Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Multidisciplinary Sciences
Paloma Cejas, Yingtian Xie, Alba Font-Tello, Klothilda Lim, Sudeepa Syamala, Xintao Qiu, Alok K. Tewari, Neel Shah, Holly M. Nguyen, Radhika A. Patel, Lisha Brown, Ilsa Coleman, Wenzel M. Hackeng, Lodewijk Brosens, Koen M. A. Dreijerink, Leigh Ellis, Sarah Abou Alaiwi, Ji-Heui Seo, Sylvan Baca, Himisha Beltran, Francesca Khani, Mark Pomerantz, Alessandra Dall'Agnese, Jett Crowdis, Eliezer M. Van Allen, Joaquim Bellmunt, Colm Morrisey, Peter S. Nelson, James DeCaprio, Anna Farago, Nicholas Dyson, Benjamin Drapkin, X. Shirley Liu, Matthew Freedman, Michael C. Haffner, Eva Corey, Myles Brown, Henry W. Long
Summary: Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but share similar histological and clinical features. The epigenetic landscape of NECs converges towards a common state, while distinct subtypes occur within neuroendocrine prostate cancer, contributing to intratumor heterogeneity in clinical samples.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Bingfeng Luo, Yuan Yuan, Yifei Zhu, Songwu Liang, Runan Dong, Jian Hou, Ping Li, Yaping Xing, Zhenquan Lu, Richard Lo, Guan-Ming Kuang
Summary: miRNA-145-5p was found to negatively regulate EMT, inhibit Pca bone metastasis, and promote apoptosis. It may serve as a potential target for treating Pca with bone metastases.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Alessandro Fulgenzi, Anita Ferraretto
Summary: Bone metastasis is a severe complication of common cancers like breast and prostate cancer, reducing survival rates and quality of life. Following a Mediterranean diet can prevent cancer and improve patient health, potentially impacting the spread of cancer to the bones.
Article
Biochemistry & Molecular Biology
Victor J. B. van Santen, Behrouz Zandieh Doulabi, Cornelis M. Semeins, Jolanda M. A. Hogervorst, Cornelia Bratengeier, Astrid D. Bakker
Summary: Once prostate cancer cells metastasize to bone, they experience 2 kPa compression, which stimulates the epithelial-to-mesenchymal transition (EMT) and alters their secretion of paracrine signals. This leads to a decrease in osteoclast resorptive activity and an increase in osteoblast mineralization. These findings provide insight into the altered behavior of prostate cancer cells under mechanical stimuli and suggest potential leads for therapies to prevent bone metastases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Xiao Hong, Yuanhao Xu, Stella W. Pang
Summary: In this study, microwell arrays with a grating-patterned bottom were designed and fabricated to systematically investigate the effects of confinement, changes in topography, and cell-cell contacts on the migration behavior of nasopharyngeal carcinoma (NPC43) and immortalized nasopharyngeal epithelial (NP460) cells. The results showed that co-culturing NPC43 and NP460 cells in microwells significantly increased the migration speed and spreading area of NPC43 cells, which can be attributed to heterotypic cell-cell contacts. Moreover, in 3D microwell arrays, NPC43 cells formed clusters on the bottom surface while NP460 cells migrated onto the sidewalls, providing potential applications for drug screening.
Article
Oncology
Anthony Turpin, Carine Delliaux, Pauline Parent, Hortense Chevalier, Carmen Escudero-Iriarte, Franck Bonardi, Nathalie Vanpouille, Anne Flourens, Jessica Querol, Aurelien Carnot, Xavier Leroy, Nicolas Herranz, Tristan Lanel, Arnauld Villers, Jonathan Olivier, Helene Touzet, Yvan de Launoit, Tian V. Tian, Martine Duterque-Coquillaud
Summary: Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer associated with resistance to androgen-deprivation therapies. This study reveals that the actin-bundling protein Fascin-1 (FSCN1) is upregulated during NEPC differentiation and is repressed by the androgen receptor (AR), contributing to NEPC aggressiveness. These findings suggest that targeting FSCN1 may be a potential therapeutic strategy for NEPC patients.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Bongjun Kim, Suhan Jung, Haemin Kim, Jun-Oh Kwon, Min-Kyoung Song, Min Kyung Kim, Hyung Joon Kim, Hong-Hee Kim
Summary: The study established a highly bone-metastatic subline of human prostate cancer cells, which exhibited elevated cell proliferation and mesenchymal properties due to the secretion of S100A4 protein. S100A4 promoted cell proliferation and EMT characteristics in tumor cells, and activated osteoclastogenesis, contributing to osteolytic bone metastasis.
