标题
EZH2 as a potential target in cancer therapy
作者
关键词
-
出版物
Epigenomics
Volume 6, Issue 3, Pages 341-351
出版商
Future Medicine Ltd
发表日期
2014-08-11
DOI
10.2217/epi.14.23
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis
- (2015) Oncotarget
- EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity
- (2013) J. Yan et al. BLOOD
- EZH2 mutations are frequent and represent an early event in follicular lymphoma
- (2013) C. Bodor et al. BLOOD
- EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
- (2013) Wendy Béguelin et al. CANCER CELL
- Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
- (2013) Eunhee Kim et al. CANCER CELL
- EZH2andCD79Bmutational status over time in B-cell non-Hodgkin lymphomas detected by high-throughput sequencing using minimal samples
- (2013) Mauro Ajaj Saieg et al. CANCER CYTOPATHOLOGY
- Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma
- (2013) A. Natsume et al. CANCER RESEARCH
- Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition
- (2013) Michael Amatangelo et al. CELL CYCLE
- Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth
- (2013) Shivani Garapaty-Rao et al. CHEMISTRY & BIOLOGY
- Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity
- (2013) Karin J. Ferrari et al. MOLECULAR CELL
- Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer
- (2013) Woojin Kim et al. Nature Chemical Biology
- The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers
- (2013) A. Hunter Shain et al. PLoS One
- Genetic heterogeneity of diffuse large B-cell lymphoma
- (2013) Jenny Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
- (2013) S. K. Knutson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
- (2013) Teruyuki Sato et al. Scientific Reports
- A Landscape of Driver Mutations in Melanoma
- (2012) Eran Hodis et al. CELL
- A687V EZH2 is a gain-of-function mutation found in lymphoma patients
- (2012) Christina R. Majer et al. FEBS LETTERS
- A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
- (2012) C. Simon et al. GENES & DEVELOPMENT
- Identification of Somatic Mutations in Parathyroid Tumors Using Whole-Exome Sequencing
- (2012) M. Kyle Cromer et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers
- (2012) Ryan S. Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- A somatic EZH2 mutation in childhood acute myeloid leukemia
- (2012) T Ernst et al. LEUKEMIA
- SMARCB1 protein and mRNA loss is not caused by promoter and histone hypermethylation in epithelioid sarcoma
- (2012) Gergő Papp et al. MODERN PATHOLOGY
- Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes
- (2012) Karolina Holm et al. Molecular Oncology
- Chromatin-modifying enzymes as modulators of reprogramming
- (2012) Tamer T. Onder et al. NATURE
- Novel mutations target distinct subgroups of medulloblastoma
- (2012) Giles Robinson et al. NATURE
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- (2012) Michael Krauthammer et al. NATURE GENETICS
- Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
- (2012) Panagiotis Ntziachristos et al. NATURE MEDICINE
- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
- (2012) M. T. McCabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
- (2012) J. G. Lohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
- (2012) K. Xu et al. SCIENCE
- Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
- (2012) Sharad K. Verma et al. ACS Medicinal Chemistry Letters
- PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins
- (2011) Muhammad Zoabi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
- (2011) A. M. Jankowska et al. BLOOD
- Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
- (2011) J. Score et al. BLOOD
- MiR-26a Inhibits Cell Growth and Tumorigenesis of Nasopharyngeal Carcinoma through Repression of EZH2
- (2011) J. Lu et al. CANCER RESEARCH
- Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
- (2011) Masashi Takawa et al. CANCER SCIENCE
- Deregulated expression of miR-26a and Ezh2 in Rhabdomyosarcoma
- (2011) Roberta Ciarapica et al. CELL CYCLE
- The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
- (2011) Tim J. Wigle et al. FEBS LETTERS
- Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy
- (2011) D. Sasaki et al. HAEMATOLOGICA
- EZH2 Y641 mutations in follicular lymphoma
- (2011) C Bödör et al. LEUKEMIA
- Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
- (2011) O Abdel-Wahab et al. LEUKEMIA
- Ovarian Cancer Stem Cell-Like Side Populations Are Enriched Following Chemotherapy and Overexpress EZH2
- (2011) S. Rizzo et al. MOLECULAR CANCER THERAPEUTICS
- Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
- (2011) Ryan D. Morin et al. NATURE
- Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
- (2011) Yaoting Gui et al. NATURE GENETICS
- Down-Regulation of miR-101 in Endothelial Cells Promotes Blood Vessel Formation through Reduced Repression of EZH2
- (2011) Michiel Smits et al. PLoS One
- EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas
- (2011) Russell J. H. Ryan et al. PLoS One
- Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101 and miR-98
- (2011) N M Alajez et al. Cell Death & Disease
- Temporal Dissection of Tumorigenesis in Primary Cancers
- (2011) Steffen Durinck et al. Cancer Discovery
- EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
- (2010) I. Velichutina et al. BLOOD
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma
- (2010) Nina Wagener et al. BMC CANCER
- Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation
- (2010) Boris G. Wilson et al. CANCER CELL
- Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer
- (2010) B. Zhang et al. CARCINOGENESIS
- Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets
- (2010) Samantha Gadd et al. LABORATORY INVESTIGATION
- Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
- (2010) H Makishima et al. LEUKEMIA
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
- (2010) C. J. Sneeringer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2
- (2009) J. M. Friedman et al. CANCER RESEARCH
- DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
- (2009) T. B. Miranda et al. MOLECULAR CANCER THERAPEUTICS
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo
- (2008) K. Sarma et al. MOLECULAR AND CELLULAR BIOLOGY
- Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
- (2008) S. Varambally et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started