Design and synthesis of optically pure 3-aryl-6-methyl-2-thioxotetrahydropyrimidin-4(1H)-ones as anti-prostate cancer agents

Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostrate cancer: A phase I/II, open-label study.

(2017) R. Dreicer et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Stereoregulations of Pyrimidinone Based Chiral Auxiliary in Aldol and Alkylation Reactions: A Convenient Route to Oxyneolignans

(2012) Mangilal Chouhan et al.   ORGANIC LETTERS

Reversal of Selectivity in Acetate Aldol Reactions of N-Acetyl-(S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one

(2012) Gopal L. Khatik et al.   ORGANIC LETTERS

Aldol reactions of 2-thioxotetrahydropyrimidin-4(1H)-ones: stereoregulations from endo- and exocyclic chiral centres

(2012) Varun Kumar et al.   TETRAHEDRON

Additive controlled, stereoselective benzylation of 2-thioxotetrahydropyrimidin-4(1H)-ones via chiral induction from a remote stereocenter

(2012) Varun Kumar et al.   TETRAHEDRON-ASYMMETRY

An efficient one-pot synthesis of 2-benzylpyrroles and 3-benzylindoles

(2011) Ratnesh Sharma et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Cp2ZrCl2-induced Reformatsky and Barbier reactions on isatins: an efficient synthesis of 3-substituted-3-hydroxyindolin-2-ones

(2011) Mangilal Chouhan et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Aldol derivatives of Thioxoimidazolidinones as potential anti-prostate cancer agents

(2011) Gopal L. Khatik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regiospecific epoxide opening: a facile approach for the synthesis of 3-hydroxy-3-aminomethylindolin-2-one derivatives

(2011) Mangilal Chouhan et al.   GREEN CHEMISTRY

Structure−Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC)

(2010) Michael E. Jung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study

(2010) Howard I Scher et al.   LANCET

Diastereoselective syntheses of 3-aryl-5-(arylalkyl)-6-methyl-1-(1-phenylethyl)thioxotetrahydropyrimidin-4(1H)-ones: A stereochemical perspective from endo and exocyclic chiral centres

(2010) Varun Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A novel one-pot synthesis of 2-benzoylpyrroles from benzaldehydes

(2010) Ratnesh Sharma et al.   TETRAHEDRON LETTERS

Stereochemical studies of 5-methyl-3-(substituted phenyl)-5-[(substituted phenyl) hydroxy methyl]-2-thiooxazolidin-4-ones

(2010) Gopal L. Khatik et al.   TETRAHEDRON LETTERS

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

(2009) C. Tran et al.   SCIENCE

Lithium perchlorate-induced electrophilic activation: one-pot synthesis of 3-aryl-2-thioxotetrahydropyrimidin-4-one derivatives from aryl isothiocyanates

(2009) Varun Kumar et al.   TETRAHEDRON LETTERS