Regulation of signaling interactions and receptor endocytosis in growing blood vessels

Ephrin signalling in the developing nervous system

(2014) Rüdiger Klein et al.   CURRENT OPINION IN NEUROBIOLOGY

Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals

(2014) H. Lindskog et al.   DEVELOPMENT

The composition of EphB2 clusters determines the strength in the cellular repulsion response

(2014) Andreas Schaupp et al.   JOURNAL OF CELL BIOLOGY

Development of the mammalian lymphatic vasculature

(2014) Ying Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

(2014) Katie Bentley et al.   NATURE CELL BIOLOGY

Cellular Mechanisms of Tissue Fibrosis. 3. Novel mechanisms of kidney fibrosis

(2013) Gabriela Campanholle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting the PDGF signaling pathway in tumor treatment

(2013) Carl-Henrik Heldin   Cell Communication and Signaling

VEGFR2 trafficking: Speed doesn’t kill

(2013) Xi Zhang et al.   CELL CYCLE

Filopodia are dispensable for endothelial tip cell guidance

(2013) Li-Kun Phng et al.   DEVELOPMENT

Notch controls retinal blood vessel maturation and quiescence

(2013) M. Ehling et al.   DEVELOPMENT

Arterial and Venous Progenitors of the Major Axial Vessels Originate at Distinct Locations

(2013) Vikram Kohli et al.   DEVELOPMENTAL CELL

ETS Factors Regulate Vegf-Dependent Arterial Specification

(2013) Joshua D. Wythe et al.   DEVELOPMENTAL CELL

Tissue-specific venous expression of the EPH family receptor EphB1 in the skin vasculature

(2013) Wenling Li et al.   DEVELOPMENTAL DYNAMICS

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy

(2013) René Hägerling et al.   EMBO JOURNAL

Coordination of VEGF receptor trafficking and signaling by coreceptors

(2013) Masanori Nakayama et al.   EXPERIMENTAL CELL RESEARCH

Ephrin-B2 controls PDGFR  internalization and signaling

(2013) A. Nakayama et al.   GENES & DEVELOPMENT

EphrinB2 Reverse Signaling Protects against Capillary Rarefaction and Fibrosis after Kidney Injury

(2013) Y. Kida et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Spatial regulation of VEGF receptor endocytosis in angiogenesis

(2013) Masanori Nakayama et al.   NATURE CELL BIOLOGY

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

(2013) Elena Seiradake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5

(2013) Kai Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development

(2013) N. Sacilotto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamin Inhibitors Impair Endocytosis and Mitogenic Signaling of PDGF

(2013) Łukasz Sadowski et al.   TRAFFIC

Structural and Functional Properties of Platelet-Derived Growth Factor and Stem Cell Factor Receptors

(2013) C.-H. Heldin et al.   Cold Spring Harbor Perspectives in Biology

VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

(2013) Makoto Hayashi et al.   Nature Communications

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

VEGF and Notch in Tip and Stalk Cell Selection

(2013) R. Blanco et al.   Cold Spring Harbor Perspectives in Medicine

Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos

(2012) Y. Yang et al.   BLOOD

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

Regulation of VEGF signaling by membrane traffic

(2012) Arie Horowitz et al.   CELLULAR SIGNALLING

Smooth muscle–endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation

(2012) Sophie Lutter et al.   JOURNAL OF CELL BIOLOGY

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling

(2012) Satish Pasula et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

(2012) Rui Benedito et al.   NATURE

An Inside View: VEGF Receptor Trafficking and Signaling

(2012) Michael Simons   PHYSIOLOGY

Orchestral actions of angiopoietin-1 in vascular regeneration

(2012) Gou Young Koh   TRENDS IN MOLECULAR MEDICINE

Molecular Mechanisms of Cell Segregation and Boundary Formation in Development and Tumorigenesis

(2012) E. Batlle et al.   Cold Spring Harbor Perspectives in Biology

Targeting Endothelium-Pericyte Cross Talk by Inhibiting VEGF Receptor Signaling Attenuates Kidney Microvascular Rarefaction and Fibrosis

(2011) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas

(2011) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Pivotal role of pericytes in kidney fibrosis

(2011) Yujiro Kida et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Eph/ephrin signaling in cell-cell and cell-substrate adhesion

(2011) Arvinder Singh   Frontiers in Bioscience-Landmark

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

(2011) Tuomas Tammela et al.   NATURE CELL BIOLOGY

A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses

(2011) Nan-Jie Xu et al.   NATURE NEUROSCIENCE

Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611Cincreases PDGF-dependent vascular smooth muscle cell proliferation

(2011) Ali R. Keramati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-SH2/PDZ reverse signaling by ephrins

(2011) Ira O. Daar   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations

(2010) Nikhil Singla et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and functional analysis of endothelial tip cell-enriched genes

(2010) R. del Toro et al.   BLOOD

Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate

(2010) Charles Williams et al.   DEVELOPMENTAL BIOLOGY

VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis

(2010) Anthony A. Lanahan et al.   DEVELOPMENTAL CELL

Spatial organization of transmembrane receptor signalling

(2010) Ioanna Bethani et al.   EMBO JOURNAL

Eph/ephrin molecules--a hub for signaling and endocytosis

(2010) M. E. Pitulescu et al.   GENES & DEVELOPMENT

Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

(2010) Markus Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Forms a Signaling Complex with Platelet-derived Growth Factor Receptor-β in Endosomes and Regulates Activation of the MAPK Pathway

(2010) Selen Catania Muratoglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding

(2010) M. L. Bochenek et al.   JOURNAL OF CELL SCIENCE

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Architecture of Eph receptor clusters

(2010) J. P. Himanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EphrinB reverse signaling in cell-cell adhesion

(2010) Hyun-Shik Lee et al.   Cell Adhesion & Migration

VEGF and endothelial guidance in angiogenic sprouting

(2010) Holger Gerhardt   Organogenesis

Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor

(2009) Nicole K. Noren et al.   BIOCHEMICAL JOURNAL

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

(2009) Boris Strilić et al.   DEVELOPMENTAL CELL

EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility

(2009) T. Yamazaki et al.   JOURNAL OF CELL SCIENCE

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LRP1 Regulates Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation

(2009) Li Zhou et al.   PLoS One

Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation

(2009) S. P. Herbert et al.   SCIENCE

Modulation of VEGF signalling output by the Notch pathway

(2008) Arndt F. Siekmann et al.   BIOESSAYS

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

(2008) Rui Benedito et al.   BMC DEVELOPMENTAL BIOLOGY

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis

(2008) Y. H. Kim et al.   DEVELOPMENT

Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling

(2008) Hideki Yamamoto et al.   DEVELOPMENTAL CELL

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing

(2008) K. Lehti et al.   JOURNAL OF CELL SCIENCE

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

(2008) E. Mattila et al.   JOURNAL OF CELL SCIENCE

A TrkB/EphrinA Interaction Controls Retinal Axon Branching and Synaptogenesis

(2008) K. J. M. Marler et al.   JOURNAL OF NEUROSCIENCE

Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos

(2008) P. Haiko et al.   MOLECULAR AND CELLULAR BIOLOGY

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE

Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors

(2008) Clara L Essmann et al.   NATURE NEUROSCIENCE