Article
Biology
Jill T. Kuwabara, Akitoshi Hara, Sumit Bhutada, Greg S. Gojanovich, Jasmine Chen, Kanani Hokutan, Vikram Shettigar, Anson Y. Lee, Lydia P. DeAngelo, Jack R. Heckl, Julia R. Jahansooz, Dillon K. Tacdol, Mark T. Ziolo, Suneel S. Apte, Michelle D. Tallquist
Summary: Reducing fibroblasts in the heart has a protective effect and can alleviate cardiac fibrosis after injury. The loss of fibroblasts does not significantly alter the quantitative composition of the extracellular matrix (ECM) but reduces the distribution and quantity of collagen VI. This study has important implications for the treatment of heart disease.
Review
Immunology
Luying He, Qianming Kang, Ka Iong Chan, Yang Zhang, Zhangfeng Zhong, Wen Tan
Summary: In this study, we reviewed the immunomodulatory role of matrix metalloproteinases (MMPs) in colitis-associated cancer (CAC) and discussed relevant clinical applications. We analyzed over 300 pharmacological studies retrieved from PubMed and the Web of Science, focusing on MMPs, cancer, colitis, CAC, and immunomodulation. MMPs are involved in various processes in CAC, such as cell proliferation, cell differentiation, angiogenesis, ECM remodeling, and the inflammatory response. They also affect the immune system by modulating immune cell differentiation and activity, as well as the recruitment of macrophages and neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi Wei, Xiao-Lin Zhou, Tai-Hang Liu, Peng Chen, Xia Jiang, Zhan-Qi Dong, Min-Hui Pan, Cheng Lu
Summary: The study revealed the crucial role of MMP1 in the remodeling of insect trachea, with its knockout affecting the number of tracheal branches in silkworms. Experimental results demonstrated that BmMMP1 regulates the development of tracheal tissue mainly by influencing the expansion of tracheal cuticles and degrading key proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Paris Jabeen Asif, Ciro Longobardi, Michael Hahne, Jan Paul Medema
Summary: Metastasis in cancer is closely associated with cancer-associated fibroblasts (CAFs), which play a key role in cancer progression by contributing to extracellular matrix deposition and remodeling, extensive crosstalk with cancer cells, epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and therapy resistance. Understanding the role of CAFs in the process of metastasis, particularly in colorectal cancer (CRC) with high stromal infiltration, is crucial for developing targeted therapeutics and advancing research in this field.
Article
Multidisciplinary Sciences
Hugh Xiao, Ryan Y. Nguyen, Ryan LaRanger, Erica L. Herzog, Michael Mak
Summary: Cellular interactions with the extracellular matrix play a key role in modulating biological processes, yet the mechanical regulation associated with these interactions is not well characterized. Through a novel image analysis platform, combined with drug studies and quantitative analysis, researchers are able to provide insights into cell mechanics and its implications in a 3D collagen gel.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Xue-min Chen, Yu-yang Liu, Bing-yan Tao, Xin-miao Xue, Xin-xin Zhang, Lin-lin Wang, Hui Zhong, Jun Zhang, Shi-ming Yang, Qing-qing Jiang
Summary: Despite progress in diagnosis and treatment of HNSC, the gene NT5E encoding CD73 is associated with immunosuppressive tumor microenvironment and poor prognosis. NT5E expression is positively correlated with CAFs and may be involved in EMT and metastasis in HNSC progression. High NT5E expression predicts resistance to immunotherapy. Targeting CAFs with high NT5E expression may be a novel therapeutic strategy for HNSC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Umberto Bracale, Roberto Peltrini, Biancamaria Iacone, Mirko Martirani, Daniele Sannino, Antonio Gargiulo, Francesco Corcione, Raffaele Serra, Umberto Marcello Bracale
Summary: This study aimed to investigate the relationship between extracellular matrix disorders and abdominal wall hernias (AWHs) and the levels of matrix metalloproteinases (MMPs). The results showed that AWHs may be a disease of the extracellular matrix, supported by increased levels of MMPs in patients with AWHs. The study also highlighted the impact of tissue inhibitors of metalloproteinases (TIMPs) on AWHs. More prospective studies are needed to confirm the relationship between these biomarkers and the risk of AWHs.
