Article
Nutrition & Dietetics
Richard C. Baybutt, Joseph T. Standard, Daniel Dim, Tim Quinn, Hana Hamdan, Dingbo Lin, Kyle Kunz, Zachary S. Bomstein, Benjamin J. Estorge, Betty Herndon, Hamid Zia, Ahmad Mansour, Manesha Lankachandra, Agostino Molteni
Summary: The study aimed to evaluate the impact of replenishing vitamin A on bone thickness in vitamin A-deficient rats, with results showing that cod liver oil (COD) supplementation more effectively restored abnormal bone thickness in the rats compared to retinoic acid (RA) treatment.
Article
Biochemistry & Molecular Biology
Maryam Honarbakhsh, Aaron Ericsson, Guo Zhong, Nina Isoherranen, Chengsheng Zhu, Yana Bromberg, Charlene Van Buiten, Kiana Malta, Laurie Joseph, Harini Sampath, Atreju Lackey, Judith Storch, Costantino Vetriani, Michael L. Chikindas, Paul Breslin, Loredana Quadro
Summary: The deficiency of lecithin:retinol acyltransferase and retinol-binding protein in mice leads to intestinal vitamin A deficiency, compromising gut morphology, barrier function, and microbial composition.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Immunology
Brendan K. Podell, Omowunmi Aibana, Chuan-Chin Huang, James E. DiLisio, Macallister C. Harris, David F. Ackart, Kody Armann, Alexander Grover, Patrice Severe, Marc Antoine Jean Juste, Kathryn Dupnik, Randall J. Basaraba, Megan B. Murray
Summary: This study demonstrates an association between baseline vitamin A deficiency and increased risk of tuberculosis progression among individuals living with HIV. Guinea pigs deficient in vitamin A also exhibited more severe pathological responses and increased bacterial growth after TB infection.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Pharmacology & Pharmacy
Noriko Takahashi, Daisuke Saito, Shinya Hasegawa, Masahiro Yamasaki, Masahiko Imai
Summary: This paper introduces the circulation of vitamin A in the body, the actions and mechanisms of retinal and RA, retinoylation as an RA mechanism independent of RA receptors, the relationship between cancer and the actions of retinol or beta-carotene, and the anti-cancer actions of vitamin A derivatives derived from fenretinide. The study suggests that nutritional management of vitamin A is effective in cancer prevention.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Ophthalmology
Jiayi Wei, Liangjing Wu, Shuai Yang, Conghui Zhang, Le Feng, Minli Wang, Hui Li, Fang Wang
Summary: Proliferative vitreoretinopathy (PVR) is a serious ocular fibrotic disease that can lead to blindness. This study focuses on the pathogenesis of PVR and the mechanism behind the epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells. The results show that the loss of E-cadherin leads to changes in the catenin-cadherin complex, activating zinc finger E-box binding homeobox 1 (ZEB1) and promoting the upregulation of N-cadherin. Overexpression of E-cadherin inhibits the EMT process and cell proliferation in RPE cells.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Claudia Griselda Cardenas-Leon, Kristina Maemets-Allas, Mariliis Klaas, Katre Maasalu, Viljar Jaks
Summary: This study investigated the role of sweat glands in the pathogenesis of Dupuytren's contracture (DC) through proteomic analysis and immunofluorescence microscopy. The researchers found that a fraction of sweat gland epithelium underwent epithelial-mesenchymal transition, and increased connective tissue growth factor expression in DC sweat glands had both autocrine and paracrine effects in sustaining DC formation and inducing pathological changes in DC-associated sweat glands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wenting Hong, Dongke Xu, Xiaowei Song, Baolin Niu, Ziyan Zhuang, Yiteng Lu, Xiaohong Lei, Runjun Ma, Chao Lu, Ning Sun, Yimin Mao, Xiaobo Li
Summary: The study revealed that there is a significant difference in the small intestine between the fasted and refed state, with long-term high-fat diet (HFD) feeding attenuating this difference. Vitamin A (VA) and retinoic acid (RA) play important roles in this process.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Fabiana M. de O. Hernandez, Marilene O. Santos, Gabriela L. Venturin, Jaqueline P. Bragato, Gabriela T. Rebech, Larissa M. Melo, Sidnei F. Costa, Jessica H. de Freitas, Carlos Eduardo Siqueira, Deborah A. Morais, Wellington T. de S. Junior, Fernando B. Junior, Flavia L. Lopes, Valeria M. F. de Lima
Summary: Canine leishmaniasis is a chronic disease caused by Leishmania infantum, and the limitations of current treatments have led to the exploration of new alternatives, such as the use of immunomodulatory nutrients. This study aimed to determine the levels of vitamin A, vitamin D, and zinc in dogs with CanL and the effects of supplementation with these nutrients on spleen leukocyte cultures. The results suggest that the tested nutrients may play a role in the leishmanicidal mechanism and warrant further investigation in future studies.
