期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 7, 期 1, 页码 87-90出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.arabjc.2013.07.057
关键词
Atorvastatin; Salting out assisted solvent extraction; Clean up; Preconcentration; Serum
A simple and rapid technique based on salting out assisted solvent extraction was developed for extraction of atorvastatin from serum sample and high performance liquid chromatography-UV was used for its detection. In the present study, 1.0 mL serum was extracted by 0.5 mL of acetonitrile and some parameters that can affect extraction such as type and volume of extraction solvent, type of salt, and pH were optimized. Under optimized experimental conditions, the calibration curve was found to be linear in the range of 0.001-10 ng mL(-1) in human serum and the correlation coefficient (R-2) and the limits of detection were >0.99 and 0.0005 ng mL(-1), respectively. The accuracy of the method in terms of average recovery of the compound in spiked serum and water samples was better than 90%. (C) 2013 Production and hosting by Elsevier B. V. on behalf of King Saud University.
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