Surface Charges and Shell Crosslinks Each Play Significant Roles in Mediating Degradation, Biofouling, Cytotoxicity and Immunotoxicity for Polyphosphoester-based Nanoparticles

Synthesis, Characterization, and In Vivo Efficacy of Shell Cross-Linked Nanoparticle Formulations Carrying Silver Antimicrobials as Aerosolized Therapeutics

(2013) Parth N. Shah et al.   ACS Nano

Polyphosphoester-Based Cationic Nanoparticles Serendipitously Release Integral Biologically-Active Components to Serve as Novel Degradable Inducible Nitric Oxide Synthase Inhibitors

(2013) Yuefei Shen et al.   ADVANCED MATERIALS

Degradable Cationic Shell Cross-Linked Knedel-like Nanoparticles: Synthesis, Degradation, Nucleic Acid Binding, and in Vitro Evaluation

(2013) Sandani Samarajeewa et al.   BIOMACROMOLECULES

Cytokines as biomarkers of nanoparticle immunotoxicity

(2013) Mahmoud Elsabahy et al.   CHEMICAL SOCIETY REVIEWS

In Vitro Efficacy of Paclitaxel-Loaded Dual-Responsive Shell Cross-Linked Polymer Nanoparticles Having Orthogonally Degradable Disulfide Cross-Linked Corona and Polyester Core Domains

(2013) Sandani Samarajeewa et al.   MOLECULAR PHARMACEUTICS

Multifunctional Hierarchically Assembled Nanostructures as Complex Stage-Wise Dual-Delivery Systems for Coincidental Yet Differential Trafficking of siRNA and Paclitaxel

(2013) Mahmoud Elsabahy et al.   NANO LETTERS

PEGylation of cationic, shell-crosslinked-knedel-like nanoparticles modulates inflammation and enhances cellular uptake in the lung

(2013) Aida Ibricevic et al.   Nanomedicine-Nanotechnology Biology and Medicine

Shell-crosslinked knedel-like nanoparticles induce lower immunotoxicity than their non-crosslinked analogs

(2013) Mahmoud Elsabahy et al.   Journal of Materials Chemistry B

Synthesis and In Vivo Pharmacokinetic Evaluation of Degradable Shell Cross-Linked Polymer Nanoparticles with Poly(carboxybetaine) versus Poly(ethylene glycol) Surface-Grafted Coatings

(2012) Ang Li et al.   ACS Nano

Bacteria-Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

(2012) Meng-Hua Xiong et al.   ADVANCED MATERIALS

Disulfide-Containing Brushed Polyethylenimine Derivative Synthesized by Click Chemistry for Nonviral Gene Delivery

(2012) Guangyan Zhang et al.   BIOCONJUGATE CHEMISTRY

Endosomal escape and siRNA delivery with cationic shell crosslinked knedel-like nanoparticles with tunable buffering capacities

(2012) Ritu Shrestha et al.   BIOMATERIALS

Design of polymeric nanoparticles for biomedical delivery applications

(2012) Mahmoud Elsabahy et al.   CHEMICAL SOCIETY REVIEWS

Strategies toward well-defined polymer nanoparticles inspired by nature: Chemistry versus versatility

(2012) Mahmoud Elsabahy et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Polyelectrolyte complex nanoparticles from chitosan and poly(acrylic acid) and Polystyrene-block-poly(acrylic acid)

(2012) Julien Rolland et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Functional aliphatic polyesters and nanoparticles prepared by organocatalysis and orthogonal grafting chemistry

(2012) Angela L. Silvers et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Hyperbranched polymers as delivery vectors for oligonucleotides

(2012) Jian Hong Tan et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Rapid and Versatile Construction of Diverse and Functional Nanostructures Derived from a Polyphosphoester-Based Biomimetic Block Copolymer System

(2012) Shiyi Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses

(2012) Zhou J. Deng et al.   Nanotoxicology

Synthesis and characterization of amphiphilic poly(ɛ-caprolactone)-b-polyphosphoester diblock copolymers bearing multifunctional pendant groups

(2012) Haiyan Shao et al.   POLYMER

Facile Synthesis of Clickable, Water-Soluble, and Degradable Polyphosphoesters

(2012) Shiyi Zhang et al.   ACS Macro Letters

PRINT: A Novel Platform Toward Shape and Size Specific Nanoparticle Theranostics

(2011) Jillian L. Perry et al.   ACCOUNTS OF CHEMICAL RESEARCH

Tunable, High Modulus Hydrogels Driven by Ionic Coacervation

(2011) Jasmine N. Hunt et al.   ADVANCED MATERIALS

Degradability of Poly(Lactic Acid)-Containing Nanoparticles: Enzymatic Access through a Cross-Linked Shell Barrier

(2011) Sandani Samarajeewa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymer Brushes Showing Non-Fouling in Blood Plasma Challenge the Currently Accepted Design of Protein Resistant Surfaces

(2011) Cesar Rodriguez-Emmenegger et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Cross-linked antioxidant nanozymes for improved delivery to CNS

(2011) Natalia L. Klyachko et al.   Nanomedicine-Nanotechnology Biology and Medicine

Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity

(2011) Andrew J. Keefe et al.   Nature Chemistry

Nanoparticles that communicate in vivo to amplify tumour targeting

(2011) Geoffrey von Maltzahn et al.   NATURE MATERIALS

Hyperbranched Polyphosphates for Drug Delivery Application: Design, Synthesis, and In Vitro Evaluation

(2010) Jinyao Liu et al.   BIOMACROMOLECULES

Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery

(2010) Yu-Cai Wang et al.   CHEMICAL COMMUNICATIONS

Synthesis and physicochemical characterization of biodegradable and pH-responsive hydrogels based on polyphosphoester for protein delivery

(2010) Jinlin He et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Toxicity Pathway Focused Gene Expression Profiling of PEI-Based Polymers for Pulmonary Applications

(2010) Andrea Beyerle et al.   MOLECULAR PHARMACEUTICS

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

(2009) Parag Aggarwal et al.   ADVANCED DRUG DELIVERY REVIEWS

Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications

(2009) Shaoyi Jiang et al.   ADVANCED MATERIALS

Carbon black and titanium dioxide nanoparticles induce pro-inflammatory responses in bronchial epithelial cells: Need for multiparametric evaluation due to adsorption artifacts

(2009) Stéphanie Val et al.   INHALATION TOXICOLOGY

Synthesis of PEG-Armed and Polyphosphoester Core-Cross-Linked Nanogel by One-Step Ring-Opening Polymerization

(2009) Meng-Hua Xiong et al.   MACROMOLECULES

Thermoresponsive Block Copolymers of Poly(ethylene glycol) and Polyphosphoester: Thermo-Induced Self-Assembly, Biocompatibility, and Hydrolytic Degradation

(2008) Yu-Cai Wang et al.   BIOMACROMOLECULES

Synthesis and characterization of amphiphilic block copolymer of polyphosphoester and poly(L-lactic acid)

(2008) Xian-Zhu Yang et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes

(2008) L ZHANG et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Self-Assembled Micelles of Biodegradable Triblock Copolymers Based on Poly(ethyl ethylene phosphate) and Poly(ϵ-caprolactone) as Drug Carriers

(2007) Yu-Cai Wang et al.   BIOMACROMOLECULES

Biodegradable polycation and plasmid DNA multilayer film for prolonged gene delivery to mouse osteoblasts

(2007) Zhen-Zhen Lu et al.   BIOMATERIALS

Differential binding of cytokines to environmentally relevant particles: A possible source for misinterpretation of in vitro results?

(2007) A. Kocbach et al.   TOXICOLOGY LETTERS