Article
Biochemistry & Molecular Biology
Xiaoru Zhang, Vinay Singh Tanwar, Cynthia C. Jose, Hyun-Wook Lee, Suresh Cuddapah
Summary: This study demonstrates that nickel exposure leads to persistent downregulation of E-cadherin by causing loss of Sp1 binding at the CDH1 promoter, which induces EMT. Continuous upregulation of ZEB1 is also a key factor in the loss of E-cadherin, and knocking out ZEB1 using CRISPR-Cas9 technology can restore E-cadherin expression.
MOLECULAR CARCINOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Carina Becerril, Martha Montano, Jose Cisneros, Criselda Mendoza-Milla, Annie Pardo, Blanca Ortiz-Quintero, Moises Selman, Carlos Ramos
Summary: The study observed a possible mesenchymal-epithelial transition (MET) in human lung fibroblasts under culture conditions, leading to phenotypic changes and significant gene expression alterations. Cells obtained from normal and lungs affected by interstitial diseases showed distinct miRNA expression profiles, indicating potential differences in regulatory mechanisms between the two types of fibroblasts.
Review
Nutrition & Dietetics
Irene Degrassi, Ilaria Leonardi, Elisabetta Di Profio, Chiara Montanari, Gianvincenzo Zuccotti, Elvira Verduci
Summary: This review identifies the current indications and gaps in the management of fat-soluble vitamins in pediatric patients with cholestasis. A comprehensive literature review was conducted, and relevant studies published in the past 20 years were selected. The causes of malabsorption, recommended methods of supplementation, and monitoring complications were discussed. The literature suggests that children with cholestasis are at a higher risk of fat-soluble vitamin deficiency, but there is no uniform validated treatment for vitamin deficiency.
Article
Biochemistry & Molecular Biology
Iason Psilopatis, Jule Ida Schaefer, Dimitrios Arsenakis, Dimitrios Bolovis, Georgia Levidou
Summary: This study provides preliminary evidence suggesting that overexpression of SOX11 might promote EMT in metastatic serous ovarian cancer, thereby enhancing tumor metastasis.
Review
Oncology
Xiaoyu Zhu, Xiaoping Wang, Yifei Gong, Junlin Deng
Summary: Thyroid carcinoma is a common and problematic cancer, with recurrence and metastasis being significant issues. Understanding the role of EMT and E-cadherin in tumors is crucial for cancer therapeutics.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Miaomiao Zhang, Juan Qin, Xinyue Guo, Zongjia Li, Christian Rankl, Bailin Zhang, Jilin Tang
Summary: During tumor-associated epithelial-mesenchymal transition (EMT), the expression of the EMT marker E-cadherin is challenging to detect on cancer cell surfaces in the middle and late stages of EMT. This study investigated the changes in trace E-cadherin on the living bladder cancer T24 cell surface during EMT using force-distance curve-based atomic force microscopy. The results showed that T24 cells remain in an intermediate state and can be transformed into the mesenchymal phenotype through long-term TGF-β1 induction.
