Review
Cell Biology
Elizabeth G. Ames, Jess G. Thoene
Summary: Cystinosis is a lethal genetic disease with specific treatments. The cellular mechanisms are still unknown, but programmed cell death and apoptosis may be involved. Studies have shown that apoptosis rate is increased in cystinosis, but can be partially reversed with cysteamine.
Article
Medicine, Research & Experimental
Wataru Jomen, Takaaki Ohtake, Takayuki Akita, Daisuke Suto, Hideki Yagi, Yosuke Osawa, Yutaka Kohgo
Summary: This study aimed to elucidate the mechanism of the combination effect of tyrosine kinase inhibitor sorafenib (SOR) and iron chelator deferasirox (DFX) in human hepatoma cell lines. The results showed that the combination therapy of SOR and DFX exhibited additive antitumor effects for hepatocellular carcinoma (HCC) through the modulation of programmed cell deaths and NF-kB signal pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Juan J. Fraire-Zamora, Sebastien Tosi, Jerome Solon, Jordi Casanova
Summary: This study investigates how hormone-driven extracellular matrix remodeling controls tissue shortening and apoptotic cell removal through the transcriptional activity of Yki, leading to organ disassembly during animal development.
Review
Pharmacology & Pharmacy
Sweata Hanson, Aiswarya Dharan, P. V. Jinsha, Sanjay Pal, Bipin G. Nair, Rekha Kar, Nandita Mishra
Summary: Programmed cell death (PCD) is a universal process that regulates cellular homeostasis and plays a crucial role in disease conditions, including cancer. Apoptosis is a major PCD, but cancer cells develop resistance to it, necessitating the search for alternative forms of programmed cell death such as paraptosis. Paraptosis is characterized by vacuolation and damage to cellular structures and has potential therapeutic implications in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kakali Bhadra
Summary: This article reviews the alternative pathways of cancer cell death targeted by anticancer drug molecules, providing a molecular basis for new strategies in cancer treatment. Many drugs can effectively induce cell death through targeting the caspase-independent cell death pathway, which is significant for cancer therapy.
Review
Cell Biology
Qi Zhang, Xin-xing Wan, Xi-min Hu, Wen-juan Zhao, Xiao-xia Ban, Yan-xia Huang, Wei-tao Yan, Kun Xiong
Summary: Stem cell therapies show promising effects in restoring damaged tissue, but multiple types of programmed cell death post-transplantation can compromise their efficiency. Understanding and targeting cell death signaling pathways are crucial for successful stem cell therapies in treating diabetes and related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yifan Cheng, Misha Mao, Yong Lu
Summary: YAP plays a critical role in regulating tumor progression and is closely related to programmed cell death (PCD). YAP activity can be regulated by kinase cascade pathways and other proteins. It has been found that YAP can affect multiple forms of PCD and act as a bridge between different forms of PCD in tumor development.
BIOMARKER RESEARCH
(2022)
Article
Oncology
Douglas R. Green
Summary: Genetically identical cells in a tissue can exhibit different responses to environmental stress, influencing their decision to repair or die, and affecting surrounding cells. These responses play a role in controlling the health and fitness of individual cells and their competition with other genetically identical cells.