Review
Biochemistry & Molecular Biology
Mediha Becirovic-Agic, Upendra Chalise, Michael J. Daseke, Shelby Konfrst, Jeffrey D. Salomon, Paras K. Mishra, Merry L. Lindsey
Summary: MMP-9 plays a dual role in myocardial infarction wound healing by exacerbating inflammatory response and aiding in transition to reparative cells, as well as influencing neovascularization and scar formation. Targeting MMP-9 only for its detrimental actions is important for effective treatment strategies.
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Desiree Napolitano, Pasquale Mastroroberto, Umberto Marcello Bracale, Michele Andreucci, Raffaele Serra
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic condition characterized by altered collagen turnover of the extracellular matrix. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are abnormally released in patients with HCM. This systematic review found that MMP levels, particularly MMP2, were higher in HCM patients compared to healthy subjects. MMPs can be used as biomarkers for HCM and for monitoring treatment outcomes.
Article
Environmental Sciences
Chien-Liang Fang, Catherine Reena Paul, Cecilia Hsuan Day, Ruey-Lin Chang, Chia-Hua Kuo, Tsung-Jung Ho, Dennis Jine-Yuan Hsieh, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Summary: Poria cocos extract showed significant protective effects against H2O2-induced cell death, with a reduction in ROS accumulation. The extract suppressed the expression of metallomatrix proteinases, inflammatory markers, and skin aging markers while increasing TGF-beta 1 levels and antioxidant related proteins.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Stephan Niland, Johannes A. Eble
Summary: The tumor microenvironment (TME) is a key focus in cancer research and treatment, involving various components including ECM and modifying enzymes. Cells within the TME interact with the ECM, influencing tumor progression through feedback mechanisms involving cellular receptors, cytokines, and exosomes. Matrix remodeling in the TME, particularly by matrix metalloproteinases (MMPs), plays a crucial role in modifying ECM barriers and releasing soluble ECM fragments that impact cells both within and outside the TME.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ziqiang Liu, Jiacheng Lai, Heng Jiang, Chengyuan Ma, Haiyan Huang
Summary: COL11A1 is upregulated in various cancers and is associated with tumor progression, poor prognosis, angiogenesis, invasion, and drug resistance. While the specific mechanism by which COL11A1 regulates tumor progression remains unclear, it shows potential as a target for cancer treatment.
Article
Cell Biology
Katharina Joechle, Huda Jumaa, Kerstin Thriene, Claus Hellerbrand, Birte Kulemann, Stefan Fichtner-Feigl, Sven A. Lang, Jessica Guenzle
Summary: The study showed that OSI-027, a dual kinase inhibitor targeting mTOR complexes, can significantly impact the migratory and metastatic capacity of cholangiocarcinoma cells by reducing cell mobility and migration, decreasing colony-forming ability, and downregulating MMP2 and MMP9 expression. Additionally, OSI-027 impaired survival and anti-apoptotic signaling as determined by AKT and MAPK blotting, suggesting that dual targeting of mTORC1/2 may be a viable option for anti-neoplastic therapy in CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Nutrition & Dietetics
Ruixuan Geng, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: UV radiation is the main factor causing skin photoaging, while dietary components have been shown to have positive effects in combating it. Skin photoaging is a complex process involving various regulators and mechanisms.
