Synthesis and Evaluation of Acyl-Chain- and Galactose-6′′-Modified Analogues of α-GalCer for NKT Cell Activation

Cutting Edge: Nonglycosidic CD1d Lipid Ligands Activate Human and Murine Invariant NKT Cells

(2014) J. D. Silk et al.   JOURNAL OF IMMUNOLOGY

Structural and Functional Characterization of a Novel Nonglycosidic Type I NKT Agonist with Immunomodulatory Properties

(2012) J. Kerzerho et al.   JOURNAL OF IMMUNOLOGY

Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: Reversing tumor-induced defects

(2011) Mark A. Exley et al.   CLINICAL IMMUNOLOGY

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

(2011) Sandrine Aspeslagh et al.   EMBO JOURNAL

Galacto-Configured Aminocyclitol Phytoceramides Are Potent in Vivo Invariant Natural Killer T Cell Stimulators

(2011) Youssef Harrak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The stimulating adventure of KRN 7000

(2011) Aline Banchet-Cadeddu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy

(2011) T.-N. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invariant natural killer T cell-based immunotherapy for cancer

(2010) Shinichiro Motohashi et al.   Immunotherapy

Synthesis and evaluation of 3″- and 4″-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000

(2009) Ravinder Raju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells

(2009) Barbara A. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands

(2009) André Schiefner et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis and in vitro Evaluation of α‐GalCer Epimers

(2008) Matthias Trappeniers et al.   ChemMedChem

α-Galactosylceramide-loaded, antigen-expressing B cells prime a wide spectrum of antitumor immunity

(2008) Yeon-Jeong Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis of α-Galactosyl Ceramide (KRN7000) and Analogues Thereof via a Common Precursor and Their Preliminary Biological Assessment

(2008) Mario Michieletti et al.   JOURNAL OF ORGANIC CHEMISTRY

6′-Derivatised α-GalCer Analogues Capable of Inducing Strong CD1d-Mediated Th1-Biased NKT Cell Responses in Mice

(2008) Matthias Trappeniers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Microarray Analysis of Intact Glycolipid−CD1d Interaction and Correlation with Cell-Based Cytokine Production

(2008) Pi-Hui Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RCAI-61, the 6′-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-γ in vivo

(2008) Takuya Tashiro et al.   TETRAHEDRON LETTERS

RCAI-8, 9, 18, 19, and 49–52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines

(2007) Ken-ichi Fuhshuku et al.   BIOORGANIC & MEDICINAL CHEMISTRY