Review
Immunology
Hai-Di Li, Yong-Ke You, Bao-Yi Shao, Wei-Feng Wu, Yi-Fan Wang, Jian-Bo Guo, Xiao-Ming Meng, Haiyong Chen
Summary: Diabetic nephropathy is the most common chronic kidney disease, and the activation and transition of resident macrophages play a crucial role in causing renal inflammation and fibrosis. Inhibiting macrophage activation and macrophage-cell interactions may be a promising approach to attenuate diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alina Mihaela Stanigut, Camelia Pana, Manuela Enciu, Mariana Deacu, Bogdan Cimpineanu, Liliana Ana Tuta
Summary: Research has found that hypoxia response and hypoxia-inducible factors play critical roles in the pathogenesis of diabetic nephropathy, and HIF stabilizers are considered as novel therapeutic agents for treating anemia in CKD patients and relieving oxidative stress in renal tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Luna Jimenez-Castilla, Gema Marin-Royo, Macarena Orejudo, Lucas Opazo-Rios, Teresa Caro-Ordieres, Ines Artaiz, Tatiana Suarez-Cortes, Arturo Zazpe, Gonzalo Hernandez, Carmen Gomez-Guerrero, Jesus Egido
Summary: The synthetic flavonoid hidrosmin has shown protective effects against diabetic nephropathy by reducing inflammation, oxidative stress, and senescence pathways. It may have potential as an adjuvant therapy for chronic complications of diabetes mellitus. Additionally, hidrosmin demonstrated no cytotoxicity at effective concentrations, making it a promising treatment option.
Article
Immunology
Yinyu Wei, Lele Hu, Guoying Liu
Summary: This study evaluated the efficacy of nifedipine controlled-release tablets combined with sacubitril valsartan in hypertensive diabetic nephropathy (DN) patients. The observation group, treated with the combination therapy, showed significantly lower levels of clinical indexes, renal function indicators, endothelial function indicators, and inflammatory response factors compared to the control group after three months of treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Mitsugi Ookawara, Yasunori Nio
Summary: Phosphodiesterase subtype 4 (PDE4) plays key roles in inflammatory and fibrotic responses by hydrolyzing cyclic AMP, but its inhibition with PDE4 inhibitors can also lead to adverse effects. Studies have shown that PDE4 inhibitors may have beneficial effects on improving symptoms of diabetes, particularly in relation to hyperglycemia and insulin resistance, yet the mechanisms of action in diabetic nephropathy are still unknown.
CELLULAR SIGNALLING
(2022)
Article
Plant Sciences
Wu Luo, Xiaojun Chen, Lin Ye, Xuemei Chen, Wenjing Jia, Yanni Zhao, Aleksandr Samorodov, Yali Zhang, Xueting Hu, Fei Zhuang, Jianchang Qian, Chao Zheng, Guang Liang, Yi Wang
Summary: The study showed that KPF can significantly reduce renal inflammation, fibrosis, and kidney dysfunction in diabetic mice. The downregulation of TRAF6 in diabetic mouse kidneys was associated with these effects, suggesting the potential role of TRAF6. Treatment with KPF in NRK-52E cells attenuated high glucose-induced inflammatory and fibrogenic responses, with downregulated TRAF6 expression.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Shadab Ahmad, Alka Raj Pandey, Amit K. Rai, Suriya P. Singh, Pawan Kumar, Sushmita Singh, Farah Gulzar, Ishbal Ahmad, Koneni V. Sashidhara, Akhilesh K. Tamrakar
Summary: The study aimed to demonstrate the preventive effects of Moringa oleifera leaves extract on protein glycation and its renoprotective effect in diabetic rats. The study found that the extract efficiently prevented glycation of protein and improved glucose metabolism and renal function in diabetic rats. It also showed anti-inflammatory and antioxidant effects. Therefore, Moringa oleifera leaves could be a potential therapeutic intervention for the management of diabetic nephropathy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Immunology
Xiaokang Wang, Jingqian Zhao, Yuanqing Li, Jiaoyu Rao, Gengrui Xu