CANCER IMMUNOLOGY RESEARCH
(2021)
Review
Immunology
Jianan Zhao, Kai Wei, Ping Jiang, Cen Chang, Lingxia Xu, Linshuai Xu, Yiming Shi, Shicheng Guo, Yu Xue, Dongyi He
Summary: Gout is a chronic inflammatory arthritis disease characterized by hyperuricemia and triggered by interactions among various factors. Recent studies have shown that multiple programmed cell death pathways are involved in the inflammatory response, contributing to the initiation of inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Subashani Maniam, Sandra Maniam
Summary: Targeted chemotherapy has become the forefront of cancer treatment, offering more effective treatment with reduced side effects through selective and specific features; Research targeting the compensatory mechanisms in tumor cells is progressing in order to overcome drug resistance; Promising small molecules that target autophagy and apoptosis are being developed for the difficult-to-treat TNBC, showing potential in preclinical data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Chunhui Liu, Xiangzhao Mao, Lingyun Meng, Jiao Li
Summary: In recent years, programmed cell death (PCD) has attracted the attention of many scholars as an active death process. This phenomenon has not only been observed in multicellular organisms but also in microbes. Different stressors during modern food processing have been found to induce various forms of programmed death in microbes. Microbial PCD can be classified into apoptosis-like death, autolytic death, and toxin-antitoxin systems based on their intrinsic mechanisms. Potential applications of these PCD mechanisms include searching for new antimicrobial targets, developing new types of preservatives, engineering design in synthetic biology, and modifying fermentation strains.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Dachao Tang, Cheng Han, Shaofeng Lin, Xiaodan Tan, Weizhi Zhang, Di Peng, Chenwei Wang, Yu Xue
Summary: This study provides a comprehensive database for programmed cell death (iPCD), consisting of annotations for regulatory proteins involved in various PCD forms across different eukaryotic species. The database integrates information from multiple resources and covers a wide range of aspects, making it a valuable tool for further analysis of PCD in eukaryotes.
Review
Environmental Sciences
Sukhbir Singh, Hema Rani, Neelam Sharma, Tapan Behl, Ishrat Zahoor, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazm, Lotfi Aleya
Summary: Apoptosis is a mechanism used to maintain tissue homeostasis and can be induced by nanowires through a triple attack that integrates vibration, heat, and drug delivery. This review provides a comprehensive summary of the mechanisms and factors influencing apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Cell Biology
Chang Liu, Zecheng Jiang, Zhongjie Pan, Liang Yang
Summary: Atherosclerosis is a chronic inflammatory vascular disease, and macrophages play a significant role in its progression. Recent studies have highlighted the critical role of programmed cell death in macrophages in the development of vulnerable plaques in atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Nutrition & Dietetics
M. Teresa Cabezuelo, Rosa Zaragoza, Teresa Barber, Juan R. Vina
Article
Oncology
Saverio Caini, Sara Gandini, Francesca Botta, Elena Tagliabue, Sara Raimondi, Eduardo Nagore, Ines Zanna, Patrick Maisonneuve, Julia Newton-Bishop, David Polsky, DeAnn Lazovich, Rajiv Kumar, Peter A. Kanetsky, Veronica Hoiom, Paola Ghiorzo, Maria Teresa Landi, Gloria Ribas, Chiara Menin, Alexander J. Stratigos, Giuseppe Palmieri, Gabriella Guida, Jose Carlos Garcia-Borron, Hongmei Nan, Julian Little, Francesco Sera, Susana Puig, Maria Concetta Fargnoli
Letter
Dermatology
I. Stefanaki, A. J. Stratigos, K. P. Kypreou, E. Evangelou, S. Gandini, P. Maisonneuve, D. Polsky, D. Lazovich, J. Newton-Bishop, P. A. Kanetsky, S. Puig, N. A. Gruis, P. Ghiorzo, C. Pellegrini, A. De Nicolo, G. Ribas, G. Guida, J. C. Garcia-Borron, M. C. Fargnoli, H. Nan, M. T. Landi, J. Little, F. Sera, S. Raimondi
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Physiology
Rosa Zaragoza
FRONTIERS IN PHYSIOLOGY
(2020)
Letter
Oncology
Bianca Tod, Willie Visser, Johann de Wet, Maritha Kotze, Anne Bowcock, Birhanu Ayele, Michael McCaul, Johann Schneider
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Multidisciplinary Sciences
L. Rodriguez-Fernandez, S. Company, R. Zaragoza, J. R. Vina, E. R. Garcia-Trevijano
Summary: This study reveals the role of CAPN2 during mitosis, uncovers the critical role of CAPN2 in the interactions among nuclear components, identifies LIMK1 as a new target of CAPN2, and provides a novel mechanism for LIMK1 activation. It also highlights the importance of CFL1 in cytoskeleton remodeling, mitosis, nuclear structure maintenance, chromosome movement, and transcription modulation in cancer cells, suggesting that the role of CAPN2 in the nuclear compartment might extend to other actin-associated biological and pathological processes.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Anna Adam-Artigues, Iris Garrido-Cano, Juan Antonio Carbonell-Asins, Ana Lameirinhas, Soraya Simon, Belen Ortega-Morillo, Maria Teresa Martinez, Cristina Hernando, Vera Constancio, Octavio Burgues, Begona Bermejo, Rui Henrique, Ana Lluch, Carmen Jeronimo, Pilar Eroles, Juan Miguel Cejalvo
Summary: The study developed and validated a plasma microRNA signature as a non-invasive biomarker for early-stage breast cancer diagnosis. Results confirmed the value of the signature based on miR-30b and miR-99a levels in plasma samples, demonstrating its potential for very early detection. The proposed microRNA signature presents a high value as a fast, cost-effective, and non-invasive biomarker for early-stage breast cancer detection.