Article
Oncology
Yuxiang Liu, Taolin Chen, Mingyue Guo, Yu Li, Qian Zhang, Guixiang Tan, Li Yu, Yongjun Tan
Summary: FOXP2, a language-related gene, interacts with FOXA2 in breast cancer cells to inhibit EMT by activating the transcription of certain genes like E-cadherin and PHF2. The results suggest a collaborative role of FOXP2 and FOXA2 in regulating EMT in breast cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rosa Zaragoza, Elena R. Garcia-Trevijano, Ana Lluch, Gloria Ribas, Juan R. Vina
Article
Biochemistry & Molecular Biology
Lucia Rodriguez-Fernandez, Ivan Ferrer-Vicens, Concha Garcia, Sara S. Oltra, Rosa Zaragoza, Juan R. Vina, Elena R. Garcia-Trevijano
BIOCHEMICAL JOURNAL
(2016)
Article
Multidisciplinary Sciences
Desamparados Roda, Josefa Castillo, Marcelino Telechea-Fernandez, Anabel Gil, Gerardo Lopez-Rodas, Luis Franco, Patricia Gonzalez-Rodriguez, Susana Rosello, J. Alejandro Perez-Fidalgo, Elena R. Garcia-Trevijano, Andres Cervantes, Rosa Zaragoza
Review
Nutrition & Dietetics
M. Teresa Cabezuelo, Rosa Zaragoza, Teresa Barber, Juan R. Vina
Review
Physiology
Rosa Zaragoza
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
L. Rodriguez-Fernandez, S. Company, R. Zaragoza, J. R. Vina, E. R. Garcia-Trevijano
Summary: This study reveals the role of CAPN2 during mitosis, uncovers the critical role of CAPN2 in the interactions among nuclear components, identifies LIMK1 as a new target of CAPN2, and provides a novel mechanism for LIMK1 activation. It also highlights the importance of CFL1 in cytoskeleton remodeling, mitosis, nuclear structure maintenance, chromosome movement, and transcription modulation in cancer cells, suggesting that the role of CAPN2 in the nuclear compartment might extend to other actin-associated biological and pathological processes.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Jose Luis Garcia-Gimenez, Elena R. Garcia-Trevijano, Ana Aviles-Alia, Jose Santiago Ibanez-Cabellos, Miquel Bovea-Marco, Teresa Bas, Federico Pallardo, Juan R. Vina, Rosa Zaragoza
Summary: This study identified a potential molecular signature consisting of circulating miR-122-5p/miR-192-5p/miR-323-3p and biochemical parameters that could be used for prognosis and stratification of patients with limb-girdle muscular dystrophy (LGMD).
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Review
Cell Biology
Elena R. Garcia-Trevijano, Elena Ortiz-Zapater, Amparo Gimeno, Juan R. Vina, Rosa Zaragoza
Summary: This review discusses the role of calpain-1 and -2 in mammary tissue, both under normal physiological conditions and in the pathological context of breast cancer. It emphasizes the importance of calpain in maintaining tissue homeostasis and promoting tumor development, and highlights the future challenges in this field.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Gisselle Perez-Machado, Ester Berenguer-Pascual, Miquel Bovea-Marco, Pedro Antonio Rubio-Belmar, Eva Garcia-Lopez, Maria Jose Garzon, Salvador Mena-Molla, Federico Pallardo, Teresa Bas, Juan R. Vina, Jose Luis Garcia-Gimenez
Meeting Abstract
Biochemistry & Molecular Biology
R. Zaragoza, I. Ferrer-Vicens, L. Rodriguez-Fernandez, S. Oltra, G. Ribas, C. Garcia, E. R. Garcia-Trevijano, J. R. Vina