Article
Biochemistry & Molecular Biology
Leonid Serebreni, Lisa-Marie Pleyer, Vanja Haberle, Oliver Hendy, Anna Vlasova, Vincent Loubiere, Filip Nemcko, Katharina Bergauer, Elisabeth Roitinger, Karl Mechtler, Alexander Stark
Summary: Different classes of promoters have distinct mechanisms of transcription initiation, resulting in either focused or dispersed initiation patterns.
Article
Microbiology
Kristina Kovacikova, Marina Gorostiola Gonzalez, Rhian Jones, Juan Reguera, Alba Gigante, Maria-Jesus Perez-Perez, Gerhard Puerstinger, Julia Moesslacher, Thierry Langer, Lak Shin Jeong, Leen Delang, Johan Neyts, Eric J. Snijder, Gerard J. P. van Westen, Martijn J. van Hemert
Summary: This study compared the antiviral efficacy of nsP1 inhibitors and found that CHVB and MADTP series had similar modes of action while differing from the FHNA series. Molecular-docking studies revealed the binding sites and potential actions of different series of inhibitors within the nsP1 structure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biology
Jonathon Alexis Coates, Elliot Brooks, Amy Louise Brittle, Emma Louise Armitage, Martin Peter Zeidler, Iwan Robert Evans
Summary: Vertebrate macrophages are highly heterogeneous, and recent studies have revealed the presence of subpopulations within Drosophila plasmatocytes, showing functional differences and varying in abundance across development. Enhancer analysis identified candidate genes regulating plasmatocyte behavior and exposure to increased apoptotic cell death levels modulated subpopulation cell numbers. These findings demonstrate macrophage heterogeneity in Drosophila and provide insights into subpopulation specification and function.
Article
Immunology
Shoumo Bhattacharya, Patricia Anne Nuttall
Summary: Chemokines play a key role in leucocyte migration during injury or infection, and tick saliva contains proteins which can neutralize these functions. Evasins can be classified into two functional classes, A and B, with specific binding preferences for CC- or CXC- chemokines. Through biochemical analysis and phylogenetic studies of various tick species, it was found that A1 evasins are predominantly present in Metastriate ticks, while A2 evasins are mainly found in Prostriate ticks, and class B evasins are present in both lineages. Evasins show specificity in binding either CC- or CXC-chemokines, depending on the tick species.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Construction & Building Technology
E. Yazhini, R. Chithra
Summary: This study focuses on the development and performance examination of Functionally Graded Concrete (FGC) in concrete pipes. FGC is made by varying the material composition, resulting in changes in the overall behavior of structures. The study uses micro steel fiber and basalt fiber to create functional gradation. The mechanical performance of the fiber reinforced concrete is studied with different volumetric fractions, and the optimal FGC is used to cast functionally graded concrete pipes (FGCP) and analyze their performance.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Cell Biology
Mark A. Landy, Megan Goyal, Katherine M. Casey, Chen Liu, Helen C. Lai
Summary: The transcription factor Prdm12 plays a crucial role in nociceptor neurogenesis, with mutations causing congenital insensitivity to pain. While constitutive loss of Prdm12 affects proliferation during sensory neurogenesis, adult knockout in dorsal root ganglia (DRGs) shows dispensability for most pain-sensation and injury-induced hypersensitivity. Transcriptomic analysis suggests that PRDM12 acts as a transcriptional activator in adulthood, highlighting its changing function over developmental time.
Article
Biology
Shivathmihai Nagappan, Kevin M. Franks
Summary: The study found that semilunar (SL) and superficial pyramidal (PYR) neurons play different roles in odor processing in the olfactory cortex, with SLs receiving and integrating olfactory bulb input, and PYRs transforming and transmitting this input.
Article
Multidisciplinary Sciences
Kevin J. Selva, Carolien E. van de Sandt, Melissa M. Lemke, Christina Y. Lee, Suzanne K. Shoffner, Brendon Y. Chua, Samantha K. Davis, Thi H. O. Nguyen, Louise C. Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C. Jackson, Katie L. Flanagan, Jane Crowe, Shidan Tosif, Melanie R. Neeland, Philip Sutton, Paul Licciardi, Nigel W. Crawford, Allen C. Cheng, Denise L. Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran, Daniel Watterson, Paul Young, Wen Shi Lee, Bruce D. Wines, P. Mark Hogarth, Robyn Esterbauer, Hannah G. Kelly, Hyon-Xhi Tan, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Kelly B. Arnold, Katherine Kedzierska, Amy W. Chung
Summary: The study reveals that elderly individuals have higher levels of cross-reactive antibodies before the COVID-19 pandemic, while children have fewer exposures to coronaviruses before the emergence of the virus, resulting in less-experienced but stronger humoral immunity. Age-dependent analysis in COVID-19 patients shows elevated class-switched antibodies in the elderly and stronger Fc responses in children.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Aleksandar I. Mihajlovic, Jenna Haverfield, Greg FitzHarris
Summary: This study reveals two mechanistically distinct classes of chromosome motion in lagging chromosomes in mouse oocytes, with class-I laggards being more likely to lead to aneuploidy while class-II laggards are relatively benign. Controlled prolongation of meiosis I can reduce class-I lagging, thus preventing aneuploidy formation. Manipulating the cell cycle could potentially increase the yield of useful oocytes in some contexts.
DEVELOPMENTAL CELL
(2021)
Article
Biology
Leo Delalandre, Pierre Gauzere, Wilfried Thuiller, Marc Cadotte, Nicolas Mouquet, David Mouillot, Francois Munoz, Pierre Denelle, Nicolas Loiseau, Xavier Morin, Cyrille Violle
Summary: This study investigates the impact of species with functional distinctiveness on ecosystem productivity. The findings suggest that under harsh environmental conditions, the loss of distinct species leads to a long-term decrease in ecosystem productivity. On the other hand, productivity is more dependent on ordinary species in milder environments.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yani Arhab, Anna Miscicka, Tatyana Pestova, Christopher U. T. Hellen
Summary: Unlike Picornaviridae members, which have long 5 ' untranslated regions (5 'UTRs) with internal ribosomal entry sites (IRESs), Caliciviridae members typically have short 5 'UTRs and translation initiation is mediated by the interaction between the viral 5 ' terminal genome-linked protein (VPg) and eIF4F subunits instead of IRES. However, it was unexpected to find calicivirus genomes with unusually long 5 'UTRs, prompting a detailed examination. Sequence analysis and structural modeling revealed that these atypically long 5 ' UTRs of Caliciviridae isolates contain picornavirus-like type 2 IRESs, offering evidence for a common evolutionary origin between calicivirus and picornavirus IRESs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Anesthesiology
Cathrin Flauaus, Patrick Engel, Fangyuan Zhou, Jonas Petersen, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui Lu
Summary: This study reveals that Slick is involved in modulating heat-induced pain in sensory neurons, while it inhibits capsaicin-induced pain but facilitates somatostatin-induced itch in spinal cord interneurons.
Article
Multidisciplinary Sciences
Chinweike N. Asogwa, Changjiu Zhao, Brandon J. Polzin, Alyse N. Maksimoski, Sarah A. Heimovics, Lauren V. Riters
Summary: This study provides evidence that distinct regions within the periaqueductal gray (PAG) in songbirds may context-specifically regulate song, agonistic, and courtship behaviors. The findings also suggest that inputs to the PAG from subregions of the medial preoptic nucleus may contribute to song and behaviors indicative of social dominance. These results highlight the role of PAG and its inputs in context-specific vocal and social behaviors.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Neurosciences
Nasim Biglari, Isabella Gaziano, Jonas Schumacher, Jan Radermacher, Lars Paeger, Paul Klemm, Weiyi Chen, Svenja Corneliussen, Claudia M. Wunderlich, Michael Sue, Stefan Vollmar, Tim Kloeckener, Tamara Sotelo-Hitschfeld, Amin Abbasloo, Frank Edenhofer, Frank Reimann, Fiona M. Gribble, Henning Fenselau, Peter Kloppenburg, Frank T. Wunderlich, Jens C. Bruening
Summary: Biglari et al. discovered distinct subgroups of POMC neurons in the arcuate nucleus, each with unique molecular signatures and regulatory functions in feeding, revealing new insights into body weight control mechanisms.
