Article
Chemistry, Multidisciplinary
Bin Li, Fuli Tian, Yupeng Hua
Summary: A novel fluorescent probe L modified with 3-methyl-2-thiophenecarboxaldehyde has been developed for the detection of Hg2+. The probe shows a unique off-on-type response towards Hg2+ and exhibits good selectivity and sensitivity. Moreover, the probe can be used for colorimetric sensing of Hg2+ and has potential applications in genetic and environmental samples.
Article
Chemistry, Physical
Mahmoud Basseem I. Mohamed, Mervat S. El-Sedik, Yehya A. Youssef, Nadia A. Mohamed, Tarek S. Aysha
Summary: A new symmetrical compound TUS was synthesized and characterized as a fluorescent probe and colorimetric chemosensor for detection of mercury cation. The probe showed good selectivity and sensitivity towards Hg2+ ion, and could be directly observed by naked eye. It was also used for intracellular detection of Hg2+.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Review
Chemistry, Analytical
Ajay Kumar
Summary: Mercury is a highly toxic heavy metal that poses significant risks to the environment and health. Organic chromophores, particularly small molecules, have emerged as promising materials for sensing Hg2+ ions due to their selectivity, sensitivity, and ease of synthesis. This review provides a systematic overview of recent advancements in the field of fluorescent chemosensors for Hg2+ ions detection, covering various probes and discussing their detection capabilities, mechanisms, limits of detection, and design strategies. Focusing on studies conducted between 2022 and 2023, this review offers valuable insights into the performance and advancements in fluorescent chemosensors for Hg2+ ions detection.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoping Zhang, Jinxiao Liu, Jun Wang, Lu Han, Shengtao Ma, Mingqin Zhao, Gaolei Xi
Summary: A novel highly selective and sensitive turn-on fluorescent chemosensor PCE has been developed for the recognition of Zn2+, displaying remarkable fluorescent enhancement in aqueous acetonitrile solution. The PCE-Zn ensemble can be utilized for monitoring ATP in live cells with selective fluorescence enhancement.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Chemistry, Analytical
Tianyuan Zhong, Donglin Li, Chen Li, Zhuo Zhang, Guang Wang
Summary: Two fluorescent chemosensors based on MOF-5 and curcumin were designed and synthesized, showing highly selective fluorescence enhancement responses towards Al3+ with low detection limits. These materials can be used as fluorescent sensors to identify and detect Al3+ in water samples.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Irina I. Shepeleva, Kirill P. Birin, Daria A. Polivanovskaia, Alexander G. Martynov, Alexander V. Shokurov, Aslan Yu. Tsivadze, Sofiya L. Selektor, Yulia G. Gorbunova
Summary: Detection of nitroaromatic compounds (NAC) is important due to their hazardous nature. A new pyrene-imidazoporphyrin dyad is reported to exhibit an unusual 'turn-on' response to NAC with the appearance of a new band attributed to exciplex emission. The dyad's porphyrin backbone allows for ratiometric detection using its own fluorescence as an internal reference signal. Association constants of the dyad are reported to be in the order of 10(4) M-1.
Article
Chemistry, Multidisciplinary
Seong-Soo Lee, Mirkomil Sharipov, Won June Kim, Yong-Ill Lee
Summary: Poly(ionic liquids) (PILs) have been widely used for CO2 capture due to their resemblance to ionic liquids and properties of polymers. In this study, the amine-functionalized poly(vinylimidazole)-based PIL (PVIm-NH2) was successfully prepared and characterized as a chemosensor for CO2 gas detection. The detection limit of PVIm-NH2 in the presence of triethylamine (TEA) was found to be 2.86 x 10-3 M with R2 = 0.9906. The mechanism of PVIm-NH2 generating N-heterocyclic carbenes (NHCs) in the presence of TEA and their reaction with CO2 gas to form a carboxylic acid was investigated. Structural modifications of PIL were also shown to make it a promising candidate for chemosensor applications.
Article
Chemistry, Multidisciplinary
Yan Liu, Yaping Zhou, Hongyu Li, Jie Gao, Mingyan Yang, Zeli Yuan, Xinmin Li
Summary: Fluoride ions play a vital role in the human body, but their detection and imaging in aqueous solutions remain challenging. This study presents a novel fluorescent probe that can efficiently and selectively detect fluoride ions in water, and successfully image them in living cells.
Article
Spectroscopy
Yucun Liu, Lili Zhang, Lei Chen, Zhixue Liu, Chunbo Liu, Guangbo Che
Summary: The synthesized fluorescent chemosensor showed high selectivity and sensitivity for Al3+, with a detection limit of 4.22 x 10(-8) M and a stability constant of 4.82 x 10(4) M-1. The 1:1 binding stoichiometry of the compound to Al3+ was confirmed from the Job's plot based on fluorescence titrations.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Pramod Kumar Mehta, Hyojin Park, Eun-Taex Oh, Heon Joo Park, Keun-Hyeung Lee
Summary: In this study, a reversible fluorescent sensor was synthesized for the turn-on monitoring of Hg2+ in water, and a fluorescent sensing method was developed for the selective detection of CH3Hg+ over Hg2+. The sensor showed rapid response (<30 s), high sensitivity and/or selectivity, low detection limits (107 nM), and significant enhancement of fluorescence for CH3Hg+.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
B. U. Gauthama, B. Narayana, B. K. Sarojini, N. K. Suresh, Y. Sangappa, Avinash K. Kudva, G. Satyanarayana, Shamprasad Varija Raghu
Summary: RhB, a fluorimetric sensor based on the rhodamine moiety, shows selective and sensitive sensing towards Hg2+. It forms a rapid 1:1 stoichiometric irreversible reaction with Hg2+ through coordination bonds. The selective sensing of Hg2+ is achieved by the spirolactam ring opening followed by the formation of suitable coordinate geometry in RhB.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Guanjun Pan, Tingting Xia, Yi He
Summary: The newly synthesized sensor 1 can dissolve in water and exhibit significant fluorescence enhancement response towards PO43- with high selectivity and sensitivity.
Article
Chemistry, Physical
Hyeongjin Kim, Minji Lee, Jae Jun Lee, Eun Ki Min, Ki-Tae Kim, Cheal Kim
Summary: A new fluorescent chemosensor NTHC was synthesized, which can selectively sense Hg2+ and Zn2+ ions and be applied for the bioimaging of zinc in zebrafish.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Donghwan Choe, Cheal Kim
Summary: We have developed a novel diacylhydrazone-based fluorescent sensor, HMPD, for the detection of Al3+ ions. The sensor exhibited a significant fluorescence increment in the presence of Al3+ ions, with a stoichiometry of 1:2 for HMPD to Al3+. The detection limit of HMPD for Al3+ ions was determined as 0.76 μM. HMPD was able to determine Al3+ ions regardless of the presence of Ga3+ or In3+ ions. It was successfully applied for the qualification of Al3+ ions in real water samples and test strips. The sensing process of HMPD for Al3+ ions was reversible by EDTA application.
Article
Chemistry, Analytical
Shutang Ruan, Suzhen Wu, Lijuan Yang, Mingxin Li, Yan Zhang, Zhonglong Wang, Shifa Wang
Summary: A novel turn-on fluorescent probe TB has been successfully designed and synthesized for detecting both Hg2+ and ClO-. It shows good selectivity and sensitivity towards these ions in CH3OH/PBS solution and has practical applications in water sample analysis, plant cell imaging, and zebrafish bioimaging.
MICROCHEMICAL JOURNAL
(2021)
Review
Chemistry, Inorganic & Nuclear
P. Chinna Ayya Swamy, Gandhi Sivaraman, Ragam N. Priyanka, Sufi O. Raja, Kandhasamy Ponnuvel, Jeyabalan Shanmugpriya, Akash Gulyani
COORDINATION CHEMISTRY REVIEWS
(2020)
Correction
Nanoscience & Nanotechnology
Mookkandi Palsamy Kesavan, Niranjan G. Kotla, Srinivasan Ayyanaar, Gujuluva Gangatharan Vinoth Kumar, Gurusamy Rajagopal, Gandhi Sivaraman, Thomas J. Webster, Jegathalaprathaban Rajesh
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Analytical
G. Mahalakshmi, P. Saravana Kumar, K. N. Vennila, G. Sivaraman, M. Seenivasaperumal, Kuppanagounder P. Elango
METHODS AND APPLICATIONS IN FLUORESCENCE
(2020)
Article
Chemistry, Physical
G. Mahalakshmi, P. Saravana Kumar, G. Sivaraman, Kuppanagounder P. Elango
Summary: An imine-based receptor has been synthesized and characterized for the selective and sensitive detection of CN- and HS- ions in neat DMSO and H2O:DMSO media. The receptor shows instantaneous color and fluorescence changes upon interaction with these ions, with detection limits below the WHO permissible limits. Additionally, the receptor has been successfully applied for the detection of these ions in live HeLa cells.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Velusamy Arul, Pitchai Chandrasekaran, Gandhi Sivaraman, Mathur Gopalakrishnan Sethuraman
Summary: The nitrogen and boron co-doped carbon nanodots (NB-CNDs) were synthesized using a simple hydrothermal carbonization method from the Solanum betaceum fruit extract. Various spectroanalytical techniques were employed to confirm the structure and optical properties of NB-CNDs, demonstrating their electrocatalytic activity in hydrazine hydrate oxidation and application in cell imaging.
DIAMOND AND RELATED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chinna Ayya Swamy Pothulapadu, Anjitha Jayaraj, N. Swathi, Ragam N. Priyanka, Gandhi Sivaraman
Summary: Metal ions play a crucial role in environmental and biological applications, with a focus on detecting specific ions at minute levels. Benzothiazole-based chemosensors have been designed and synthesized for highly selective and sensitive detection of biologically important metal ions like Zn2+, Cu2+, and Ni2+. The sensors exhibit ratiometric and colorimetric responses to the target ions, making them valuable tools for bioimaging and environmental monitoring.