Article
Dentistry, Oral Surgery & Medicine
Yue Du, Die Lv, Bomiao Cui, Xiaoying Li, Hongli Chen, Yingzhu Kang, Qianming Chen, Yun Feng, Ping Zhang, Jiao Chen, Xuedong Zhou
Summary: In this study, it was found that PKD1 is correlated with metastasis and poor prognosis in SACC patients. Inhibition of PKD1 attenuated proliferation, migration, invasion, and EMT of SACC cells, while kinase active PKD1 promoted cell migration. The mechanism involves PKD1 regulating Snail protein stability to impact SACC metastasis.
Article
Biochemistry & Molecular Biology
Hao Jia, Yuquan Yang, Mengying Li, Yimin Chu, Huan Song, Jie Zhang, Dan Zhang, Qun Zhang, Ying Xu, Jiamin Wang, Hong Xu, Xiuqun Zou, Haixia Peng, Zhaoyuan Hou
Summary: The study reveals that Snail promotes colorectal cancer migration by stabilizing argininosuccinate synthase 1 through preventing the degradation mediated by non-coding RNA LOC113230. Conversely, overexpression of LOC113230 suppresses CRC cell growth, migration, and lung metastasis. The findings suggest that TGF-beta and Snail promote arginine synthesis by inhibiting the LOC113230-mediated LRPPRC/TRAF2/ASS1 complex assembly, providing a potential target for new therapeutic approaches to treat CRC.
Review
Biochemistry & Molecular Biology
Enrique A. Castellon, Sebastian Indo, Hector R. Contreras
Summary: This article explores the presence and role of cancer stem cells (CSCs) and the Epithelial-Mesenchymal transition (EMT) in prostate cancer (PCa), and finds that the stemness-mesenchymal axis is a critical process related to relapse, metastasis, and resistance. Manipulating the stemness-EMT axis genes on the androgen receptor (AR) may shed light on the effect of this axis on metastasis and castration resistance in PCa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xueping Lei, Zhan Li, Yihang Zhong, Songpei Li, Jiacong Chen, Yuanyu Ke, Sha Lv, Lijuan Huang, Qianrong Pan, Lixin Zhao, Xiangyu Yang, Zisheng Chen, Qiudi Deng, Xiyong Yu
Summary: Gli1 promotes the metastasis of non-small cell lung carcinoma and is associated with poor patient survival.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Genetics & Heredity
Tabatha Gutierrez Prieto, Camila Machado Baldavira, Juliana Machado-Rugolo, Eloisa Helena Ribeiro Olivieri, Eduardo Caetano Abilio da Silva, Alexandre Muxfeldt Ab Saber, Teresa Yae Takagaki, Vera Luiza Capelozzi
Summary: This study investigated the expression of EMT genes and their association with PNENs histotypes. The results showed that these EMT genes are involved in cellular processes such as proliferation, extracellular matrix degradation, apoptosis regulation, oncogenesis, and tumor invasion. Four of these EMT genes are also involved in neurological diseases, brain metastasis, and interact with chemotherapy. These findings are important for improving histologic diagnosis and chemotherapeutic strategies in PNENs.
Article
Environmental Sciences
Yan Wang, Siling Li, Jing Zhao, Qiuyue Li, Chunjie Xu, Huihui Wu, Zhonghui Zhu, Lin Tian
Summary: The study revealed that partial EMT may be involved in the development of pulmonary fibrosis diseases, with Snail playing a critical role in the process. The process of EMT in epithelial cells promoted the differentiation of lung myofibroblasts, and this epithelial-mesenchymal crosstalk was mainly controlled by Snail.
Article
Oncology
Junhui Yu, Shan Li, Zhengshui Xu, Jing Guo, Xiaopeng Li, Yunhua Wu, Jianbao Zheng, Xuejun Sun
Summary: The study revealed that CDX2 inhibits EMT and metastasis of CRC by regulating Snail expression and beta-catenin stabilisation via transactivation of PTEN expression.
BRITISH JOURNAL OF CANCER
(2021)