NATURE NEUROSCIENCE
(2021)
Letter
Dermatology
Hao-Jui Weng, Tsen-Fang Tsai
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2017)
Review
Cell Biology
Jing Xie, Matthew Wooten, Vuong Tran, Xin Chen
TRENDS IN CELL BIOLOGY
(2017)
Letter
Dermatology
H. -J. Weng, T. -S. Wang, T. -F Tsai
BRITISH JOURNAL OF DERMATOLOGY
(2018)
Letter
Dermatology
Hao-Jui Weng, Ko-Jen Li, Tsen-Fang Tsai
DERMATOLOGICA SINICA
(2018)
Article
Biochemistry & Molecular Biology
Matthew Wooten, Jonathan Snedeker, Zehra F. Nizami, Xinxing Yang, Rajesh Ranjanl, Elizabeth Urban, Jee Min Kim, Joseph Gall, Jie Xiao, Xin Chen
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2019)
Article
Biochemical Research Methods
Matthew Wooten, Yingying Li, Jonathan Snedeker, Zehra F. Nizami, Joseph G. Gall, Xin Chen
Review
Genetics & Heredity
Matthew Wooten, Rajesh Ranjan, Xin Chen
TRENDS IN GENETICS
(2020)
Article
Cell Biology
Matthew E. Hurlock, Ivana Cavka, Lisa E. Kursel, Jocelyn Haversat, Matthew Wooten, Zehra Nizami, Rashi Turniansky, Philipp Hoess, Jonas Ries, Joseph G. Gall, Ofer Rog, Simone Koehler, Yumi Kim
JOURNAL OF CELL BIOLOGY
(2020)
Article
Medicine, General & Internal
Hao-Jui Weng, Ming-Hsiung Shih, Tsen-Fang Tsai, Yi-Chun Song, Yi-Chin Pan, Jia-Yu Hu, Rosaline Chung-Yee Hui, Wan-Ruoh Lee, Yu-Huei Huang, Su-Hsun Liu
Summary: The Chinese version of the Eppendorf Itch Questionnaire (EIQ) has been validated for use in adult patients with chronic itch in outpatient settings. The questionnaire demonstrated good reliability and validity, with patients showing different responses to itch across various dermatoses. The multi-scale EIQ index was found to be more effective in distinguishing eczema-related itch from psoriasis or xerosis-related itch than the visual analogue scale alone.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Review
Cell Biology
James Meixiong, Xinzhong Dong, Hao-Jui Weng
Review
Genetics & Heredity
H. J. Weng, T. F. Tsai
Summary: ABCB1 is a crucial protein in skin that is involved in drug transport and treatment responsiveness. It is also associated with the pathogenesis of several dermatoses, warranting further investigation into its roles in dermatology.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Environmental Sciences
Lo-Yun Chen, Bo-Rong Peng, Guan-Yi Lai, Hao-Jui Weng, Mohamed El-Shazly, Chun-Han Su, Jui-Hsin Su, Ping-Jyun Sung, Chung-Ping Liao, Kuei-Hung Lai
Summary: In-depth analysis of metabolomics diversity of marine species through advanced mass spectrometric analysis reveals the potential of sponge-derived scalaranes as therapeutic agents for neurofibromas.
FRONTIERS IN MARINE SCIENCE
(2022)
Review
Chemistry, Medicinal
Hao-Jui Weng, Quoc Thao Trang Pham, Chia-Wei Chang, Tsen-Fang Tsai
Summary: Pain and itch are important manifestations of various disorders and share mediators and neural circuitry. Concurrent treatment for pain and itch is significant.
Article
Dermatology
Chen-Yun Yeh, Sheng-Han Su, Yeh Fong Tan, Tsen-Fang Tsai, Pi -Hui Liang, Musin Kelel, Hao-Jui Weng, Yu -Ping Hsiao, Chun-Hao Lu, Ching -Hui Tsai, Chih-Hung Lee, Bjoern E. Clausen, Fu -Tong Liu, Yungling Leo Lee
Summary: Psoriasis is an inflammatory autoimmune dermatosis mediated by IL-23/IL-17, and UVB may suppress immunity and improve symptoms. One mechanism of UVB therapy involves the production of cis-urocanic acid (cis-UCA) by keratinocytes. This study found that FLG expression and serum cis-UCA levels were lower in psoriasis patients compared to healthy controls. It was also observed that cis-UCA inhibited psoriasiform inflammation by reducing Vg4+ gdT17 cells in mouse skin and lymph nodes. Additionally, cis-UCA induced PD-L1 expression on Langerhans cells, leading to suppressed proliferation and migration of gdT-cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
Hao-Jui Weng, Yi-Hua Liao, Pei-Jung Lin, Jau-Shiuh Chen, Yu-Ping Cheng, Woan-Ruoh Lee, Shiou-Hwa Jee
DERMATOLOGICA SINICA
(2021)