Innate immune responses regulate morphogenesis and degeneration: roles of Toll-like receptors and Sarm1 in neurons

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Toll-like receptor 9 deficiency impacts sensory and motor behaviors

(2013) Veronika Khariv et al.   BRAIN BEHAVIOR AND IMMUNITY

Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice

(2013) Chia-Wen Lin et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death

(2013) Piyali Mukherjee et al.   IMMUNITY

Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains

(2013) Chia-Wen Lin et al.   Innate Immunity

Death of developing neurons: New insights and implications for connectivity

(2013) Martijn P.J. Dekkers et al.   JOURNAL OF CELL BIOLOGY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

TLR7 Negatively Regulates Dendrite Outgrowth through the Myd88-c-Fos-IL-6 Pathway

(2013) H.-Y. Liu et al.   JOURNAL OF NEUROSCIENCE

SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria

(2013) Hitoshi Murata et al.   MOLECULAR BIOLOGY OF THE CELL

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Activation of Autoreactive B Cells by Endogenous TLR7 and TLR3 RNA Ligands

(2012) Nathaniel M. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The immunology of neurodegeneration

(2012) Eva Czirr et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellularly Delivered Single-Stranded Viral RNA Causes Neurodegeneration Dependent on TLR7

(2012) S. M. Lehmann et al.   JOURNAL OF IMMUNOLOGY

Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

(2012) Sophie Leow-Dyke et al.   Journal of Neuroinflammation

Imiquimod Enhances Excitability of Dorsal Root Ganglion Neurons by Inhibiting Background (K2P) and Voltage-Gated (Kv1.1 and Kv1.2) Potassium Channels

(2012) Jaekwang Lee et al.   Molecular Pain

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Expression of Toll-Like Receptors in the Developing Brain

(2012) David Kaul et al.   PLoS One

Evidence for a Developmental Role for TLR4 in Learning and Memory

(2012) Eitan Okun et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Dissecting negative regulation of Toll-like receptor signaling

(2012) Takeshi Kondo et al.   TRENDS IN IMMUNOLOGY

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans

(2011) Chieh Chang et al.   DEVELOPMENT

Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

(2011) Chiung-Ya Chen et al.   JOURNAL OF CELL BIOLOGY

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

(2011) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death

(2010) Mukesh Kumar et al.   Journal of Neuroinflammation

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

(2010) E. Okun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5

(2008) Joari De Miranda et al.   FASEB JOURNAL

SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis

(2008) Hsu-Wen Chao et al.   JOURNAL OF CELL BIOLOGY

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-Like Receptor 3 Is a Negative Regulator of Embryonic Neural Progenitor Cell Proliferation

(2008) J. D. Lathia et al.   JOURNAL OF NEUROSCIENCE