Article
Computer Science, Interdisciplinary Applications
Maxwell Salvatore, Lauren J. Beesley, Lars G. Fritsche, David Hanauer, Xu Shi, Alison M. Mondul, Celeste Leigh Pearce, Bhramar Mukherjee
Summary: This study developed a summary risk score (PheRS) from electronic health records (EHR) data to identify individuals at high-risk for pancreatic cancer. PheRS demonstrated independent predictive value and effectively assisted in prediction in a joint model.
JOURNAL OF BIOMEDICAL INFORMATICS
(2021)
Article
Health Care Sciences & Services
Brianne Molloy-Paolillo, David Mohr, Deborah R. Levy, Sarah L. Cutrona, Ekaterina Anderson, Justin Rucci, Christian Helfrich, George Sayre, Seppo T. Rinne
Summary: The study examined EHR usability and uptake at a VA site transitioning to a new EHR system, finding that EHR use metrics improved over time, yet healthcare workers expressed ongoing concerns about usability and inefficiencies up to a year post-transition. The integration of quantitative and qualitative data provided a nuanced understanding of EHR adoption and use patterns during transitions.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Green & Sustainable Science & Technology
Faiza Hashim, Khaled Shuaib, Farag Sallabi
Summary: This study highlights the significance of blockchain technology in healthcare applications and the role of sharding in addressing scalability issues in blockchain networks.
Review
Health Care Sciences & Services
Obinwa Ozonze, Philip J. Scott, Adrian A. Hopgood
Summary: Information systems like EHR systems are prone to data quality issues. There is a growing demand for strategies and tools to ensure the fitness of available data. However, developing reliable tools for data quality assessment remains a challenge.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Article
Health Care Sciences & Services
Jessica S. Ancker, J. Travis Gossey, Sarah Nosal, Chenghuiyun Xu, Samprit Banerjee, Yuming Wang, Yulia Veras, Hannah Mitchell, Yuhua Bao
Summary: The study examined the impact of an EHR prescribing redesign on opioid prescribing choices and keystrokes. Findings indicated that autocompleting prescription forms with guideline-recommended values significantly increased guideline concordance in one organization with low baseline concordance, but not in another with already high concordance. However, the redesign led to a significant reduction in total keystrokes needed for order placement, which has important implications for reducing EHR-related stress.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Review
Biology
Martin Chapman, Shahzad Mumtaz, Luke Rasmussen, Andreas Karwath, Georgios Gkoutos, Chuang Gao, Dan Thayer, Jennifer A. Pacheco, Helen Parkinson, Rachel L. Richesson, Emily Jefferson, Spiros Denaxas, Vasa Curcin
Summary: This study presents a set of desiderata for the design of a next-generation phenotype library that aims to ensure the quality of hosted definitions by combining functionality currently offered by disparate tooling. Researchers examined phenotype models, implementation, validation, and contemporary phenotype libraries, resulting in 14 library desiderata that promote high-quality phenotype definitions.
Article
Health Care Sciences & Services
Erik J. Zhang, Heng Tan, Joseph A. Sanford, James D. Michelson, Brian M. Waldschmidt, Mitchell H. Tsai
Summary: This article reviews the historical problems and limitations of the electronic health record (EHR) and proposes using agile processes and redesigning the EHR. In the future, EHR should be redesigned using a middle-out framework and empowering dual-type champions to achieve sustainable diffusion of innovations.
JOURNAL OF MEDICAL SYSTEMS
(2022)
Article
Plant Sciences
Yong Jiang, Stephan Weise, Andreas Graner, Jochen C. Reif
Summary: Genome-wide predictions have high precision in predicting both unordered categorical traits and quantitative traits in barley collection, enhancing the information available for genotyped but not phenotyped accessions. Deeply phenotyped core collections are a promising training population for calibrating genome-wide prediction models, ultimately contributing to the attractiveness and evolution of gene banks as bio-digital resource centers.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Computer Science, Interdisciplinary Applications
Mark S. Pfaff, Ozgur Eris, Charlene Weir, Amanda Anganes, Tina Crotty, Mohammad Rahman, Merry Ward, Jonathan R. Nebeker
Summary: This study aimed to understand the cognitive demands clinicians face when using an EHR system and identify expert clinicians' cues and strategies for managing those demands. Through cognitive task analysis, 145 unique cognitive demands of using an EHR were revealed and categorized into 22 themes across seven categories. The study found that EHR systems may not support clinicians in developing overall awareness, reasoning about patients' states and potential treatments, and working collaboratively.