Article
Biochemistry & Molecular Biology
Anjitha Jayaraj, M. S. Gayathri, Gandhi Sivaraman, Chinna Ayya Swamy P
Summary: In this study, two acyclic Schiff base receptors CS-1 and CS-2 were reported as selective fluorescent turn on for Zn(2+) ions and colorimetric chemosensors for Zn2+, Cu2+, and Co2+ ions. The probes exhibited a color change from colorless to yellow in a 1:1 ratio of acetonitrile and HEPES buffer, without interference from other metal ions. The binding mode of CS-1 and CS-2 with metal ions was supported by spectral and computational analysis, and the probes showed potential as fluorescent probes for Zn2+ ions in living cells.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Chemistry, Physical
Kettalu Ananthan Karthick, Kalairajan Kaleeswari, C. Uma Maheswari, Gandhi Sivaraman, Bhaskaran Shankar, Arunachalam Tamilselvi
Summary: This study reports a new facile molecular sensor for the selective detection of Zn2+ ions in solid and solution medium. The synthesized sensor shows a low limit of detection and practical applications in qualitative detection of zinc(II) on TLC plate based test strips and imaging of intracellular zinc(II) ions in HeLa cells.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuman Qin, Tong Zhang, H. Y. Vincent Ching, Gandhi Siva Raman, Shoubhik Das
Summary: This study presents an integrated strategy for synthesizing lower aromatics and bioactive compounds from real-life polystyrene-based wastes. Gram-scale transformations of the waste materials were achieved to demonstrate practicality, and detailed mechanistic investigations provided insights into the reaction mechanism and the role of reagents involved.
Article
Chemistry, Physical
Prakash Kumar Sahoo, Yu Zhang, Yuman Qin, Peng Ren, Robin Cauwenbergh, Gandhi Siva Raman, Shoubhik Das
Summary: In this study, a transition metal-free approach for regioselective functionalization of benzylic C (sp3)-H bonds was reported in the presence of various heterocyclic amines as nucleophiles. This method provides a straightforward and general route for synthesizing various benzylic amines, including twelve pharmaceutically relevant compounds.
JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Yu Zhang, Prakash Kumar Sahoo, Peng Ren, Yuman Qin, Robin Cauwenbergh, Philippe Nimmegeers, Gandhi SivaRaman, Steven Van Passel, Andrea Guidetti, Shoubhik Das
Summary: A transition metal-free method has been reported for the selective functionalization of benzylic C(sp(3))-H bonds using alcohols and carboxylic acids as nucleophiles. This straightforward and general approach has provided various benzylic ethers and esters, including twelve pharmaceutically relevant compounds.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Pitchai Chandrasekaran, Gandhi Sivaraman, Swetha Rasala, Mathur Gopalakrishnan Sethuraman, Niranjan G. Kotla, Yury Rochev
Summary: In this study, nitrogen-doped carbon dots (NDCDs) were developed as a drug carrier for anti-cancer drug delivery using quercetin (QC) as a model drug. The NDCDs were prepared using a simple hydrothermal method and exhibited small particle size and enhanced fluorescence properties. The NDCDs-QC conjugate showed nontoxicity to colon cancer cells and demonstrated the ability to kill cancer cells in the NDCDs-QC form. This development holds promise for drug delivery and bio-imaging in cancer therapy.
Article
Materials Science, Biomaterials
Siddan Gouthaman, Anjitha Jayaraj, Madurai Sugunalakshmi, Gandhi Sivaraman, Chinna Ayya P. Swamy
Summary: The discovery of aggregation-induced emission (AIE) has opened up a new avenue for exploring beneficial luminescent materials. Novel fluorene-based fluorogens exhibit bright emission, mechanical stimuli-responsive optical properties, and aggregation-induced emissive ability. Compound 4d shows superior properties compared to other derivatives, with very low cytotoxicity in live cell applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Sufi O. Raja, Gandhi Sivaraman, Sayan Biswas, Gaurav Singh, Fouzia Kalim, Ponnuvel Kandaswamy, Akash Gulyani
Summary: Environment-sensitive molecular probes are used for a comprehensive mapping of the complex cellular milieu. A new strategy involving multiplexing highly sensitive, spectrally tuned fluorescent dyes is presented for sensing cellular microenvironment, enabling two-color, two-dye imaging of the mitochondrial microenvironment. Multiplexed dye imaging allows the quantitative imaging of mitochondrial membrane order and cellular microenvironment, revealing dynamic heterogeneity with distinct spatiotemporal signatures.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Waldemar Schilling, Yu Zhang, Prakash Kumar Sahoo, Samir Kumar Sarkar, Sivaraman Gandhi, Herbert W. Roesky, Shoubhik Das
Summary: Chlorophyll catalyzes chemical reactions to directly produce alpha-amino carbonyl compounds from enaminones. Singlet oxygen generated during photosynthesis can react with unsaturated double bonds, facilitating the synthesis of valuable compounds. The photosensitizer used in this research is cheap, commercially available, and provides high efficiency for singlet oxygen mediated chemistry.
