Article
Hematology
Natalja Jackmann, Sofia Englund, Per Frisk, Outi Makitie, Pauliina Utriainen, Anette Mortberg, Birgitta Henriques-Normark, Katrin Putsep, Arja Harila-Saari
Summary: This study established the reference range of serum hCAP-18 levels in healthy children and compared levels between different diagnostic groups. It was found that children with diseases that affect myelopoiesis had lower hCAP-18 levels, while patients with non-hematological malignancies had levels similar to healthy children. Children with chronic myeloid leukemia had higher circulating levels of hCAP-18.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emanuela Spagnolo, Alejandra Martinez, Andrea Mascaros-Martinez, Josep Mari-Alexandre, Maria Carbonell, Eva Gonzalez-Canto, Eva Manuela Pena-Burgos, Barbara Andrea Mc Cormack, Sarai Tomas-Perez, Juan Gilabert-Estelles, Ana Lopez-Carrasco, Paula Hidalgo, Martina Aida Angeles, Andres Redondo, Alejandro Gallego, Alicia Hernandez
Summary: This study aimed to compare the spatial distribution of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) in ovarian endometriosis (OE) and endometriosis-associated ovarian cancer (EAOC), and analyze the relationship between immunosuppressive cell populations and T-cell exhaustion markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Shuwen Ma, Yuxin Zhao, Xingyi Liu, Alexander Sun Zhang, Hong Zhang, Guang Hu, Xiao-Feng Sun
Summary: Through the analysis of CRC patients' samples, this study identifies the different expressions of CD163 in various tissues and a positive correlation between CD163 dysfunction and worse prognosis. CD163 could be a new biomarker to predict patient prognosis in CRC.
Review
Pharmacology & Pharmacy
Tuan Hiep Tran, Phuong Thi Thu Tran, Duy Hieu Truong
Summary: Lactoferrin (Lf), a glycoprotein with diverse applications, has potential in infection inhibition, anti-inflammation, antioxidant properties, immune modulation, and inhibiting cancerous tumors. Its unique properties, such as iron-binding and positive charge, allow Lf to interrupt cancer cell membranes and influence apoptosis pathways. Furthermore, Lf, as a common mammalian excretion, shows promise in targeting delivery and cancer diagnosis. Recently, nanotechnology has significantly improved the therapeutic index of Lf and other glycoproteins. This review summarizes the understanding of Lf and discusses different nano-preparation strategies, including inorganic nanoparticles, lipid-based nanoparticles, and polymer-based nanoparticles, in cancer management. Potential future applications of Lf are also discussed.
Article
Immunology
Guozeng Xu, Lei Jiang, Cheng Ye, Guizhen Qin, Zhanxiong Luo, Yuzhen Mo, Jian Chen
Summary: The ratio of stromal CD86+TAM/CD163+TAM (CD86/CD163) was investigated as a prognostic biomarker for colorectal cancer, with results showing its effectiveness in predicting recurrence-free survival and overall survival. The ratio was found to be an independent predictor in different cohorts and showed better predictive values than tumor stage. The stromal CD86/CD163 ratio could be useful for individual risk assessment and personalized treatment in stage II-III colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anette Mortberg, Katrin Putsep, Petter Hoglund
Summary: Levels of hCAP-18 in blood plasma can predict severe neutropenia, with patients having lower levels showing more severe disease. Neutropenic patients have lower levels of hCAP-18 compared to blood donors, while those with neutrophil antibodies show higher levels.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diana A. Ramirez-Sanchez, Izamar G. Arredondo-Beltran, Adrian Canizalez-Roman, Hector Flores-Villasenor, Kamran Nazmi, Jan G. M. Bolscher, Nidia Leon-Sicairos
Summary: This study focused on the effect of bovine lactoferrin (bLF) and LF peptides on cervical and endometrial cancer cell lines, finding that they inhibited cell proliferation and caused cellular morphological changes and damage. bLF induced apoptosis, LFcin17-30 and LFampin265-284 induced both apoptosis and necrosis, while LF chimera induced necrosis. Additionally, bLF and LF chimera showed an additive interaction with cisplatin against uterine cancer cells.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Gerardo Ramirez-Rico, Maria Elisa Drago-Serrano, Nidia Leon-Sicairos, Mireya de la Garza
Summary: This review focuses on the regulatory effects of orally administered bovine lactoferrin (Lf) on the inflammatory response associated with colorectal cancer (CRC). This approach suggests that bovine Lf, as a safe natural compound, may be used alone or as an adjunct agent to increase the effectiveness and reduce the side effects of anticancer chemotherapy for CRC, which is a frequently diagnosed cancer with clinical and epidemiologic relevance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Se Ik Kim, Suhyun Hwangbo, Kisoon Dan, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Dohyun Han, Maria Lee