JOURNAL OF BIOMEDICAL INFORMATICS
(2021)
Article
Computer Science, Information Systems
Ebtsam Adel, Shaker El-Sappagh, Sherif Barakat, Jong-Wan Hu, Mohammed Elmogy
Summary: This paper proposes a fuzzy ontology-based semantic interoperability framework for distributed EHR systems, addressing the issue of querying EHR data. By creating separate standard ontologies and merging them into a unified ontology, and then extending the crisp ontology into a fuzzy one, the system is able to handle vague queries effectively. The resulting ontology is tested with real datasets and proves useful for accurate data querying by physicians.
Article
Genetics & Heredity
Kelsey S. Lau-Min, Danielle McKenna, Stephanie Byers Asher, Tanya Bardakjian, Colin Wollack, Joseph Bleznuck, Daniel Biros, Arravinth Anantharajah, Dana F. Clark, Courtney Condit, Jessica E. Ebrahimzadeh, Jessica M. Long, Jacquelyn Powers, Anna Raper, Anna Schoenbaum, Michael Feldman, Lauren Steinfeld, Sony Tuteja, Christine VanZandbergen, Susan M. Domchek, Marylyn D. Ritchie, Jeffrey Landgraf, Jessica Chen, Katherine L. Nathanson
Summary: This study describes the successful integration of genetic testing orders and results with discrete genetic data in the electronic health record (EHR) through the PennChart Genomics Initiative (PGI) at the University of Pennsylvania. The PGI has collaborated with 4 genetic testing laboratories to create 420 unique computerized genetic testing orders in the EHR. Results show that using the EHR significantly reduces the time spent on ordering and managing genetic results compared to using online laboratory-specific portals. Key informant interviews highlight the importance of multidisciplinary collaboration and institutional buy-in for the success of the PGI's efforts to integrate genomic medicine into the EHR.
GENETICS IN MEDICINE
(2022)
Review
Health Care Sciences & Services
Dominik Ose, Emmanuel Adediran, Robert Owens, Elena Gardner, Matthew Mervis, Cindy Turner, Emily Carlson, Danielle Forbes, Caitlyn Lydia Jasumback, John Stuligross, Susan Pohl, Bernadette Kiraly
Summary: This review examines the role of electronic health records (EHR) in supporting interventions in primary care to strengthen hypertension management for racial and ethnic minoritized groups in the United States.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Medicine, General & Internal
Ting-Yuan Liu, Wen-Ling Liao, Tzu-Yuan Wang, Chia-Jung Chan, Jan-Gowth Chang, Yu-Chia Chen, Hsing-Fang Lu, Hsien-Hui Yang, Shih-Yin Chen, Fuu-Jen Tsai
Summary: This study conducted a genome-wide analysis of hyperthyroidism in a cohort of 35,009 patients in Taiwan using electronic medical record-derived phenotypes and genotype information. The researchers identified 44 novel genomic risk markers in 10 loci and found a strong correlation between hyperthyroidism patients with thyroid storm and stroke.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Ravi Jhaveri, Jordan John, Marc Rosenman
Summary: The increasing use of electronic health records (EHR) for clinical care has led to efforts to leverage EHR data for research in the field of infectious diseases. These studies can help identify patients at higher risk for complications or better candidates for treatment. The review discusses the rationale for network projects, opportunities, challenges, and previous studies within the field of infectious diseases.
