Investigating Saccharomyces cerevisiae alkene reductase OYE 3 by substrate profiling, X-ray crystallography and computational methods

Nazarov cyclization of divinyl ketones bearing an ester group at the β-position: a remarkable effect of α-substitution and alkene geometry on regioselectivity

(2016) Gangarajula Sudhakar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Applications of protein engineering to members of the old yellow enzyme family

(2015) Erica D. Amato et al.   BIOTECHNOLOGY ADVANCES

An Engineered Old Yellow Enzyme that Enables Efficient Synthesis of (4R,6R)-Actinol in a One-Pot Reduction System

(2015) Shoichiro Horita et al.   CHEMBIOCHEM

Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning

(2015) Chad W. Hopkins et al.   Journal of Chemical Theory and Computation

Structural and Functional Consequences of Circular Permutation on the Active Site of Old Yellow Enzyme

(2015) Ashley B. Daugherty et al.   ACS Catalysis

Pichia stipitis OYE 2.6 variants with improved catalytic efficiencies from site-saturation mutagenesis libraries

(2014) Athéna Patterson-Orazem et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New developments in ‘ene’-reductase catalysed biological hydrogenations

(2014) Helen S Toogood et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Library construction and evaluation for site saturation mutagenesis

(2013) Bradford Sullivan et al.   ENZYME AND MICROBIAL TECHNOLOGY

Unusual reactions mediated by FMN-dependent ene- and nitro-reductases

(2013) Katharina Durchschein et al.   GREEN CHEMISTRY

Improved Biocatalysts from a Synthetic Circular Permutation Library of the Flavin-Dependent Oxidoreductase Old Yellow Enzyme

(2013) Ashley B. Daugherty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate scope and synthetic applications of the enantioselective reduction of α-alkyl-β-arylenones mediated by Old Yellow Enzymes

(2013) Elisabetta Brenna et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Iron-Catalyzed Aerobic Oxidation of Allylic Alcohols: The Issue of C═C Bond Isomerization

(2013) Jinxian Liu et al.   ORGANIC LETTERS

X-ray Crystallography Reveals How Subtle Changes Control the Orientation of Substrate Binding in an Alkene Reductase

(2013) Yuri A. Pompeu et al.   ACS Catalysis

Old Yellow Enzyme-mediated reduction of β-cyano-α,β-unsaturated esters for the synthesis of chiral building blocks: stereochemical analysis of the reaction

(2013) Elisabetta Brenna et al.   Catalysis Science & Technology

Structural and Catalytic Characterization of Pichia stipitis OYE 2.6, a Useful Biocatalyst for Asymmetric Alkene Reductions

(2012) Yuri A. Pompeu et al.   ADVANCED SYNTHESIS & CATALYSIS

Crystal Structure Determination and Mutagenesis Analysis of the Ene Reductase NCR

(2012) Sabrina Reich et al.   CHEMBIOCHEM

A Substrate-Driven Approach to Determine Reactivities of α,β-Unsaturated Carboxylic Esters Towards Asymmetric Bioreduction

(2012) Gábor Tasnádi et al.   CHEMISTRY-A EUROPEAN JOURNAL

SPFP: Speed without compromise—A mixed precision model for GPU accelerated molecular dynamics simulations

(2012) Scott Le Grand et al.   COMPUTER PHYSICS COMMUNICATIONS

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Stereo-Controlled Asymmetric Bioreduction of α,β-Dehydroamino Acid Derivatives

(2011) Clemens Stueckler et al.   ADVANCED SYNTHESIS & CATALYSIS

A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity

(2011) Helen S. Toogood et al.   CHEMBIOCHEM

Enantioenriched Compounds via Enzyme-Catalyzed Redox Reactions

(2011) Mélanie Hall et al.   CHEMICAL REVIEWS

Total Synthesis of Hoiamide C

(2011) Lei Wang et al.   ORGANIC LETTERS

Biocatalytic Reductions of Baylis–Hillman Adducts

(2011) Adam Z. Walton et al.   ACS Catalysis

Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with α,β-unsaturated nitroolefins

(2011) Anna Fryszkowska et al.   Catalysis Science & Technology

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure of a thermostable Old Yellow Enzyme from Thermus scotoductus SA-01

(2010) Diederik J. Opperman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site-Saturated Libraries

(2010) Martyn E. Hulley et al.   CHEMBIOCHEM

Directed Evolution of an Enantioselective Enoate-Reductase: Testing the Utility of Iterative Saturation Mutagenesis

(2009) Despina J. Bougioukou et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalysis with Thermostable Enzymes: Structure and Properties of a Thermophilic ‘ene’-Reductase related to Old Yellow Enzyme

(2009) Björn V. Adalbjörnsson et al.   CHEMBIOCHEM

Bad Seeds Sprout Perilous Dynamics: Stochastic Thermostat Induced Trajectory Synchronization in Biomolecules

(2009) Daniel J. Sindhikara et al.   Journal of Chemical Theory and Computation

Asymmetric Bioreduction of Activated C=C Bonds UsingZymomonas mobilis NCR Enoate Reductase and Old Yellow Enzymes OYE 1–3 from Yeasts

(2008) Mélanie Hall et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY