be associated with the pathophysiology of OSA, and experimental validation studies revealed potential key proteins involved in OSA.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Allergy
Peng Liu, Tianyong Hu, Chenglin Kang, Jiangqi Liu, Jin Zhang, Hong Ran, Xianhai Zeng, Shuqi Qiu
Summary: Allergic rhinitis is a serious global medical and economic problem, and conventional anti-allergic drugs have side effects that limit patients' quality of life. Probiotics have been shown to have anti-allergic effects, improving symptoms and quality of life by regulating the immune system and gut microbiome.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Review
Immunology
Peng Liu, Chenglin Kang, Jin Zhang, Yue Liu, Jiangqi Liu, Tianyong Hu, Xianhai Zeng, Shuqi Qiu
Summary: Allergic diseases are common and important diseases affecting many patients worldwide. Dendritic cells (DC) play a crucial role in these diseases by presenting allergens, secreting cytokines, and participating in immune regulation. However, current research on DC is limited and further exploration is needed to understand their role in different allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Duan Fei-Peng, Li Yi-Sheng, Hu Tian-Yong, Pan Xin-Quan, Ma Fang, Feng Yue, Qiu Shu-Qi, Zheng Yi-Qing
Summary: This study investigated the mechanism by which Dendrobium nobile (Shihu) extract may improve allergic rhinitis. The results showed that Shihu extract restored the balance in intestinal flora, alleviated inflammation in the lungs of allergic rhinitis mice, and predicted a potential therapeutic approach using Traditional Chinese Medicine for allergic rhinitis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyu Liu, Yuwei Wang, Desheng Chen, Shuyu Ji, Li-Teng Yang, Qinmiao Huang, Lvxin Guan, Kexin Chang, Dan Li, Ruyi Yuan, Chunyan Ouyang, Tian-Yong Hu, Zhi-Qiang Liu, Baoqing Sun, Guorong Xu, Zhi-Gang Liu, Ping-Chang Yang
Summary: House dust mite-derived protein PDI binds to dendritic cells (DCs) and promotes Foxp3 expression through DEC205-mediated endocytosis, inducing the development of tolerogenic DCs. This pathway activation contributes to immune regulation and shows potential for treating immune disorders like asthma.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Min Xu, Tian-Yong Hu, Dong-Cai Li, Li Ma, Hua Zhang, Jun-Ting Fan, Xiao-Mei Fan, Xian-Hai Zeng, Shu-Qi Qiu, Zhi-Qiang Liu, Bao-Hui Cheng
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)