CLINICAL THERAPEUTICS
(2021)
Article
Computer Science, Information Systems
Aaron Z. Hettinger, Edward R. Melnick, Raj M. Ratwani
Summary: Despite federal requirements for user-centered design in EHR development, there are still usability and safety risks. Four vendors showed improvement in their user-centered design processes and usability testing methods, but need to focus more on safety and benchmarking. Increasing transparency in vendor practices is a positive step forward in addressing EHR usability challenges.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Napatt Kanjanahattakij, Pattara Rattanawong, Parasuram Krishnamoorthy, Benjamin Horn, Pakawat Chongsathidkiet, Veronica Garvia, Prapaipan Putthapiban, Natee Sirinvaravong, Vincent M. Figueredo
Article
Cardiac & Cardiovascular Systems
Bret D. Alvis, Monica Polcz, Jessica H. Huston, Timothy S. Hopper, Phil Leisy, Kelly Mishra, Susan S. Eagle, Colleen M. Brophy, Joann Lindenfeld, Kyle M. Hocking
JOURNAL OF CARDIAC FAILURE
(2020)
Letter
Cardiac & Cardiovascular Systems
Bret D. Alvis, Jessica H. Huston, Joann Lindenfeld, Kyle M. Hocking
JOURNAL OF CARDIAC FAILURE
(2020)
Review
Cardiac & Cardiovascular Systems
Jessica H. Huston, Evan L. Brittain, Ivan M. Robbins
CARDIOLOGY CLINICS
(2020)
Letter
Cardiac & Cardiovascular Systems
Jessica H. Huston, Evan L. Brittain
Article
Cardiac & Cardiovascular Systems
Bret Alvis, Jessica Huston, Jeffery Schmeckpeper, Monica Polcz, Marisa Case, Rene Harder, Jonathan S. Whitfield, Kendall G. Spears, Meghan Breed, Lexie Vaughn, Colleen Brophy, Kyle M. Hocking, Joann Lindenfeld
Summary: Background: Heart failure is a leading cause of hospitalization among the elderly, and it is difficult to predict acute congestion in advance. Noninvasive venous waveform analysis in heart failure (NIVAHF) is a novel technology that can monitor volume status and hemodynamic congestion. This study aimed to assess the correlation between NIVAHF and pulmonary capillary wedge pressure (PCWP), as well as the ability of NIVAHF to predict 30-day hospital admission after right heart catheterization. Methods and Results: The study compared NIVAHF with PCWP in 106 patients undergoing right heart catheterization. The NIVAHF algorithm was developed to estimate PCWP. The study found a positive correlation between NIVAHF score and PCWP, and the NIVAHF score could predict 30-day hospital admission with good accuracy. Conclusions: NIVAHF is a noninvasive monitoring technology that can estimate PCWP and predict the risk of hospital admission within 30 days. This measurement has the potential to guide decongestive therapy and prevent hospital admission in heart failure patients.
JOURNAL OF CARDIAC FAILURE
(2022)
Review
Cardiac & Cardiovascular Systems
Jessica H. Huston, Sanjiv J. Shah
Summary: The development of pulmonary hypertension in patients with heart failure due to left heart disease is common and has adverse prognostic implications. However, there are currently no known specific treatments for this condition. Diagnostic criteria and clinical classification for pulmonary hypertension due to left heart disease are still evolving, posing challenges for researchers. The pathobiology of this condition is not well understood, but factors such as increased wall stress and endothelial dysfunction are believed to contribute to pulmonary vascular remodeling. Further investigation is needed to better understand the drivers of this condition and develop effective prevention and treatment strategies.
CIRCULATION RESEARCH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Parasuram Krishnamoorthy, George Dangas
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Parasuram Krishnamoorthy, Gilbert H. L. Tang
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
John F. Kingrey, Chad E. Miller, Veronica Franco, Jimmy S. Smith, Ronald Zolty, Ronald J. Oudiz, Jean M. Elwing, Jessica H. Huston, Lana Melendres-Groves, Ashwin Ravichandran, Vijay Balasubramanian, Benjamin Wu, Stephanie Hwang, Scott Seaman, Meredith Broderick, Franck F. Rahaghi
Summary: Treprostinil is an effective treatment for pulmonary arterial hypertension and higher doses have been shown to provide greater clinical benefit. The EXPEDITE trial investigated the use of rapid parenteral treprostinil induction to achieve high doses of oral treprostinil in prostacyclin naive patients.
PULMONARY CIRCULATION
(2023)
Article
Cardiac & Cardiovascular Systems
Monica Polcz, Kyle M. Hocking, Devin Chang, Philip Leisy, Jenna H. Sobey, Jessica Huston, Susan Eagle, Colleen Brophy, Bret D. Alvis
JRSM CARDIOVASCULAR DISEASE
(2020)
Article
Cardiac & Cardiovascular Systems
Carlos D. Davila, Saurabh Sharma, Parasuram Krishnamoorthy, Pablo Rengifo-Moreno, Igor F. Palacios, William O'Neill, Navin K. Kapur, Christian F. Witzke
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Jessica Huston, Joyce Johnson, Anna Hemnes, Meredith Pugh
PULMONARY CIRCULATION
(2020)
Article
Respiratory System
Timothy E. Thayer, Shi Huang, Rebecca T. Levinson, Eric Farber-Eger, Tufik R. Assad, Jessica H. Huston, Jonathan D. Mosley, Quinn S. Wells, Evan L. Brittain
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2019)
Article
Medicine, General & Internal
Eric J. Hall, Jonathan Menachem, Lynne Warner Stevenson, Jessica Huston
CASE REPORTS IN MEDICINE
(2020)