Summary: This study aimed to investigate novel blood-based prognostic biomarkers for high-grade serous ovarian carcinoma (HGSOC) using mass spectrometry-based proteomics methods. By comparing proteomic profiles between good and poor prognosis groups, overlapping protein biomarkers were selected as candidate biomarkers and validated using ELISA. The newly developed model, including GSN and VCAN as key predictors, showed a good predictive performance for the 18-month progression-free survival rate.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Oncology
Tao Xue, Kejing Yan, Yiqi Cai, Jiancheng Sun, Zhejing Chen, Xiaolei Chen, Wenyi Wu
Summary: Infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients, with high-level infiltration associated with shorter overall survival and disease-free survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Catia Santos-Pereira, Joana P. Guedes, Debora Ferreira, Ligia R. Rodrigues, Manuela Corte-Real
Summary: The milk-derived bovine lactoferrin (bLf) has selective anticancer activity against highly metastatic cancer cells with V-ATPase at the plasma membrane. It co-localizes with V-ATPase and cholesterol-rich lipid rafts, perturbs cellular trafficking, induces cholesterol accumulation and disrupts lipid rafts, downregulates PI3K and AKT/p-AKT, and inhibits glycolysis of cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Kasper Munch Lauridsen, Marianne Hokland, Sinan Al-Karradi, Holger Jon Moller, Frede Donskov, Morten Norgaard Andersen
Summary: The levels of monocyte mCD163 were reduced and the levels of serum sCD163 were increased in mRCC patients compared to healthy controls. A negative correlation between mCD163 and sCD163 levels was observed. Intermediate levels of monocyte mCD163 were associated with the longest overall survival, while both lower and higher levels of mCD163 were associated with worse outcomes. Higher levels of sCD163 at diagnosis were associated with poor overall survival.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yichen Li, Qian Zhang, Mandi Wu, Peidong Zhang, Liang Huang, Xiaolin Ai, Zhengnan Yang, Qiuhong Shen, Yiran Wang, Ping Wang, Shengtao Zhou, Ming-Liang He
Summary: A study has found that a LncRNA associated with ovarian cancer metastasis, LncOVM, is highly correlated with poor prognosis and survival. LncOVM interacts with and stabilizes PPIP5K2, promoting the secretion of complement C5 from ovarian cancer cells, which then attracts myeloid-derived suppressor cells (MDSCs) infiltration in the tumor microenvironment (TME) to facilitate metastasis. Targeting the LncOVM-PPIP5K2-complement axis can inhibit MDSC infiltration and restore the suppression of tumorigenesis and metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Jun Kinoshita, Sachio Fushida, Takahisa Yamaguchi, Hideki Moriyama, Hiroto Saito, Mari Shimada, Shiro Terai, Koichi Okamoto, Keishi Nakamura, Itasu Ninomiya, Shintaro Yagi, Noriyuki Inaki
Summary: This study aimed to evaluate the association between tumor-infiltrating immune cells (TIICs) and the treatment outcome of conversion surgery (CS) in metastatic gastric cancer (MGC). The study found that patients in the CS group who had a pathological response to chemotherapy showed low infiltration of CD163(+) macrophages and high infiltration of CD8(+) lymphocytes. The low CD163 group had a significantly prolonged survival in patients who underwent CS.
Article
Chemistry, Multidisciplinary
Sarah Mokhtar, Sherine N. Khattab, Kadria A. Elkhodairy, Mohamed Teleb, Adnan A. Bekhit, Ahmed O. Elzoghby, Marwa A. Sallam
Summary: The study describes a hybrid carrier system for the simultaneous targeted delivery of two drugs, EXE and MTX, for the treatment of breast cancer. The findings show that the dual drug-loaded nanoparticles have excellent drug loading and cytotoxic activity, making them a promising candidate for combinational hormonal therapy/chemotherapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Paula J. Correa, Pia Venegas, Yasna Palmeiro, Daniela Albers, Gregory Rice, Jaime Roa, Jorge Cortez, Max Monckeberg, Manuel Schepeler, Eduardo Osorio, Sebastian E. Illanes
JOURNAL OF PERINATAL MEDICINE
(2019)
Article
Obstetrics & Gynecology
Manuel B. Donoso, Ramon Serra, Gregory E. Rice, Maria Teresa Gana, Carolina Rojas, Maroun Khoury, Jose Antonio Arraztoa, Lara J. Monteiro, Stephanie Acuna, Sebastian E. Illanes
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Lara J. Monteiro, Manuel Varas-Godoy, Max Monckeberg, Ornella Realini, Marcela Hernandez, Gregory Rice, Roberto Romero, Jose F. Saavedra, Sebastian E. Illanes, Alejandra Chaparro
Article
Medicine, Research & Experimental
Suchismita Dutta, Andrew Lai, Katherin Scholz-Romero, Muhammad J. A. Shiddiky, Yusuke Yamauchi, Jay S. Mishra, Gregory E. Rice, Jon Hyett, Sathish Kumar, Carlos Salomon
Article
Medicine, General & Internal