Article
Biochemistry & Molecular Biology
Noa Moshkovitz, Gali Epstein Shochet, David Shitrit
Summary: In this study, we investigated the effects of a PGE2 and PDE4 inhibitor, Roflumilast, in an IPF-CM system. The results showed that a combination of PGE2 and Roflumilast could block the large aggregate formation induced by IPF-CM and also inhibit cell migration, proliferation, and pro-fibrotic gene expression. Moreover, a review of patient records revealed a higher proportion of slow-progressing patients who were exposed to NSAIDs. These findings suggest the involvement of PGE2/PDE4 signaling in IPF progression and warrant further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Sanya-Eduarda Kuzet, Cedric Gaggioli
CELL AND TISSUE RESEARCH
(2016)
Article
Oncology
Stephanie Bonan, Jean Albrengues, Eloise Grasset, Sanya-Eduarda Kuzet, Nicolas Nottet, Isabelle Bourget, Thomas Bertero, Bernard Mari, Guerrino Meneguzzi, Cedric Gaggioli
Article
Oncology
Eloise M. Grasset, Thomas Bertero, Alexandre Bozec, Jonas Friard, Isabelle Bourget, Sabrina Pisano, Margaux Lecacheur, Majdi Maiel, Caroline Bailleux, Alexander Emelyanov, Marius Ilie, Paul Hofman, Guerrino Meneguzzi, Christophe Duranton, Dmitry V. Bulavin, Cedric Gaggioli
Article
Biochemical Research Methods
Regine C. Toelle, Cedric Gaggioli, Joern Dengjel
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Cell Biology
Thomas Bertero, William M. Oldham, Eloise M. Grasset, Isabelle Bourget, Etienne Boulter, Sabrina Pisano, Paul Hofman, Floriant Bellvert, Guerrino Meneguzzi, Dmitry Bulavin, Soline Estrach, Chloe C. Feral, Stephen Y. Chan, Alexandre Bozec, Cedric Gaggioli
Article
Biochemistry & Molecular Biology
Stephanie Torrino, Francois-Rene Roustan, Lisa Kaminski, Thomas Bertero, Sabrina Pisano, Damien Ambrosetti, Maeva Dufies, Jay P. Uhler, Emmanuel Lemichez, Amel Mettouchi, Maeva Gesson, Kathiane Laurent, Cedric Gaggioli, Jean-Francois Michiels, Christophe Lamaze, Frederic Bost, Stephan Clavel
Letter
Dermatology
V. R. Mittapalli, T. Kuehl, S. E. Kuzet, C. Gretzmeier, D. Kiritsi, C. Gaggioli, L. Bruckner-Tuderman, A. Nystroem
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Oncology
Christophe A. Girard, Margaux Lecacheur, Rania Ben Jouira, Ilona Berestjuk, Serena Diazzi, Virginie Prod'homme, Aude Mallavialle, Frederic Larbret, Maeva Gesson, Sebastien Schaub, Sabrina Pisano, Stephane Audebert, Bernard Mari, Cedric Gaggioli, Eleonora Leucci, Jean-Christophe Marine, Marcel Deckert, Sophie Tartare-Deckert
Article
Oncology
Mounir El Mai, Serena Janho dit Hreich, Cedric Gaggioli, Armelle Roisin, Nicole Wagner, Jing Ye, Pierre Jalinot, Julien Cherfils-Vicini, Eric Gilson
Summary: TRF2, upregulated in human cancers, plays a crucial role in both telomere protection and extrinsic effects like angiogenesis and immunosuppression. Two compounds identified through a cell-based screening method, AR-A014418 and alexidine center dot 2HCl, were found to inhibit TRF2's pro-oncogenic properties in vivo. This highlights the potential therapeutic strategy of targeting TRF2 in aggressive tumors.
Article
Medicine, Research & Experimental
Ilona Berestjuk, Margaux Lecacheur, Alexandrine Carminati, Serena Diazzi, Christopher Rovera, Virginie Prod'homme, Mickael Ohanna, Ana Popovic, Aude Mallavialle, Frederic Larbret, Sabrina Pisano, Stephane Audebert, Thierry Passeron, Cedric Gaggioli, Christophe A. Girard, Marcel Deckert, Sophie Tartare-Deckert
Summary: The study reveals that physical and structural signals from fibroblast-derived ECM can cause the antiproliferative responses to BRAF/MEK inhibitors to fail in melanoma. Drug-induced linear clustering of DDR1 and DDR2 mediates ECM-mediated drug resistance. Targeting DDR1 and DDR2 can overcome resistance to BRAF-targeted therapy mediated by ECM.