Summary: Proteinuria and nephrotic syndrome are symptoms of kidney diseases caused by direct or indirect damage to podocytes. Inflammation plays a crucial role in the development and progression of diabetic nephropathy, the leading cause of end-stage renal disease worldwide. The impact of podocyte damage on metabolic and inflammatory disorders has been documented. Epigenetic and endoplasmic reticulum stress are also observed in diabetic nephropathy. Targeting inflammation pathway and endoplasmic reticulum stress in podocytes may offer potential therapies to prevent the progression of diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jiahao Chen, Qinhui Liu, Jinhan He, Yanping Li
Summary: Diabetic nephropathy (DN) is a chronic, inflammatory disease that affects millions of diabetic patients worldwide. The immune system may inadvertently contribute to the pathogenesis of DN, leading to kidney damage. Strategies targeting the immune response are being studied for the treatment of DN.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Ruyu Ma, Yinghao He, Qing Fang, Gaoyu Xie, Minyou Qi
Summary: This study aimed to investigate the nephroprotective effect of ferulic acid (FA) on diabetic nephropathy (DN) and its underlying mechanism using a mouse model. The results showed that FA reduced body weight and fasting blood glucose levels, improved renal organ coefficient, and decreased protein and nitrogen levels in urine and blood, as well as cholesterol levels in serum. Additionally, FA enhanced autophagy and suppressed inflammation in the renal tissues. These findings suggest that FA plays a positive role in alleviating renal injury in DN mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Li Wang, Hong-Lian Wang, Tong-Tong Liu, Hui-Yao Lan
Summary: This review discusses the diverse roles and signaling mechanisms of TGF-beta in diabetic nephropathy, focusing on latent versus active TGF-beta 1, TGF-beta receptors, and downstream Smad signaling molecules. The regulatory mechanisms of TGF-beta/Smad signaling in the development of DN, including Smad-dependent non-coding RNAs, are also dissected. Finally, potential therapeutic strategies for DN targeting TGF-beta signaling with various approaches are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Amit K. Maiti
Summary: Diabetic Nephropathy is a serious complication of diabetes affecting the kidneys, with current diagnosis and treatment options insufficient to halt disease progression. Advances in genetics and genomics have identified susceptibility genes associated with DN, many of which have inflammatory functions, providing new insights for precision medicine in treating the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Xiaoyuan Guo, You Wu, Chengfei Zhang, Lili Wu, Lingling Qin, Tonghua Liu
Summary: This study investigated the pharmacological mechanisms of ZiShenWan (ZSW) in treating diabetic nephropathy using a network pharmacology approach. Results showed that ZSW achieved renoprotective effects by regulating multiple targets and signaling pathways, particularly by alleviating inflammation. Experimental validation in db/db mice confirmed the regulatory effects of ZSW on core targets and signaling pathways associated with inflammation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Hong-Qin Li, Nian Liu, Zong-Yu Zheng, Hao-Lin Teng, Jin Pei
Summary: The study found that clopidogrel significantly reduced renal collagen deposition and fibrosis in DB mice, preventing renal dysfunction by inhibiting macrophage infiltration and associated inflammation.
WORLD JOURNAL OF DIABETES
(2022)
Review
Immunology
Qi Jin, Tongtong Liu, Yuan Qiao, Donghai Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Liang Peng, Yongli Zhan
Summary: Diabetic nephropathy (DN) can cause end-stage renal disease. Oxidative stress plays a crucial role in the development of DN, leading to various pathological processes and promoting inflammation. Polyphenols, such as quercetin, resveratrol, curcumin, and phenolic acid, have shown antioxidant and anti-inflammatory effects by targeting Nrf2, SIRT1, HMGB1, NF-κB, and NLRP3. However, further research is needed to fully understand the molecular mechanisms and clinical applications of polyphenols in DN.
FRONTIERS IN IMMUNOLOGY
(2023)