Lara J. Monteiro, Manuel Varas-Godoy, Stephanie Acuna-Gallardo, Paula Correa, Gianluca Passalacqua, Max Monckeberg, Gregory E. Rice, Sebastian E. Illanes
Article
Dentistry, Oral Surgery & Medicine
Alejandra Chaparro, Ornella Realini, Marcela Hernandez, Daniela Albers, Laura Weber, Valeria Ramirez, Fernanda Param, Juan Pedro Kusanovic, Timo Sorsa, Gregory Edward Rice, Sebastian E. Illanes
Summary: The study found that concentrations of MMP-8 and -9 in gingival crevicular fluid during early pregnancy are increased in women with severe periodontitis and associated with the development of GDM.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Luis Federico Batiz, Yasna K. Palmeiro-Silva, Gregory E. Rice, Lara J. Monteiro, Albert M. Galaburda, Roberto Romero, Mahesh A. Choolani, Ursula Wyneken, Pelusa Orellana, Sebastian E. Illanes
Summary: This study found that maternal exposure to stressful events can lead to impaired pre-reading skills in children, especially those exposed to earthquakes during the first trimester of pregnancy. Females were more impacted in alphabet knowledge, whereas males were more affected in print knowledge skills.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Alejandra Chaparro, Maximiliano Monckeberg, Ornella Realini, Marcela Hernandez, Fernanda Param, Daniela Albers, Valeria Ramirez, Juan Pedro Kusanovic, Roberto Romero, Gregory Rice, Sebastian E. Illanes
Summary: This study evaluated the performance of a model combining GCF-PLAP concentration and systolic blood pressure in predicting the risk of developing pre-eclampsia (PE). The model showed potential utility in identifying pre-symptomatic women who may later develop PE, with GCF-PLAP concentrations showing an association with the likelihood of developing the condition.
Article
Medicine, Research & Experimental
Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacos, Fatima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon
Summary: Gestational diabetes mellitus (GDM) poses a significant public health concern, affecting 9-15% of pregnancies worldwide. This study found that EV-associated miRNAs in GDM patients undergo significant changes during gestation and can be effectively used for classification. A set of proteins associated with JAK-STAT signaling in skeletal muscle biopsies from GDM patients was identified, which may be targeted by the miRNA-92a-3p carried by circulating EVs. Overexpression of miRNA-92a-3p was shown to increase insulin sensitivity in primary skeletal muscle cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Mona Alharbi, Andrew Lai, Shayna Sharma, Priyakshi Kalita-de Croft, Nihar Godbole, America Campos, Dominic Guanzon, Alexis Salas-Burgos, Flavio Carrion, Felipe A. Zuniga, Lewis Perrin, Yaowu He, Tanja Pejovic, Carmen Winters, Terry Morgan, John D. Hooper, Gregory E. Rice, Carlos Salomon
Summary: Ovarian cancer is one of the most lethal cancers worldwide affecting women, with non-specific early symptoms. sEVs produced under low oxygen tension can induce a metabolic switch in ovarian cancer cells, promoting resistance to carboplatin. The presence of glycolysis pathway proteins in sEVs is closely associated with ovarian cancer recurrence.
Review
Cell Biology
Priyakshi Kalita-de Croft, Shayna Sharma, Nihar Godbole, Gregory E. Rice, Carlos Salomon
Summary: Ovarian cancer is one of the most diagnosed gynecological cancers in women, often diagnosed at an advanced stage due to the lack of effective early screening. Extracellular vesicles play a crucial role in the tumor microenvironment of ovarian cancer, with potential applications in diagnosis, delivery of therapeutic agents, and disease monitoring.
Editorial Material
Biochemistry & Molecular Biology
Bent Honore, Gregory Edward Rice, Henrik Vorum
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Carlos Salomon, Saumya Das, Uta Erdbrugger, Raghu Kalluri, Sai Kiang Lim, Jerrold M. Olefsky, Gregory E. Rice, Susmita Sahoo, W. Andy Tao, Pieter Vader, Qun Wang, Alissa M. Weaver
Summary: The hormone-like role of extracellular vesicles (EVs) in cell-to-cell communication has gained significant interest in the past decade. EVs, as a heterogeneous population of membrane-bound vesicles, carry endocrine signals and play a role in various biological activities. They can also serve as indicators of diseases. This article aims to highlight the importance of EV research and its potential role in the field of endocrinology.
Article
Medicine, General & Internal
Mario Arias, Lara J. Monteiro, Stephanie Acuna-Gallardo, Manuel Varas-Godoy, Gregory E. Rice, Max Monckeberg, Pilar Diaz, Sebastian E. Illanes
REVISTA MEDICA DE CHILE
(2019)
Article
Obstetrics & Gynecology
A. P. Mahyuddin, L. Liu, C. Zhao, N. Kothandaraman, M. Salto-Tellez, B. N. K. Pang, D. G. S. Lim, L. Annalamai, J. K. Y. Chan, T. Y. K. Lim, A. Biswas, G. Rice, K. Razvi, M. Choolani
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2018)