EMBO MOLECULAR MEDICINE
(2022)
Article
Oncology
Christopher Rovera, Ilona Berestjuk, Margaux Lecacheur, Cassandre Tavernier, Serena Diazzi, Sabrina Pisano, Marie Irondelle, Aude Mallavialle, Jean Albrengues, Cedric Gaggioli, Christophe A. Girard, Thierry Passeron, Marcel Deckert, Sophie Tartare-Deckert, Virginie Prod'homme
Summary: This study found that dedifferentiated melanoma cells have different effects on the contractile properties of lymph node fibroblasts compared to melanocytic cells. Factors secreted by dedifferentiated cells strongly inhibit the contractile forces of fibroblasts, while those secreted by melanocytic cells do not. Furthermore, dedifferentiated melanoma cells also modulate the biomechanical properties of lymph nodes, promoting tumor invasion.
Article
Surgery
Marine Benois, Enora Lecorgne, Radwan Kassir, Marjorie Piche, Virginie Ben Amor, Hichem Chenaitia, Jocelyn Gal, Taycir Skhiri, Jean Gugenheim, Cedric Gaggioli, Imed Ben Amor
Summary: This study aimed to investigate the effects of locally administered MSCs and PRP on leak closure following sleeve gastrectomy (SG) in rats. Anatomopathological examination indicated that the closure of the leak orifice was faster in the experimental group, with significantly increased mucosae renewal and fibrosis score. These findings suggest that PRP and MSCs may accelerate the closure of leaks following SG in rats and could potentially be a new treatment for human gastric leaks.
Article
Oncology
Alexandra Mousset, Enora Lecorgne, Isabelle Bourget, Pascal Lopez, Kitti Jenovai, Julien Cherfils-Vicini, Chloe Dominici, Geraldine Rios, Cedric Girard-Riboulleau, Bodu Liu, David L. Spector, Sidse Ehmsen, Shufang Renault, Caroline Hego, Fatima Mechta-Grigoriou, Francois-Clement Bidard, Mikkel Green Terp, Mikala Egeblad, Cedric Gaggioli, Jean Albrengues
Summary: Metastasis is a major cause of cancer death, often accompanied by therapy resistance. In this study, we discovered that chemotherapy induces neutrophil recruitment and NET formation, leading to reduced therapy response in breast cancer lung metastasis mouse models. We further elucidate that chemotherapy-treated cancer cells secrete IL-1(3, which triggers NET formation. NET-associated proteins, integrin-αv(β3 and matrix metalloproteinase 9, play crucial roles in activating latent TGF-β3 and promoting chemoresistance. Our findings suggest that targeting the IL-1(3-NET-TGF-β3 axis could potentially reduce or prevent chemoresistance in the metastatic setting.
Article
Clinical Neurology
Neringa Jurkute, Michele Bertacchi, Gavin Arno, Chiara Tocco, Ungsoo Samuel Kim, Adam M. Kruszewski, Robert A. Avery, Emma C. Bedoukian, Jinu Han, Sung Jun Ahn, Nikolas Pontikos, James Acheson, Indran Davagnanam, Richard Bowman, Marios Kaliakatsos, Alice Gardham, Emma Wakeling, Ngozi Oluonye, Maddy Ashwin Reddy, Elaine Clark, Elisabeth Rosser, Patrizia Amati-Bonneau, Majida Charif, Guy Lenaers, Isabelle Meunier, Sabine Defoort, Catherine Vincent-Delorme, Anthony G. Robson, Graham E. Holder, Luc Jeanjean, Antonio Martinez-Monseny, Mariona Vidal-Santacana, Chloe Dominici, Cedric Gaggioli, Nadia Giordano, Matteo Caleo, Grant T. Liu, Andrew R. Webster, Michele Studer, Patrick Yu-Wai-Man
Summary: Pathogenic NR2F1 variants cause a rare autosomal dominant neurodevelopmental disorder, contributing to visual impairment due to abnormal retinal and optic nerve head development. The study suggests NR2F1 as a major gene orchestrating early retinal and optic nerve head development, playing a key role in the maturation of the visual system.
BRAIN COMMUNICATIONS
(2021)
Article
Oncology
Thomas Bertero, Cedric Gaggioli
MOLECULAR & CELLULAR ONCOLOGY
(2019)