Article
Oncology
Yasemin C. Cole, Yu-Zhi Zhang, Beatrice Gallo, Adam P. Januszewski, Anca Nastase, David J. Essex, Caroline M. H. Thaung, Victoria M. L. Cohen, Mandeep S. Sagoo, Anne M. Bowcock
Summary: A study on 100 uveal melanomas from the UK revealed that loss of nuclear BAP1 (nBAP1) predicts shorter overall survival. Tumors with BAP1 loss of function mutations frequently exhibited heterogeneous BAP1 staining, and tumors with >= 25% loss of nBAP1 were a more reliable prognostic indicator than chromosome 3 loss (LOH3) or chromosome 8q gain. Majority of BAP1 mutations result in loss of nBAP1 and aberrant expression of cBAP1.
Article
Genetics & Heredity
Jose Luis Garcia-Gimenez, Elena R. Garcia-Trevijano, Ana Aviles-Alia, Jose Santiago Ibanez-Cabellos, Miquel Bovea-Marco, Teresa Bas, Federico Pallardo, Juan R. Vina, Rosa Zaragoza
Summary: This study identified a potential molecular signature consisting of circulating miR-122-5p/miR-192-5p/miR-323-3p and biochemical parameters that could be used for prognosis and stratification of patients with limb-girdle muscular dystrophy (LGMD).
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Review
Cell Biology
Elena R. Garcia-Trevijano, Elena Ortiz-Zapater, Amparo Gimeno, Juan R. Vina, Rosa Zaragoza
Summary: This review discusses the role of calpain-1 and -2 in mammary tissue, both under normal physiological conditions and in the pathological context of breast cancer. It emphasizes the importance of calpain in maintaining tissue homeostasis and promoting tumor development, and highlights the future challenges in this field.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Sara S. Oltra, Maria Pena-Chilet, Maria T. Martinez, Eduardo Tormo, Juan Miguel Cejalvo, Joan Climent, Pilar Eroles, Ana Lluch, Gloria Ribas
BREAST CANCER-BASIC AND CLINICAL RESEARCH
(2020)
Article
Oncology
J. C. Trivino, A. Ceba, E. Rubio-Solsona, D. Serra, I. Sanchez-Guiu, G. Ribas, R. Rosa, M. Cabo, L. Bernad, G. Pita, A. Gonzalez-Neira, G. Legarda, J. L. Diaz, A. Garcia-Vigara, A. Martinez-Aspas, M. Escrig, B. Bermejo, P. Eroles, J. Ibanez, D. Salas, A. Julve, A. Cano, A. Lluch, R. Minambres, J. Benitez
Review
Endocrinology & Metabolism
Gisselle Perez-Machado, Ester Berenguer-Pascual, Miquel Bovea-Marco, Pedro Antonio Rubio-Belmar, Eva Garcia-Lopez, Maria Jose Garzon, Salvador Mena-Molla, Federico Pallardo, Teresa Bas, Juan R. Vina, Jose Luis Garcia-Gimenez